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Search Results: 1 - 10 of 7541 matches for " Ivan Beale "
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Helping Oncology Nurses Advise Younger Patients about Self Care: Feasibility of Using Animated and DVD Formats for Nurse Instruction  [PDF]
Ivan Beale, Vivien Lane
Creative Education (CE) , 2010, DOI: 10.4236/ce.2010.11008
Abstract: This study explored the perceptions of oncology nurses about the usefulness of a video-game or an animated DVD intervention designed to teach young patients about self care. The study also measured the effects of these interventions on nurses’ cancer knowledge and perceived self-efficacy to communicate with patients about self-care. Twenty-two oncology nurses were randomly assigned either to use a video game “Re-Mission” or to view instructional animations from the game on DVD. They completed tests and rating scales before and after, then rated the acceptability of the game or DVD. Only ten participants completed the study. For these ten, ratings of the acceptability and credibility of the game or DVD were moderately positive, regardless of age or nursing experience. Self-efficacy for communicating to patients about self-care increased following use of the game or DVD. Cancer knowledge was not affected. It was concluded that oncology nurses in Australia are not generally enthusiastic about the concept of instruction via video game and animated DVD formats, although those who participated rated the experience positively.
Case Report on Feline Polycythemia Vera  [PDF]
Corinna Beale
Open Journal of Veterinary Medicine (OJVM) , 2017, DOI: 10.4236/ojvm.2017.71001
Abstract: Polycythemia vera has been reported as a known condition in cats as early as 1966. This condition manifests as an increased mass in red blood cells and elevated hematocrit and is defined as an idiopathic chronic myeloproliferative disorder. The patient described in this paper presented with hyperemic gums and pinna and an acute onset of progressive ataxia and lethargy. Several possible underlying primary conditions such as cardiac disease and renal malignancy were excluded by running basic blood work and radiographic imaging. Initial blood work revealed a significantly elevated packed cell volume (88%). After diagnosis, treatment with phlebotomy and chemotherapy lead to a reduction in hematocrit and elimination of neurologic signs. This case study represents the diagnosis and successful management of this disease in a private practice setting. Polycythemia vera is relatively uncommon in dogs and cats, but should still be considered in cases of neurologic disorders, especially with the presence of bright red ears, paws, or gums.
Jo Beale
Revista de Administra??o FACES Journal , 2007,
Abstract: Poucas pesquisas t am explorado o que determina a motiva § £o entre funcion rios, argumentada como essencial para a implementa § £o bem sucedida de pr ticas produtivas "lean". O artigo analisa o impacto de v rios fatores de n -vel individual (relacionados com trabalho, personalidade e demografia) relatados pela disposi § £o dos funcion rios em adotar comportamentos "lean". As entrevistas, grupos focais (n = 38) e dados da pesquisa (n = 331) coletados de trabalhadores oriundos de uma empresa de manufatura iniciando mudan §as "lean" sugerem que a motiva § £o para "lean" diretamente influenciada pelas atitudes dos empregado, e pela habilidade e press μes sociais percebidas ao adotarem comportamentos "lean". Antecedentes indiretos incluem a auto-efic cia, satisfa § £o profissional, comprometimento organizacional e n -vel organizacional. Os resultados abarcam implica § μes pr ticas importantes. Atrav s de uma comunica § £o cuidadosamente concebida e programas de treinamento, poss -vel gerir a motiva § £o entre funcion rios direcionada e receptiva ao "lean". O artigo conclu -do com uma discuss £o sobre futuras linhas de pesquisa.
Jo Beale
Revista de Administra??o FACES Journal , 2007,
Abstract: Poucas pesquisas têm explorado o que determina a motiva o entre funcionários, argumentada como essencial para a implementa o bem sucedida de práticas produtivas "lean". O artigo analisa o impacto de vários fatores de nível individual (relacionados com trabalho, personalidade e demografia) relatados pela disposi o dos funcionários em adotar comportamentos "lean". As entrevistas, grupos focais (n = 38) e dados da pesquisa (n = 331) coletados de trabalhadores oriundos de uma empresa de manufatura iniciando mudan as "lean" sugerem que a motiva o para "lean" é diretamente influenciada pelas atitudes dos empregado, e pela habilidade e press es sociais percebidas ao adotarem comportamentos "lean". Antecedentes indiretos incluem a auto-eficácia, satisfa o profissional, comprometimento organizacional e nível organizacional. Os resultados abarcam implica es práticas importantes. Através de uma comunica o cuidadosamente concebida e programas de treinamento, é possível gerir a motiva o entre funcionários direcionada e receptiva ao "lean". O artigo é concluído com uma discuss o sobre futuras linhas de pesquisa.
