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Search Results: 1 - 10 of 7976 matches for " Irfan Newaz Khan "
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THROMBOLYTIC & CYTOTOXIC EFFECT OF DIFFERENT HERBAL EXTRACTS
Irfan Newaz Khan et al.
International Journal of Pharmaceutical Sciences and Research , 2011,
Abstract: An in-vitro thrombolytic model was used to check the clot lysis effect of four herbal extracts viz., Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens along with Streptokinase as a positive control and water as a negative control. And also brine shrimp lethality bio-assay was done using brine shrimp Nauplii and 5% of DMSO as a solvent for the ethanol extracts of Nigella sativa & Capsicum frutescens and Honey. Using an in vitro thrombolytic model, Honey, Nigella sativa, Capsicum frutescens, Brassica oleracea, combination of Honey & Nigella sativa and Honey & Capsicum frutescens showed 26.82%, 47.13%, 57.40%, 62.44%, 56.58% and 44.54% clot lysis effect respectively. From our study, we found that Brassica oleracea, Capsicum frutescens, and combination of Honey & Nigella sativa showed significant % of clot lysis effect with reference to Streptokinase. Again from in vitro brine shrimp lethality bio-assay, we found that the LC50 of Honey, Capsicum frutescens & Nigella sativa were 129.62 μg/ml, 83.33 μg/ml & 45.45 μg/ml respectively.
Thrombolytic potential of Ocimum sanctum L., Curcuma longa L., Azadirachta indica L. and Anacardium occidentale L.
Irfan Newaz Khan,Sourav Hawlader,Md. Razibul Habib,Md. Mominur Rahman
Journal of Basic and Clinical Pharmacy , 2011,
Abstract: Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formed in blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels; however, these drugs have certain limitations which cause serious and sometimes fatal consequences. Herbal preparations have been used since ancient times for the treatment of several diseases. The aim of this study was to investigate whether herbal preparations possess thrombolytic activity or not. An in vitro thrombolytic model was used to check the clot lysis effectof four aqueous herbal extracts viz., O. sanctum, C. longa, A. indica, A. occidentale along with Streptokinase as a positive control and water as a negative control. The percentage (%) clot lysis was statistically significant (p<0.0001)when compared with vehicle control. Using an in vitro thrombolytic model, O. sanctum, C. longa, A. indica & A.occidentale showed moderate clot lysis activity (30.01 ± 6.168%, 32.94 ± 3.663%, 27.47 ± 6.943%, 33.79 ± 2.926% respectively) whereas standard streptokinase showed 86.2 ± 10.7 % clot lysis effect. From our study we found that all the herbs showed reasonable % of clot lysis. These herbal extracts possess thrombolytic properties that could lyse blood clots in vitro; however, in vivo clot dissolving properties and active component(s) of these extracts for clot lysis are yet to be discovered.
Fuzzy Geometric Programming in Multivariate Stratified Sample Surveys in Presence of Non-Response with Quadratic Cost Function  [PDF]
Shafiullah  , Mohammad Faisal Khan, Irfan Ali
American Journal of Operations Research (AJOR) , 2014, DOI: 10.4236/ajor.2014.43017
Abstract:

In this paper, the problem of non-response with significant travel costs in multivariate stratified sample surveys has been formulated of as a Multi-Objective Geometric Programming Problem (MOGPP). The fuzzy programming approach has been described for solving the formulated MOGPP. The formulated MOGPP has been solved with the help of LINGO Software and the dual solution is obtained. The optimum allocations of sample sizes of respondents and non respondents are obtained with the help of dual solutions and primal-dual relationship theorem. A numerical example is given to illustrate the procedure. 

 

