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Search Results: 1 - 10 of 2695 matches for " Ikuo Saito "
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Successful Treatment of Elderly Diffuse Large B-Cell Lymphoma with Central Nervous System Recurrence by Rituximab, Ranimusutine, Ifosfamide, Procarbazine, Dexamethasone, and Etoposide Therapy  [PDF]
Junya Miyahara, Naoki Takezako, Miyuki Wagatsuma, Kiyoe Midorikawa, Ichiro Fukuda, Satoshi Noto, Ikuo Saito, Kazuaki Yamada, Akiyoshi Miwa, Naohiro Sekiguchi
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.43A054

The prognosis of CD20-positive (CD20+) diffuse large B-cell lymphoma (DLBCL) with central nervous system (CNS) recurrence is still poor. A standard treatment for CD20+ DLBCL with CNS recurrence in elderly patients has not been established mainly due to adverse effects. We previously reported the efficacy and safety of MIND-E (ranimustine, ifosfamide, procarbazine, dexamethasone, and etoposide) therapy for elderly CD20+ DLBCL patients with CNS recurrence. Here, we report the use of R-MIND-E therapy (rituximab, ranimustine, ifosfamide, procarbazine, dexamethasone and etoposide) in an elderly CD20+ DLBCL patient with CNS recurrence. The patient achieved a complete response according to Revised Response Criteria for Malignant Lymphoma, and treatment-related toxicity was tolerable. R-MIND-E therapy may be a feasible and useful treatment option for elderly CD20+ DLBCL patients with CNS recurrence.

Myocardial insulin resistance does not always parallel skeletal muscle and whole body insulin resistance: A mini review
—Myocardial Insulin Resistance

Ikuo Yokoyama
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.61005

Insulin resistance (IR) is recognized to be of critical importance in a variety of metabolic diseases and coronary artery disease (CAD). Impaired skeletal muscle glucose utilization (SMGU) plays an important role in the pathogenesis of IR, whereas it is controversial whether myocardial IR is similar in this respect. Methods: Twenty-two studies of myocardial IR and skeletal muscle IR using positron emission tomography (PET) and/or whole body IR were reviewed. Heart and skeletal muscle IR were measured with PET and18F-FDG under hyperinsulinemic euglycemic insulin clamp technique. Whole body IR was also determined at the time of PET under hyperinsulinemic euglycemic insulin clamp technique. Results: One study reported that heart and skeletal muscle IR is present in untreated type 2 diabetes mellitus (T2DM), hypertension and CAD (as reflected in a myocardial glucose utiliation rate (MGU) in T2DM vs control [p < 0.01], and an SMGU in T2DM vs control [p < 0.01]). A significant negative relationship between MGU and FFA (r = -0.665, p < 0.01) and a significant positive relationship between MGU and whole body IR (r = 0.855, p < 0.01) was also observed in T2DM. Significantly reduced MGU and SMGU and a positive correlation between them (r = 0.78, P < 0.0001) were noted in the normal myocardial segments of patients with CAD. Another study showed that heart and skeletal muscle IR was present in T2DM both with CAD (MGU):, p < 0.01; SMGU: p < 0.01) or without CAD (MGU: p < 0.01; SMGU: p = 0.06). A significant positive relationship between the whole body glucose disposal rate and MGU (r = 0.60, p < 0.01) as well as SMGU (r = 0.76, p < 0.01) was also reported. Much more severe myocardial IR in T2DM and hypertriglyceridemia (p < 0.05) due to increased plasma free fatty acids, FFA (r = -0.60, p < 0.01) and plasma triglycerides levels (r =-0.74, p < 0.001) was reported. A significant negative relationship between MGU and plasma triglycerides (r = -0.74, p < 0.001) was also noted. However, other studies reported that MGU was increased in essential hypertension despite the fact that SMGU and whole body IR were present. Furthermore, it has also been

Ezetimibe Completely Replaced LDL-Apheresis for the Treatment of Familial Hypercholesterolemia and Coronary Artery Disease after CABG—A Case Report  [PDF]
Ikuo Yokoyama
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.62A028
Intensive treatment of hyperlipidemia is an important factor in the prevention of cardiovascular disease. Among several therapies, statins are well recognized as playing a central role, although low density lipoprotein bound cholesterol-apheresis can be used to treat very severe cases of familial hypercholesterolemia. However, statins are not always effective on their own and, recently, ezetimibe has emerged as a unique anti- hypercholesterolemic drug that acts as a cholesterol transporter inhibitor; its role is only partially understood. I experienced rare case that appeared to benefit from ezetimibe therapy, and report them as they help increase our knowledge of this novel drug.
