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Search Results: 1 - 10 of 297497 matches for " J. Maricic "
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SiPMs characterization and selection for the DUNE far detector photon detection system
Yujing Sun,Jelena Maricic
Physics , 2015,
Abstract: The Deep Underground Neutrino Experiment (DUNE) together with the Long Baseline Neutrino Facility (LBNF) hosted at the Fermilab will provide a unique, world-leading program for the exploration of key questions at the forefront of neutrino physics and astrophysics. CP violation in neutrino flavor mixing is one of its most important potential discoveries. Additionally, the experiment will determine the neutrino mass hierarchy and precisely measure the neutrino mixing parameters which may potentially reveal new fundamental symmetries of nature. Moreover, the DUNE is also designed for the observation of nucleon decay and supernova burst neutrinos. The photon detection (PD) system in the DUNE far detector provides trigger for cosmic backgrounds, enhances supernova burst trigger efficiency and improves the energy resolution of the detector. The DUNE adopts the technology of liquid argon time projection chamber (LArTPC) that requires the PD sensors, silicon photomultipliers (SiPM), to be carefully chosen to not only work properly in cryostat, but also meet certain specifications for the life of the experiment. A comprehensive testing of SiPMs in cryostat is necessary since the datasheet provided by the manufactures in the market does not cover this temperature regime. This paper gives the detailed characterization results of SenSL C-Series 60035 SiPMs, including gain, dark count rate (DCR), cross-talk and after-pulse rate. Characteristic studies on SiPMs from other vendors are also discussed in order to avoid any potential problems associated with using a single source. Moreover, the results of the ongoing mechanical durability tests are shown for the current candidate, SenSL B/C-Series 60035 SiPMs.
Earth Radioactivity Measurements with a Deep Ocean Anti-neutrino Observatory
S. T. Dye,E. Guillian,J. G. Learned,J. Maricic,S. Matsuno,S. Pakvasa,G. Varner,M. Wilcox
Physics , 2006, DOI: 10.1007/s11038-006-9129-z
Abstract: We consider the detector size, location, depth, background, and radio-purity required of a mid-Pacific deep-ocean instrument to accomplish the twin goals of making a definitive measurement of the electron anti-neutrino flux due to uranium and thorium decays from Earth's mantle and core, and of testing the hypothesis for a natural nuclear reactor at the core of Earth. We take the experience with the KamLAND detector in Japan as our baseline for sensitivity and background estimates. We conclude that an instrument adequate to accomplish these tasks should have an exposure of at least 10 kilotonne-years (kT-y), should be placed at least at 4 km depth, may be located close to the Hawaiian Islands (no significant background from them), and should aim for KamLAND radio-purity levels, except for radon where it should be improved by a factor of at least 100. With an exposure of 10 kT-y we should achieve a 24% measurement of the U/Th content of the mantle plus core. Exposure at multiple ocean locations for testing lateral heterogeneity is possible.
Multiplexed DNA Sequence Capture of Mitochondrial Genomes Using PCR Products
Tomislav Maricic,Mark Whitten,Svante P??bo
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014004
Abstract: To utilize the power of high-throughput sequencers, target enrichment methods have been developed. The majority of these require reagents and equipment that are only available from commercial vendors and are not suitable for the targets that are a few kilobases in length.
Interacting linear polymers on three-dimensional Sierpinski fractals
Jelena Maricic,Suncica Elezovic-Hadzic
Physics , 2002,
Abstract: Using self-avoiding walk model on three-dimensional Sierpinski fractals (3d SF) we have studied critical properties of self-interacting linear polymers in porous environment, via exact real-space renormalization group (RG) method. We have found that RG equations for 3d SF with base b=4 are much more complicated than for the previously studied b=2 and b=3 3d SFs. Numerical analysis of these equations shows that for all considered cases there are three fixed points, corresponding to the high-temperature extended polymer state, collapse transition, and the low-temperature state, which is compact or semi-compact, depending on the value of the fractal base b. We discuss the reasons for such different low--temperature behavior, as well as the possibility of establishing the RG equations beyond b=4.
