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Search Results: 1 - 10 of 629 matches for " Isabela Lovizutto Iessi "
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Influência do ciclo lunar no parto: mito ou constata??o científica?
Bueno, Aline;Iessi, Isabela Lovizutto;Damasceno, Débora Cristina;
Revista Brasileira de Enfermagem , 2010, DOI: 10.1590/S0034-71672010000300021
Abstract: superstitions are found everywhere in our lives, and medicine, a profession that is prides itself on an evidence-based approach to treatment, is not exempt. a superstition that pervades the labor and delivery floor is that it is busier during certain phases of the lunar cycle, specifically the full moon. although some studies have demonstrated an increase in deliveries that are related to the lunar cycle, there has been disagreement about when, in the lunar cycle, the peak volume occurs. front to the divergence of the existent results in the literature to relate the events of the lunar cycle with deliveries, the aim of this review was to accomplish the literature in the attempt of explaining this popular culture with base in the results presented by different researchers.
Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
Yuri Karen Sinzato,Gustavo Tadeu Volpato,Isabela Lovizutto Iessi,Aline Bueno,Iracema de Mattos Paranhos Calderon,Marilza Vieira Cunha Rudge,Débora Cristina Damasceno
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/108163
Abstract: The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.
Evaluation of placental glycogen storage in mild diabetic rats
Bueno, Aline;Iessi, Isabela Lovizutto;Calderon, Iracema de Mattos Paranhos;Rudge, Marilza Vieira Cunha;Santos, Carlos Eduardo Meirelles dos;Damasceno, Débora Cristina;
Acta Cirurgica Brasileira , 2010, DOI: 10.1590/S0102-86502010000200002
Abstract: purpose: to evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. methods: at the birth day, 147 female rats were randomly distributed in two experimental groups: 1) non-diabetic group (control, n=45) - received the vehicle; 2) diabetic group (stz, n=102) - received 100 mg streptozocin/kg in neonatal period. at day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dl and, in the group stz with glycemia between 120 and 300 mg/dl. at day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. the newborns (nb) were classified in small (sga), appropriate (aga) and large (lga) for gestational age. results: rats stz presented higher glycemia at days 0 and 14 of pregnancy. at end of pregnancy, rats stz showed higher proportion of nb sga and lga; reduced rate of nb aga and unaltered glycemia, insulin and placental glycogen determinations. conclusion: mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.
Neonatally induced diabetes: liver glycogen storage in pregnant rats
Iessi, Isabela Lovizutto;Bueno, Aline;Sinzato, Yuri Karen;Spada, Ana Paula Machado;Rudge, Marilza Vieira Cunha;Heubel, Maricê Thereza Correa Domingues;Damasceno, Débora Cristina;
Brazilian Archives of Biology and Technology , 2012, DOI: 10.1590/S1516-89132012000200010
Abstract: the aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. wistar rats were divided in to two groups: 1) mild diabetes (stz) - received streptozotocin (glycemia from 120 to 300 mg/dl), 2) control - received vehicle (glycemia below 120 mg/dl). at days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. at day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the stz group as compared to the controls. in the stz group, maternal weight gain were lower as compared to those in the control group. significantly increased glycemia was observed at days 0 and 14 of the pregnancy in the stz group. therefore, neonatally induced diabetes in the rats did not cause metabolic changes that impaired insulin and liver glycogen relation in these rats.
Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
Yuri Karen Sinzato,Gustavo Tadeu Volpato,Isabela Lovizutto Iessi,Aline Bueno,Iracema de Mattos Paranhos Calderon,Marilza Vieira Cunha Rudge,Débora Cristina Damasceno
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/108163
Abstract: The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100?mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women. 1. Background Pregnant women with type 1 or type 2 diabetes are at increased risk of miscarriage, stillbirth, congenital malformations, placental abnormalities, and intrauterine malprogramming. Despite current treatments, maternal diabetes is an unfavorable environment for embryonic and fetoplacental development [1–7]. These important aspects of human diabetic pregnancies can be studied using the appropriate animal models [8], not only by ethical reasons but also by the multiplicity of uncontrolled variables that may modify the intrauterine environment [9]. Experimental models of severe diabetes (glycemia > 300?mg/dL), which reproduce the clinical conditions of poorly controlled type-1 diabetes, have been widely used [10–14]. However, only a few studies have evaluated the repercussions of diabetes on pregnant rats and/or their offspring [9, 15–18] using models of mild diabetes (glycemia between 120 and 300?mg/dL). In a previous study conducted at our laboratory [19], experimental mild diabetes induced at 5 days of life was not effective in reproducing the reproductive outcomes (miscarriage, fetal viability, and morbidity) observed in diabetic pregnant women. Although glycemic levels were consistent with those reported elsewhere,
Evaluation of neonatally-induced mild diabetes in rats: Maternal and fetal repercussions
Isabela L Iessi, Aline Bueno, Yuri K Sinzato, Kristin N Taylor, Marilza VC Rudge, Débora C Damasceno
Diabetology & Metabolic Syndrome , 2010, DOI: 10.1186/1758-5996-2-37
