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Search Results: 1 - 10 of 654405 matches for " JáVOR A. "
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METODELE GENETICII MOLECULARE CA INSTRUMENTE PENTRU AMELIORAREA OVINELOR
JáVOR A.,HUSZENICZA G.,CZEGLéDI L.,áRNYASI MARIANN
Lucrari Stiintifice : Zootehnie si Biotehnologii , 2007,
Abstract: Autorii au prezentat pe scurt proiectele lor de cercetare din ultimii 10 ani ndomeniul geneticii moleculare la oaie. S-au realizat investiga ii asupra receptoruluide melatonin 1a (Mel1A) ca gen candidat care influen eaz sezonalitateareproduc iei la oaie. Cercet rile s-au efectuat pe trei rase, i anume Awassi,Merinos prolific maghiar i igaie. La aceste rase s-au determinat pozi iilemuta iilor genelor n func ie de secven a d referin a GeneBank nr. U14109. ntotal, la cele trei rase s-au identificat un num r de 16 polimorfisme nucleotidicesingulare (SNP). Exonul II a genei Mel1A este puternic polimorfic. ase din SNPidentifica i produc modific ri ale aminoacizilor din proteina care poate fi cauzamodific rilor func iei i/sau construc iei receptorului de melatonin . Studiul se vacontinua pentru a investiga cele trei rase pentru muta iile func ionale, construireade haplotipuri i asocierile dintre haplotipuri i activitatea ovarian extrasezon. Oalt abordare o reprezint studiul de caz a programului maghiar de ameliorarefolosind berbeci importan i din rasa Booroola. n Europa, Ungaria a fost prima ar care a importat berbeci i oi din rasa Merinos Booroola, pe baza c rora s-a formato nou ras Merinos Prolific Maghiar, recunoscut n 1992. n concluzia studiilor depan acum, rezultatele au ar tat c rata ridicat de ovula ie la cast ras esteprodus de muta ia receptorului genei BMPR-1B. Eficien a programului deameliorare dea cre te frecven a alelei FecB n aceast popula ie de ovine a fost ntarziat de aplicarea anterioar a metodelor improprii de clasificare genotipic .Un proiect mai amplu al echipei de cercet tori este acela de a estima diferen elegenetice dintre variatele tipuri de oi igaie i urcan din Estul, Centrul i SudulEuropei. n prezent, n cadrul institutului se deruleaz urm toarele proiecte decercetare: cartografierea locilor nsu irilor cantitative pentru produc ia de lapte dincromozomul 6 la rasa Awassi; polimorfismul genelor proteinei din lapte la rasa igaie; determinarea genotipurilor Callipyge la popula ia SuffolkMaghiar; ncruci area raselor de ovine de lan pentru a produce ovine pentru p r.
Relationship between plant communities and developmental stage of natural spruce forest in the subalpine forest belt of National Nature Reserve of Babia hora
Ján Mergani?,Katarína Mergani?ová,Ján Vor?ák,Jozef I?toňa
?asopis Beskydy , 2008,
Abstract: The work presents the results from the survey of plant communities in forest stands of national nature reserve Babia hora. The relevés were collected on 57 sample plots situated at an elevation ranging from 1,222 m to 1,503 m above sea level. The plots are equally divided between the three developmental stages of virgin forests. The analysis revealed that in the studied area no plant species can be accounted for the differentiation between the developmental stages. Our results indicate that in the conditions of Babia hora two types of cyclical changes of plant species occur: a small and a large cycle of plant communities. The analysis of the influence of developmental stage on the proportion coverage of plant species with the same Ellenberg's indicator value showed that environmental ecological conditions are not affected by the developmental stage of virgin forest. The status of forest stands (permanently released canopy) and specific climate conditions of Babia hora are preconditions for spatially homogenous plant communities.
