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Search Results: 1 - 10 of 345596 matches for " J. J.; González-Santos "
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Amiloidosis hepática como causa de colestasis severa intrahepática
Gavilán,J. C.; Bermúdez,F. J.; Márquez,A.; Sánchez-Carrillo,J. J.; González-Santos,P.;
Anales de Medicina Interna , 2003, DOI: 10.4321/S0212-71992003000100006
Abstract: the liver is frequently involved by amyloidosis, but hyperbilirubinemia and liver failure are uncommon features. a mild elevation of the serum alkaline phosphatase value and, less frequently, hepatomegaly are the most common findings. usually the patients have no symptoms related with the liver involvement; the clinical manifestation and the long term prognosis depends on the renal and cardiac disease. we report an unusual clinical presentation of primary amyloidosis in a previously asymptomatic 65 years old woman who was admitted to the hospital because of ictericia and ascitis mimicking a drug induced acute hepatic failure.
Effectiveness of antiretroviral treatment in patients from Pereira and Manizales
Machado-Alba,Jorge E; González-Santos,Diana M; Vidal-Guitart,Xavier;
Revista de Salud Pública , 2011, DOI: 10.1590/S0124-00642011000300011
Abstract: objective evaluating the effectiveness of antiretroviral therapy in a sample of colombian patients diagnosed as having hiv/aids and being treated by the colombian health social security system (chsss) methods a descriptive study was conducted among 134 hiv/aids patients of any age or gender who had received antiretroviral therapy in the cities of pereira and manizales between july 1st 2008 and june 30th 2009. the following factors were assessed from the clinical history of the patients seen in three health insurance companies: viral load, cd4 count, antiretroviral treatment regimens, prescribed daily doses of medications, length of disease evolution, duration of therapy, history of opportunistic diseases, and drug costs. results there was male predominance (91 men cf 43 women), mean age beingf 39 years, and an average of 59 months since diagnosis. all treatment regimens were defined by each drug's defined daily dose (ddd). the therapy was effective in 74.5 % of patients. effectiveness was defined as being viral load < 400 copies/ml. about 79.1 % of patients had had their viral load measured during the last 6 months. non-adherence to treatment and a history of having acquired 2 other sexually- transmitted infections were associated with an increased risk of uncontrolled hiv infection. the average value of drugs per year per patient was $4,077.2 ± 3,043.8 u.s. dollars/year. conclusions non-adherence to treatment remains one of the most important issues regarding antiretroviral therapy effectiveness, so programmes intended to control hiv/aids must address this problem.
Dispensación de antibióticos de uso ambulatorio en una población colombiana
Machado-Alba,Jorge E.; González-Santos,Diana M.;
Revista de Salud Pública , 2009, DOI: 10.1590/S0124-00642009000500006
Abstract: objectives analysing how systemic antibiotic agents were dispensed to outpatients in a colombian population between january 2005 and december 2006 and assessing their economic cost as antibiotic use and abuse have been related to serious bacterial resistance. methods this was a descriptive observational study of antibiotic drug use; a database was compiled from medication usage records maintained by dispensing pharmacies in 10 colombian cities regarding the total of users who had received some type of antibiotic. the defined daily dose (ddd) and cost per 1,000 inhabitants/day were assessed. the commonly used antibiotic associations were analysed. results ddd was 1.58 per 1,000 inhabitants per day. the antibiotics most frequently prescribed were penicillin (amoxiciline; dicloxaciline), followed by first-generation cephalosporines and sulphonamides. injectable antibiotic use was 10.4 % in 2005 and 9.3 % in 2006; an association of anti-bacterial agents was used for 11 % of the patients. total antibiotic dispensation cost in 2005 was us$ 1,708,350 and cost per 1,000 inhabitants per day was us$ 1.13 in 2005 and us$ 1 in 2006. conclusions ddd per 1,000 inhabitants per day and cost per inhabitant per day was low compared to other countries.
