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17 -Ethynyl-androst-5-ene-3 ,7 ,17 -triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson’s Disease
Ferdinando Nicoletti,Ingrid Philippens,Paolo Fagone,Clarence N. Ahlem,Christopher L. Reading,James M. Frincke,Dominick L. Auci
Parkinson's Disease , 2012, DOI: 10.1155/2012/969418
Abstract: 17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and efficacy in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson’s disease (PD). We found that HE3286 freely penetrated the BBB. HE3286 treatment significantly improved motor function compared to vehicle in the rotarod test (mean 58.2?sec versus 90.9?sec, ), and reduced inflammatory mediator gene expression in the brain (inducible nitric oxide synthase, 20%, ; tumor necrosis factor α, 40%, , and interleukin-1β, 33%, ) measured by reverse-transcriptase polymerase chain reaction. Brain tissue histopathology and immunohistochemistry showed that HE3286 treatment increased the numbers of tyrosine hydroxylase-positive cells by 17% compared to vehicle ( ), and decreased the numbers of damaged neurons by 38% relative to vehicle ( ). L-3,4-dihydroxyphenylalanine (L-DOPA) efficacy was not enhanced by concurrent administration of HE3286. HE3286 administration prior to MPTP did not enhance efficacy. Our data suggest a potential role for HE3286 in PD treatment, and provides incentive for further investigation. 1. Introduction PD is a neurodegenerative disorder characterized by a progressive degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc) and decreased levels of dopamine in the putamen of the dorsolateral striatum. The loss of dopamine in the striatum manifests clinically as motor disabilities that include bradykinesia, resting tremor, and muscular rigidity. Diagnosis is based on motor symptoms, which become evident only after the loss of more than 50% of the SNpc DAergic neurons and 60–80% of striatal dopamine [1]. Prolonged treatment of PD with L-DOPA usually results in a dyskinesia that can be more disabling than the disease itself; therefore, there is a great need for alternative therapeutic modalities. The acute MPTP mouse model of nigrostriatal degeneration recapitulates the DAergic neuron loss seen in PD and currently represents the most commonly used toxin-induced mouse model of PD [2]. MPTP’s mechanism of toxicity is complex, and exerted through its toxic metabolite, methyl-4-phenylpyridinium (MPP+) ion, which is taken up selectively by DAergic neurons through the dopamine transporter. Inside the cell, MPP+ is a mitochondrial toxin, which induces neuronal death through several mechanisms that include oxidative stress [3], excitotoxicity [4], and
Dynamical Phase Transitions in Quantum Systems  [PDF]
Ingrid Rotter
Journal of Modern Physics (JMP) , 2010, DOI: 10.4236/jmp.2010.15043
Abstract: Many years ago Bohr characterized the fundamental differences between the two extreme cases of quantum mechanical many-body problems known at that time: between the compound states in nuclei at extremely high level density and the shell-model states in atoms at low level density. It is shown in the present paper that the compound nucleus states at high level density are the result of a dynamical phase transition due to which they have lost any spectroscopic relation to the individual states of the nucleus. The last ones are shell-model states which are of the same type as the shell-model states in atoms. Mathematically, dynamical phase transitions are caused by singular (exceptional) points at which the trajectories of the eigenvalues of the non-Hermitian Hamilton operator cross. In the neighborhood of these singular points, the phases of the eigenfunctions are not rigid. It is possible therefore that some eigenfunctions of the system align to the scattering wavefunctions of the environment by decoupling (trapping) the remaining ones from the environment. In the Schrödinger equation, nonlinear terms appear in the neighborhood of the singular points.
Creativity in Teams: The Impact of Team Members’ Affective Well-Being and Diversity  [PDF]
Ingrid Dackert
Open Journal of Social Sciences (JSS) , 2016, DOI: 10.4236/jss.2016.49003
The purpose of the research reported in this article was to examine how team mem-bers’ affective well-being influences creativity in teams. Furthermore, the impact of diversity in gender, age and education on affective well-being and team creativity was investigated. Twenty-nine project teams with 173 team members, involved in projects for 20 weeks as a part of a project management course, participated in the study. In terms of diversity dimensions, age and education were found to have no significant in-fluence either on affective well-being or team creativity. Diversity in gender had a sig-nificant positive impact on contentment. Team member enthusiasm was found to have a strong direct impact on team creativity, while contentment had an indirect effect. The results support the integration of affects into creativity theory. In addition, the result suggests managers to focus more on the feelings of the team members and the interaction in the team in order to facilitate well-being and creativity.