Clinicolopathological, Cytogenetic, and Radiographical Analysis of Waldenstrom Macroglobulinemia in Japan: Unique Disease Manifestation  [PDF]
Naohiro Sekiguch, Naoki Takezako, Miyuki Wagatsuma, Chen A. Kunihiro, Akihisa Nagata, Ichiro Fukuda, Satoshi Noto, Ikuo Saito, Kazuaki Yamada, Akiyoshi Miwa
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.36134
Abstract: Waldenstr?m macroglobulinemia (WM) is a rare lymphoid malignancy. Many studies, including clinicopathological, cytogenetic, gene expression profile, and therapy studies have been reported from the US and Europe, although only a few reports are available from East Asia, including Japan. To further clarify the clinicopathological, radiological, and cytogenetic features of WM in Japan, we performed a retrospective analysis of WM in our institute between March 2007 and January 2012. Clinical data, laboratory data, the results of flow cytometric analysis (FCM), and chromosomal abnormalities were analyzed, and a radiological review was performed. The treatment regimen, response, and survival were also estimated. Six patients were enrolled in this study. The median age was 71 years. All patients were symptomatic, 3 had hyperviscosity syndrome, 1 had bone lesions, and 1 had an extra-medullary mass. FCM data showed that all patients were positive for CD38, while 2 were positive for CD56. Four had chromosomal abnormalities including some abnormalities also reported in myeloma. On radiological review, four showed diffuse invasion of the retro-peritoneum. Five patients received treatment, 4 of which achieved a response. At a median follow-up of 527 days, 4 were alive and 2 died because of disease progression. The present study revealed that WM in Japan might be heterogeneous and have a unique disease manifestation. Invasion sites other than bone marrow were very common, and the results of clinical, FCM, and cytogenetic studies revealed that WM in Japanese cases might have manifestations of both myeloma and B-cell lymphoma.
A case of squamous cell carcinoma arising from a suprapubic cystostomy tract
Hiroki Ito, Masayuki Arao, Hanako Ishigaki, Noboru Ohshima, Ayako Horita, Ikuo Saito, Kotaro Hirai
BMC Urology , 2011, DOI: 10.1186/1471-2490-11-20
Abstract: A 58-year-old man with a complete spinal cord injury was referred to our hospital with a chief complaint of an abdominal mass. Abdominal enhanced computed tomography (CT) showed a 7-cm mass surrounding the suprapubic cystostomy and bilateral inguinal and para-aortic lymph nodes metastasis. Histopathological examination of percutaneous biopsy specimens was performed. The diagnosis was stage IV (cT4N1M1) epidermal SCC, which was treated with palliative external radiation therapy.The SCC in this case was thought to arise from mechanical stimulus of the suprapubic cystostomy. Physicians and patients should pay careful attention to any signs of neoplasms with long-term indwelling catheters, such as skin changes around the suprapubic cystostomy site. This case presentation is only the fourth report of SCC arising from the suprapubic cystostomy tract in the literature. In cases of unresectable tumors and contraindications to chemotherapy, palliative radiotherapy may lead to disease remission and symptom relief.Patients with spinal cord injury and a chronic indwelling urinary catheter are known to have an increased risk of bladder malignancy. This condition has been attributed to chronic inflammation and mechanical stimuli from the catheter. Chronic bladder irritation or infection is often associated with squamous metaplasia [1]. Kaufman et al. [2] reported that squamous metaplasia is more likely in patients with indwelling catheters placed for more than 10 years than in those with indwelling catheters for less than 10 years (80% vs 42%). In particular, the clinical significance of keratinizing squamous metaplasia in the setting of indwelling urinary catheters remains unclear, but some studies have linked this entity to the development of invasive squamous cell carcinoma (SCC) [3].This can be considered in light of the fact that epidermal SCC is the second most common type of skin cancer and most cases are caused by exposure to the sun's harmful ultraviolet rays or to mecha
