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Search Results: 1 - 10 of 2282 matches for " Isabelle Devambez "
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Antiprotozoal Activities of Organic Extracts from French Marine Seaweeds
Catherine Vonthron-Sénécheau,Marcel Kaiser,Isabelle Devambez,Antoine Vastel,Isabelle Mussio,Anne-Marie Rusig
Marine Drugs , 2011, DOI: 10.3390/md9060922
Abstract: Marine macrophytes contain a variety of biologically active compounds, some reported to have antiprotozoal activity in vitro. As a part of a screening program to search for new natural antiprotozoals, we screened hydroalcoholic and ethyl acetate extracts of 20 species of seaweeds from three phyla (Rhodophyta, Heterokontophyta and Chlorophyta), sampled along the Normandy (France) coast. We tested them in vitro against the protozoa responsible for three major endemic parasitic diseases: Plasmodium falciparum, Leishmania donovani and Trypanosoma cruzi. The selectivity of the extracts was also evaluated by testing on a mammalian cell line (L6 cells). Ethyl acetate extracts were more active than hydroalcoholic ones. Activity against T. cruzi and L. donovani was non-existent to average, but almost half the extracts showed good activity against P. falciparum. The ethyl acetate extract of Mastocarpus stellatus showed the best antiplasmodial activity as well as the best selectivity index (IC 50 = 2.8 μg/mL; SI > 30). Interestingly, a red algae species, which shares phylogenetic origins with P. falciparum, showed the best antiplasmodial activity. This study is the first to report comparative antiprotozoal activity of French marine algae. Some of the species studied here have not previously been biologically evaluated.
Gαo Is Required for L-Canavanine Detection in Drosophila
Isabelle Devambez, Moutaz Ali Agha, Christian Mitri, Jo?l Bockaert, Marie-Laure Parmentier, Frédéric Marion-Poll, Yves Grau, Laurent Soustelle
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0063484
Abstract: Taste is an essential sense for the survival of most organisms. In insects, taste is particularly important as it allows to detect and avoid ingesting many plant toxins, such as L-canavanine. We previously showed that L-canavanine is toxic for Drosophila melanogaster and that flies are able to detect this toxin in the food. L-canavanine is a ligand of DmXR, a variant G-protein coupled receptor (GPCR) belonging to the metabotropic glutamate receptor subfamily that is expressed in bitter-sensitive taste neurons of Drosophila. To transduce the signal intracellularly, GPCR activate heterotrimeric G proteins constituted of α, β and γ subunits. The aim of this study was to identify which Gα protein was required for L-canavanine detection in Drosophila. By using a pharmacological approach, we first demonstrated that DmXR has the best coupling with Gαo protein subtype. Then, by using genetic, behavioral assays and electrophysiology, we found that Gαo47A is required in bitter-sensitive taste neurons for L-canavanine sensitivity. In conclusion, our study revealed that Gαo47A plays a crucial role in L-canavanine detection.
Asymptotic Expansion of Temperature Close to a Singularity of a Plate  [PDF]
Isabelle Titeux
World Journal of Mechanics (WJM) , 2011, DOI: 10.4236/wjm.2011.13015
Abstract: The thermal conduction in a thin laminated plate is considered here. The lateral surface of the plate is not regular. Consequently, the boundary of the middle plane admits a geometrical singularity. Close to the origin, the lateral edge forms an angle. We shall prove that the classical bidimensional problem associated with the thin plate problem is not valid. In this paper, using the boundary layer theory, we describe the local behavior of the plate, close to the perturbation.
Peri-Orbital Non-Invasive and Painless Skin Tightening-Safe and Highly Effective Use of Multisource Radio-Frequency Treatment Platform  [PDF]
Isabelle Rousseaux
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2015, DOI: 10.4236/jcdsa.2015.53025
Abstract: The periorbital area is the third highest-ranking area for cosmetic surgery. However, surgery in this area presents a number of difficulties and safety concerns. First generation Monopolar RF treatments in this area were usually associated with considerable pain and long downtime. In the present clinical study, we used the iFine handpiece of the EndyMed PRO, multi-source phase-controlled radiofrequency (RF) for Non-invasive, pain free, skin rejuvenation of the periorbital area. The study included eleven (11) subjects, treated for periorbital signs of aging (iFine handpiece, EndyMed PRO platform, EndyMed Medical, Caesarea, Israel). The degree of clinical improvement was assessed by the global aesthetic improvement scale (GAIS) and subjects satisfaction by post treatment questionnaires. 91% of patients showed good to excellent improvement as a result of the treatment. Subjects satisfaction showed that 55% of patients reported that they were very satisfied, 45% were satisfied while none were dissatisfied. There were no incidences of infections, scarring, hypopigmentation, or any other serious complications.
Carotid Endothelial VCAM-1 Is an Early Marker of Carotid Atherosclerosis and Predicts Coronary Artery Disease in Swine  [PDF]
Isabelle Masseau, Douglas K. Bowles
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.811073
Abstract: Objective: The aim was to determine if endothelial VCAM-1 (eVCAM-1) expression in the common carotid artery (CCA) would correlate with predictive markers of atherosclerotic disease, would precede reduction of markers of endothelial cell function and would predict coronary artery disease (CAD). Methods and results: Carotid arterial segments (bifurcation, proximal and distal CCA) were harvested from 14 and 24 month-old male castrated familial hypercholesterolemic (FH) swine, a model of spontaneous atherosclerosis. Quantification of local expression of eVCAM-1, intimal macrophage accumulation, oxidative stress, intima-media (I/M) ratio, intima-media thickness (IMT), endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (p-eNOS) in selected regions of the carotids revealed a relationship between local inflammation and atherosclerotic plaque progression. Importantly, inflammation was not uniform throughout the CCA. Endothelial VCAM-1 expression was the greatest at the bifurcation and increased with age. Finally, eVCAM-1 best estimated the severity of CAD compared to blood levels of glucose, hypercholesterolemia, carotid IMT, and p-eNOS. Conclusion: Our data suggested that eVCAM-1 was closely associated with atherosclerotic plaque progression and preceded impairment of EDD. Thus, this study supported the use of carotid VCAM-1 targeting agents to estimate the severity of CAD.