Contemporary Genetic Structure, Phylogeography and Past Demographic Processes of Wild Boar Sus scrofa Population in Central and Eastern Europe
Szilvia Kusza, Tomasz Podgórski, Massimo Scandura, Tomasz Borowik, András Jávor, Vadim E. Sidorovich, Aleksei N. Bunevich, Mikhail Kolesnikov, Bogumi?a J?drzejewska
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091401
Abstract: The wild boar (Sus scrofa) is one of the most widely distributed mammals in Europe. Its demography was affected by various events in the past and today populations are increasing throughout Europe. We examined genetic diversity, structure and population dynamics of wild boar in Central and Eastern Europe. MtDNA control region (664 bp) was sequenced in 254 wild boar from six countries (Poland, Hungary, Belarus, Ukraine, Moldova and the European part of Russia). We detected 16 haplotypes, all known from previous studies in Europe; 14 of them belonged to European 1 (E1) clade, including 13 haplotypes from E1-C and one from E1-A lineages. Two haplotypes belonged respectively to the East Asian and the Near Eastern clade. Both haplotypes were found in Russia and most probably originated from the documented translocations of wild boar. The studied populations showed moderate haplotype (0.714±0.023) and low nucleotide diversity (0.003±0.002). SAMOVA grouped the genetic structuring of Central and Eastern European wild boar into three subpopulations, comprising of: (1) north-eastern Belarus and the European part of Russia, (2) Poland, Ukraine, Moldova and most of Belarus, and (3) Hungary. The multimodal mismatch distribution, Fu's Fs index, Bayesian skyline plot and the high occurrence of shared haplotypes among populations did not suggest strong demographic fluctuations in wild boar numbers in the Holocene and pre-Holocene times. This study showed relatively weak genetic diversity and structure in Central and Eastern European wild boar populations and underlined gaps in our knowledge on the role of southern refugia and demographic processes shaping genetic diversity of wild boar in this part of Europe.
Vigorous, but differential mononuclear cell response of cirrhotic patients to bacterial ligands
Varenka J Barbero-Becerra, María Concepción Gutiérrez-Ruiz, Carmen Maldonado-Bernal, Félix I Téllez-Avila, Roberto Alfaro-Lara, Florencia Vargas-Vorácková
World Journal of Gastroenterology , 2011,
Abstract: AIM: To study the role of gram-positive and gram-negative bacteria in the pathogenesis of liver injury, specifically the activation of inflammatory mediators.METHODS: Peripheral blood mononuclear cells of 20 out-patients were studied, 10 of them with cirrhosis. Peripheral blood mononuclear cells were isolated and exposed to lipopolysaccharide or lipoteichoic acid. CD14, Toll-like receptor 2 and 4 expression was determined by flow cytometry, and tumor necrosis factor (TNF) α, interleukin (IL)-1β, IL-6, IL-12 and IL-10 secretion in supernatants was determined by ELISA.RESULTS: Higher CD14, Toll-like receptor 2 and 4 expression was observed in peripheral blood mononuclear cells from cirrhotic patients, (P < 0.01, P < 0.006, P < 0.111) respectively. Lipopolysaccharide and lipoteichoic acid induced a further increase in CD14 expression (P < 0.111 lipopolysaccharide, P < 0.013 lipoteichoic acid), and a decrease in Toll-like receptor 2 (P < 0.008 lipopolysaccharide, P < 0.008 lipoteichoic acid) and Toll-like receptor 4 (P < 0.008 lipopolysaccharide, P < 0.028 lipoteichoic acid) expression. With the exception of TNFα, absolute cytokine secretion of peripheral blood mononuclear cells was lower in cirrhotic patients under non-exposure conditions (P < 0.070 IL-6, P < 0.009 IL-1β, P < 0.022 IL-12). Once exposed to lipopolysaccharide or lipoteichoic acid, absolute cytokine secretion of peripheral blood mononuclear cells was similar in cirrhotic and non-cirrhotic patients, determining a more vigorous response in the former (P < 0.005 TNFα, IL-1β, IL-6, IL-2 and IL-10 lipopolysaccharide; P < 0.037 TNFα; P < 0.006 IL-1β; P < 0.005 IL-6; P < 0.007 IL-12; P < 0.014 IL-10 lipoteichoic acid). Response of peripheral blood mononuclear cells was more intense after lipopolysaccharide than after lipoteichoic acid exposure.CONCLUSION: Peripheral blood mononuclear cells of cirrhotic patients are able to respond to a sudden bacterial ligand exposure, particularly lipopolysaccharide, suggesting that immune regulation mechanisms are still present.
