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Search Results: 1 - 10 of 2282 matches for " Isabelle Dusfour? "
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Incrimination of Anopheles (Anopheles) intermedius Peryassú, An. (Nyssorhynchus) nuneztovari Gabaldón, An. (Nys.) oswaldoi Peryassú as natural vectors of Plasmodium falciparum in French Guiana
Dusfour, Isabelle;Issaly, Jean;Carinci, Romuald;Gaborit, Pascal;Girod, Romain;
Memórias do Instituto Oswaldo Cruz , 2012, DOI: 10.1590/S0074-02762012000300021
Abstract: anopheles darlingi root is the major vector of human malaria in the neotropics and has been considered to be the sole malaria vector in french guiana. the presence of other potential vectors suggests that malaria may be transmitted by other species under certain conditions. from 2006-2011, all anopheline specimens collected from 11 localities were assayed to determine if the plasmodium circumsporozoite protein was present. in addition to an. darlingi, we found anopheles oswaldoi, anopheles intermedius and anopheles nuneztovari specimens that were infected with plasmodium sp. further investigations on the behaviour and ecology of an. oswaldoi, an. intermedius and an. nuneztovari are necessary to determine their role in malaria transmission in french guiana.
Multiple insecticide resistance in Aedes aegypti (Diptera: Culicidae) populations compromises the effectiveness of dengue vector control in French Guiana
Dusfour, Isabelle;Thalmensy, Véronique;Gaborit, Pascal;Issaly, Jean;Carinci, Romuald;Girod, Romain;
Memórias do Instituto Oswaldo Cruz , 2011, DOI: 10.1590/S0074-02762011000300015
Abstract: in french guiana, pyrethroids and organophosphates have been used for many years against aedes aegypti. we aimed to establish both the resistance level of ae. aegypti and the ultra low volume spray efficacy to provide mosquito control services with practical information to implement vector control and resistance management. resistance to deltamethrin and fenitrothion was observed. in addition, the profound loss of efficacy of aquak'othrine? and the moderate loss of efficacy of paluthion? 500 were recorded. fenitrothion remained the most effective candidate for spatial application in french guiana until its removal in december 2010. further investigation of the mechanism of resistance to deltamethrin demonstrated the involvement of mixed-function oxidases and, to a lesser extent, of carboxylesterases. however, these observations alone cannot explain the level of insecticide resistance we observed during tube and cage tests.
Deltamethrin Resistance Mechanisms in Aedes aegypti Populations from Three French Overseas Territories Worldwide
Isabelle Dusfour,Pilar Zorrilla?,Amandine Guidez?,Jean Issaly?,Romain Girod?,Laurent Guillaumot?,Carlos Robello?,Clare Strode
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0004226
Abstract: Background Aedes aegypti is a cosmopolite mosquito, vector of arboviruses. The worldwide studies of its insecticide resistance have demonstrated a strong loss of susceptibility to pyrethroids, the major class of insecticide used for vector control. French overseas territories such as French Guiana (South America), Guadeloupe islands (Lesser Antilles) as well as New Caledonia (Pacific Ocean), have encountered such resistance. Methodology/Principal Findings We initiated a research program on the pyrethroid resistance in French Guiana, Guadeloupe and New Caledonia. Aedes aegypti populations were tested for their deltamethrin resistance level then screened by an improved microarray developed to specifically study metabolic resistance mechanisms. Cytochrome P450 genes were implicated in conferring resistance. CYP6BB2, CYP6M11, CYP6N12, CYP9J9, CYP9J10 and CCE3 genes were upregulated in the resistant populations and were common to other populations at a regional scale. The implication of these genes in resistance phenomenon is therefore strongly suggested. Other genes from detoxification pathways were also differentially regulated. Screening for target site mutations on the voltage-gated sodium channel gene demonstrated the presence of I1016 and C1534. Conclusion /significance This study highlighted the presence of a common set of differentially up-regulated detoxifying genes, mainly cytochrome P450 genes in all three populations. GUA and GUY populations shared a higher number of those genes compared to CAL. Two kdr mutations well known to be associated to pyrethroid resistance were also detected in those two populations but not in CAL. Different selective pressures and genetic backgrounds can explain such differences. These results are also compared with those obtained from other parts of the world and are discussed in the context of integrative research on vector competence.