Thyroid Disorders in Patients with Inflammatory Bowel Diseases  [PDF]
Mustafa Yakut, Yusuf üstün, G?khan Kabacan, Irfan Soykan
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.22018
Abstract: Background: The rate of thyroid disorders is reported to be increased in patients with Ulcerative Colitis (UC) and Crohn’s disease (CD) than the normal population. The purpose of this study is to evaluate the prevalance of Thyroid disorders in a group of patients with inflammatory bowel diseases (IBD). Material and Methods: 146 IBD patients (113 UC and 33 CD patients) and 66 healthy control subjects were enrolled into the study. Serum free T4 (FT4), free T3 (FT3), TSH and anti TPO levels of the patients were analyzed retrospectively and and compared with a control group. These cases were also investigated with thyroid ultrasound and nuclear (scintigraphy) imaging. Results: The mean age of IBD patients (76 women) was 42.9 ± 12.4 years. Among the control group 42 were female and their mean age was 40.9 ± 12.1 years. Thyroid gland disease was found in 14 (9.5%, 8 female, 6 male) of 146 IBD patients. The frequency of thyroid disorders has been found to be higher than the control group in patients with control group (14/146 vs. 1/66, p = 0.042). No statistically significant difference has been observed at the thyroid disorder rates between the UC and CD patients (11/113 vs. 3/33, p = 0.912). Hashimoto thyroiditis has been found at 4 (2.7%) of the IBD patients. Conclusion: In accordance with several works published in literature, we have found a higher rate of thyroid disease apperance at IBD patients.
Chebyshev Approximate Solution to Allocation Problem in Multiple Objective Surveys with Random Costs  [PDF]
Mohammed Faisal khan, Irfan Ali, Qazi Shoeb Ahmad
American Journal of Computational Mathematics (AJCM) , 2011, DOI: 10.4236/ajcm.2011.14029
Abstract: In this paper, we consider an allocation problem in multivariate surveys as a convex programming problem with non-linear objective functions and a single stochastic cost constraint. The stochastic constraint is converted into an equivalent deterministic one by using chance constrained programming. The resulting multi-objective convex programming problem is then solved by Chebyshev approximation technique. A numerical example is presented to illustrate the computational procedure.
Allocation of Repairable and Replaceable Components for a System Availability Using Selective Maintenance with Probabilistic Maintenance Time Constraints  [PDF]
Irfan Ali, Mohammed Faisal Khan, Yashpal Singh Raghav, Abdul Bari
American Journal of Operations Research (AJOR) , 2011, DOI: 10.4236/ajor.2011.13016
Abstract: In this paper, we obtain optimum allocation of replaceable and repairable components in a system design. When repair and replace time are considered as random in the constraints. We convert probabilistic constraint into an equivalent deterministic constraint by using chance constrained programming. We have used the selective maintenance policy to determine how many components to be replaced & repaired within the limited maintenance time interval and cost. A Numerical example is presented to illustrate the computational procedure and problem is solved by using LINGO Software.
Allocation in Multivariate Stratified Surveys with Non-Linear Random Cost Function  [PDF]
Mohammed Faisal Khan, Irfan Ali, Yashpal Singh Raghav, Abdul Bari
American Journal of Operations Research (AJOR) , 2012, DOI: 10.4236/ajor.2012.21012
Abstract: In this paper, we consider an allocation problem in multivariate surveys with non-linear costs of enumeration as a problem of non-linear stochastic programming with multiple objective functions. The solution is obtained through Chance Constrained programming. A different formulation of the problem is also presented in which the non-linear cost function is minimised under the precision constraints on estimates of various characters. The solution is then obtained by using Modified E-model. A numerical example is solved for both the formulations.
Stability Analysis for Pod and Seed Production in Dry Bean (Phaseolus vulgaris L.)
S.A. Raffi,M.A. Newaz,N. Khan
Asian Journal of Plant Sciences , 2004,
Abstract: Genotype-environment interaction was studied for number of pods and seeds plant-1 in nine genotypes of dry bean under four cultural environments during rabi season of 2001-2002. There were significant variations due to genotypes (G), environments (E) and GxE interaction for both the characters, which were also highly correlated between themselves (r=0.920**). On the basis of stability parameters (Pi, bi, S2di) genotype PB-S8 was found to be most desirable and stable.
The Pharmacogenomic Consideration of Lipid Homeostasis: Role of Pharmacist in Ethical and Economic Consideration  [PDF]
Paul Serafin, Mohammad Newaz
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.41017
Abstract: Usage of lipid lowering drugs is a common therapeutic steps in preventing or treating diseases. With the advent of Pharmacogenetics and Pharmacogenomics, it is now important to understand the implication of pharmacogenetic testing in patient care. Ethical and economic concerns are wide considered to be an issue in a pharmacy setting and it is important that the health care professionals in the pharmacy setting need to be aware. This article encompasses current pharmacogenomic information that is relevant to lipid homeostasis and addressed the concerns of patient that may be a factor in ultimate decision making process.
Docking of human rhodopsin mutant (Gly90àAsp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness
Shagufta Kanwal,Sumaira Nishat,Muhammad Irfan Khan
Bioinformation , 2012,
Abstract: Motivation: Rhodopsin is a visual pigment present in rod cells of retina. It belongs to GPCR family and involves photoisomerization of 11-cis-retinal to all-trans-retinal isomers, conformational changes in rhodopsin and signal transduction cascade to generate a nerve impulse. This signaling pathway has been targeted to eliminate the effect of a mutation (Gly90àAsp) responsible for abnormal activation of G-protein without retinal conformations in the absence of light leading to congenital night blindness. A theoretical model of rhodopsin with induced mutation has been deliberated in order to find potential ligands which can offset this mutational effect. The binding interactions between the target mutated rhodopsin model and potential ligands have been predicted with the help of molecular docking. The results indicated strong functional benefits of ligands as an inhibitor and an agonist for mutated rhodopsin model. Therefore, we propose a new visual cascade model which can initiate the normal signaling of rhodopsin mutant with the help of proposed ligands and can provide a hope for vision in future.
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