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Search Results: 1 - 10 of 36549 matches for " Ingrid; Gross-Martínez "
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Agentes etiológicos de onicomicosis diagnosticadas en el laboratorio de micología médica de la Universidad de Costa Rica
Salas-Campos,Ingrid; Gross-Martínez,Norma T;
Acta Médica Costarricense , 2012,
Abstract: background and aim: among the onychodistrophies, onychomycosis are the most frequently encountered. this infection not only constitutes an esthetic problem for the patients, but can also affect their daily activities. for dermatologists, it is crucial to make a differential diagnosis; thus, the medical mycology laboratory plays an important role to achieve this purpose. the fungal agents most frequently encountered are the dermatophytes, however, other filamentous non-dermatophyte fungi have been isolated and are known to be less susceptible to antifungals. in the present work, the frequency of onychomycosis among patients attending the medical mycology laboratory, ucr, was studied during four years, according to the age and sex of the patients, as well as the isolated etiological agents identified. methods: the study included all patients that requested the community service provided by the department of medical mycology, school of microbiology, ucr, between january 2007 and december 2010 and that showed nail alterations suspicious for onychomycosis. the age and sex of each patient were registered and samples were processed for direct microscopy and culture. results: a total of 431 nail samples were collected, of which 85.4% were toenails and 14.6% fingernails. the mean age of the patients was 49 years, of which 64% were females and 36% males. onychomycosis was diagnosed, either by direct microscopy and culture, or only with positive direct microscopy, in 73.4% of the sample population, of which 89.4% were toenails and 10.6% fingernails. trichophyton rubrum was the etiological agent most frequently isolated from toenails, followed by fusarium spp. c albicans was the most frequent fungal agent observed in fingernails. conclusion: the diagnosis of onychomycosis relies upon both the clinical and laboratory diagnosis. dermatophytes, yeasts and non-dermatophyte filamentous fungi were identified in the population studied. these findings should be considered due to their
Agentes etiológicos de onicomicosis diagnosticadas en el laboratorio de micología médica de la Universidad de Costa Rica Etiological agents of onychomycosis diagnosed in the medical mycology laboratory of the University of Costa Rica
Ingrid Salas-Campos,Norma T Gross-Martínez
Acta Médica Costarricense , 2012,
Abstract: Justificación y objetivos: Entre las onicodistrofias, la onicomicosis es la afección más frecuente. Esta infección no solo representa un problema estético para el paciente, sino que puede afectar sus actividades diarias. Para el dermatólogo se hace indispensable realizar el diagnóstico diferencial, por lo que el laboratorio de micología médica es de gran ayuda para este propósito. En cuanto a los agentes etiológicos incriminados, los dermatofitos son los más frecuentes; sin embargo, otros hongos filamentosos no dermatofitos se han aislado, cuya sensibilidad a los antimicóticos es menor. En este trabajo se estudió la frecuencia de las onicomicosis diagnosticadas en el laboratorio de Micología Médica de la UCR durante cuatro a os, según edad y sexo de los pacientes, así como agentes etiológicos identificados. Métodos: Se incluyó a todos los pacientes que solicitaron el servicio de acción social que brinda la sección de Micología Médica, Facultad de Microbiología, Universidad de Costa Rica, entre enero del 2007 a diciembre del 2010 y que presentaban alteraciones ungueales sospechosas de onicomicosis. Se registró la edad y sexo de los pacientes y las muestras se procesaron por examen directo y cultivo. Resultados: Se procesaron 431 muestras de u as, el 85,4% eran de pie y el 14,6% de mano, la edad promedio de los pacientes fue de 49 a os, el 64% eran mujeres y el 36% eran hombres. En el 73,4% se diagnosticó onicomicosis, ya sea por examen directo positivo y cultivo positivo, o solo con el examen directo, de las cuales 89,4% eran u as de pie y 10,6% u as de manos. De las u as de los pies se aisló más frecuentemente Trichophyton rubrum y en segundo lugar Fusarium spp. En u as de manos C. albicans fue el agente etiológico más frecuente. Conclusión: En el diagnóstico de las onicomicosis se debe considerar tanto la clínica como los hallazgos de laboratorio. En la población estudiada se identificaron dermatofitos, levaduras y hongos filamentosos no dermatofitos, lo que es importante tener en cuenta por las implicaciones en la elección del tratamiento. Background and aim: Among the onychodistrophies, onychomycosis are the most frequently encountered. This infection not only constitutes an esthetic problem for the patients, but can also affect their daily activities. For dermatologists, it is crucial to make a differential diagnosis; thus, the medical mycology laboratory plays an important role to achieve this purpose. The fungal agents most frequently encountered are the dermatophytes, however, other filamentous non-dermatophyte fungi have been isolated and are kno