Chikungunya Virus Transmission Potential by Local Aedes Mosquitoes in the Americas and Europe
Anubis Vega-Rúa?,Ricardo Louren?o-de-Oliveira?,Laurence Mousson?,Marie Vazeille?,Sappho Fuchs?,André Yébakima?,Joel Gustave?,Romain Girod?,Isabelle Dusfour,Isabelle Leparc-Goffart
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0003780
Abstract: Background Chikungunya virus (CHIKV), mainly transmitted in urban areas by the mosquitoes Aedes aegypti and Aedes albopictus, constitutes a major public health problem. In late 2013, CHIKV emerged on Saint-Martin Island in the Caribbean and spread throughout the region reaching more than 40 countries. Thus far, Ae. aegypti mosquitoes have been implicated as the sole vector in the outbreaks, leading to the hypothesis that CHIKV spread could be limited only to regions where this mosquito species is dominant. Methodology/Principal Findings We determined the ability of local populations of Ae. aegypti and Ae. albopictus from the Americas and Europe to transmit the CHIKV strain of the Asian genotype isolated from Saint-Martin Island (CHIKV_SM) during the recent epidemic, and an East-Central-South African (ECSA) genotype CHIKV strain isolated from La Réunion Island (CHIKV_LR) as a well-characterized control virus. We also evaluated the effect of temperature on transmission of CHIKV_SM by European Ae. albopictus. We found that (i) Aedes aegypti from Saint-Martin Island transmit CHIKV_SM and CHIKV_LR with similar efficiency, (ii) Ae. aegypti from the Americas display similar transmission efficiency for CHIKV_SM, (iii) American and European populations of the alternative vector species Ae. albopictus were as competent as Ae. aegypti populations with respect to transmission of CHIKV_SM and (iv) exposure of European Ae. albopictus to low temperatures (20°C) significantly reduced the transmission potential for CHIKV_SM. Conclusions/Significance CHIKV strains belonging to the ECSA genotype could also have initiated local transmission in the new world. Additionally, the ongoing CHIKV outbreak in the Americas could potentially spread throughout Ae. aegypti- and Ae. albopictus-infested regions of the Americas with possible imported cases of CHIKV to Ae. albopictus-infested regions in Europe. Colder temperatures may decrease the local transmission of CHIKV_SM by European Ae. albopictus, potentially explaining the lack of autochthonous transmission of CHIKV_SM in Europe despite the hundreds of imported CHIKV cases returning from the Caribbean.
Asymptotic Expansion of Temperature Close to a Singularity of a Plate  [PDF]
Isabelle Titeux
World Journal of Mechanics (WJM) , 2011, DOI: 10.4236/wjm.2011.13015
Abstract: The thermal conduction in a thin laminated plate is considered here. The lateral surface of the plate is not regular. Consequently, the boundary of the middle plane admits a geometrical singularity. Close to the origin, the lateral edge forms an angle. We shall prove that the classical bidimensional problem associated with the thin plate problem is not valid. In this paper, using the boundary layer theory, we describe the local behavior of the plate, close to the perturbation.
Peri-Orbital Non-Invasive and Painless Skin Tightening-Safe and Highly Effective Use of Multisource Radio-Frequency Treatment Platform  [PDF]
Isabelle Rousseaux
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2015, DOI: 10.4236/jcdsa.2015.53025
Abstract: The periorbital area is the third highest-ranking area for cosmetic surgery. However, surgery in this area presents a number of difficulties and safety concerns. First generation Monopolar RF treatments in this area were usually associated with considerable pain and long downtime. In the present clinical study, we used the iFine handpiece of the EndyMed PRO, multi-source phase-controlled radiofrequency (RF) for Non-invasive, pain free, skin rejuvenation of the periorbital area. The study included eleven (11) subjects, treated for periorbital signs of aging (iFine handpiece, EndyMed PRO platform, EndyMed Medical, Caesarea, Israel). The degree of clinical improvement was assessed by the global aesthetic improvement scale (GAIS) and subjects satisfaction by post treatment questionnaires. 91% of patients showed good to excellent improvement as a result of the treatment. Subjects satisfaction showed that 55% of patients reported that they were very satisfied, 45% were satisfied while none were dissatisfied. There were no incidences of infections, scarring, hypopigmentation, or any other serious complications.
