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Search Results: 1 - 10 of 297497 matches for " Jürgen Sonnemann "
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Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patients
Jürgen Sonnemann, Jennifer G?nge, Sabine Pilz, Christine St?tzer, Ralf Ohlinger, Antje Belau, Gerd Lorenz, James F Beck
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-183
Abstract: We compared a prototypic histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), and paclitaxel for their treatment efficacy in ovarian cancer cell lines and in primary patient-derived ovarian cancer cells. The primary cancer cells were isolated from malignant ascites collected from five patients with stage III ovarian carcinomas. Cytotoxic activities were evaluated by Alamar Blue assay and by caspase-3 activation. The ability of SAHA to kill drug-resistant 2780AD cells was also assessed.By employing the cell lines OVCAR-3, SK-OV-3, and A2780, we established SAHA at concentrations of 1 to 20 μM to be as efficient in inducing cell death as paclitaxel at concentrations of 3 to 300 nM. Consequently, we treated the patient-derived cancer cells with these doses of the drugs. All five isolates were sensitive to SAHA, with cell killing ranging from 21% to 63% after a 72-h exposure to 20 μM SAHA, while four of them were resistant to paclitaxel (i.e., <10% cell death at 300 nM paclitaxel for 72 hours). Likewise, treatment with SAHA led to an increase in caspase-3 activity in all five isolates, whereas treatment with paclitaxel had no effect on caspase-3 activity in three of them. 2780AD cells were responsive to SAHA but resistant to paclitaxel.These ex vivo findings raise the possibility that SAHA may prove effective in the treatment of paclitaxel-resistant ovarian cancer in vivo.Ovarian cancer is the most lethal gynaecological neoplasm, accounting for over 6% of deaths from cancer in women [1]. The standard treatment is a combination of surgery and chemotherapy, the latter usually consisting of a taxane/platinum combination. By this regimen, initial response rates of more than 80% are achieved [2]. Unfortunately, in the vast majority of women, diagnosis occurs after the disease has already disseminated beyond the ovaries. These patients typically relapse and eventually die as the tumours become refractory to treatment. Actually, drug resistance is supposed to
β-Actin and γ-Actin Are Each Dispensable for Auditory Hair Cell Development But Required for Stereocilia Maintenance
Benjamin J. Perrin,Kevin J. Sonnemann,James M. Ervasti
PLOS Genetics , 2010, DOI: 10.1371/journal.pgen.1001158
Abstract: Hair cell stereocilia structure depends on actin filaments composed of cytoplasmic β-actin and γ-actin isoforms. Mutations in either gene can lead to progressive hearing loss in humans. Since β-actin and γ-actin isoforms are 99% identical at the protein level, it is unclear whether each isoform has distinct cellular roles. Here, we compared the functions of β-actin and γ-actin in stereocilia formation and maintenance by generating mice conditionally knocked out for Actb or Actg1 in hair cells. We found that, although cytoplasmic actin is necessary, neither β-actin nor γ-actin is required for normal stereocilia development or auditory function in young animals. However, aging mice with β-actin– or γ-actin–deficient hair cells develop different patterns of progressive hearing loss and distinct pathogenic changes in stereocilia morphology, despite colocalization of the actin isoforms. These results demonstrate overlapping developmental roles but unique post-developmental functions for β-actin and γ-actin in maintaining hair cell stereocilia.
Operator Splitting Method for Coupled Problems:Transport and Maxwell Equations  [PDF]
Jürgen Geiser
American Journal of Computational Mathematics (AJCM) , 2011, DOI: 10.4236/ajcm.2011.13019
Abstract: In this article a new approach is considered for implementing operator splitting methods for transport problems, influenced by electric fields. Our motivation came to model PE-CVD (plasma-enhanced chemical vapor deposition) processes, means the flow of species to a gas-phase, which are influenced by an electric field. Such a field we can model by wave equations. The main contributions are to improve the standard discretization schemes of each part of the coupling equation. So we discuss an improvement with implicit Runge- Kutta methods instead of the Yee’s algorithm. Further we balance the solver method between the Maxwell and Transport equation.