Micosis superficiales diagnosticadas en el laboratorio de micología médica de la Universidad de Costa Rica
Salas-Campos,Ingrid; Gross-Martínez,Norma; Carrillo-Dover,Pedro;
Revista Costarricense de Ciencias Médicas , 2007,
Abstract: superficial mycosis is a frequent cause of consultation in dermatology and general medicine. the microbiological studies of this fungal condition are important not only to do the differential diagnosis, but also to establish the causing agent of the disease as well as its epidemiological aspects and the treatment. in this study 265 skin and nail samples have been collected from individuals at the laboratory of medical mycology of school of microbiology, costa rica university. nail diseases represent 67,5% of the total cases studied. trichophyton rubrum was the most frequent isolated fungus; also, other dermatophytes and candida sp. were isolated from nail and skin. fusarium sp., a filamentous nondermatophyte fungus, was isolated from both finger and toe nails. this finding is of relevant, since fusarium sp., an emergent etiological agent of onychomycosis, does not respond well to treatment based on fluconazol.
Inhibidores de bomba de protones y clopidogrel: Evidencia de interacción farmacológica de gran impacto clínico
Martínez,Ingrid; Coy,Vivian; Otero,William;
Revista Colombiana de Gastroenterologia , 2010,
Abstract: clopidogrel, a thienopyridine, is an antiplatelet drug which currently represents the cornerstone for the treatment of acute coronary events. it is a pro-drug that must be converted at hepatic level into its active form by the cyp2c19 isoenzyme. recently the interaction between proton pump inhibitors and clopidogrel has been widely brought to attention. the competitive inhibition that these generate on the hepatic enzymatic system probably activates clopidogrel, thus causing a decrease in its effectiveness as an antithrombotic. nevertheless, evidence is contradictory, and until now no clinical trials have been performed to clear up doubts. if a ppi is to be used on patients who take clopidogrel, the use of pantoprazole or esomeprazole is recommended because they exert minimal inhibition on cyp2c19.
Inhibidores de bomba de protones y clopidogrel: Evidencia de interacción farmacológica de gran impacto clínico Proton pump inhibitors and clopidogrel: Evidence of a Pharmacological interaction of great clinical impact
Ingrid Martínez,Vivian Coy,William Otero
Revista Colombiana de Gastroenterologia , 2010,
Abstract: Clopidogrel, una tienopiridina, es un antiagregante plaquetario que en la actualidad constituye la piedra angular del tratamiento médico en pacientes que presentan eventos coronarios agudos. Es una prodroga que debe ser convertida en la forma activa a nivel hepático, por la isoenzima CYP2C19. Recientemente, se ha llamado ampliamente la atención sobre la probable interacción entre los inhibidores de la bomba de protones y el clopidogrel por la inhibición competitiva que estos hacen sobre el sistema enzimático hepático activador de clopidogrel, que causa disminución de la eficacia del mismo como antitrombótico. Sin embargo, la evidencia sobre esta interacción es contradictoria y hasta el momento no se han realizado ensayos clínicos para resolver esta duda. Si se necesita utilizar un IBP en pacientes que utilizan clopidogrel, se recomienda el pantoprazol o el esomeprazol por la mínima inhibición que ejercen sobre el CYP2C19. Clopidogrel, a thienopyridine, is an antiplatelet drug which currently represents the cornerstone for the treatment of acute coronary events. It is a pro-drug that must be converted at hepatic level into its active form by the CYP2C19 isoenzyme. Recently the interaction between proton pump inhibitors and clopidogrel has been widely brought to attention. The competitive inhibition that these generate on the hepatic enzymatic system probably activates clopidogrel, thus causing a decrease in its effectiveness as an antithrombotic. Nevertheless, evidence is contradictory, and until now no clinical trials have been performed to clear up doubts. If a PPI is to be used on patients who take clopidogrel, the use of Pantoprazole or Esomeprazole is recommended because they exert minimal inhibition on CYP2C19.