Congenic Mapping and Allele-Specific Alteration Analysis of Stmm1 Locus Conferring Resistance to Early-Stage Chemically Induced Skin Papillomas
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Ryo Kominami, Yuichi Wakabayashi
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097201
Abstract: Genome-wide association studies have revealed that many low-penetrance cancer susceptibility loci are located throughout the genome; however, a very limited number of genes have been identified so far. Using a forward genetics approach to map such loci in a mouse skin cancer model, we previously identified strong genetic loci conferring resistance to early-stage chemically induced skin papillomas on chromosome 7 with a large number of [(FVB/N×MSM/Ms)×FVB/N] F1 backcross mice. In this report, we describe a combination of congenic mapping and allele-specific alteration analysis of the loci on chromosome 7. We used linkage analysis and congenic mouse strains to refine the location of Stmm1 (Skin tumor modifier of MSM 1) locus within a genetic interval of about 3 cM on proximal chromosome 7. In addition, we used patterns of allele-specific imbalances in tumors from F1 backcross and N10 congenic mice to narrow down further the region of Stmm1 locus to a physical distance of about 5.4 Mb. To gain the insight into the function of Stmm1 locus, we carried out a long term BrdU labelling experiments with congenic mice containing Stmm1 locus. Interestingly, we observed a decrease of BrdU-LRCs (Label Retaining Cells) in a congenic strain heterozygous or homozygous for MSM allele of Stmm1. These results suggest that Stmm1 responsible genes may have an influence on papillomagenesis in the two-stage skin carcinogenesis by regulating epidermal quiescent stem cells.
Inhibition of Exotoxin Production by Mobile Genetic Element SCCmec-Encoded psm-mec RNA Is Conserved in Staphylococcal Species
Mariko Ikuo, Gentaro Nagano, Yuki Saito, Han Mao, Kazuhisa Sekimizu, Chikara Kaito
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100260
Abstract: Staphylococcal species acquire antibiotic resistance by incorporating the mobile-genetic element SCCmec. We previously found that SCCmec-encoded psm-mec RNA suppresses exotoxin production as a regulatory RNA, and the psm-mec translation product increases biofilm formation in Staphylococcus aureus. Here, we examined whether the regulatory role of psm-mec on host bacterial virulence properties is conserved among other staphylococcal species, S. epidermidis and S. haemolyticus, both of which are important causes of nosocomial infections. In S. epidermidis, introduction of psm-mec decreased the production of cytolytic toxins called phenol-soluble modulins (PSMs) and increased biofilm formation. Introduction of psm-mec with a stop-codon mutation that did not express PSM-mec protein but did express psm-mec RNA also decreased PSM production, but did not increase biofilm formation. Thus, the psm-mec RNA inhibits PSM production, whereas the PSM-mec protein increases biofilm formation in S. epidermidis. In S. haemolyticus, introduction of psm-mec decreased PSM production, but did not affect biofilm formation. The mutated psm-mec with a stop-codon also caused the same effect. Thus, the psm-mec RNA also inhibits PSM production in S. haemolyticus. These findings suggest that the inhibitory role of psm-mec RNA on exotoxin production is conserved among staphylococcal species, although the stimulating effect of the psm-mec gene on biofilm formation is not conserved.
