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Search Results: 1 - 10 of 297332 matches for " J. Kushida "
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Blazar Variability and Evolution in the GeV Regime
S. Tsujimoto,J. Kushida,K. Nishijima,K. Kodani
Physics , 2015,
Abstract: One of the most important problem of the blazar astrophysics is to understand the physical origin of the blazar sequence. In this study, we focus on the GeV gamma-ray variability of blazars and evolution perspective we search the relation between the redshift and the variability amplitude of blazars for each blazar subclass. We analyzed the Fermi-LAT data of the TeV blazars and the bright AGNs (flux $\geq$ 4$\times10^{-9}$ cm$^{-2}$s$^{-1}$) selected from the 2LAC (the 2nd LAT AGN catalog) data base. As a result, we found a hint of the correlation between the redshift and the variability amplitude in the FSRQs. Furthermore the BL Lacs which have relatively lower peak frequency of the synchrotron radiation and relatively lower redshift, have a tendency to have a smaller variability amplitude.
Bone marrow cell transplantation efficiently repairs tendon and ligament injuries
Taketoshi Kushida
Frontiers in Cell and Developmental Biology , 2014, DOI: 10.3389/fcell.2014.00027
Abstract: Abstract Growth factors play key roles during the various stages of the tendon healing process and stimulate fibroblasts within or outside the tendon to induce type-I collagen synthesis. Furthermore, localized administration of growth factors has been successfully used for treating tendon and ligament injuries in animal models. Mesenchymal stem cells (MSCs) transplants have also been previously used to treat tendon and ligament injuries. MSCs can differentiate into fibroblasts, which secrete growth factors and cytokines that are essential for extrinsic healing and improved vascularization of the damaged tendon or ligament tissue. In addition, hematopoietic stem cells (HSCs)-derived hematolymphoid cells secrete growth factors and cytokines required for extrinsic healing. Therefore, a novel cost-efficient approach involves injecting fresh whole bone marrow cells, consisting of both MSCs and HSCs, into the injured tissue enables rapid healing. 1. Introduction Growth factors such as transforming growth factor-β (TGF-β), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), platelet-derived growth factor (PDGF), and basic fibroblast growth factor (bFGF) have been associated with the tendon healing process (Molloy et al., 2003; Zhang et al., 2003). Among these growth factors, TGF-β1 plays a key role during the various tissue repair stages and is secreted not only by fibroblasts differentiated from mesenchymal stem cells (MSCs), but also by several types of cells that differentiate from hematopoietic stem cells (HSCs; Sporn et al.,1986). In this review, the role of TGF-β and MSC-derived fibroblasts in tendon or ligament tissue repair is described. Furthermore, the potential application of bone marrow cell transplantation (BMCT) as a novel method for treating tendon and ligament injuries is also discussed. 2.1 Healing process Human tendon healing process is classified into five phases as follows: immediate post injury phase, inflammatory phase, proliferation phase, reparative phase, and remodeling phase (Molloy et al., 2003). Tissue repair depends on both intrinsic and extrinsic processes. Intrinsic healing occurs within the tendon itself as a result of the activity of intrinsic fibroblasts and an increased intratendinous blood supply from the synovium and osseous insertion (Rank et al., 1980; Deie et al., 1995; Koga et al., 2007). Extrinsic factors that influence tissue repair include the availability of proteins originating from peripheral fibroblasts, plasma, inflammatory cells, and extratendinous vascular invasion (DesRosiers et
The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series  [PDF]
Natsuko Kakudo, Satoshi Kushida, Tsunetaka Ogura, Tomoya Hara, Kenji Suzuki, Kenji Kusumoto
Open Journal of Regenerative Medicine (OJRM) , 2012, DOI: 10.4236/ojrm.2012.13005
Abstract: Platelet rich plasma (PRP) contains a high concentration of thrombocytes and the a granules of platelets contain platelet released growth factors. The usefulness of PRP for regeneration of bone and soft tissues has been reported previously. We firstly reported the efficacy of PRP prepared using the Magellan Autologous Platelet Separator System for intractable skin ulcers such as diabetic and venous ulcers. The system consists of a microprocessor controlled centrifuge, syringe pumps, and necessary single use processing components. No complications occurred in any patients and the wounds achieved complete epithelialization. Our results have shown the efficiency of platelet rich plasma for the treatment of intractable skin ulcers.