Proteína LIC10494 de Leptospira interrogans serovar Copenhageni: modelo estructural y regiones funcionales asociadas
George Emílio Barreto,Orlando Emilio Acevedo,Janneth González-Santos
Universitas Scientiarum , 2012,
Abstract: Protein LIC10494 of Leptospira interrogans serovar Copenhageni: structural model and associated functional regions. Objective.Predict by computational means the 3D structure of the antigenic protein LIC10494 and report associated important functional regionsfor its pathogenicity and immunogenicity. Materials and methods. We performed a computational analysis of the primary structure ofLIC10494 using the servers BLAST, PROTPARAM, PROTSCALE, DAS, SOSUI, TOPPRED, TMAP, TMpred, SPLIT4, PHDHTM,TMHMM2, HMMTOP2, GLOBPLOT and PROSITE. The secondary structure was obtained by consensus of the algorithms SOPM,PREDATOR GOR4, DPM and DSC. The approach to the tertiary structure was obtained using the algorithm MUSTER. The energyminimization was done using the AMBER94 force field of the Schrodinger suite of molecular analysis, and the stereochemistry andenergy model validation was performed by the RAMPAGE server. The final model was visualized using PyMol V.0,98. Results. Thisstudy proposes a computational model that describes the 3D structure of the hypothetical lipoprotein LIC10494 and agrees with previousexperimental reports; thus, our study demonstrates the existence of patterns that could play an important role in the pathogenicity andprotection of the bacteria against the host immune system; the presence of a disorganized region between amino acids 80 and 140, andof a transmembrane segment between amino acids 8 and 22. Conclusion. The coincidence between structural and functional segments suggests that our model can be used to predict certain aspects of the biological behaviour of the protein according to the pathogenic andimmunogenic characteristics of the bacteria.
Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report
Pedro Valdivielso, José Rioja, Carlota García-Arias, Miguel Sánchez-Chaparro, Pedro González-Santos
Cardiovascular Diabetology , 2009, DOI: 10.1186/1475-2840-8-1
Abstract: Patients with type 2 diabetes and mixed hyperlipidemia were recruited. Fasting lipid profile was taken when patients were treated with diet, diet plus 80 mg of fluvastatin and diet plus fluvastatin 80 mg and 4 g of prescription omega 3 fatty acids. The intestinal lipoproteins were quantified by the fasting concentration of apolipoprotein B48 using a commercial ELISA.The addition of 4 g of prescription omega 3 was followed by significant reductions in the levels of triglycerides, VLDL triglycerides and the triglyceride/HDL cholesterol ratio, and an increase in HDL cholesterol (P < 0.05). Fluvastatin induced a reduction of 26% in B100 (P < 0.05) and 14% in B48 (NS). However, the addition of omega 3 fatty acids enhanced this reduction to 32% in B100 (NS) and up to 36% in B48 (P < 0.05).Our preliminary findings therefore suggest an additional benefit on postprandial atherogenic particles when omega 3 fatty acids are added to standard treatment with fluvastatin.Type 2 diabetes is characterized by hypertriglyceridemia, low concentrations of HDL cholesterol, increased small-dense LDL (sdLDL), greater postprandial lipidemia and a considerable increase in vascular risk [1]. It has been clearly established that LDL cholesterol levels should be kept below 100 mg/dL (with an optional goal of < 70 mg/dL) or, if hypertriglyceridemia is present, a non-HDL cholesterol < 130 mg/dL (optional < 100 mg/dL). Together with dietary recommendations and lifestyle changes, statins are the drugs of choice for this goal [2].Postprandial lipoprotein particles have been shown to be atherogenic in experimental animal [3], case-control [4] and histological studies [5]. Indeed, nonfasting triglycerides predict the vascular risk better than fasting measurements [6]. Additionally, postprandial triglycerides are independently associated with carotid [7] and peripheral atheromatosis [8] in patients with type 2 diabetes. Accordingly, it seems reasonable to seek additional control of the triglycerides in