A new type of Neutrino Detector for Sterile Neutrino Search at Nuclear Reactors and Nuclear Nonproliferation Applications
C. Lane,S. M. Usman,J. Blackmon,C. Rasco,H. P. Mumm,D. Markoff,G. R. Jocher,R. Dorrill,M. Duvall,J. G. Learned,V. Li,J. Maricic,S. Matsuno,R. Milincic,S. Negrashov,M. Sakai,M. Rosen,G. Varner,P. Huber,M. L. Pitt,S. D. Rountree,R. B. Vogelaar,T. Wright,Z. Yokley
Physics , 2015,
Abstract: We describe a new detector, called NuLat, to study electron anti-neutrinos a few meters from a nuclear reactor, and search for anomalous neutrino oscillations. Such oscillations could be caused by sterile neutrinos, and might explain the "Reactor Antineutrino Anomaly". NuLat, is made possible by a natural synergy between the miniTimeCube and mini-LENS programs described in this paper. It features a "Raghavan Optical Lattice" (ROL) consisting of 3375 boron or $^6$Li loaded plastic scintillator cubical cells 6.3\,cm (2.500") on a side. Cell boundaries have a 0.127\,mm (0.005") air gap, resulting in total internal reflection guiding most of the light down the 3 cardinal directions. The ROL detector technology for NuLat gives excellent spatial and energy resolution and allows for in-depth event topology studies. These features allow us to discern inverse beta decay (IBD) signals and the putative oscillation pattern, even in the presence of other backgrounds. We discuss here test venues, efficiency, sensitivity and project status.
Neutrino mass hierarchy determination and other physics potential of medium-baseline reactor neutrino oscillation experiments
A. B. Balantekin,H. Band,R. Betts,J. J. Cherwinka,J. A. Detwiler,S. Dye,K. M. Heeger,R. Johnson,S. H. Kettell,K. Lau,J. G. Learned,C. J. Lin,J. J. Ling,B. Littlejohn,D. W. Liu,K. B. Luk,J. Maricic,K. McDonald,R. D. McKeown,J. Napolitano,J. C. Peng,X. Qian,N. Tolich,W. Wang,C. White,M. Yeh,C. Zhang,T. Zhao
Physics , 2013,
Abstract: Medium-baseline reactor neutrino oscillation experiments (MBRO) have been proposed to determine the neutrino mass hierarchy (MH) and to make precise measurements of the neutrino oscillation parameters. With sufficient statistics, better than ~3%/\sqrt{E} energy resolution and well understood energy non-linearity, MH can be determined by analyzing oscillation signals driven by the atmospheric mass-squared difference in the survival spectrum of reactor antineutrinos. With such high performance MBRO detectors, oscillation parameters, such as \sin^22\theta_{12}, \Delta m^2_{21}, and \Delta m^2_{32}, can be measured to sub-percent level, which enables a future test of the PMNS matrix unitarity to ~1% level and helps the forthcoming neutrinoless double beta decay experiments to constrain the allowed values. Combined with results from the next generation long-baseline beam neutrino and atmospheric neutrino oscillation experiments, the MH determination sensitivity can reach higher levels. In addition to the neutrino oscillation physics, MBRO detectors can also be utilized to study geoneutrinos, astrophysical neutrinos and proton decay. We propose to start a U.S. R&D program to identify, quantify and fulfill the key challenges essential for the success of MBRO experiments.
Two Domains of Vimentin Are Expressed on the Surface of Lymph Node, Bone and Brain Metastatic Prostate Cancer Lines along with the Putative Stem Cell Marker Proteins CD44 and?CD133
Nicole F. Steinmetz,Jochen Maurer,Huiming Sheng,Armand Bensussan,Igor Maricic,Vipin Kumar,Todd A. Braciak
Cancers , 2011, DOI: 10.3390/cancers3032870
Abstract: Vimentin was originally identified as an intermediate filament protein present only as an intracellular component in many cell types. However, this protein has now been detected on the surface of a number of different cancer cell types in a punctate distribution pattern. Increased vimentin expression has been indicated as an important step in epithelial-mesenchymal transition (EMT) required for the metastasis of prostate cancer. Here, using two vimentin-specific monoclonal antibodies (SC5 and V9 directed against the coil one rod domain and the C-terminus of the vimentin protein, respectively), we examined whether either of these domains would be displayed on the surface of three commonly studied prostate cancer cell lines isolated from different sites of metastases. Confocal analysis of LNCaP, PC3 and DU145 prostate cancer cell lines (derived from lymph node, bone or brain prostate metastases, respectively) demonstrated that both domains of vimentin are present on the surface of these metastatic cancer cell types. In addition, flow cytometric analysis revealed that vimentin expression was readily detected along with CD44 expression but only a small subpopulation of prostate cancer cells expressed vimentin and the putative stem cell marker CD133 along with CD44. Finally, Cowpea mosaic virus (CPMV) nanoparticles that target vimentin could bind and internalize into tested prostate cancer cell lines. These results demonstrate that at least two domains of vimentin are present on the surface of metastatic prostate cancer cells and suggest that vimentin could provide a useful target for nanoparticle- or antibody- cancer therapeutic agents directed against highly invasive cancer and/or stem cells.