Development of a computer vision system to monitor pig locomotion  [PDF]
Jrgen Kongsro
Open Journal of Animal Sciences (OJAS) , 2013, DOI: 10.4236/ojas.2013.33038
Abstract: Avoiding lameness or leg weakness in pig production is crucial to reduce cost, improve animal welfare and meat quality. Detection of lameness detection by the use of vision systems may assist the farmer or breeder to obtain a more accurate and robust measurement of lameness. The paper presents a low-cost vision system for measuring the locomotion of moving pigs based on motion detection, frame-grabbing and multivariate image analysis. The first step is to set up a video system based on web camera technology and choose a test area. Secondly, a motion detection and data storage system are used to build a processing system of video data. The video data are analyzed measuring the properties of each image, stacking them for each animal and then analyze these stacks using multivariate image analysis. The system was able to obtain and decompose information from these stacks, where components could be extracted, representing a particular motion pattern. These components could be used to classify or score animals according to this pattern, which might be an indicator of lameness. However, further improvement is needed with respect to standardization of herding, test area and tracking of animals in order to have a robust system to be used in a farm environment.
The Motley World of “International Values”: Modes of Production on the World Market  [PDF]
Jrgen Sandemose
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.63058
Abstract: I venture to describe the world market from the viewpoint of those different extant modes of production which deliver commodities in “foreign” trade. The world market is, then, understood strictly in its basic feature, as a market for material products, all called commodities. The term “exchange”, which has to be used with some indeterminacy to begin with, is explained in greater detail as I proceed. In this regard, the most important sections are nos. 2 and 3. The term “modes of production” will also be clarified in due place, and primarily in Sections 9 and 10. I find such a concept necessary for an adequate background description of the products which are poured onto any market. I primarily analyze the capitalist mode of production through the concept of intensity of labour (cf. 4 and 9), which plays a main role even in Marx’s theory of the “modifications” of the law of value on the world market. Also, I find what is often labelled “Karl Marx’s theory of international values” to be correct in its foundations, and I will take a point of departure in it—especially apparent in sections 1, 2 and 3. A target for criticism in this article is the modern mainstream theory of “factors of production” in so far as it is found feasible for an analysis of the movements on the world market. This is briefly done in Section 8. In Section 6, I consider David Ricardo’s theory of “comparative advantages” as a counter-example to that theory. I use some terrain to show that the real historical and social background of the economic functioning of the so-called “factors”—capital, land and labour—must be a measuring rod for whether a factor theory is viable or not. To do this, I depend (cf. again Sections 9 and 10) to a high degree of Marx’s theory of those factors considered as forms of organized class forces—a viewpoint which played a central role in his preparing of the three volumes of Capital. While the Marxian theory insofar is adequate, it is also useful in analyzing the aborted or undeveloped state of those modes of production which, beneath the advanced capitalist one, supply the world market with material products. This ought to become clear especially in Sections 10 and 11. As my text expands, I try to show how the said inconsistency in the Ricardian model is based on
On the Exposition of the Transformation of Commodity-Values into Production Prices in the Third Volume of Capital—A Textual Analysis  [PDF]
Jrgen Sandemose
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.65098
Abstract: The article is about the exposition of the Karl Marx’s concept of production prices in his main work Capital. It focuses on the structure of the central text in question, Chapter 9 of the third volume, on “transformation [Verwandlung] of commodity-values into production prices”. The actual content and structure of the chapter has to some degree been overlooked or distorted in the literature. The aim of the article is to establish (or re-establish) a sound view of the chapter, freed from prejudices nurtured by—especially—a theory of price formation which, albeit “modernized” by i.a. Walras, dates back to Steuart and Ricardo. These prejudices have had an immense significance for misunderstandings of the Marxian theory of measure of value and standard of prices reflected in the text of the chapter mentioned. For this reason, the article is furnished with an Appendix, underlining the difficult situation for Marxist-minded research today. It should be noted that it is not an objective of the article to discuss any extant interpretation of Marx’s exposition. However, the paradigm of criticism that was introduced early in the 20th century by Ladislaus von Bortkiewicz is used as a perspective. Specific references—other than to Marx’s own texts—are held at a minimum in the article proper. I have chosen such a mode of approach because I find that misunderstandings of the chapter are evenly distributed among authors regardless of how their views on the “transformation” collide. On the other hand, such a consciousness of “misunderstandings” among commentators certainly does imply that the author should at least shortly clarify his own view of the main problems in the paradigmatic criticism mentioned above. In the first section, I point out the importance of Marx’s way of presenting his concept of the composition of capital. In the next, I make some remarks on the concept of the socially necessary labour time and its relation to abstract labour. In the third and fourth, I investigate Marx’s different models of analysis. In the fifth section, it will be shown how Marx, contrary to
Paradoxes, Self-Referentiality, and Hybrid Systems: A Constructive Approach  [PDF]
Jürgen Klüver
Open Journal of Philosophy (OJPP) , 2017, DOI: 10.4236/ojpp.2017.71004
Abstract:
Since the discovery of the paradoxes of self-referentiality or self-reference respectively logicians and mathematicians tried to avoid self-reference when constructing formal systems. Yet “real” complex systems like the mind are characterized by self-reference and can accordingly only be modeled by formal systems that are also basically self-referential. In this article I show that and how self-referential computer programs, understood as algorithmic formal systems, are not only possible but also since some time quite common in special branches of computer science. Examples for this argument are neural networks and so-called hybrid systems, i.e. combination of different sub systems. The hybrid system SOCAIN, a combination of a cellular automaton, a neural network and a genetic algorithm is an example for the fruitfulness of using self-reference in a systematic way. In particular, such systems consist of mutually dependent sub systems, i.e. form no static hierarchy.
