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Search Results: 1 - 10 of 2082 matches for " Ioannis Stefanidis "
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Mark Mazower (ed.), Networks of Power in Modern Greece: Essays in Honour of John Campbell
Ioannis D. Stefanidis
Historical Review , 2010,
Abstract: No abstract
A Flexible Framework for Defining, Representing and Detecting Changes on the Data Web
Yannis Roussakis,Ioannis Chrysakis,Kostas Stefanidis,Giorgos Flouris,Yannis Stavrakas
Computer Science , 2015,
Abstract: The dynamic nature of Web data gives rise to a multitude of problems related to the identification, computation and management of the evolving versions and the related changes. In this paper, we consider the problem of change recognition in RDF datasets, i.e., the problem of identifying, and when possible give semantics to, the changes that led from one version of an RDF dataset to another. Despite our RDF focus, our approach is sufficiently general to engulf different data models that can be encoded in RDF, such as relational or multi-dimensional. In fact, we propose a flexible, extendible and data-model-independent methodology of defining changes that can capture the peculiarities and needs of different data models and applications, while being formally robust due to the satisfaction of the properties of completeness and unambiguity. Further, we propose an ontology of changes for storing the detected changes that allows automated processing and analysis of changes, cross-snapshot queries (spanning across different versions), as well as queries involving both changes and data. To detect changes and populate said ontology, we propose a customizable detection algorithm, which is applicable to different data models and applications requiring the detection of custom, user-defined changes. Finally, we provide a proof-of-concept application and evaluation of our framework for different data models.
Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study
Nikos Zdoukopoulos, Chrysa Doxani, Ioannis E Messinis, Ioannis Stefanidis, Elias Zintzaras
BMC Pregnancy and Childbirth , 2011, DOI: 10.1186/1471-2393-11-89
Abstract: We examined the association of three common variants of the NOS3 gene (4b/a, T-786C and G894T) and their haplotypes in a case-control sample of 102 patients with preeclampsia and 176 women with a history of uncomplicated pregnancies. Genotyping for the NOS3 variants was performed and odds ratios and 95% confidence intervals were obtained to evaluate the association between NOS3 polymorphisms and preeclampsia.The single locus analysis for the three variants using various genetic models and a model-free approach revealed no significant association in relation to clinical status. The analysis of haplotypes also showed lack of significant association.Given the limitations of the candidate-gene approach in investigating complex traits, the evidence of our study does not support the major contributory role of these common NOS3 variants in preeclampsia. Future larger studies may help in elucidating the genetics of preeclampsia further.Preeclampsia is a medical condition in which high blood pressure and elevated urinary excretion of protein develop in pregnancy [1]. Family-based studies have shown that genetic factors may play a role in preeclampsia [2]. In addition, candidate-gene association studies (GAS) on preeclampsia have not produced conclusive results so far [3]. However, the pathogenesis of preeclampsia is poorly understood and the search for low-penetrance genes by hypothesis-driven candidate-gene studies (genetic association study-GAS) and hypothesis-free genome-wide association studies is ongoing [4].The leading hypotheses, concerning the pathogenesis of preeclampsia, are based on disturbed placental function and impaired remodelling of the spiral arteries [5]. Endothelial nitric oxide synthase (NOS3) is an important regulator of vascular tone and contributes to the reduction of the uteroplacental resistance seen in normal pregnancy [6-8]. Therefore, the endothelial nitric oxide synthase gene (NOS3), located at the 7q35-q36 region, has emerged as a logical candi
Moving towards Personalized Geospatial Queries  [PDF]
Giorgos Mountrakis, Anthony Stefanidis
Journal of Geographic Information System (JGIS) , 2011, DOI: 10.4236/jgis.2011.34031
Abstract: Geospatial datasets are typically available as distributed collections contributed by various government or commercial providers. Supporting the diverse needs of various users that may be accessing the same dataset for different applications remains a challenging issue. In order to overcome this challenge there is a clear need to develop the capabilities to take into account complicated patterns of preference describing user and/or application particularities, and use these patterns to rank query results in terms of suitability. This paper offers a demonstration on how intelligent systems can assist geospatial queries to improve retrieval accuracy by customizing results based on preference patterns. We outline the particularities of the geospatial domain and present our method and its application.