Abstract: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insufficient insulin secretion, and receptor insensitivity to endogenous insulin. Its incidence is associated with high morbidity and mortality rates [1]. In pregnancies complicated by diabetes, hyperglycemia and alterations in lipid metabolism are associated with both maternal and fetal complications [2,3], causing reproductive abnormalities that enhance spontaneous abortion, congenital anomalies, and neonatal morbidity and mortality [4,5].Congenital anomalies are more common in infants of diabetic women than in children of nondiabetic women. The etiology, pathogenesis and prevention of diabetes-induced anomalies have spurred considerable clinical and basic research efforts. The infant of the diabetic mother also has increased risk for several neonatal complications, such as macrosomia, hypoglycemia, hypocalcemia, polycythemia and hyperbilirubinemia. Up to 25% of such offspring have been reported with these complications. It also appears that early detection and subsequent strict metabolic control of pregnant women with diabetes in pregnancy should decrease the frequency and severity of some of these short- and long-term complications in the offspring of the diabetic mother [4].Despite increased clinical efforts to improve glycemic control during diabetic pregnancy, however, the rate of congenital malformations remains increased in studies of Diabetes mellitus (DM) of type 1 [6-9], DM type 2 [9-12], and gestational diabetes (GDM) [10,13]. The prevalence of major congenital malformations is approximately three to five times higher in infants of diabetic mothers [14-17] and is presently the most common cause of perinatal death among these infants [18,19]. Diabetes is associated with a variety of anomalies, primarily cardiovascular, neurological, and musculoskeletal [20]. The malformation considered to be most pathognomic to the infants of diabetic mothers - caudal regression syndrome or sa
Um desafio ao respeito e à tolerancia: reflex?es sobre o campo religioso daimista na atualidade
Oliveira, Isabela;
Religi?o & Sociedade , 2011, DOI: 10.1590/S0100-85872011000200008
Abstract: the article analyzes the composition of the santo daime religious field today and how the main groups that are part of the religion - daime centers located in the alto santo region in rio branco and the churches affiliated to the iceflu (church of the eclectic cult of the universal flowing light - patron sebasti?o mota de melo) - legitimize their practice of the religion. it also demonstrates how the different political and ideological positions assumed by these groups in the santo daime religious field are historically constructed and reveal how these positions are also part of the broader social dynamics of religions today.
Conceito(s) de burnout: quest?es atuais da pesquisa e a contribui??o da clínica
Vieira, Isabela;
Revista Brasileira de Saúde Ocupacional , 2010, DOI: 10.1590/S0303-76572010000200009
Abstract: considering the growing scientific interest in burnout phenomenon, we present a sample of the theoretic diversity that constitutes the research field in this area presenting some of the debates currently being held on its concept. we discuss apparent limitations of the empirical approach on the comprehension of burnout conceptual nature, indicating a possible contribution from the clinical practice (within the field of psychiatry) to this debate.
Povos indígenas versus petrolíferas: controle constitucional na resistência
Figueroa, Isabela;
Sur. Revista Internacional de Direitos Humanos , 2006, DOI: 10.1590/S1806-64452006000100004
Abstract: the ecuadorian constitution, oriented by guidelines of international law, has established a multi-cultural state, and devotes one of its chapters to the collective rights of the indigenous and afro-ecuadorian peoples. since approval in 1998, new possibilities have arisen regarding claims of such rights before courts, as well as their development in domestic laws.in ecuador's amazonian regions, there are two cases in which indigenous peoples have made use of the new legal mechanisms to defend their collective rights against the oil industry. both cases demonstrate the aggressiveness with which oil companies -allied with the government and the world bank - impose their "public relations programs" in indigenous territories, applying the same divide-and-conquer dynamics historically used by the oil industry in the legal arena. (original in spanish.)
Screening for thyroid disorders in asymptomatic adults from Brazilian populations
Bense?or, Isabela;
Sao Paulo Medical Journal , 2002, DOI: 10.1590/S1516-31802002000500005
Abstract: advances in thyroid disorder diagnosis have created new thyroid disorder categories such as subclinical hyperthyroidism and subclinical hypothyroidism. in the 1980s, immunometric assaying for thyroid stimulating hormone (tsh) emerged and became defined as the most cost-effective test in thyroid disorder screening. the second step in the screening of thyroid disorders is to determine free thyroxine (ft4), and cost-effective methods for its detection are now available. using tsh and ft4, it is possible to determine four situations: clinical hyperthyroidism, clinical hypothyroidism, subclinical hyperthyroidism and subclinical hypothyroidism. subclinical hypothyroidism can be a strong indicator of risk for atherosclerosis and myocardial infarction in elderly women. cardiovascular mortality among brazilian women is one of the highest in the western world. the best-known risk factors for cardiovascular diseases are high blood pressure, smoking, diabetes, and hypercholesterolemia. although these are recognized as primary risk factors, there are other risk factors that could be identified as primordial risk factors. this may be the case for subclinical hypothyroidism. early detection of thyroid disorders in women over fifty could be a highly cost-effective option in the prevention of cardiovascular disorders among brazilian women.
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