La citocinina BAP promueve la acumulación de hexosas e incrementa la actividad de fosfoenolpiruvato carboxilasa y fosfoenlopiruvato carboxicinasa durante el retraso de la senescencia foliar de trigo
González-Santos, Rosalinda;Delgado-Alvarado, Adriana;Zavaleta-Mancera, H. Araceli;Herrera-Cabrera, B. Edgar;
Agrociencia , 2009,
Abstract: cytokinins reduce their concentration during leaf senescence; but spraying of the cytokinin bencylaminopurine (bap) delays this process; this may have applications in the control of the senescence pasture, ornamental foliage and green vegetables. the objective of the present study was to investigate the effect of bap application on primary metabolism during the leaf senescence of triticum aestivum l. cv. temporalera studying the photosynthetic pigments content, soluble proteins, rubisco, carbohydrates, enzyme activity of phosphoenolpyruvate carboxylase (pepc) and phosphoenolpyruvate carboxykinase (pepck), major components of plant primary metabolism. seedlings 21 d after sowing (das) were sprayed with 0.1 mm bap or water (control). after 41 das the leaves treated with bap delayed their senescence; they retained 60 % of chlorophyll and 44 % of their initial total soluble proteins, especially rubisco. in contrast, control leaves, senesced, loosing 92 % of chlorophyll and more than 90% of proteins in the same period. the bap promoted the accumulation of hexoses. results indicated that bap can increase the activity of pepc and pepck enzymes during senescence. it is discussed the function of these enzymes in the regulation of ph and the translocation of nitrogen compounds during the delay of leaf senescence.
Mutación en el gen EDA1, Ala349Thr en paciente con displasia ectodérmica hipohidrótica ligada a X Mutation in the ED1, Ala349Thr in a patient with X-linked hypohidrotic ectodermal dysplasia
Julio C Salas-Alanis,Rodrigo Cepeda-Valdés,Adriana González-Santos,Mario Amaya-Guerra
Revista médica de Chile , 2011,
Abstract: Hypohidrotic ectodermal dysplasia (HED) is a very rare disease characterized by the absence of eccrine glands, dry skin, scanty hair, and dental abnormalities. It is caused by mutations within the ED1 gene, which encodes a protein, ectodysplasin-A (EDA). Clinical characteristic are frontal bossing, saddle nose, pointed chin, a prominent supraorbital ridge with periorbital hyperpigmenta-tion, and anodontia. Those affected show great intolerance to heat. We report the first Mexican 2-year-old boy with an Ala349Thr missense mutation from Tamaulipas, México.
Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis
Inmaculada Coca-Prieto, Pedro Valdivielso, Gunilla Olivecrona, María Ariza, José Rioja, Pilar Font-Ugalde, Carlota García-Arias, Pedro González-Santos
BMC Gastroenterology , 2009, DOI: 10.1186/1471-230x-9-46
Abstract: Twenty-four survivors of acute hypertriglyceridaemic pancreatitis (cases) and 31 patients with severe hypertriglyceridaemia (controls) were included. Clinical and anthropometrical data, chylomicronaemia, lipoprotein profile, postheparin lipoprotein lipase mass and activity, hepatic lipase activity, apolipoprotein C II and CIII mass, apo E and A5 polymorphisms were assessed.Only five cases were found to have LPL mass and activity deficiency, all of them thin and having the first episode in childhood. No cases had apolipoprotein CII deficiency. No significant differences were found between the non-deficient LPL cases and the controls in terms of obesity, diabetes, alcohol consumption, drug therapy, gender distribution, evidence of fasting chylomicronaemia, lipid levels, LPL activity and mass, hepatic lipase activity, CII and CIII mass or apo E polymorphisms. However, the SNP S19W of apo A5 tended to be more prevalent in cases than controls (40% vs. 23%, NS).Primary defects in LPL and C-II are rare in survivors of acute hypertriglyceridaemic pancreatitis; lipase activity measurements should be restricted to those having their first episode during