Simultaneous clinical resolution of focal segmental glomerulosclerosis associated with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab
Spyridon Arampatzis, Nikolaos Giannakoulas, Vassilios Liakopoulos, Theodoros Eleftheriadis, Panagiota Kourti, Foteini Karasavvidou, Panagiota Matsouka, Ioannis Stefanidis
BMC Nephrology , 2011, DOI: 10.1186/1471-2369-12-33
Abstract: A 53-year-old Caucasian man, previously healthy, with no history of hypertension, alcohol use or smoking presented with rapid weight gain, massive peripheral oedema, and hypertension. Laboratory findings included a white blood cell count of 49,800 cells/mm3 with an absolute lymphocyte count of 47,000 cells/mm3, serum albumin of 2.3 g/dL, urea 65 mg/dL, and creatinine 1.5 mg/dL. A 24-hour urine collection contained 7.1 g protein and significant haematuria. A peripheral blood smear showed mature lymphocytosis and smudge cells. Diagnostic imaging showed mild paraaortic lymphadenopathy with no renal abnormalities. Bone marrow aspiration and trephine biopsy showed diffuse and focal infiltration with B-CLL lymphocytes. Percutaneous renal biopsy revealed total sclerosis in 3/21(14%) of the glomeruli and focal and segmental solidification and sclerosis in 4/21 (19%) glomeruli. A regimen of fludarabine, cyclophosphamide and rituximab was successful in inducing remission of the CLL and clinical resolution of the nephritic-range proteinuria.A multidisciplinary approach to monitor both the malignancy and the glomerular lesions is crucial for the optimal management of paraneoplastic glomerulonephritis. Although chemotherapy with fludarabine, cyclophosphamide and rituximab successfully treated CLL-associated nephrotic syndrome in our patient, further studies are required to confirm efficacy in this setting.Although renal involvement in advanced haematological malignancies is common, glomerulonephritis associated with lymphoproliferative disorders is rare, and the related pathogenetic mechanisms are still poorly understood [1]. Chronic lymphocytic leukemia (CLL) is more commonly associated with membranoproliferative glomerulonephritis and membranous nephropathy whereas minimal change disease is the most common paraneoplastic glomerulonephritis associated with Hodgkin lymphoma, followed by focal segmental glomerulosclerosis (FSGS) [2]. We report on a patient with CLL who presented
Postpartal recurrent non-ST elevation myocardial infarction in essential thrombocythaemia: case report and review of the literature
Spyridon Arampatzis, Ioannis Stefanidis, Vassilios Liakopoulos, Luigi Raio, Daniel Surbek, Markus G Mohaupt
Thrombosis Journal , 2010, DOI: 10.1186/1477-9560-8-12
Abstract: Essential thrombocythaemia (ET) is a chronic myeloproliferative disorder characterized by a sustained elevated platelet count with a tendency to both thrombosis and hemorrhage [1,2]. In ET the median age of presentation is 60 years with female predominance [3] and has a favorable outcome [4]. A small subset of patients is being diagnosed at an earlier age [5,6]. Young women with ET constitute a special group due to their anticipated long survival and childbearing potential [7-9]. Pregnancies in ET patients are likely to be complicated, primarily due to first trimester spontaneous abortions but for those carried to term, obstetric or thrombohemorrhagic complications are rare [10].Pregnancy is an acquired risk factor for thromboembolism associated with increased coagulation and decreased fibrinolysis [11]. Hemodynamic and hormonal alterations during pregnancy may further potentiate the risk of vascular events [12,13]. Although rare, acute myocardial infarction does complicate pregnancy and is estimated to occur in about 6 per 100,000 women during the peripartal period [14].Pregnancy-related complications in patients with ET remains a challenge as platelet count has not been shown to represent a risk factor for pregnancy complications, nor the use of aspirin has been demonstrated to influence pregnancy outcome [9]. We describe a case involving recurrent non-ST elevation myocardial infarction in the immediate postpartum period in a young woman with ET. We review the current literature for pregnancy-related risk factors of myocardial infarction with respect to ET.A 40-year-old caucasian woman, gravida 3 para 2, developed postpartal arterial hypertension. Her first pregnancy, three years earlier, had been complicated by an early spontaneous abortion at gestational week 7. In the following pregnancy, one year later, while on prophylactic low-molecular weight heparin due to the previous miscarriage, a cesarean section was performed at gestational week 32 due to intrauterine
Evidence of Increased Muscle Atrophy and Impaired Quality of Life Parameters in Patients with Uremic Restless Legs Syndrome
Christoforos D. Giannaki,Giorgos K. Sakkas,Christina Karatzaferi,Georgios M. Hadjigeorgiou,Eleftherios Lavdas,Vassilios Liakopoulos,Nikolaos Tsianas,Georgios N. Koukoulis,Yiannis Koutedakis,Ioannis Stefanidis
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0025180
Abstract: Restless Legs Syndrome is a very common disorder in hemodialysis patients. Restless Legs Syndrome negatively affects quality of life; however it is not clear whether this is due to mental or physical parameters and whether an association exists between the syndrome and parameters affecting survival.