Hacia una disertación socioeducativa desde la perspectiva de la transdisciplinariedad e interdisciplinariedad de los derechos humanos
Revilla Madrid,Ingrid; Martínez de Correa,Luz María;
Frónesis , 2009,
Abstract: basic disciplines related to the concept, nature and fundamentals of human rights are analyzed. this subject should not be considered merely from a juridical viewpoint, since its vision would become strictly limited to considering ?law about human rights?. documentary type methodology is used through analyzing doctrinal sources supported by the analytic method. conclusions indicate the need for a holistic vision and treatment of human rights where historic, ethical, juridical, political and sociological dimensions stand out due to their importance.
Factores que influyen en la coordinación entre niveles asistenciales según la opinión de directivos y profesionales sanitarios
Henao Martínez,Diana; Vázquez Navarrete,M. Luisa; Vargas Lorenzo,Ingrid;
Gaceta Sanitaria , 2009, DOI: 10.1590/S0213-91112009000400005
Abstract: objective: to analyze coordination among healthcare levels from the viewpoint of healthcare managers and health professionals in integrated healthcare systems (ihs). methods: a qualitative, exploratory and descriptive study was conducted by means of individual semi-structured interviews to a criterion sample. we performed two-stage sampling: in the first stage, ihs were selected and in the second, managers (n=18) and professionals (n=23). a content analysis was carried out with mixed generation of categories, segmented by themes and informants. results: coordination among healthcare levels was defined differently by the two groups of informants. however, the informants agreed that coordination was complicated but necessary to improve access to and the efficiency of the system. factors central to achieving coordination were communication, knowledge and good relationships among professionals. these factors were influenced by professionals' values and the existence of appropriate institutional coordination mechanisms. in turn, these elements depended mainly on internal but also external structural and organizational conditions, which determined the development of coordination. improvement strategies were directly related to the factors identified. conclusions: opinions on healthcare coordination reflect not only the complexity of the concept, but also the traditional separation of healthcare levels. improving coordination requires specific organizational interventions to address its determinants, not only within but also among all healthcare providers in an area.
IDENTIFICACIóN DEL AGENTE CAUSANTE DE LA MARCHITEZ DE PROTEAS (Leucadendron sp.)
Salazar,Ingrid Carolina; Martínez Granja,Edgar; Pe?a,Fernando; Cabezas,Marco; Gómez,John;
Revista U.D.C.A Actualidad & Divulgación Científica , 2010,
Abstract: plantations of proteas are new at the department of cundinamarca, where businesses of production of leucadendron have been carried out. in these plantations a new disease denominated wilting has been observed. to identify the causal agent of this disease conventional plant pathological tests were conducted to isolate and to verify the pathogenicity of the causal agent under laboratory conditions. also a molecular characterization was conducted through extraction and amplification of dna. the dna amplified fragment was sequenced by bigdye? terminator v3.1 cycle sequencing kit according to the manufacturer specifications in a sequencer abi3730xl (applied biosystems). under laboratory conditions the pathogenicity and disease incidence caused by two isolates of fungi obtained were evaluated on the varieties gold strike and petra. the fungi were inoculated both individually and in mixture, using a completely randomized design with a factorial arrangement of 2 x 4. in the inoculations was used a suspension of 105 macroconidia ml-1 of water. also they were evaluated under field conditions at the same concentration and on the same varieties, using a complete block design with factorial arrangement of 2 x 4. the laboratory analysis indicated the presence of two species of fusarium, which were differentiated through the color of their colonies. according to the molecular analysis, they belong to f. oxysporum (white colony) and fusarium sp. (red colony). it was confirmed the pathogenicity of both species on the tested varieties.