Case report: Severe mercuric sulphate poisoning treated with 2,3-dimercaptopropane-1-sulphonate and haemodiafiltration
Paul I Dargan, Lucy J Giles, Craig I Wallace, Ivan M House, Alison H Thomson, Richard J Beale, Alison L Jones
Critical Care , 2003, DOI: 10.1186/cc1887
Abstract: A 40-year-old man presented with haematemesis after ingestion of 1 g mercuric sulphate and rapidly deteriorated in the emergency department, requiring intubation and ventilation. His initial blood mercury was 15 580 μg/l. At 4.5 hours after ingestion he was started on DMPS. He rapidly developed acute renal failure and so he was started on CVVHDF for renal support and in an attempt to improve mercury clearance; CVVHDF was continued for 14 days.Regular ultradialysate and pre- and post-filtrate blood samples were taken and in addition all ultradialysate generated was collected to determine its mercury content.The total amount of mercury in the ultrafiltrate was 127 mg (12.7% of the ingested dose). The sieving coefficient ranged from 0.13 at 30-hours to 0.02 at 210-hours after ingestion. He developed no neurological features and was discharged from hospital on day 50. Five months after discharge from hospital he remained asymptomatic, with normal creatinine clearance.We describe a patient with severe inorganic mercury poisoning in whom full recovery occurred with the early use of the chelating agent DMPS and CVVHDF. There was removal of a significant amount of mercury by CVVHDF.We feel that CVVHDF should be considered in patients with inorganic mercury poisoning, particularly those who develop acute renal failure, together with meticulous supportive care and adequate doses of chelation therapy with DMPS.Ingestion of inorganic mercury compounds can result in severe toxicity, and blood mercury concentrations in excess of 220 μg/l are associated with severe clinical effects [1]. Fatalities have been reported after ingestion of 0.5 g by an adult, with a mean lethal adult dose of 1–4 g [1]. Inorganic mercury causes toxicity by two mechanisms. First, mercuric ions precipitate proteins that cause direct necrosis on contact with tissues; this occurs in the mouth, stomach, large bowel and kidney [2]. Mercuric ions accumulate in the kidneys (accounting for 85–90% of the body burd
Pitfalls in haemodynamic monitoring based on the arterial pressure waveform
Luigi Camporota, Richard Beale
Critical Care , 2010, DOI: 10.1186/cc8845
Abstract: In recent years, there has been a trend toward the use, in intensive care units (ICUs) and in operating theatres, of 'minimally invasive' haemodynamic monitoring systems for the continuous measurement of cardiac output (CO). In this context, 'minimally invasive' has come to mean 'less invasive than a pulmonary artery catheter' and is arguably an unhelpful term. Nevertheless, among the available devices, the FloTrac-Vigileo system (FTV) (Edwards Lifesciences LLC, Irvine, CA, USA) does perhaps deserve this epithet as it is designed to run from any arterial line (frequently present in patients in the ICU or undergoing major surgery, at least in Europe) and requires no calibration. This latter capability is a consequence of a sophisticated algorithm that the device employs to analyse the arterial pressure waveform (APW), whether obtained from the radial or the femoral artery, to determine the presumed non-linear proportionality between arterial blood pressure (ABP) and stroke volume (SV) and hence give an estimate of CO. However, despite its simplicity of use, the reliability of this system is uncertain during conditions of haemodynamic instability, when the dose of vasopressors changes rapidly but having an accurate CO is essential to guide appropriate management.The FloTrac algorithm analyses the statistical distribution of data points of the ABP sampled at 100 Hz and is based on the principle that aortic pulse pressure is proportional to SV, measured as the standard deviation of the arterial pressure (σAP) around the mean arterial pressure (MAP). σAP is then multiplied by a scaling parameter derived by a multivariate polynomial equation that includes the patient's demographic data, arterial compliance, skewness (symmetry of the waveform) to adjust for vascular tone, and kurtosis (measure of how peaked the APW is) to compensate for the differences in APW due to arterial site.The fundamental problem with this approach is to be sure that it can identify and accurately r
A new class of scalable parallel pseudorandom number generators based on Pohlig-Hellman exponentiation ciphers
Paul D. Beale
Physics , 2014,
Abstract: Parallel supercomputer-based Monte Carlo applications depend on pseudorandom number generators that produce independent pseudorandom streams across many separate processes. We propose a new scalable class of parallel pseudorandom number generators based on Pohlig--Hellman exponentiation ciphers. The method generates uniformly distributed floating point pseudorandom streams by encrypting simple sequences of integer \textit{messages} into \textit{ciphertexts} by exponentiation modulo prime numbers. The advantages of the method are: the method is trivially parallelizable by parameterization with each pseudorandom number generator derived from an independent prime modulus, the method is fully scalable on massively parallel computing clusters due to the large number of primes available for each implementation, the seeding and initialization of the independent streams is simple, the method requires only a few integer multiply--mod operations per pseudorandom number, the state of each instance is defined by only a few integer values, the period of each instance is different, and the method passes a battery of intrastream and interstream correlation tests using up to $10^{13}$ pseudorandom numbers per test. The 32-bit implementation we propose has millions of possible instances, all with periods greater than $10^{18}$. A 64-bit implementation depends on 128-bit arithmetic, but would have more than $10^{15}$ possible instances and periods greater than $10^{37}$.
