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Search Results: 1 - 10 of 57259 matches for " Inna Y. Gong "
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Clinical and Genetic Determinants of Warfarin Pharmacokinetics and Pharmacodynamics during Treatment Initiation
Inna Y. Gong,Ute I. Schwarz,Natalie Crown,George K. Dresser,Alejandro Lazo-Langner,GuangYong Zou,Dan M. Roden,C. Michael Stein,Marc Rodger,Philip S. Wells,Richard B. Kim,Rommel G. Tirona
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0027808
Abstract: Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients. During the first nine days of treatment with pharmacogenetics-guided dosing, S-warfarin plasma levels and international normalized ratio were obtained to serve as inputs to a pharmacokinetic-pharmacodynamic (PK-PD) model. Individual PK (S-warfarin clearance) and PD (Imax) parameter values were estimated. Regression analysis demonstrated that CYP2C9 genotype, kidney function, and gender were independent determinants of S-warfarin clearance. The values for Imax were dependent on VKORC1 and CYP4F2 genotypes, vitamin K status (as measured by plasma concentrations of proteins induced by vitamin K absence, PIVKA-II) and weight. Importantly, indication for warfarin was a major independent determinant of Imax during initiation, where PD sensitivity was greater in atrial fibrillation than venous thromboembolism. To demonstrate the utility of the global PK-PD model, we compared the predicted initial anticoagulation responses with previously established warfarin dosing algorithms. These insights and modeling approaches have application to personalized warfarin therapy.
Baroclinic Instability on Hot Extrasolar Planets
Inna Polichtchouk,James Y-K. Cho
Physics , 2012, DOI: 10.1111/j.1365-2966.2012.21312.x
Abstract: We investigate baroclinic instability in flow conditions relevant to hot extrasolar planets. The instability is important for transporting and mixing heat, as well as for influencing large-scale variability on the planets. Both linear normal mode analysis and non-linear initial value calculations are carried out -- focusing on the freely-evolving, adiabatic situation. Using a high-resolution general circulation model (GCM) which solves the traditional primitive equations, we show that large-scale jets similar to those observed in current GCM simulations of hot extrasolar giant planets are likely to be baroclinically unstable on a timescale of few to few tens of planetary rotations, generating cyclones and anticyclones that drive weather systems. The growth rate and scale of the most unstable mode obtained in the linear analysis are in qualitative, good agreement with the full non-linear calculations. In general, unstable jets evolve differently depending on their signs (eastward or westward), due to the change in sign of the jet curvature. For jets located at or near the equator, instability is strong at the flanks -- but not at the core. Crucially, the instability is either poorly or not at all captured in simulations with low resolution and/or high artificial viscosity. Hence, the instability has not been observed or emphasized in past circulation studies of hot extrasolar planets.
The Region of Matching of Central-Asian Mobile Belt and Pacific Mobile Belt  [PDF]
Inna Derbeko
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.43055

Central Asian and Pacific mobile belts are the two geological superstructures of Eastern Asia. They keep many geological secrets. There is a region of the interaction of the structures in the frames of the margin ofEast Asia. The region is ambiguous. It is denominated in tectonic superposition or covering (interference) of the segments of the structures. The main goal of the research work is to establish the boundary line of the jointing of two superstructures. Here we show the role of the Mesozoic tectonic restructuring and magmatism in the interaction of the structures. The region of their jointing is the boundary line between Bureja-Jziamusy and Badzhal terrains. The boundary line in the frames of Mongol-Okhotsk orogenic belt is disputable. Geochronological and paleomagnetic data and chemical composition of the volcano-plutonic rocks of the eastern margin of Mongol-Okhotsk belt and of the structures of Central-Asian mobile belt were recently obtained. The data allow us to review the region of the joint of the two structures of easternAsia. It was suggested to draw the boundary line of the joint (in this case-interference) of Central Asian mobile belt and Pacific mobile belt in the frames of the eastern margin of Mongol-Okhotsk orogenic belt along the margin of the disappearance of late Mesozoic oversubductional volcano-plutonic complexes in the western direction. The structure of Bureja-Jziamusy superterrain was related to the structures of the Pacific mobile belt. The proposed model of the region of jointing of two East Asian superstructures enables us to reconsider the tectonic and geodynamical and metallogeny schemes of evolution of the Eastern margin ofAsia.