Pig Compost Use on Zinc and Copper Concentrations in Soils and Corn Plants  [PDF]
Juan Hirzel, Ingrid Walter
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.64057
Abstract: The use of pig compost (PC) in agricultural land has increased in Chile in the last years. This organic amendment is a valuable nutritional source for crops, but its applying must be done in a controlled manner since it exhibited high copper (Cu) and zinc (Zn) concentrations. A short-term field experiment was conducted out to study the effects of increasing PC rates on the production and quality corn crop in two soils located at south central Chile. Five treatments were evaluated: control without fertilization (C), conventional fertilization (CF) (350 kg N ha-1), and three increasing PC rates (15.33, 30.65, and 61.31 Mg·ha-1, corresponding to 350, 700, and 1400 kg N ha-1, respectively) in a split plot design with four replicates. The overall results indicated that dry matter production, grain yield, and plant Zn and Cu concentrations were similar among fertilization sources and rates. Extractable soil Zn concentration exhibited a rate-related increase of PC in both locations, while Cu concentration exhibited this behavior only at the soil located in Chillan. Nevertheless, the values obtained were below of those considered phytotoxic levels. Therefore, the contribution of Zn and Cu through PC applying at different rates to the soils studied showed a slight affect in soil extractable Zn and Cu values without negatively effects on quantity and quality corn crop. The organic amendment applied can be a good and cheaper substitute to conventional fertilization, although further monitoring of Zn and Cu soil levels should be carried out to avoid any environmental risk.
Patient Perspectives of Sharing Experiences in Group-Based Diabetes Education: A Second-Order Analysis  [PDF]
Vibeke Stenov, Ingrid Willaing
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.71003
Abstract: The study aimed to develop a second-order theoretical analysis based on qualitative interviews exploring the experiences of persons with diabetes attending group-based diabetes education. Bruner’s cultural psychology and White and Epston’s narrative therapy provided a theoretical foundation for the analysis. The analysis indicated that telling and listening to stories from everyday life with diabetes in a peer group can assist participants in reinterpreting ways of living with diabetes. Sharing experiences with peers in group-based diabetes education seems to be supportive and useful when individuals are trying to find strategies to cope with diabetes in everyday life.
The Health and Well-Being among Children with Diabetes and Low HbA1c—A Qualitative Study in Sweden  [PDF]
Lena Lendahls, Ingrid Edvardsson
Health (Health) , 2018, DOI: 10.4236/health.2018.105044
Abstract: Aims and objectives: To examine health and well-being, as well as the need for support among children and parents where the child has T1DM with low HbA1c (<52 mmol/mole). The purpose was also to investigate the extent to which children’s and parents’ experiences match. Introduction: Studies have shown that children with diabetes type 1 (T1DM) rate their lives as worse than healthy peer ratings. In Sweden, views have been expressed that children, as well as their parents, feel pressurized by the diabetes teams to achieve low HbA1c values, which can lead to poorer mental health for the family. Design: A qualitative study. Methods: A consecutive sample of 11 children and their parents (one father, ten mothers) was interviewed together but individually guided by a semi structured interview guide. Interviews were analyzed using thematic content analysis. Results: Four main categories were consistent across children and their parents; 1) attitude to the illness, 2) sadness about diabetes, 3) the importance of the social network, and 4) the importance of the diabetes team. Worries about hyperglycemia were more prominent than worries about hypoglycemia in both children and parents. A distinguishing feature of the interviewed children was that they were responsible, strict and targeted. Many of them were competitive and took part in various sports, even at a very advanced level. Conclusions: This study shows that children with low HbA1c values experience good health and good well-being. Family support, good planning, and high acceptance of their illness contributed to this.
Untersuchungen über den einfluss des maternalen effektes auf die heritabilit?t der wurfgr?sse bei sauen
Ingrid Alsing
Genetics Selection Evolution , 1977, DOI: 10.1186/1297-9686-9-1-136b
Estructura anatómica de la corteza de algunas especies arbóreas Venezolanas de Euphorbiaceae
Acta Botánica Venezuelica , 2005,
Abstract: this study analyzes the anatomical structure of the barks of 16 species of forestal trees of the euphorbiaceace family from the rain forest of the venezuelan guayana. the shared characters found were: laticiferous or secretory cells, profusion of stone cells in hard bast, thin rays, suber with "u" shaped wall thickenings and druses or solitary rhomboidal crystals. due to the polyphyletic origin of the euphorbiaceae family, the shared characters found may be attributed to the arboreal habit of the studied species.
Teoría Queer: ?Cambio de paradigma, nuevas metodologías para la investigación social o promoción de niveles de vida más dignos?
Estudios pedagógicos (Valdivia) , 2012, DOI: 10.4067/S0718-07052012000200017
Abstract: this article deals with queer theory, which has been developed since the 1980s, and its implications in the way of thinking and research on the topic of identity of sex and gender. entailing a new vision of humanism, where individual and group differences can be accepted as well as a research methodology that may be useful for the studies in this field.
Un pensamiento emergente sobre el arte contemporáneo
Solana, Ingrid;
Andamios , 2009,
Abstract: this paper tries to configure an emerging thought on current reflexivity about art. in order to do so, stencil and net.art are analyzed as eminently self-critical expressive ways. this essay gathers some theoretical aspects about current thinking on art. it is mainly based on the aesthetic theories of gilles deleuze and felix guattari in what is philosophy?, although it points out multiple issues concerning postmodern thought. the two artistic forms analyzed in this work -reflection of the same theoretical thinking that was collapsed by postmodernity- are seen as culminating moments within the emerging thought that requests aesthetics. they are brought out as the few revolutionary ways that still allow for the development of a theoretical thinking at the edge of the institutional canons. therefore, the two spaces (under the temporal irruptive denomination of the event) are offered as a construct of possibility in our contemporarity.
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