Uniform error estimates for Navier-Stokes flow with an exact moving boundary using the immersed interface method
J. Thomas Beale
Mathematics , 2015,
Abstract: We prove that uniform accuracy of almost second order can be achieved with a finite difference method applied to Navier-Stokes flow at low Reynolds number with a moving boundary, or interface, creating jumps in the velocity gradient and pressure. Difference operators are corrected to $O(h)$ near the interface using the immersed interface method, adding terms related to the jumps, on a regular grid with spacing $h$ and periodic boundary conditions. The force at the interface is assumed known within an error tolerance; errors in the interface location are not taken into account. The error in velocity is shown to be uniformly $O(h^2|\log{h}|^2)$, even at grid points near the interface, and, up to a constant, the pressure has error $O(h^2|\log{h}|^3)$. The proof uses estimates for finite difference versions of Poisson and diffusion equations which exhibit a gain in regularity in maximum norm.
Aqueous Geochemistry and Limnology of the Sleeper Pit Lake, Nevada, USA: Evidence for Long-Term Subaqueous Solute Generation in Mine Pit Lakes  [PDF]
Connor P. Newman, Tyler Cluff, Thomas Gray, Geoff Beale
Journal of Geoscience and Environment Protection (GEP) , 2019, DOI: 10.4236/gep.2019.73004
Abstract: Predictive geochemical and limnologic modeling of pit lakes is an important aspect of modern mine-site permitting. One of the key assumptions of many predictive pit-lake models is that open-pit high walls and in-pit backfill become geochemically unreactive once submerged by the filling pit lake. Existing pit lakes provide useful data to test this assumption. The Sleeper pit lake (northwestern Nevada, USA) is approaching hydrologic equilibrium and contains good-quality water that generally meets regulatory requirements for pit lakes. Despite the overall stable geochemical composition, seasonal trends in the hypolimnion indicate the generation of dissolved metals associated with the ore deposit (e.g., Mn and Zn) and cyclical variations in pH. This study applies mass balance, analysis of subaqueous pyrite oxidation, and trends in solute concentrations to evaluate the potential causes of long-term solute generation in the hypolimnion of the Sleeper pit lake. Three separate conceptual models (subaqueous pyrite oxidation; redox reactions; and diffusion of solutes from a permanently stratified bottom layer) were tested against the high-quality dataset available for the pit lake. Evaluation of the monitoring dataset for the pit lake indicates that the Sleeper pit lake has variable limnologic behavior, wherein the lake is consistently stratified (meromictic) in some years, while it undergoes full mixing (holomixis) in other time periods. Comparison of the data with the three conceptual models illustrates that none of these models can be completely implicated as causing the seasonal geochemical variations in the bottom of the pit lake, but that a combination of the processes is likely partially responsible. Additional data collection including sediment cores and in-situ pore-water analysis would aid in understanding geochemical processes occurring over time.
Leading the way: finding genes for neurologic disease in dogs using genome-wide mRNA sequencing
Elaine A Ostrander, Holly Beale
BMC Genetics , 2012, DOI: 10.1186/1471-2156-13-56
Abstract: Forman and colleagues apply high-throughput sequencing to a single case of canine neonatal cerebellar cortical degeneration. This implementation of whole genome mRNA sequencing, the first reported in dog, is additionally unusual due to the analysis: the data was used not to examine transcript levels or annotate genes, but as a form of target capture that revealed the sequence of transcripts of genes associated with ataxia in humans. This approach entails risks. It would fail if, for example, the relevant transcripts were not sufficiently expressed for genotyping or were not associated with ataxia in humans. But here it pays off handsomely, identifying a single frameshift mutation that segregates with the disease. This work sets the stage for similar studies that take advantage of recent advances in genomics while exploiting the historical background of dog breeds to identify disease-causing mutations.
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