Space-Precise Computation of a Singular Nonlinear Evolution Equation for the Risk Preference
Hitoshi IMAI,Naoyuki ISHIMURA,Masahiro KUSHIDA
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
The optical reflector system for the CANGAROO-II imaging atmospheric Cherenkov telescope
A. Kawachi,Y. Hayami,J. Jimbo,S. Kamei,T. Kifune,H. Kubo,J. Kushida,S. LeBohec,K. Miyawaki,M. Mori,K. Nishijima,J. R. Patterson,R. Suzuki,T. Tanimori,S. Yanagita,T. Yoshikoshi,A. Yuki
Physics , 2000, DOI: 10.1016/S0927-6505(00)00131-6
Abstract: A new imaging atmospheric Cherenkov telescope (CANGAROO-II) with a light-weight reflector has been constructed. Light, robust, and durable mirror facets of containing CFRP (Carbon Fiber Reinforced Plastic) laminates were developed for the telescope. The attitude of each facet can be adjusted by stepping motors. In this paper, we describe the design, manufacturing, alignment procedure, and the performance of the CANGAROO-II optical reflector system.
Down-Regulation of Claudin-1 Expression in Gastric Cancer Mucosa Is Correlated with Poor Prognosis  [PDF]
Eiichiro Hirakawa, Yasunori Tokuhara, Tatsuya Morinishi, Hiroyuki Ohsaki, Erika Uemura, Yukari Miki, Toru Matsunaga, Yoshio Kushida, Reiji Haba
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.44026
Abstract:

Background: Cell adhesion molecule abnormalities are given as one reason for the occurrence of invasion and metastasis in various cancers. In this study, we conducted an immunohistochemical examination of cell adhesion molecule claudin-1 in mucosa and invasive front of gastric cancer, and investigated the correlation of claudin-1 expression and clinicopathological factors. Methods: Immunohistochemical examination was performed for 35 patients who underwent surgery be-tween January 2010 and October 2011, to assess the correlation of claudin-1 with primary gastric cancer. Results: The expression rate of claudin-1 was 48.6% (17/35) in 35 gastric carcinoma patients. The positive rates of claudin-1 were 42.9% (15/35) in mucosa and 28.6% (10/35) in invasive front of gastric cancer. The expression rate of claudin-1 in invasive front was lower than in mucosa. From comparing claudin-1 expression in mucosa, it was found that well-to moderately-differentiated adenocarcinoma had significantly more claudin-1 expression than poorly-differrentiated adenocarcinoma. Claudin-1 expression of well-to moderately-differentiated adenocar-cinoma decreased in the invasive front of gastric cancer. Expression of claudin-1 in mucosa was negative in many cases with advanced tumor invasion (T2, T3, T4) and positive in many cases with early tumor invasion (T1), with a significant difference between the two (p < 0.05). In mucosa, many cases at an advanced stage (Stage II, III, IV) were negative for claudin-1 expression and many cases at an early stage (Stage I) were positive for claudin-1 expression. A significant difference was seen between the two (p < 0.05). However, claudin-1 expression in the invasive front was not correlated with histological type, depth of tumor invasion and stage. Conclusion: From the above results, it is considered that decreased claudin-1expression in mucosa is related to histological type, gastric cancer invasion and stage, and this information may be useful when making a pathological diagnosis of advanced gastric cancer and estimating outcomes.

A noninvasive transfer system for polarized renal tubule epithelial cell sheets using temperature-responsive culture dishes
Kushida A.,Yamato M.,Isoi Y.,Kikuchi A.
European Cells and Materials (ECM) , 2005,
Abstract: We used temperature-responsive culture dishes onto which the temperature-responsive polymer, poly(Nisopropylacrylamide), was covalently grafted for tissue engineering. Confluent cells harvested as intact sheets from these surfaces by simple temperature reduction can be transferred to various surfaces including additional culture dishes, other cell sheets, and tissues. In order to examine the maintenance of cell polarity, Madin-Darby canine kidney cells and human primary renal proximal tubule epithelial cells which had developed apical-basal cell polarity in culture, were subjected to cell sheet transfer. This functional and structural cell polarity, which is susceptible to treatment with trypsin, was examined by immunohistochemistry and transmission electron microscopy. Using our cell-sheet method, the noninvasive transfer of these cell sheets retaining typical distributions of Na+/K+-ATPase, GLUT-1, SGLT-1, aquaporin-1, neutral endopeptidase and dipeptidylendopeptidase IV, could be achieved. The transferred cell sheets also developed numerous microvilli and tight junctions at the apical and lateral membranes, respectively. For biochemical analysis, immunoblotting of occludin, a transmembrane protein that composes tight junctions, was conducted and results confirmed that occludin remained intact after cell sheet transfer. This two-dimensional cell sheet manipulation method promises to be useful for tissue engineering as well as in the investigation of epithelial cell polarity.
