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Search Results: 1 - 10 of 297493 matches for " J. Milli "
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Use of the tumor necrosis factor-blockers for Crohn's disease
Alan BR Thomson,Milli Gupta,Hugh J Freeman
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i35.4823
Abstract: The use of anti-tumor necrosis factor-α therapy for inflammatory bowel disease represents the most important advance in the care of these patients since the publication of the National Co-operative Crohn’s disease study thirty years ago. The recommendations of numerous consensus groups worldwide are now supported by a wealth of clinical trials and several meta-analyses. In general, it is suggested that tumor necrosis factor-α blockers (TNFBs) are indicated (1) for persons with moderately-severe Crohn’s disease or ulcerative colitis (UC) who have failed two or more causes of glucocorticosteroids and an acceptably long cause (8 wk to 12 wk) of an immune modulator such as azathioprine or methotrexate; (2) non-responsive perianal disease; and (3) severe UC not responding to a 3-d to 5-d course of steroids. Once TNFBs have been introduced and the patient is responsive, therapy given by the IV and SC rate must be continued. It remains open to definitive evidence if concomitant immune modulators are required with TNFB maintenance therapy, and when or if TNFB may be weaned and discontinued. The supportive evidence from a single study on the role of early versus later introduction of TNFB in the course of a patient’s illness needs to be confirmed. The risk/benefit profile of TNFB appears to be acceptable as long as the patient is immunized and tested for tuberculosis and viral hepatitis before the initiation of TNFB, and as long as the long-term adverse effects on the development of lymphoma and other tumors do not prone to be problematic. Because the rates of benefits to TNFB are modest from a population perspective and the cost of therapy is very high, the ultimate application of use of TNFBs will likely be established by cost/benefit studies.
High Contrast Imaging of the Close Environment of HD 142527 -
J. Rameau,G. Chauvin,A. -M. Lagrange,P. Thebault,J. Milli,J. H. Girard,M. Bonnefoy
Physics , 2012, DOI: 10.1051/0004-6361/201219736
Abstract: Context. It has long been suggested that circumstellar disks surrounding young stars may be the signposts of planets, and still more since the recent discoveries of embedded substellar companions. The planet-disk interaction may create, according to models, large structures, gaps, rings or spirals, in the disk. In that sense, the Herbig star HD 142527 is particularly compelling as, its massive disk displays intriguing asymmetries that suggest the existence of a dynamical peturber of unknown nature. Aims. Our goal was to obtain deep thermal images of the close circumstellar environment of HD 142527 to re-image the reported close-in structures (cavity, spiral arms) of the disk and to search for stellar and substellar companions that could be connected to their presence. Results. The circumstellar environment of HD 142527 is revealed at an unprecedented spatial resolution down to the sub arcsecond level for the first time at 3.8 microns. Our images reveal important radial and azimuthal asymmetries which invalidate an elliptical shape for the disk as previously proposed. It rather suggests a bright inhomogeneous spiral arm plus various fainter spiral arms. We also confirm an inner cavity down to 30 AU and two important dips at position angles of 0 and 135 deg. The detection performance in angular differential imaging enables the exploration of the planetary mass regime for projected physical separations as close as 40 AU. The use of our detection map together with Monte Carlo simulations sets stringent constraints on the presence of planetary mass, brown dwarf or stellar companions as a function of the semi-major axis. They severely constrain the presence of massive giant planets with semi-major axis beyond 50AU, i.e. probably within the large disk's cavity that radially extends up to 145 AU or even further outside.
An Extreme-AO Search for Giant Planets around a White Dwarf --VLT/SPHERE performance on a faint target GD 50
S. Xu,S. Ertel,Z. Wahhaj,J. Milli,P. Scicluna,G. H. -M. Bertrang
Physics , 2015, DOI: 10.1051/0004-6361/201526179
Abstract: CONTEXT. Little is known about the planetary systems around single white dwarfs although there is strong evidence that they do exist. AIMS. We performed a pilot study with the extreme-AO system on the Spectro-Polarimetric High-contrast Exoplanet REsearch (SPHERE) on the Very Large Telescopes (VLT) to look for giant planets around a young white dwarf, GD 50. METHODS. We were awarded science verification time on the new ESO instrument SPHERE. Observations were made with the InfraRed Dual-band Imager and Spectrograph in classical imaging mode in H band. RESULTS. Despite the faintness of the target (14.2 mag in R band), the AO loop was closed and a strehl of 37\% was reached in H band. No objects were detected around GD 50. We achieved a 5-sigma contrast of 6.2, 8.0 and 8.25 mags at 0{\farcs}2, 0{\farcs}4 and 0{\farcs}6 and beyond, respectively. We exclude any substellar objects more massive than 4.0 M$_\textrm{J}$ at 6.2 AU, 2.9 M$_\textrm{J}$ at 12.4 AU and 2.8 M$_\textrm{J}$ at 18.6 AU and beyond. This rivals the previous upper limit set by Spitzer. We further show that SPHERE is the most promising instrument available to search for close-in substellar objects around nearby white dwarfs.