Necessity for Vitamin D Screening among Urban Bedouin Women of Childbearing Age  [PDF]
Inna Rudoy, Ilia Volkov
Health (Health) , 2015, DOI: 10.4236/health.2015.75066
Abstract: Vitamin D (Vit D) plays multiple roles in bodily functions. Vit D deficiency is a common, but often under-diagnosed condition with possible serious complications. According to some research, Vit D is important particularly among women and children. No data were found concerning the Vit D status among urban Bedouin women of childbearing age. The research study is retrospective and descriptive. We analyzed 202 medical histories of patients undergoing blood tests for Vit D level for various reasons. The main objectives of the research were: 1) determining the prevalence of the Vit D deficiency among the Bedouin women of childbearing age; 2) identifying the causes for the physicians’ reasons for suspecting Vit D deficiency: the complaints or symptoms which cause the doctor to test for Vit D level. As a result, in 80.7% of those tested for Vit D, levels were less than 10 ng/ml, and in 19.3%, levels of 10 to 20 ng/ml were found. In lieu of our findings and in order to prevent serious health problems, Vit D screening plan should be seriously considered and discussed in the Bedouin population with high risk of deficiency.
Religion: A Subset of Culture and an Expression of Spirituality  [PDF]
Inna Reddy Edara
Advances in Anthropology (AA) , 2017, DOI: 10.4236/aa.2017.74015
Abstract: Cultures or cultural values, which are described as constructively created behaviors based on collective beliefs, are omnipresent at multiple levels in every human behavior and interaction, including in the sphere of religion. Scholars described religion as a cultural system of symbols, which establish powerful, pervasive, and long-lasting moods and motivations and naturalized conceptions of a general order of existence. Thus, religion is considered to be a part of culture and it acts as one among many forms of overtly expressing and experiencing spirituality that is inward, personal, subjective, transcendental, and unsystematic. In other words, cultural values are seen as a foundation to religiosity. Based on this assumption, this paper reviewed the literature to provide empirical evidence to the overt practice of religiosity that is embedded in particular cultural experiences and values as a form of expressing and experiencing the human universal of spirituality.
Social and Spiritual Dimensions as Protective Factors in the Relationship between Acculturative Stress and Subjective Well-Being among International Students in Taiwan  [PDF]
Inna Reddy Edara
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.97096
Abstract: The purpose of this study was to use the resilience model in investigating the selected factors that reduce acculturative stress and promote well-being among international students in Taiwan. Research has indicated that acculturative stress has been identified as a major issue experienced by many international students in various host countries, resulting in an increase in mental illness and decrease in well-being. A few international studies suggested that factors such as social support and coping strategies mitigated the effects of acculturative stress on negative emotions. In the absence of such studies and as the international student population continues to increase in Taiwan, this project examined the role of social connectedness, social assurance, and spiritual well-being as potential mediators or protective factors in the relationship between acculturative stress and subjective well-being (positive affect and satisfaction with life) in a sample of international students. Data from 214 participants were subjected to regression analyses to analyze for mediation effects. The results indicated significant effects of social connectedness and spiritual well-being on subjective well-being. Of the two significant mediators, social connectedness emerged as a stronger mediator, accounting for 53% and 55% of the mediation effect on positive affect and satisfaction with life, respectively. Spiritual well-being accounted for 7% and 4% of the variance, respectively. These results validate the resilient and positive psychology model, in which the resilience part evades pathological signs when individuals are exposed to stressors, while the positive aspect promotes subjective well-being. These results are discussed in detail and the implication of such results for building appropriate social and spiritual resources and designing interventions are elucidated.
Information and Signs: The Language of Images
Inna Semetsky
Entropy , 2010, DOI: 10.3390/e12030528
Abstract: Since time immemorial, philosophers and scientists were searching for a “machine code” of the so-called Mentalese language capable of processing information at the pre-verbal, pre-expressive level. In this paper I suggest that human languages are only secondary to the system of primitive extra-linguistic signs which are hardwired in humans and serve as tools for understanding selves and others; and creating meanings for the multiplicity of experiences. The combinatorial semantics of the Mentalese may find its unorthodox expression in the semiotic system of Tarot images, the latter serving as the ”keys” to the encoded proto-mental information. The paper uses some works in systems theory by Erich Jantsch and Erwin Laszlo and relates Tarot images to the archetypes of the field of collective unconscious posited by Carl Jung. Our subconscious beliefs, hopes, fears and desires, of which we may be unaware at the subjective level, do have an objective compositional structure that may be laid down in front of our eyes in the format of pictorial semiotics representing the universe of affects, thoughts, and actions. Constructing imaginative narratives based on the expressive “language” of Tarot images enables us to anticipate possible consequences and consider a range of future options . The thesis advanced in this paper is also supported by the concept of informational universe of contemporary cosmology.
Mass media education in the USSR in 1930 and 1960
Inna Kozachenko
Koncept : Scientific and Methodological e-magazine , 2013,
Abstract: The article considers the basic stages of development of media education in the USSR in the pre-war and post-war years. Describes the intensification of the implementation of media education in secondary schools, as well as popularization it in mass media and publishing specialized magazines for different ages.
Проекты загородных домов Проекты загородных домов
Inna Druzhinina
Project Baikal , 2005,
Две постройки Две постройки
Inna Druzhinina
Project Baikal , 2004,
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