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Search Results: 1 - 10 of 282 matches for " Inna Djagaeva "
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Dual Regulation of Dendritic Morphogenesis in Drosophila by the COP9 Signalosome
Inna Djagaeva,Sergey Doronkin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007577
Abstract: Altered dendritic arborization contributes to numerous physiological processes including synaptic plasticity, behavior, learning and memory, and is one of the most consistent neuropathologic conditions found in a number of mental retardation disorders, schizophrenia, and neurodegenerative disease. COP9 signalosome (CSN), an evolutionarily conserved regulator of the Cullin-based ubiquitin ligases that act in the proteasome pathway, has been found associated with diverse debilitating syndromes, suggesting that CSN may be involved in regulation of dendritic arborization. However, the mechanism of this control, if it exists, is unknown. To address whether the CSN pathway plays a role in dendrites, we used a simple and genetically tractable model, Drosophila larval peripheral nervous system. Our model study identified the COP9 signalosome as the key and multilayer regulator of dendritic arborization. CSN is responsible for shaping the entire dendritic tree through both stimulating and then repressing dendritic branching. We identified that CSN exerts its dualistic function via control of different Cullins. In particular, CSN stimulates dendritic branching through Cullin1, and inhibits it via control of Cullin3 function. We also identified that Cullin1 acts in neurons with the substrate-specific F-box protein Slimb to target the Cubitus interruptus protein for degradation.
COP9 Limits Dendritic Branching via Cullin3-Dependent Degradation of the Actin-Crosslinking BTB-Domain Protein Kelch
Inna Djagaeva,Sergey Doronkin
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007598
Abstract: Components of the COP9 signalosome (CSN), a key member of the conserved 26S proteasome degradation pathway, have been detected to be altered in patients of several debilitating syndromes. These findings suggest that CSN acts in neural circuits, but the exact function of CSN in brain remains unidentified. Previously, using Drosophila peripheral nervous system (PNS) as a model system, we determined that CSN is a critical regulator of dendritic morphogenesis. We found that defects in CSN led to the strikingly contrast phenotype of either reducing or stimulating dendritic branching. In particular, we have reported that CSN stimulates dendritic branching via Cullin1-mediated proteolysis. Here we describe that CSN inhibits dendritic arborization in PNS neurons acting via control of Cullin3 function: loss of Cullin3 causes excessive dendritic branching. We also identified a downstream target for Cullin3-dependent degradation in neurons – the actin-crosslinking BTB-domain protein Kelch. Inappropriate accumulation of Kelch, either due to the impaired Cullin3-dependent turnover, or ectopic expression of Kelch, leads to uncontrolled dendritic branching. These findings indicate that the CSN pathway modulates neuronal network in a multilayer manner, providing the foundation for new insight into the CSN role in human mental retardation disorders and neurodegenerative disease.
The Region of Matching of Central-Asian Mobile Belt and Pacific Mobile Belt  [PDF]
Inna Derbeko
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.43055

Central Asian and Pacific mobile belts are the two geological superstructures of Eastern Asia. They keep many geological secrets. There is a region of the interaction of the structures in the frames of the margin ofEast Asia. The region is ambiguous. It is denominated in tectonic superposition or covering (interference) of the segments of the structures. The main goal of the research work is to establish the boundary line of the jointing of two superstructures. Here we show the role of the Mesozoic tectonic restructuring and magmatism in the interaction of the structures. The region of their jointing is the boundary line between Bureja-Jziamusy and Badzhal terrains. The boundary line in the frames of Mongol-Okhotsk orogenic belt is disputable. Geochronological and paleomagnetic data and chemical composition of the volcano-plutonic rocks of the eastern margin of Mongol-Okhotsk belt and of the structures of Central-Asian mobile belt were recently obtained. The data allow us to review the region of the joint of the two structures of easternAsia. It was suggested to draw the boundary line of the joint (in this case-interference) of Central Asian mobile belt and Pacific mobile belt in the frames of the eastern margin of Mongol-Okhotsk orogenic belt along the margin of the disappearance of late Mesozoic oversubductional volcano-plutonic complexes in the western direction. The structure of Bureja-Jziamusy superterrain was related to the structures of the Pacific mobile belt. The proposed model of the region of jointing of two East Asian superstructures enables us to reconsider the tectonic and geodynamical and metallogeny schemes of evolution of the Eastern margin ofAsia.