Effects of Self-Presentation on One’s Self-Regulatory Resources When One Is Faced with the Multiple Audience Problem  [PDF]
Yu Kasagi, Ikuo Daibo
Psychology (PSYCH) , 2015, DOI: 10.4236/psych.2015.612141
Abstract: This study examined the effects of self-presentation on participants’ self-regulatory resources when the participants were faced with the multiple audience problem. In the experiment, participants (N = 38) were assigned to either the consistent condition or inconsistent condition, and were asked to make a speech in three sessions. The inconsistent condition was manipulated such that the participants would be confronted with the multiple audience problem in speech session 3. After the three speech sessions, the participants were told to work on 200 multiplication problems (3 digits × 3 digits) until they had finished solving all the problems or until they gave up or felt that they were unable to continue working on the problems. An experimenter timed the participants with a stopwatch as they worked on the problems. The results showed that the participants in the inconsistent condition gave up faster than the participants in the consistent condition. Moreover, the participants in the inconsistent condition solved less multiplication problems than the participants in the consistent condition. On the basis of these results, we concluded that when one was faced with the multiple audience problem, self-presentation was extremely difficult and entailed effortful forms of self-presentation that depleted one’s self-regulatory resources. Further research is necessary to examine the effects of compensatory self-enhancement, which has been found to be an effective coping strategy on self-regulatory resources when one is faced with the multiple audience problem.
Multiple genome alignment for identifying the core structure among moderately related microbial genomes
Ikuo Uchiyama
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-515
Abstract: The method was applied to genome comparisons of two well-characterized families, Bacillaceae and Enterobacteriaceae, and identified their core structures comprising 1438 and 2125 OGs, respectively. The core sets contained most of the essential genes and their related genes, which were primarily included in the intersection of the two core sets comprising around 700 OGs. The definition of the genomic core based on gene order conservation was demonstrated to be more robust than the simpler approach based only on gene conservation. We also investigated the core structures in terms of G+C content homogeneity and phylogenetic congruence, and found that the core genes primarily exhibited the expected characteristic, i.e., being indigenous and sharing the same history, more than the non-core genes.The results demonstrate that our strategy of genome alignment based on gene order conservation can provide an effective approach to identify the genomic core among moderately related microbial genomes.A growing body of evidence is supporting the idea that horizontal gene transfers (HGT) have played a significant role in prokaryotic genome evolution [1-6]. Although these observations have stimulated researchers to develop a new paradigm of HGT-driven reticulate evolution that challenges the traditional tree-based phylogeny concept [7-9], it can be argued that prokaryotic phylogeny can still be inferred using a certain subset of genes ("core genes") that have mainly transferred vertically throughout evolution [10-12]. In fact, the genes constituting a prokaryotic genome appear to be divided into two classes: a "core gene pool" that comprises intrinsic genes encoding the proteins of basic cellular functions, and a "flexible gene pool" that comprises HGT-acquired genes encoding proteins which function under particular conditions, such as genomic islands [13]. Therefore, the identification of the genomic core conserved among each taxonomic group is crucial, not only for establishing t
Flat structure for the simple elliptic singularity of type $\widetilde {\bf E_6}$ and Jacobi form
Ikuo Satake
Physics , 1993,
Abstract: In order to construct the inverse mapping of the period mapping for the primitive form for the semi-universal deformation of a simple elliptic singularity, K.Saito introduced in [5] the ``flat structure'' for the extended affine root system. In section 3, we construct explicitly the flat theta invariants in the case of type $E_6$ using the Jacobi form introduced by Wirthm\"uller [7]. Combining the results of Kato [3], Noumi [4] (explicit description of the flat coordinates), this gives an answer to Jacobi's inversion problem (up to linear isomorphism) of this period mapping for a simple elliptic singularity of type $\tilde E_6$ (see also [6]). The details will be published elsewhere.
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