Mycobacterium avium Paratuberculosis (MAP) and Cytomegalovirus (CMV) Are Frequently Detected in the Saliva of Patients Recently Diagnosed with Crohn Disease (CD) Whereas Oral Propionibacterium Acnes (PA) or Methylacetate (MA) in Their Breath Is Rare  [PDF]
Donatini Bruno, Le Blaye Isabelle
Journal of Biosciences and Medicines (JBM) , 2015, DOI: 10.4236/jbm.2015.312003
Abstract:

We investigated the presence of MAP, CMV, or Epstein-Barr virus (EBV) in the saliva of patients presenting with periodontal disease, gingivitis or oral aphthosis. We also measured methylacetate in their breath and looked for the presence of PA on their tongue. All patients were prospectively enrolled into a two-year cohort study. We compared the group presenting with CD versus the group without CD. 167 patients were enrolled. 24 patients presented with CD. CMV and MAP were found concomitantly in 67% of CD patients (17 patients) whereas only 1 patient (<0.1%; p < 0.001) has these infectious agents in the comparative group. PA was rare in CD (25% versus 70.6%; p < 0.001). MA was low, especially with an empty stomach (0.59 ppm +/? 1.45 versus 5.14 ppm +/? 8.97; p < 0.001). It was concluded that the association MAP + CMV was frequently found in oral lesions of CD at an early stage. Detection of PA, MAP and CMV, as well as breath test could be easily performed and may participate to the early diagnosis of CD.

O paradoxal estatuto do conhecimento jornalístico: entre a desconsidera??o e o protagonismo do saber produzido pelas notícias nas sociedades modernas
Anchieta, Isabelle;
Intercom: Revista Brasileira de Ciências da Comunica??o , 2011, DOI: 10.1590/S1809-58442011000200009
Abstract: the knowledge of journalism debate produces a paradox: on the one hand, it is the most appropriate way to meet the present and historical events in modern societies, on the other hand, is considered insufficient knowledge, fragmented and ideologically committed to the social reality . in this article we ask: which is, after all the place of knowledge generated for journalism in modern society? let's get into the discussion in the context of the crisis of traditional knowledge and science as truth. its effects reach particularly the form of journalism and creates a dilemma: whether journalism can not be legitimized in scientific terms would then be closer to the knowledge based on common sense? for that, compared two theoretical perspectives on knowledge news: the german tobias peucer, seventeenth century, and the american robert park, of the twentieth century. in this comparison we are interested in observing the changes, but especially that which remains in journalistic practices to finally establish the ethics of journalistic knowledge.
From street to job: integrating juvenile delinquents
Coutant,Isabelle;
Etnográfica , 2010,
Abstract: since the 1970s, given the transformations of the job market and the changes in ?street culture?, professional morals replace ?street morals? less easily than before, and the shop floor is less integrative for juvenile delinquents. in that sense, the importance of the role played by the institutions involved in the process of normalization has grown in proportion. by studying an integration system for juvenile delinquents, in a french banlieue, it is precisely that sort of ambition i wished to apprehend. through the case studies of three young men, i explain the reasons why the young people involved in the system participate in it, and the conditions that need to be met for a street educator?s moral authority to be acknowledged. i underscore the acculturation that takes place at the heart of the system and the type of competences that can be acquired there. i show also, the stigmata linked to a delinquent past can always get in the way of the process and reactivate habits developed in the ?street?.
Uso de los datos de plumbemia para evaluar y prevenir el envenenamiento infantil por plomo en Latinoamérica
Romieu,Isabelle;
Salud Pública de México , 2003, DOI: 10.1590/S0036-36342003000800012
Abstract: exposure to lead is a widespread and serious threat to the health of children in latin america. health officials should monitor sources of exposure and health outcomes to design, implement, and evaluate prevention and control activities. to evaluate the magnitude of lead as a public health problem, three key elements must be defined: 1) the potential sources of exposure, 2) the indicators to evaluate health effects and environmental exposure, and 3) the sampling methods for the population at risk. several strategies can be used to select the study population depending on the study objectives, the time limitations, and the available resources. if the objective is to evaluate the magnitude and sources of the problem, the following sampling methods can be used: 1) population-based random sampling; 2) facility-based random sampling within hospitals, daycare centers, or schools; 3) target sampling of high risk groups; 4) convenience sampling of volunteers; and 5) case reporting (which can lead to the identification of populations at risk and sources of exposures). for all sampling methods, information gathering should include the use of a questionnaire to collect general information on the participants and on potential local sources of exposure, as well as the collection of biological samples. in interpreting data, one should consider the type of sampling used and the non-response rates, as well as factors that might influence blood lead measurements, such as age and seasonal variability. blood lead measurements should be integrated in an overall strategy to prevent lead toxicity in children.
Diet and breast cancer
Romieu,Isabelle;
Salud Pública de México , 2011, DOI: 10.1590/S0036-36342011000500011
Abstract: both diet and nutrition have been studied in relationship with breast cancer risk, as the great variation among different countries in breast cancer incidence could possibly be explained through the inflammatory and immune response, as well as antioxidant intake, among others.to date, no clear association with diet beyond overweight and weight gain has been found, except for alcohol consumption. nonetheless, the small number of studies done in middle to low income countries where variability of food intake is wider,is beginning to show interesting results.
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