Height structure of spruce mountain forests of Babia hora -- Oravské Beskydy
Ján Mergani?,Katarína Mergani?ová,Ján Vor?ák
?asopis Beskydy , 2011,
Abstract: The paper analyses the height structure of mountain spruce forests in the nature reserve Babia hora, Slovakia. The analysis consisted of the three partial tasks (1) analysis of the relationship between maximum tree height and elevation, (2) derivation and evaluation of height-diameter curves separately for species and elevation categories, (3) frequency analysis of tree heights. The results revealed a tight correlation of maximum tree height to elevation (correlation index equal to 0.91), and between tree height and diameter (correlation index varied from 0.93 to 0.99). For Norway spruce (Picea abies L./Karst), height-diameter relationship was described by a five-parameter exponential function, because simpler functions were not able to represent the small values below the usual truncation point satisfactorily. In case of rowan (Sorbus aucuparia L.), Gompertz function was used for the description of height-diameter relationship. Tree height frequencies were analysed by frequency analysis. The results indicated that the most differentiated vertical structure is in the stage of growth. The stage of breakdown is characterised by bimodal distribution. With increasing elevation the differences between the vertical structure of the stage of optimum and breakdown diminish, while the differences between the stage of growth and the stages of optimum and breakdown become more distinct.
Contribution to understanding precipitation regime in the mountain spruce forests of Babia hora -- Oravské Beskydy using throughfall index
Ján Vor?ák,Ján Mergani?,Jaroslav ?kvarenina,Katarína Mergani?ová
?asopis Beskydy , 2009,
Abstract: The presented paper analyses how fog precipitation affects interception and throughfall in spruce mountain forests in the temperate zone of Europe. The plots selected for the collection of rainfall and throughfall were located within the area of nature reserve Babia hora, from which the data were collected from the year 2001 to 2005. The gauges were situated in four different locations (open space, crown's periphery, young stand and forest opening) at an elevation ranging from 1330 to 1350 m above sea level. The results indicate that in the examined region, the deposition of horizontal precipitation on vegetation surfaces occurs, which reduces the interception losses, and even causes the net gain of water. The positive effect of horizontal precipitation on water regime grows with the decreasing gross precipitation at open space, while this effect is evident for the precipitation in the form of rain, but not snow. The correlation coefficients between throughfall and rainfall fluctuated from 0.69 to 0.99 in the case of rainfall, and from 0.424 to 0.955 in the case of snowfall, which indicates strong correlation between throughfall and gross precipitation. High values of throughfall indices underneath crown's periphery suggest that under drip points we can expect the net gain of water, which has a positive effect on natural regeneration and understorey vegetation. The regeneration underneath crown's periphery is promoted not only by higher net precipitation, but also by higher amount of nutrients dissolved in precipitation.
Einsatz von formativen, elektronischen Testsystemen in der Pr senzlehre [Use of formative e-assessment in lectures]
Ehlers, Jan P.,M?bs, Daniel,vor dem Esche, J.,Blume, K.