Volumetric Brain Morphometry Changes in Patients with Obstructive Sleep Apnea Syndrome: Effects of CPAP Treatment and Literature Review
Nelly T. Huynh,Olga Prilipko,Clete A. Kushida,Christian Guilleminault
Frontiers in Neurology , 2014, DOI: 10.3389/fneur.2014.00058
Abstract: Introduction: Obstructive sleep apnea syndrome (OSAS) is a frequent breathing disorder occurring during sleep that is characterized by recurrent hypoxic episodes and sleep fragmentation. It remains unclear whether OSAS leads to structural brain changes, and if so, in which brain regions. Brain region-specific gray and white matter volume (GMV and WMV) changes can be measured with voxel-based morphometry (VBM). The aims of this study were to use VBM to analyze GMV and WMV in untreated OSAS patients compared to healthy controls (HC); examine the impact of OSAS-related variables (nocturnal hypoxemia duration and sleep fragmentation index) on GMV and WMV; and assess the effects of therapeutic vs. sham continuous positive airway pressure (CPAP) treatment. We discuss our results in light of previous findings and provide a comprehensive literature review.
Search for TeV Gamma Rays from the SNR RXJ1713.7-3946
H. Muraishi,T. Tanimori,S. Yanagita,T. Yoshida,T. Kifune,S. A. Dazeley,P. G. Edwards,S. Gunji,S. Hara,T. Hara,J. Jinbo,A. Kawachi,H. Kubo,J. Kushida,Y. Matsubara,Y. Mizumoto,M. Mori,M. Moriya,Y. Muraki,T. Naito,K. Nishijima,J. R. Patterson,M. D. Roberts,G. P. Rowell,T. Sako,K. Sakurazawa,Y. Sato,R. Susukita,T. Tamura,T. Yoshikoshi,A. Yuki
Physics , 1999,
Abstract: The shell type SNR RXJ1713.7-3946 is a new SNR discovered by the ROSAT all sky survey. Recently, strong non-thermal X-ray emission from the northwest part of the remnant was detected by the ASCA satellite. This synchrotron X-ray emission strongly suggests the existence of electrons with energies up to hundreds of TeV in the remnant. This SNR is, therefore, a good candidate TeV gamma ray source, due to the Inverse Compton scattering of the Cosmic Microwave Background Radiation by the shock accelerated ultra-relativistic electrons, as seen in SN1006. In this paper, we report a preliminary result of TeV gamma-ray observations of the SNR RXJ1713.7-3946 by the CANGAROO 3.8m telescope at Woomera, South Australia.
Construction of New 7m Imaging Air ?erenkov Telescope of CANGAROO
T. Tanimori,S. A. Dazeley,P. G. Edwards,S. Gunji,S. Hara,T. Hara,J. Jinbo,A. Kawachi,T. Kifune,H. Kubo,J. Kushida,Y. Matsubara,Y. Mizumoto,M. Mori,M. Moriya,H. Muraishi,Y. Muraki,T. Naito,K. Nishijima,J. R. Patterson,M. D. Roberts,G. P. Rowell,T. Sako,K. Sakurazawa,Y. Sato,R. Susukita,T. Tamura,S. Yanagita,T. Yoshida,T. Yoshikoshi,A. Yuki
Physics , 1999,
Abstract: CANGAROO group has constructed the new large imaging Air \v Cerenkov telescope to exploit hundred GeV region gamma-ray astronomy in March 1999 at Woomera, South Australia. It has a 7m parabolic mirror consisting of 60 small plastic spherical mirrors, and a fine imaging camera with 512 PMTs covering the field of view of 3 degree. Observation will start from July 1999.
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