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We investigated the presence of MAP, CMV,
or Epstein-Barr virus (EBV) in the saliva of patients presenting with periodontal
disease, gingivitis or oral aphthosis. We also measured methylacetate in their
breath and looked for the presence of PA on their tongue. All patients were
prospectively enrolled into a two-year cohort study. We compared the group
presenting with CD versus the group without CD. 167 patients were enrolled. 24
patients presented with CD. CMV and MAP were found concomitantly in 67% of CD
patients (17 patients) whereas only 1 patient (<0.1%; p < 0.001) has
these infectious agents in the comparative group. PA was rare in CD (25% versus
70.6%; p < 0.001). MA was low, especially with an empty stomach (0.59 ppm +/?
1.45 versus 5.14 ppm +/? 8.97; p < 0.001). It was concluded that the
association MAP + CMV was frequently found in oral lesions of CD at an early
stage. Detection of PA, MAP and CMV, as well as breath test could be easily
performed and may participate to the early diagnosis of CD.