Impact of angular differential imaging on circumstellar disk images
J. Milli,D. Mouillet,A. M. Lagrange,A. Boccaletti,D. Mawet,G. Chauvin,M. Bonnefoy
Physics , 2012, DOI: 10.1051/0004-6361/201219687
Abstract: Direct imaging of circumstellar disks requires high-contrast and high-resolution techniques. The angular differential imaging (ADI) technique is one of them, initially developed for point-like sources but now increasingly applied to extended objects. This new field of application raises many questions because the disk images reduced with ADI depend strongly on the amplitude of field rotation and the ADI data reduction strategy. Both of them directly affect the disk observable properties. Our aim is to characterize the applicability and biases of some ADI data reduction strategies for different disk morphologies. A particular emphasis is placed on parameters mostly used for disks: their surface brightness, their width for a ring, and local features such as gaps or asymmetries. We first present a general method for predicting and quantifying those biases. In a second step we illustrate them for some widely used ADI algorithms applied to typical debris disk morphologies: inclined rings with various inner/outer slopes and width. Last, our aim is also to propose improvements of classical ADI to limit the biases on extended objects. Simulated disks seen under various observing conditions were used to reduce ADI data and quantify the resulting biases. These conclusions complements previous results from NaCo L' real-disk images of HR4796A. ADI induces flux losses on disks. This makes this technique appropriate only for low- to medium-inclination disks. A theoretical criterion is derived to predict the amount of flux loss for a given disk morphology, and quantitative estimates of the biases are given in some specific configurations. These biases alter the disk observable properties, such as the slopes of their surface brightness or their radial/azimuthal extent. Additionally, this work demonstrates that ADI can very easily create artificial features without involving astrophysical processes.
Religi o, Teologia e Antropologia: o confronto entre Karl Barth e Ludwig Feuerbach (Religion, theology and anthropology: the confrontation between Karl Barth and Ludwig Feuerbach) - DOI: 10.5752/P.2175-5841.2009v7n14p156
Adriani Milli Rodrigues
Horizonte : Revista de Estudos de Teologia e Ciências da Religi?o , 2009, DOI: 10.5752/p.2175-5841.2009v7n14p156
Abstract: Resumo O objetivo deste artigo é sintetizar os principais elementos do confronto entre o pensamento do teólogo reformado Karl Barth e o do filósofo alem o Ludwig Feuerbach com rela o aos temas da religi o, teologia e antropologia, que na abordagem de ambos apresentam conex o direta. Para tanto, este estudo inicia-se com uma panoramica apresenta o feuerbachiana da interpreta o antropológica da teologia e religi o, particularmente a partir de sua obra mais famosa “A Essência do Cristianismo”, que conduz às suas conclus es de ataque à teologia e re-significa o da fun o da religi o. A seguir, a rea o de Barth às idéias de Feuerbach s o contempladas, a partir de sua vis o teológica teocêntrica. Nesse sentido, há a exposi o de duas fases da rea o barthiana ao pensamento de Feuerbach. Na primeira delas Barth apresenta certos elementos de concordancia e aproveitamento das no es feuerbachinas, ao passo que na segunda fase a discordancia é total. Em suas conclus es o artigo aponta que o debate entre Barth e Feuerbach gira em torno da idéia de reducionismo teológico ou religioso, t o presente nos debates epistemológicos dos estudos em Ciências da Religi o. Palavras-chave: Barth; Feuerbach; teologia; religi o; antropologia. Abstract This article aims to summarize the main elements of the confrontation between the reformed theologian Karl Barth’s conception and the German philosopher Ludwig Feuerbach’s thought concerning religion, theology and anthropology, which maintain straight connection in both approaches. For so much, this study begins with a feuerbachian panoramic presentation of the anthropological interpretation of theology and religion, particularly from his most famous work “The Essence of the Christianity”, which leads to his conclusions of attack upon theology and a re-signification of the function of religion. Thereafter, Barth’s reaction to Feuerbach’s ideas is discussed from his theocentric theological perspective. In this sense, there is an exposure of two phases of barthian reaction to Feuerbach. Firstly Barth presents topics of agreement with feuerbachian notions, while in the second phase the disagreement is total. Among the article’s conclusions there is an indication that the Barth-Feuerbach debate deals with religious or theological reductionism, usually present in epistemological discussions on Religious Studies. Key words: Barth; Feuerbach; theology; religion; anthropology.