Experimental and numerical analysis on PCB coupling in non uniform field environment
F. Sonnemann
Advances in Radio Science : Kleinheubacher Berichte , 2004,
Abstract: HPM and UWB pulses are capable of disrupting signal processing or even destroying semiconductor structures. Hence, it is useful to estimate the induced voltage levels on printed circuit boards (PCB) in response to different excitation signals. The considered PCB is integrated within a missile-like cylindrical structure, called GENEC, and is equipped with differential sensors to measure the E- and Hfield above the PCB. Standard transmission line theory is applied to develop a SPICE model that calculates the terminal voltages at the transmission line loads.
Treatment of chronic vulvovaginal candidiasis with posaconazole and ciclopiroxolamine  [PDF]
Hans-Jürgen Tietz
Health (Health) , 2010, DOI: 10.4236/health.2010.26077
Abstract: Therapy of chronic recurrent vulvovaginal can- didiasis (VVC) caused by Candida glabrata is still rare in comparison to C. albicans infection, but therapy remains more difficult. Combination therapy with topical antifungals may improve therapy outcome, but still standard agents as fluconazole or itraconazole often fail. Posaconazole is a new systemic triazole with a wide antifungal spectrum including rare Candida species. Up to now, no clinical trials with posa- conazole in chronic recurrent VVC have been undertaken. Here, first results of the application of a new therapy regimen consisting of oral posaconazole in combination with topical ciclopiroxolamine are presented. 15 patients with chronic recurrent VVC caused by C. glabrata have been treated. 14 of these patients experienced successful therapy, clinical and mycological cure 30 days after begin of therapy has been observed. Long-term results are promising, as in 4 patients clinical and mycologic cure persists for more than 1 year up to now.
Periodic Signals of the Milky Way Concealed in Terrestrial Sedimentary Basin Fills and in Planetary Magmatism?  [PDF]
Heinz-Jürgen Brink
International Journal of Geosciences (IJG) , 2015, DOI: 10.4236/ijg.2015.68067
Abstract: Long periodic geodynamic processes with durations between 150 and 600 Million years appear to be in phase with similar galactic cycles, caused by the path of the solar system through the spiral arms of the Milky Way. This path is assumed by some authors to cause climate change due to cosmic ray fluctuations, affecting the cloud formation and the related albedo of the Earth, which periodically lead to glaciations every 150 Ma. With the glaciations, the sea level fluctuates accordingly. Subsequently, the varying sizes of shallow seas are causing periodic changes of the Moon’stidal dissipation, which affects presumably other geodynamic processes on the Earth. The Moonmay therefore synchronize directly or indirectly long periodic Phanerozoic cycles (sea level, orogeny, magmatism, sedimentation, etc.) with the Milky Way. As sea level fluctuations, orogeny, sedimentation and magmatism can be described as members of a geodynamic feedback system; no apparent reasons appear to be required to assign a cause of the cyclicity to agents outside of thegalactic-climatically synchronized Earth-Moon system. However, recent observations of youngvolcanism on the near Earth terrestrial planets may require a new understanding. Magmatic/volcanic episodes on Venus, Mars and Mercury as well as on the Earth’s Moon are apparently contemporaneous thermal events accompanying increased magmatic/volcanic activities on theEarth,following a 300 myr cycle. Therefore, a collateral galactic thermal source within the Milky Way
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