Snowmass CF1 Summary: WIMP Dark Matter Direct Detection
P. Cushman,C. Galbiati,D. N. McKinsey,H. Robertson,T. M. P. Tait,D. Bauer,A. Borgland,B. Cabrera,F. Calaprice,J. Cooley,T. Empl,R. Essig,E. Figueroa-Feliciano,R. Gaitskell,S. Golwala,J. Hall,R. Hill,A. Hime,E. Hoppe,L. Hsu,E. Hungerford,R. Jacobsen,M. Kelsey,R. F. Lang,W. H. Lippincott,B. Loer,S. Luitz,V. Mandic,J. Mardon,J. Maricic,R. Maruyama,R. Mahapatra,H. Nelson,J. Orrell,K. Palladino,E. Pantic,R. Partridge,A. Ryd,T. Saab,B. Sadoulet,R. Schnee,W. Shepherd,A. Sonnenschein,P. Sorensen,M. Szydagis,T. Volansky,M. Witherell,D. Wright,K. Zurek
Physics , 2013,
Abstract: As part of the Snowmass process, the Cosmic Frontier WIMP Direct Detection subgroup (CF1) has drawn on input from the Cosmic Frontier and the broader Particle Physics community to produce this document. The charge to CF1 was (a) to summarize the current status and projected sensitivity of WIMP direct detection experiments worldwide, (b) motivate WIMP dark matter searches over a broad parameter space by examining a spectrum of WIMP models, (c) establish a community consensus on the type of experimental program required to explore that parameter space, and (d) identify the common infrastructure required to practically meet those goals.
Study of electron anti-neutrinos associated with gamma-ray bursts using KamLAND
K. Asakura,A. Gando,Y. Gando,T. Hachiya,S. Hayashida,H. Ikeda,K. Inoue,K. Ishidoshiro,T. Ishikawa,S. Ishio,M. Koga,S. Matsuda,T. Mitsui,D. Motoki,K. Nakamura,S. Obara,Y. Oki,T. Oura,I. Shimizu,Y. Shirahata,J. Shirai,A. Suzuki,H. Tachibana,K. Tamae,K. Ueshima,H. Watanabe,B. D. Xu,H. Yoshida,A. Kozlov,Y. Takemoto,S. Yoshida,K. Fushimi,A. Piepke,T. I. Banks,B. E. Berger,T. O'Donnell,B. K. Fujikawa,J. Maricic,J. G. Learned,M. Sakai,L. A. Winslow,Y. Efremenko,H. J. Karwowski,D. M. Markoff,W. Tornow,J. A. Detwiler,S. Enomoto,M. P. Decowski
Physics , 2015, DOI: 10.1088/0004-637X/806/1/87
Abstract: We search for electron anti-neutrinos ($\overline{\nu}_e$) from long and short-duration gamma-ray bursts~(GRBs) using data taken by the KamLAND detector from August 2002 to June 2013. No statistically significant excess over the background level is found. We place the tightest upper limits on $\overline{\nu}_e$ fluence from GRBs below 7 MeV and place first constraints on the relation between $\overline{\nu}_e$ luminosity and effective temperature.
KamLAND Sensitivity to Neutrinos from Pre-Supernova Stars
K. Asakura,A. Gando,Y. Gando,T. Hachiya,S. Hayashida,H. Ikeda,K. Inoue,K. Ishidoshiro,T. Ishikawa,S. Ishio,M. Koga,S. Matsuda,T. Mitsui,D. Motoki,K. Nakamura,S. Obara,T. Oura,I. Shimizu,Y. Shirahata,J. Shirai,A. Suzuki,H. Tachibana,K. Tamae,K. Ueshima,H. Watanabe,B. D. Xu,A. Kozlov,Y. Takemoto,S. Yoshida,K. Fushimi,A. Piepke,T. I. Banks,B. E. Berger,B. K. Fujikawa,T. O'Donnell,J. G. Learned,J. Maricic,S. Matsuno,M. Sakai,L. A. Winslow,Y. Efremenko,H. J. Karwowski,D. M. Markoff,W. Tornow,J. A. Detwiler,S. Enomoto,M. P. Decowski
Physics , 2015,
Abstract: In the late stages of nuclear burning for massive stars ($M>8~M_{\sun}$), the production of neutrino-antineutrino pairs through various processes becomes the dominant stellar cooling mechanism. As the star evolves, the energy of these neutrinos increases and in the days preceding the supernova a significant fraction of emitted electron anti-neutrinos exceeds the energy threshold for inverse beta decay on free hydrogen. This is the golden channel for liquid scintillator detectors because the coincidence signature allows for significant reductions in background signals. We find that the kiloton-scale liquid scintillator detector KamLAND can detect these pre-supernova neutrinos from a star with a mass of $25~M_{\sun}$ at a distance less than 660~pc with 3$\sigma$ significance before the supernova. This limit is dependent on the neutrino mass ordering and background levels. KamLAND takes data continuously and can provide a supernova alert to the community.
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