Necessity for Vitamin D Screening among Urban Bedouin Women of Childbearing Age  [PDF]
Inna Rudoy, Ilia Volkov
Health (Health) , 2015, DOI: 10.4236/health.2015.75066
Abstract: Vitamin D (Vit D) plays multiple roles in bodily functions. Vit D deficiency is a common, but often under-diagnosed condition with possible serious complications. According to some research, Vit D is important particularly among women and children. No data were found concerning the Vit D status among urban Bedouin women of childbearing age. The research study is retrospective and descriptive. We analyzed 202 medical histories of patients undergoing blood tests for Vit D level for various reasons. The main objectives of the research were: 1) determining the prevalence of the Vit D deficiency among the Bedouin women of childbearing age; 2) identifying the causes for the physicians’ reasons for suspecting Vit D deficiency: the complaints or symptoms which cause the doctor to test for Vit D level. As a result, in 80.7% of those tested for Vit D, levels were less than 10 ng/ml, and in 19.3%, levels of 10 to 20 ng/ml were found. In lieu of our findings and in order to prevent serious health problems, Vit D screening plan should be seriously considered and discussed in the Bedouin population with high risk of deficiency.
Religion: A Subset of Culture and an Expression of Spirituality  [PDF]
Inna Reddy Edara
Advances in Anthropology (AA) , 2017, DOI: 10.4236/aa.2017.74015
Abstract: Cultures or cultural values, which are described as constructively created behaviors based on collective beliefs, are omnipresent at multiple levels in every human behavior and interaction, including in the sphere of religion. Scholars described religion as a cultural system of symbols, which establish powerful, pervasive, and long-lasting moods and motivations and naturalized conceptions of a general order of existence. Thus, religion is considered to be a part of culture and it acts as one among many forms of overtly expressing and experiencing spirituality that is inward, personal, subjective, transcendental, and unsystematic. In other words, cultural values are seen as a foundation to religiosity. Based on this assumption, this paper reviewed the literature to provide empirical evidence to the overt practice of religiosity that is embedded in particular cultural experiences and values as a form of expressing and experiencing the human universal of spirituality.
Social and Spiritual Dimensions as Protective Factors in the Relationship between Acculturative Stress and Subjective Well-Being among International Students in Taiwan  [PDF]
Inna Reddy Edara
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.97096
Abstract: The purpose of this study was to use the resilience model in investigating the selected factors that reduce acculturative stress and promote well-being among international students in Taiwan. Research has indicated that acculturative stress has been identified as a major issue experienced by many international students in various host countries, resulting in an increase in mental illness and decrease in well-being. A few international studies suggested that factors such as social support and coping strategies mitigated the effects of acculturative stress on negative emotions. In the absence of such studies and as the international student population continues to increase in Taiwan, this project examined the role of social connectedness, social assurance, and spiritual well-being as potential mediators or protective factors in the relationship between acculturative stress and subjective well-being (positive affect and satisfaction with life) in a sample of international students. Data from 214 participants were subjected to regression analyses to analyze for mediation effects. The results indicated significant effects of social connectedness and spiritual well-being on subjective well-being. Of the two significant mediators, social connectedness emerged as a stronger mediator, accounting for 53% and 55% of the mediation effect on positive affect and satisfaction with life, respectively. Spiritual well-being accounted for 7% and 4% of the variance, respectively. These results validate the resilient and positive psychology model, in which the resilience part evades pathological signs when individuals are exposed to stressors, while the positive aspect promotes subjective well-being. These results are discussed in detail and the implication of such results for building appropriate social and spiritual resources and designing interventions are elucidated.
Information and Signs: The Language of Images
Inna Semetsky
Entropy , 2010, DOI: 10.3390/e12030528
Abstract: Since time immemorial, philosophers and scientists were searching for a “machine code” of the so-called Mentalese language capable of processing information at the pre-verbal, pre-expressive level. In this paper I suggest that human languages are only secondary to the system of primitive extra-linguistic signs which are hardwired in humans and serve as tools for understanding selves and others; and creating meanings for the multiplicity of experiences. The combinatorial semantics of the Mentalese may find its unorthodox expression in the semiotic system of Tarot images, the latter serving as the ”keys” to the encoded proto-mental information. The paper uses some works in systems theory by Erich Jantsch and Erwin Laszlo and relates Tarot images to the archetypes of the field of collective unconscious posited by Carl Jung. Our subconscious beliefs, hopes, fears and desires, of which we may be unaware at the subjective level, do have an objective compositional structure that may be laid down in front of our eyes in the format of pictorial semiotics representing the universe of affects, thoughts, and actions. Constructing imaginative narratives based on the expressive “language” of Tarot images enables us to anticipate possible consequences and consider a range of future options . The thesis advanced in this paper is also supported by the concept of informational universe of contemporary cosmology.
Mass media education in the USSR in 1930 and 1960
Inna Kozachenko
Koncept : Scientific and Methodological e-magazine , 2013,
Abstract: The article considers the basic stages of development of media education in the USSR in the pre-war and post-war years. Describes the intensification of the implementation of media education in secondary schools, as well as popularization it in mass media and publishing specialized magazines for different ages.
Проекты загородных домов Проекты загородных домов
Inna Druzhinina
Project Baikal , 2005,
Две постройки Две постройки
Inna Druzhinina
Project Baikal , 2004,
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