Finding the Right Set of Users: Generalized Constraints for Group Recommendations
Kostas Stefanidis,Evaggelia Pitoura
Computer Science , 2013,
Abstract: Recently, group recommendations have attracted considerable attention. Rather than recommending items to individual users, group recommenders recommend items to groups of users. In this position paper, we introduce the problem of forming an appropriate group of users to recommend an item when constraints apply to the members of the group. We present a formal model of the problem and an algorithm for its solution. Finally, we identify several directions for future work.
Mashing up Geographic Information for Emergency Response—An Earthquake Prototype  [PDF]
Shawn Dias, Chaowei Yang, Anthony Stefanidis, Mathew Rice
Journal of Geographic Information System (JGIS) , 2014, DOI: 10.4236/jgis.2014.65044
Abstract: Important information pertaining to emergencies and responses to the emergencies is often distributed across numerous Internet sites. In the event of a disaster like an earthquake, rapid access to such information is critical. At such moments the general public usually has a hard time navigating through numerous sites to retrieve and integrate information, and this may severely affect our capability to make critical decisions in a timely manner. Common earthquake mashups often lack relevant information like locations of first responders and routing to important facilities (e.g. hospitals and fire stations) which could save important time and lives. To address the challenges, we developed an Earthquake Information Mashup prototype. This prototype demonstrates a mashup approach to providing a Web visualization of real-time earthquake monitoring and complementary information, such as traffic conditions, the location of important facilities and routing to them. It also offers users the ability to communicate local condition. Users are thus able to better integrate information from various near real-time sources, obtain better situational awareness, and make smarter informed critical
Effects of Neonatal Overfeeding on Juvenile and Adult Feeding and Energy Expenditure in the Rat
Aneta Stefanidis, Sarah J. Spencer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052130
Abstract: Overfeeding during perinatal life leads to an overweight phenotype that persists throughout the juvenile stage and into adulthood, however, the mechanim(s) underlying this effect are poorly understood. We hypothesized that obesity due to neonatal overfeeding is maintained by changes in energy expenditure and that these changes differ between males and females. We investigated feeding, physical activity, hormonal and metabolic alterations that occur in adult rats made obese by having been nursed in small litters (SL) compared with those from control litters (CL). There were no differences in absolute food intake between the groups, and juvenile and adult SL rats ate less chow per gram body weight than the CL did in the dark (active) phase. Juvenile, but not adult SL rats did have reduced whole body energy expenditure, but there were no differences between the groups by the time they reached adulthood. Adult SL females (but not males) had reduced brown adipose tissue (BAT) temperatures compared with CL in the first half of the dark phase. Our results indicate a persistent overweight phenotype in rats overfed as neonates is not associated with hyperphagia at any stage, but is reflected in reduced energy expenditure into the juvenile phase. The reduced dark phase BAT activity in adult SL females is not sufficient to reduce total energy expenditure at this stage of life and there is an apparently compensatory effect that prevents SL and CL from continuing to diverge in weight that appears between the juvenile and adult stages.
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