GMS Zeitschrift für Medizinische Ausbildung , 2010, DOI: 10.3205/zma000696
Abstract: [english] Introduction/Objective: E-assessment can be used in a diagnostic, formative, or summative way. The purpose of this study was to evaluate whether e-assessment can be used in lectures to enhance the learning effect through providing feedback to students and teachers.Methods: In lectures and continuing education courses of veterinary medicine and medicine, two different systems in three scenarios were tested: Students were evaluated quantitatively (1: n = 472, 2: n = 82, 3: 1278) and teachers were interviewed in the first scenario qualitatively (n = 8). Results: A broad acceptance of the method and a positive impact on the lecture could be proven. Motivation of all participating groups and interaction were improved. It was possible to realize case-based training with a large group, and the participants were actively involved with the different subjects. Conclusions: The results of this study indicate that by using formative e-assessment the quality of teaching can be enhanced to such an extent as to justify a comprehensive use of the systems. [german] Einleitung/Zielsetzung: Elektronische Prüfungssysteme k nnen diagnostisch, formativ oder summativ eingesetzt werden. In dieser Studie sollte untersucht werden, ob elektronische Prüfungssysteme auch in Pr senzveranstaltungen eingesetzt werden k nnen, um sowohl den Studierenden als auch den Dozierenden Feedback über den Lernstand zu geben.Methodik: In tiermedizinischen und medizinischen Unterrichts- und Fortbildungsveranstaltungen wurden zwei verschiedene Systeme in drei unterschiedlichen Szenarien eingesetzt: Hierbei wurden sowohl Lernenden quantitativ (1: n= 472, 2: n=82, 3: 1278) als auch Lehrenden im ersten Szenario (n=8) qualitativ befragt.Ergebnisse: Es konnten eine breite Akzeptanz der Methode und positive Auswirkungen auf den Unterricht festgestellt werden. Die Motivation aller beteiligten Gruppen und die Interaktion wurden gesteigert, fallbasiertes Lernen wurde auch in Gro veranstaltungen erm glicht und die Auseinandersetzung mit dem Thema gef rdert. Schlussfolgerungen: Die Ergebnisse dieser Untersuchung deuten darauf hin, dass der Einsatz formativer, elektronischer Prüfungssysteme die Qualit t der Lehre verbessert kann und somit ein umfangreicher Einsatz gerechtfertigt ist.
Microsatellite analysis to estimate genetic relationships among five bulgarian sheep breeds
Kusza, Szilvia;Dimov, Doytcho;Nagy, István;B?sze, Zsuzsanna;Jávor, András;Kukovics, Sándor;
Genetics and Molecular Biology , 2010, DOI: 10.1590/S1415-47572010005000003
Abstract: herein, genetic relationships among five breeds of bulgarian sheep were estimated using microsatellite markers. the total number of alleles identified was 226 at the 16 loci examined. da distance values were used for phylogenetic tree construction with the upgma algorithm. the two tsigai and two maritza populations were found to be geneticallvery closely related to each other y (0.198, and 0.258 respectively). the pleven black head population was distinct from the other four. these results could be useful for preserving genes in these breeds, thereby ensuring their preservation in bulgaria.
Glycogen as a Putative Target for Diagnosis and Therapy in Brain Pathologies
Jean-François Cloix,Tobias Hévor
ISRN Pathology , 2011, DOI: 10.5402/2011/930729
Abstract:
Determinants of tick-borne encephalitis in counties of southern Germany, 2001-2008
Christian Kiffner, Walter Zucchini, Philipp Schomaker, Torsten Vor, Peter Hagedorn, Matthias Niedrig, Ferdinand Rühe
International Journal of Health Geographics , 2010, DOI: 10.1186/1476-072x-9-42
Abstract: We fitted a logistic regression model to the annual counts of reported human TBE cases in each of 140 counties over an eight year period. The model controlled for spatial autocorrelation and unexplained temporal variation. The occurrence of human TBE was found to be positively correlated with the proportions of broad-leafed, mixed and coniferous forest cover. An index of forest fragmentation was negatively correlated with TBE incidence, suggesting that infection risk is higher in fragmented landscapes. The results contradict previous evidence regarding the relevance of a specific spring-time temperature regime for TBE epidemiology. Hunting bag data of roe deer (Capreolus capreolus) in the previous year was positively correlated with human TBE incidence, and hunting bag density of red fox (Vulpes vulpes) and red deer (Cervus elaphus) in the previous year were negatively correlated with human TBE incidence.Our approach suggests that a combination of landscape and climatic variables as well as host-species dynamics influence TBE infection risk in humans. The model was unable to explain some of the temporal variation, specifically the high counts in 2005 and 2006. Factors such as the exposure of humans to infected ticks and forest rodent population dynamics, for which we have no data, are likely to be explanatory factors. Such information is required to identify the determinants of TBE more reliably. Having records of TBE infection sites at a finer scale would also be necessary.Tick-borne encephalitis (TBE) is the most important flavivirus infection of the central nervous system in Europe and Russia. The annual number of cases is estimated to be as high as 10,000 in Russia and about 3,000 in European countries [1-5]. Severe TBE infections caused by European virus strains typically take a biphasic course: After a short incubation period (usually 7-14 days, with extremes of 4-28 days), the first (viraemic) phase presents as an uncharacteristic influenza-like illness lasti
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