chilhood.Among patients with acute pancreatitis, 1.3 to 3.5% are due to hypertriglyceridaemia, also known as hypertriglyceridaemic pancreatitis [1,2], some times relapsing and being even more severe than lithiasic acute pancreatitis [3]. Acute hypertriglyceridaemic pancreatitis forms part of the Chylomicronaemia Syndrome, defined as the presence of one or more of the typical signs (eruptive xanthomas, lipidaemia retinalis, recurrent abdominal pain or acute pancreatitis) in a patient with plasma triglyceride concentrations >22.58 mmol/L[4].Genetic causes of the syndrome are rare and include deficiency of lipoprotein lipase (LPL), apolipoprotein C-II, and familial inhibitor of LPL. Other genes are also involved in the catabolism of chylomicrons, such as those for apolipoprotein E, apolipoprotein A-V [5] and glycosylphosphatidyli
Mutación en el gen EDA1, Ala349Thr en paciente con displasia ectodérmica hipohidrótica ligada a X
Salas-Alanis,Julio C; Cepeda-Valdés,Rodrigo; González-Santos,Adriana; Amaya-Guerra,Mario; Kurban,Mazen; Christiano,Angela M;
Revista médica de Chile , 2011, DOI: 10.4067/S0034-98872011001200011
Abstract: hypohidrotic ectodermal dysplasia (hed) is a very rare disease characterized by the absence of eccrine glands, dry skin, scanty hair, and dental abnormalities. it is caused by mutations within the ed1 gene, which encodes a protein, ectodysplasin-a (eda). clinical characteristic are frontal bossing, saddle nose, pointed chin, a prominent supraorbital ridge with periorbital hyperpigmenta-tion, and anodontia. those affected show great intolerance to heat. we report the first mexican 2-year-old boy with an ala349thr missense mutation from tamaulipas, méxico.
Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study
María-José Ariza, Miguel-ángel Sánchez-Chaparro, Francisco-Javier Barón, Ana-María Hornos, Eva Calvo-Bonacho, José Rioja, Pedro Valdivielso, José-Antonio Gelpi, Pedro González-Santos
BMC Medical Genetics , 2010, DOI: 10.1186/1471-2350-11-66
Abstract: A subgroup of the ICARIA study comprising 1825 Spanish subjects (80% men, mean age 36 years) was genotyped for the LPL-HindIII (rs320), S447X (rs328), D9N (rs1801177) and N291S (rs268) polymorphisms, the APOA5-S19W (rs3135506) and -1131T/C (rs662799) variants, and the APOE polymorphism (rs429358; rs7412) using PCR and restriction analysis and TaqMan assays. We used regression analyses to examine their combined effects on TG levels (with the log-transformed variable) and the association of variant combinations with TG levels and hypertriglyceridemia (TG ≥ 1.69 mmol/L), including the covariates: gender, age, waist circumference, blood glucose, blood pressure, smoking and alcohol consumption.We found a significant lowering effect of the LPL-HindIII and S447X polymorphisms (p < 0.0001). In addition, the D9N, N291S, S19W and -1131T/C variants and the APOE-ε4 allele were significantly associated with an independent additive TG-raising effect (p < 0.05, p < 0.01, p < 0.001, p < 0.0001 and p < 0.001, respectively). Grouping individuals according to the presence of TG-lowering or TG-raising polymorphisms showed significant differences in TG levels (p < 0.0001), with the lowest levels exhibited by carriers of two lowering variants (10.2% reduction in TG geometric mean with respect to individuals who were homozygous for the frequent alleles of all the variants), and the highest levels in carriers of raising combinations (25.1% mean TG increase). Thus, carrying two lowering variants was protective against HTG (OR = 0.62; 95% CI, 0.39-0.98; p = 0.042) and having one single raising polymorphism (OR = 1.20; 95% CI, 1.39-2.87; p < 0.001) or more (2 or 3 raising variants; OR = 2.90; 95% CI, 1.56-5.41; p < 0.001) were associated with HTG.Our results showed a significant independent additive effect on TG levels of the LPL polymorphisms HindIII, S447X, D9N and N291S; the S19W and -1131T/C variants of APOA5, and the ε4 allele of APOE in our study population. Moreover, some of the varian
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