O diálogo das religi es mundiais em Jürgen Moltmann: uma teologia n o-relativista das religi es
Adriani Milli Rodrigues
Caminhando , 2009,
Abstract: Este artigo procura explorar o pensamento de Jürgen Moltmann com rela o ao diálogo das religi es mundiais. Para isso s o considerados, além de sua análise acerca das influências históricas ocidentais na rela o inter-religiosa, o questionamento que esse autor faz à postura relativista da teologia das religi es em termos do diálogo inter-religioso, como também suas sugest es em rela o às condi es e características de um diálogo adequado. Nesse sentido, há uma ênfase na prática do diálogo indireto, no qual os interlocutores, em vez de discutirem assuntos relativos a si mesmos, abordam quest es práticas que visam promover a vida.
Very deep images of the innermost regions of the beta Pictoris debris disc at Lp
J. Milli,A. -M. Lagrange,D. Mawet,O. Absil,J. -C. Augereau,D. Mouillet,A. Boccaletti,J. H. Girard,G. Chauvin
Physics , 2014, DOI: 10.1051/0004-6361/201323130
Abstract: Very few debris discs have been imaged in scattered light at wavelengths beyond 3 microns because the thermal emission from both the sky and the telescope is generally too strong with respect to the faint emission of a debris disc. We present here the first analysis of a high angular resolution image of the disc of beta Pictoris at 3.8 microns. Our primary objective is to probe the innermost parts of the beta Pictoris debris disc and describe its morphology. We performed extensive forward modelling to correct for the biases induced by angular differential imaging on extended objects and derive the physical parameters of the disc. This work relies on a new analysis of seven archival datasets of beta Pictoris observed with VLT/NaCo in the Lp band, associated with disc forward modelling to correct for the biases induced by that technique. The disc is detected above a 5 sigma level between 0.4" and 3.8". The two extensions have a similar brightness within error bars. We confirm an asymmetry previously observed at larger distances from the star and at shorter wavelengths: the isophotes are more widely spaced on the north-west side (above the disc apparent midplane) than on the south-east side. This is interpreted as a small inclination of the disc combined with anisotropic scattering. Our best-fit model has an inclination of 86 degrees with an anisotropic Henyey- Greenstein coefficient of 0.36. This interpretation is supported by a new asymmetry detected in the disc: the disc is significantly bowed towards the north-west within 3" (above the apparent midplane). We also detect a possible new asymmetry within 1", but at this stage we cannot discern between a real feature and an underlying speckle.
beta Pic b position relative to the Debris Disk
A. -M. Lagrange,A. Boccaletti,J. Milli,G. Chauvin,M. Bonnefoy,D. Mouillet,J. C. Augereau,J. H. Girard,S. Lacour,D. Apai
Physics , 2012, DOI: 10.1051/0004-6361/201118274
Abstract: Context. We detected in 2009 a giant, close-by planet orbiting {\beta} Pic, a young star surrounded with a disk, extensively studied for more than 20 years. We showed that if located on an inclined orbit, the planet could explain several peculiarities of {\beta} Pictoris system. However, the available data did not permit to measure the inclination of {\beta} Pic b with respect to the disk, and in particular to establish in which component of the disk - the main, extended disk or the inner inclined component/disk-, the planet was located. Comparison between the observed planet position and the disk orientation measured on previous imaging data was not an option because of potential biases in the measurements. Aims. Our aim is to measure precisely the planet location with respect to the dust disk using a single high resolution image, and correcting for systematics or errors that degrades the precision of the disk and planet relative position measurements. Methods. We gathered new NaCo data at Ks band, with a set-up optimized to derive simultaneously the orientation(s) of the disk(s) and that of the planet. Results. We show that the projected position of {\beta} Pic b is above the midplane of the main disk. With the current data and knowledge on the system, this implies that {\beta} Pic b cannot be located in the main disk. The data rather suggest the planet being located in the inclined component.