Detección ecográfica y pronóstico de la ventriculomegalia fetal
Mercedes Hernández S,Olivia Orribo M,Ingrid Martínez W,Ana I Padilla P
Revista Chilena de Obstetricia y Ginecología , 2012,
Abstract: Antecedentes: La ventriculomegalia fetal es un signo ecográfico muy sensible para las alteraciones del sistema nervioso central fetal. La morbilidad asociada a la misma depende principalmente de la etiología y de la presencia de otras malformaciones asociadas. Si es aislada y no progresiva se puede preveer un resultado posnatal favorable hasta en el 70% de los casos aunque hay una gran disparidad de cifras entre distintos centros y autores. Objetivo: Establecer la relación entre ventriculomegalia y pronóstico perinatal. Método: Se han revisado 60 casos diagnosticados mediante ecografía prenatal en el Hospital Universitario de Canarias siguiendo los criterios ecográficos de ventriculomegalia (astas posteriores mayores de 10 mm). Se realizaron cariotipos y serología materna y en líquido amniótico para completar el estudio. Resultados: Hubo un total de 23 interrupciones voluntarias de la gestación y 28 recién nacidos sin secuelas (47%). Un 70% de las ventriculomegalias aisladas correspondieron a recién nacidos sin secuelas. El 10% de las ventriculomegalias aparecieron en fetos con aneuploidías. Conclusión: El pronóstico fue favorable en los casos de ventriculomegalia no progresiva y aislada. La medida de la ventriculomegalia no predice el resultado. La variabilidad de resultados en la literatura obliga a cada centro a disponer de sus protocolos y datos para aconsejar a la pareja que ha de tomar una decisión sobre el futuro de su embarazo. Background: Fetal ventriculomegaly is the most sensitive sonographic sign for central nervous system anomalies. Neonatal morbidity and mortality depends on the etiology of the ventriculomegaly and the presence of other malformations. Isolated non-progressive ventriculomegaly is associated with 70% favorable results, with a great disparity among studies. Aims: To establish the relationships between ventriculomegaly and perinatal outcome. Methods: The authors reviewed 60 cases of prenatally diagnosed fetal ventriculomegaly in the Canary Islands University Hospital. An ultrasonographic measurement of the lateral ventricles of 10 mm or more was considered as ventriculomegaly. Fetal and maternal serology was performed as well as fetal karyotyping. Results: 23 patients decided to terminate the pregnancy due to unfavorable prognosis. In 28 cases outcome was favorable. 70% of isolated ventriculomegaly corresponded to healthy newborns. 10% of the fetuses had aneuploidies. Conclusion: Prognosis is favorable if ventriculomegaly is isolated and non-progressive. Measurement of the lateral ventricle does not predict outcome. Disparity
Strategies for monitoring and updating clinical practice guidelines: a systematic review
Martínez García Laura,Arévalo-Rodríguez Ingrid,Solà Ivan,Haynes R
Implementation Science , 2012, DOI: 10.1186/1748-5908-7-109
Abstract: Background Scientific knowledge is in constant change. The flow of new information requires a frequent re-evaluation of the available research results. Clinical practice guidelines (CPGs) are not exempted from this phenomenon and need to be kept updated to maintain the validity of their recommendations. The objective of our review is to systematically identify, describe and assess strategies for monitoring and updating CPGs. Study design and setting We conducted a systematic review of studies evaluating one or more methods of updating (with or without monitoring) CPGs or recommendations. We searched MEDLINE (PubMed) and The Cochrane Methodology Register (The Cochrane Library) from 1966 to June 2012. Additionally, we hand-searched reference lists of the included studies and the Guidelines International Network book of abstracts. If necessary, we contacted study authors to obtain additional information. Results We included a total of eight studies. Four evaluated if CPGs were out of date, three updated CPGs, and one continuously monitored and updated CPGs. The most detailed reported phase of the process was the identification of new evidence. As opposed to studies updating guidelines, studies evaluating if CPGs were out of date applied restricted searches. Only one study compared a restricted versus an exhaustive search suggesting that a restricted search is sufficient to assess recommendations’ Validity. One study analyzed the survival time of CPGs and suggested that these should be reassessed every three years. Conclusions There is limited evidence about the optimal strategies for monitoring and updating clinical practice guidelines. A restricted search is likely to be sufficient to monitor new evidence and assess the need to update, however, more information is needed about the timing and type of search. Only the exhaustive search strategy has been assessed for the update of CPGs. The development and evaluation of more efficient strategies is needed to improve the timeliness and reduce the burden of maintaining the validity of CPGs.
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