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Search Results: 1 - 10 of 448438 matches for " J. L. Broeckx "
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An Objectivist Looks at the Concept of Aesthetic Value
J. L. Broeckx
Philosophica , 1985,
sthetische und soziologische Implikationen in Adornos 'Typen musikalischen Verhaltens'
J. L. Broeckx
Philosophica , 1971,
Impact of extreme precipitation and water table change on N2O fluxes in a bio-energy poplar plantation
D. Zona,I. A. Janssens,M. S. Verlinden,L. S. Broeckx
Biogeosciences Discussions , 2011, DOI: 10.5194/bgd-8-2057-2011
Abstract: A large fraction of the West European landscape is used for intensive agriculture. Several of these countries have very high nitrous oxide (N2O) emissions, because of substantial use of fertilizers and high rates of atmospheric nitrogen deposition. N2O production in soils is controlled by water-filled pore space (WFPS) and substrate availability (NO3). Here we show that extreme precipitation (80 mm rainfall in 48 h) after a long dry period, led to a week-long peak in N2O emissions (up to about 2200 μg N2O-N m 2 h 1). In the first four of these peak emission days, N2O fluxes showed a pronounced diurnal pattern correlated to daytime increase in temperature and wind speed. It is possible that N2O was transported through the transpiration stream of the poplar trees and emitted through the stomates. However, during the following three high emission days, N2O emission was fairly stable with no pronounced diurnal trend, and was correlated with wind speed and WFPS (at 20 and 40 cm depth) but no longer with soil temperature. We hypothesized that wind speed facilitated N2O emission from the soil to the atmosphere through a significant pressure-pumping. Successive rainfall events and similar WFPS after this first intense precipitation did not lead to N2O emissions of the same magnitude. These findings suggest that climate change-induced modification in precipitation patterns may lead to high N2O emission pulses from soil, such that sparser and more extreme rainfall events after longer dry periods could lead to peak N2O emissions. The cumulative effects of more variable climate on annual N2O emission are still largely uncertain and need further investigation.
Regenerative Therapies for Equine Degenerative Joint Disease: A Preliminary Study
Sarah Broeckx, Marieke Zimmerman, Sara Crocetti, Marc Suls, Tom Mari?n, Stephen J. Ferguson, Koen Chiers, Luc Duchateau, Alfredo Franco-Obregón, Karin Wuertz, Jan H. Spaas
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085917
Abstract: Degenerative joint disease (DJD) is a major cause of reduced athletic function and retirement in equine performers. For this reason, regenerative therapies for DJD have gained increasing interest. Platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) were isolated from a 6-year-old donor horse. MSCs were either used in their native state or after chondrogenic induction. In an initial study, 20 horses with naturally occurring DJD in the fetlock joint were divided in 4 groups and injected with the following: 1) PRP; 2) MSCs; 3) MSCs and PRP; or 4) chondrogenic induced MSCs and PRP. The horses were then evaluated by means of a clinical scoring system after 6 weeks (T1), 12 weeks (T2), 6 months (T3) and 12 months (T4) post injection. In a second study, 30 horses with the same medical background were randomly assigned to one of the two combination therapies and evaluated at T1. The protein expression profile of native MSCs was found to be negative for major histocompatibility (MHC) II and p63, low in MHC I and positive for Ki67, collagen type II (Col II) and Vimentin. Chondrogenic induction resulted in increased mRNA expression of aggrecan, Col II and cartilage oligomeric matrix protein (COMP) as well as in increased protein expression of p63 and glycosaminoglycan, but in decreased protein expression of Ki67. The combined use of PRP and MSCs significantly improved the functionality and sustainability of damaged joints from 6 weeks until 12 months after treatment, compared to PRP treatment alone. The highest short-term clinical evolution scores were obtained with chondrogenic induced MSCs and PRP. This study reports successful in vitro chondrogenic induction of equine MSCs. In vivo application of (induced) MSCs together with PRP in horses suffering from DJD in the fetlock joint resulted in a significant clinical improvement until 12 months after treatment.
The Prevalence of Nine Genetic Disorders in a Dog Population from Belgium, the Netherlands and Germany
Bart J. G. Broeckx, Frank Coopman, Geert E. C. Verhoeven, Wim Van Haeringen, Leanne van de Goor, Tim Bosmans, Ingrid Gielen, Jimmy H. Saunders, Sandra S. A. Soetaert, Henri Van Bree, Christophe Van Neste, Filip Van Nieuwerburgh, Bernadette Van Ryssen, Elien Verelst, Katleen Van Steendam, Dieter Deforce
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074811
Abstract: The objective of this study was to screen a dog population from Belgium, the Netherlands and Germany for the presence of mutant alleles associated with hip dysplasia (HD), degenerative myelopathy (DM), exercise-induced collapse (EIC), neuronal ceroid lipofuscinosis 4A (NCL), centronuclear myopathy (HMLR), mucopolysaccharidosis VII (MPS VII), myotonia congenita (MG), gangliosidosis (GM1) and muscular dystrophy (Duchenne type) (GRMD). Blood samples (K3EDTA) were collected for genotyping with Kompetitive Allele Specific PCR (n = 476). Allele and genotype frequencies were calculated in those breeds with at least 12 samples (n = 8). Hardy-Weinberg equilibrium was tested. Genetic variation was identified for 4 out of 9 disorders: mutant alleles were found in 49, 15, 3 and 2 breeds for HD, DM, EIC and NCL respectively. Additionally, mutant alleles were identified in crossbreeds for both HD and EIC. For HD, DM, EIC and NCL mutant alleles were newly discovered in 43, 13, 2 and 1 breed(s), respectively. In 9, 2 and 1 breed(s) for DM, EIC and NCL respectively, the mutant allele was detected, but the respective disorder has not been reported in those breeds. For 5 disorders (HMLR, MPS VII, MG, GM1, GRMD), the mutant allele could not be identified in our population. For the other 4 disorders (HD, DM, EIC, NCL), prevalence of associated mutant alleles seems strongly breed dependent. Surprisingly, mutant alleles were found in many breeds where the disorder has not been reported to date.