Carotid Endothelial VCAM-1 Is an Early Marker of Carotid Atherosclerosis and Predicts Coronary Artery Disease in Swine  [PDF]
Isabelle Masseau, Douglas K. Bowles
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.811073
Abstract: Objective: The aim was to determine if endothelial VCAM-1 (eVCAM-1) expression in the common carotid artery (CCA) would correlate with predictive markers of atherosclerotic disease, would precede reduction of markers of endothelial cell function and would predict coronary artery disease (CAD). Methods and results: Carotid arterial segments (bifurcation, proximal and distal CCA) were harvested from 14 and 24 month-old male castrated familial hypercholesterolemic (FH) swine, a model of spontaneous atherosclerosis. Quantification of local expression of eVCAM-1, intimal macrophage accumulation, oxidative stress, intima-media (I/M) ratio, intima-media thickness (IMT), endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (p-eNOS) in selected regions of the carotids revealed a relationship between local inflammation and atherosclerotic plaque progression. Importantly, inflammation was not uniform throughout the CCA. Endothelial VCAM-1 expression was the greatest at the bifurcation and increased with age. Finally, eVCAM-1 best estimated the severity of CAD compared to blood levels of glucose, hypercholesterolemia, carotid IMT, and p-eNOS. Conclusion: Our data suggested that eVCAM-1 was closely associated with atherosclerotic plaque progression and preceded impairment of EDD. Thus, this study supported the use of carotid VCAM-1 targeting agents to estimate the severity of CAD.
Mycobacterium avium Paratuberculosis (MAP) and Cytomegalovirus (CMV) Are Frequently Detected in the Saliva of Patients Recently Diagnosed with Crohn Disease (CD) Whereas Oral Propionibacterium Acnes (PA) or Methylacetate (MA) in Their Breath Is Rare  [PDF]
Donatini Bruno, Le Blaye Isabelle
Journal of Biosciences and Medicines (JBM) , 2015, DOI: 10.4236/jbm.2015.312003
Abstract:

We investigated the presence of MAP, CMV, or Epstein-Barr virus (EBV) in the saliva of patients presenting with periodontal disease, gingivitis or oral aphthosis. We also measured methylacetate in their breath and looked for the presence of PA on their tongue. All patients were prospectively enrolled into a two-year cohort study. We compared the group presenting with CD versus the group without CD. 167 patients were enrolled. 24 patients presented with CD. CMV and MAP were found concomitantly in 67% of CD patients (17 patients) whereas only 1 patient (<0.1%; p < 0.001) has these infectious agents in the comparative group. PA was rare in CD (25% versus 70.6%; p < 0.001). MA was low, especially with an empty stomach (0.59 ppm +/? 1.45 versus 5.14 ppm +/? 8.97; p < 0.001). It was concluded that the association MAP + CMV was frequently found in oral lesions of CD at an early stage. Detection of PA, MAP and CMV, as well as breath test could be easily performed and may participate to the early diagnosis of CD.

O paradoxal estatuto do conhecimento jornalístico: entre a desconsidera??o e o protagonismo do saber produzido pelas notícias nas sociedades modernas
Anchieta, Isabelle;
Intercom: Revista Brasileira de Ciências da Comunica??o , 2011, DOI: 10.1590/S1809-58442011000200009
Abstract: the knowledge of journalism debate produces a paradox: on the one hand, it is the most appropriate way to meet the present and historical events in modern societies, on the other hand, is considered insufficient knowledge, fragmented and ideologically committed to the social reality . in this article we ask: which is, after all the place of knowledge generated for journalism in modern society? let's get into the discussion in the context of the crisis of traditional knowledge and science as truth. its effects reach particularly the form of journalism and creates a dilemma: whether journalism can not be legitimized in scientific terms would then be closer to the knowledge based on common sense? for that, compared two theoretical perspectives on knowledge news: the german tobias peucer, seventeenth century, and the american robert park, of the twentieth century. in this comparison we are interested in observing the changes, but especially that which remains in journalistic practices to finally establish the ethics of journalistic knowledge.
From street to job: integrating juvenile delinquents
Coutant,Isabelle;
Etnográfica , 2010,
Abstract: since the 1970s, given the transformations of the job market and the changes in ?street culture?, professional morals replace ?street morals? less easily than before, and the shop floor is less integrative for juvenile delinquents. in that sense, the importance of the role played by the institutions involved in the process of normalization has grown in proportion. by studying an integration system for juvenile delinquents, in a french banlieue, it is precisely that sort of ambition i wished to apprehend. through the case studies of three young men, i explain the reasons why the young people involved in the system participate in it, and the conditions that need to be met for a street educator?s moral authority to be acknowledged. i underscore the acculturation that takes place at the heart of the system and the type of competences that can be acquired there. i show also, the stigmata linked to a delinquent past can always get in the way of the process and reactivate habits developed in the ?street?.
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