An insight in the surroundings of HR4796
A. -M. Lagrange,J. Milli,A. Boccaletti,S. Lacour,P. Thebault,G. Chauvin,D. Mouillet,J. C. Augereau,M. Bonnefoy,D. Ehrenreich,Q. Kral
Physics , 2012, DOI: 10.1051/0004-6361/201219187
Abstract: HR4796 is a young, early A-type star harbouring a well structured debris disk, shaped as a ring with sharp inner edges. It forms with the M-type star HR4796B a binary system, with a proj. sep. ~560 AU. Our aim is to explore the surroundings of HR4796A and B, both in terms of extended or point-like structures. Adaptive optics images at L'-band were obtained with NaCo in Angular Differential Mode and with Sparse Aperture Masking (SAM). We analyse the data as well as the artefacts that can be produced by ADI reduction on an extended structure with a shape similar to that of HR4796A dust ring. We determine constraints on the presence of companions using SAM and ADI on HR4796A, and ADI on HR4796B. We also performed dynamical simulations of a disk of planetesimals and dust produced by collisions, perturbed by a planet located close to the disk outer edge. The disk ring around HR4796A is well resolved. We highlight the potential effects of ADI reduction of the observed disk shape and surface brightness distribution, and side-to-side asymmetries. No planet is detected around the star, with masses as low as 3.5 M_Jup at 0.5" (58 AU) and less than 3 M_Jup in the 0.8-1" range along the semi-major axis. We exclude massive brown dwarfs at separations as close as 60 mas (4.5 AU) from the star thanks to SAM data. The detection limits obtained allow us to exclude a possible close companion to HR4796A as the origin of the offset of the ring center with respect to the star; they also allow to put interesting constraints on the (mass, separation) of any planet possibly responsible for the inner disk steep edge. Using detailed dynamical simulations, we show that a giant planet orbiting outside the ring could sharpen the disk outer edge and reproduce the STIS images published by Schneider et al. (2009).
Direct exoplanet detection and characterization using the ANDROMEDA method: Performance on VLT/NaCo data
F. Cantalloube,D. Mouillet,L. M. Mugnier,J. Milli,O. Absil,C. A. Gomez Gonzalez,G. Chauvin,J. -L Beuzit,A. Cornia
Physics , 2015, DOI: 10.1051/0004-6361/201425571
Abstract: Context. The direct detection of exoplanets with high-contrast imaging requires advanced data processing methods to disentangle potential planetary signals from bright quasi-static speckles. Among them, angular differential imaging (ADI) permits potential planetary signals with a known rotation rate to be separated from instrumental speckles that are either statics or slowly variable. The method presented in this paper, called ANDROMEDA for ANgular Differential OptiMal Exoplanet Detection Algorithm is based on a maximum likelihood approach to ADI and is used to estimate the position and the flux of any point source present in the field of view. Aims. In order to optimize and experimentally validate this previously proposed method, we applied ANDROMEDA to real VLT/NaCo data. In addition to its pure detection capability, we investigated the possibility of defining simple and efficient criteria for automatic point source extraction able to support the processing of large surveys. Methods. To assess the performance of the method, we applied ANDROMEDA on VLT/NaCo data of TYC-8979-1683-1 which is surrounded by numerous bright stars and on which we added synthetic planets of known position and flux in the field. In order to accommodate the real data properties, it was necessary to develop additional pre-processing and post-processing steps to the initially proposed algorithm. We then investigated its skill in the challenging case of a well-known target, $\beta$ Pictoris, whose companion is close to the detection limit and we compared our results to those obtained by another method based on principal component analysis (PCA). Results. Application on VLT/NaCo data demonstrates the ability of ANDROMEDA to automatically detect and characterize point sources present in the image field. We end up with a robust method bringing consistent results with a sensitivity similar to the recently published algorithms, with only two parameters to be fine tuned. Moreover, the companion flux estimates are not biased by the algorithm parameters and do not require a posteriori corrections. Conclusions. ANDROMEDA is an attractive alternative to current standard image processing methods that can be readily applied to on-sky data.
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