The Dark Side of EGFP: Defective Polyubiquitination
Mathijs Baens, Heidi Noels, Vicky Broeckx, Sofie Hagens, Sabine Fevery, An D. Billiau, Hugo Vankelecom, Peter Marynen
PLOS ONE , 2006, DOI: 10.1371/journal.pone.0000054
Abstract: Enhanced Green Fluorescent Protein (EGFP) is the most commonly used live cell reporter despite a number of conflicting reports that it can affect cell physiology. Thus far, the precise mechanism of GFP-associated defects remained unclear. Here we demonstrate that EGFP and EGFP fusion proteins inhibit polyubiquitination, a posttranslational modification that controls a wide variety of cellular processes, like activation of kinase signalling or protein degradation by the proteasome. As a consequence, the NF-κB and JNK signalling pathways are less responsive to activation, and the stability of the p53 tumour suppressor is enhanced in cell lines and in vivo. In view of the emerging role of polyubiquitination in the regulation of numerous cellular processes, the use of EGFP as a live cell reporter should be carefully considered.
Probabilistic Verification over GF(2m) Using Mod2-OBDDs  [PDF]
J.L. Imana
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.22012
Abstract: Formal verification is fundamental in many phases of digital systems design. The most successful verification procedures employ Ordered Binary Decision Diagrams (OBDDs) as canonical representation for both Boolean circuit specifications and logic designs, but these methods require a large amount of memory and time. Due to these limitations, several models of Decision Diagrams have been studied and other verification techniques have been proposed. In this paper, we have used probabilistic verification with Galois (or finite) field GF(2m) modifying the CUDD package for the computation of signatures in classical OBDDs, and for the construction of Mod2-OBDDs (also known as ?-OBDDs). Mod2-OBDDs have been constructed with a two-level layer of ?-nodes using a positive Davio expansion (pDE) for a given variable. The sizes of the Mod2-OBDDs obtained with our method are lower than the Mod2-OBDDs sizes obtained with other similar methods.
Empirical Analysis of Factors Affecting the E-Book Adoption—Research Agenda  [PDF]
J. K. L. Poon
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.25011
Abstract: Advances in information technology encourage the development of e-books. The 2010 Horizon Report predicts that e-book will be one of the six technologies most likely to affect higher education in coming years. Despite the huge investment in developing the e-book market, customer take-up over the past decades is still far below expectations. The success of e-book adoption depends on the implementation of an educational model that addresses learner needs as well as content relevance. To understand customer behavior intention in adopting e-books and to address the lack of holistic approach in adoption research, this project is proposed to investigate the intention of college students in using e-books. This cross-sectional research utilizes the Technology Acceptance Model (TAM) and four additional variables, namely, personal innovativeness of information technology, social influences, perceived costs, and environmental consciousness. The study is expected to contribute to the literature by providing an empirically validated extended TAM regarding e-books. Moreover, the results will provide important and useful information for academicians and publishers.
The Use of Microcontrollers by Scientists in Experimental Research Applications  [PDF]
J. L. Genicot
World Journal of Nuclear Science and Technology (WJNST) , 2015, DOI: 10.4236/wjnst.2015.51003
Abstract: If the microcontrollers are devices quite easy to use for experts in electronics, a scientist devoted to different research topics from digital electronics is generally totally unable to develop and use these complex components. Most of the time, the researcher is looking for simple devices able to control different parameters during his experimentation. He is obliged in this case to request the intervention of an expert in electronics to develop such a device and the result is sometimes different from the precise initial requirement. Nowadays, it is possible to find on the market, simple units able to satisfy the requirements of the scientist and easy enough to be manipulated by him in specific applications. The purpose of this paper is to present some of these devices and to compare their possibilities and the ways to use them. These devices are compared in optically stimulated dosimetry with applications found in external dosimetry, interventional radiology, nuclear medicine and space dosimetry.
Preservation of Minority Languages in North America: French Immersion Programs in the Province of Alberta  [PDF]
Baltasar J. López Ruiz
Open Journal of Social Sciences (JSS) , 2015, DOI: 10.4236/jss.2015.34012
Abstract: Canada, which was officially declared a bilingual nation after the proclamation of the Official Language Act (1969), counts with a low percentage of French speaking population who hardly reaches a quarter of the total population. We must add the fact that there is a very little fraction of the population who speaks French outside the province of Quebec. Social, cultural and ethnic realities which are present within the Canadian territories enable us to observe and investigate the diversity of identities and the different linguistic assimilation processes experienced by non Anglophone citizens. Facts seem to indicate that the francophone minority groups, living in areas of the country where the most spoken language is different from their mother tongue, struggle for the preservation of their cultural heritage at the same time that keep alive their Canadian identity. The possibility of contrasting the situation of the Francophones in Western Canada with the reality of other minority groups which represent a similar percentage with respect to the total population—such as the Germans and the Ukrainian origin citizens—constitutes a valuable resource in order to predict the evolution of the demographic patterns and the use of French as a heritage language within the Canadian territories. The present work reviews the diverse political, linguistic and demographic contexts that may support our idea that using an additional language—French and English in the case of most Francophones in Western Canada—represents an advantage from a cognitive, social and linguistic point of view. The high degree of acceptance of the francophone schools and the popularity of the French immersion programs set up by Albertan authorities are considered within this article in order to support this hypothesis.
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