OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Ikoni Ogaji” ,找到相关结果约28条。
Some physicochemical properties of acetaminophen pediatric suspensions formulated with okra gums obtained from different extraction processes as suspending agent
Ikoni Ogaji
Asian Journal of Pharmaceutics , 2011,
Abstract: The purpose of this work was to evaluate the effect of the extraction process and the potential of okra gum as a suspending agent in pharmaceutical oral formulations containing acetaminophen as a model drug. Clarified mucilage of dried okra was either extracted directly with ethanol 96% (F1) or was first treated with base (F2), acid (F3) or heating in the presence of salt (F4) before extraction with ethanol 96%. The samples were used at 0.5% w/v as suspending agents in acetaminophen acetaminophen suspension to deliver 125 mg/5 mL acetaminophen. A binary mixture of F2 and F4 (1:1) was also used. Similar suspensions of acetaminophen containing either hydroxymethylpropylcellulose (HPMC) or tragacanth gum (TRAGA) were produced. Some physicochemical properties of the formulations were evaluated. The rheological properties of acetaminophen-containing treated okra gums (F2-F5) were generally similar. Changes in viscosity with storage were slower in the F2-F5 formulations as compared with F1. Particle size and particle size distribution were different for all formulations, and hysteresis was a function of time and the suspending agent used. The re-dispersion time of the formulations with treated okra gums was generally shorter than that observed with the untreated okra gum. The use of a binary mixture of F2 and F4 resulted in different physicochemical properties from those of either F2 or F4. The physicochemical properties of the formulations were comparable to those with HPMC and TRAGA. It can thus be concluded that treating okra gum with acid, base or salt impacted better physicochemical properties on an acetaminophen pediatric suspension when they were used as suspending agents.
Film coating potential of okra gum using paracetamol tablets as a model drug
Ogaji Ikoni,Nnoli Obiageli
Asian Journal of Pharmaceutics , 2010,
Abstract: The purpose of this work was to study the film coating potential of okra gum extracted from pods of Abelmoschus esculentus plant using paracetamol as a model drug. Core tablets of paracetamol were obtained from a pharmacy shop in the locality and the physicochemical properties such as weight, hardness, friability, and disintegration time were evaluated. Aqueous coating suspensions of okra gum and hydroxypropylmethylcellulose (0.6%w/v) were prepared and used to coat the tablets in Hi-coater. The coated tablets were evaluated for weight uniformity, diameter, thickness, hardness, friability, disintegration time, and moisture uptake at controlled humidity. The coating remained intact, durable, and resistant to chipping when challenged to catastrophic fall or rubbed on a white paper. The coated tablets had lower friability, increased disintegration time (24 min) compared to the core (3 min) and improved hardness, but there was no difference in the dissolution profile of the samples from the batches containing okra and hydroxypropylmethylcellulose as film formers. Changes were observed in some of the physicochemical properties of the formulations containing okra gum as with the known film former and it was convenient to conclude that these changes were due to the effect of the mechanical properties of the film formers. It was our conclusion that okra gum is a promising natural, biodegradable, cheap and eco-friendly film former in aqueous tablet film coating operation, particularly when masking of taste or objectionable odor in a solid dosage formulation is desired.
Effect of Adansonia digitata Gum on Some Physicochemical Properties of Paracetamol Pediatric Suspension Formulations
Joshua Ikoni Ogaji*,,Jessica Achuta Omachi,Titus Afolabi Iranloye
International Journal of Research in Pharmacy and Science , 2012,
Abstract: The purpose of this study was to investigate the effect of Adansonia digitata (AD) as a suspending agent in pharmaceutical formulations using paracetamol as the model drug. Paracetamol pediatric 125 mg/5ml suspensions containing AD at 0.1, 0.2, 0.3, and 0.4 % w/v as suspending agent were formulated. Similar formulations of paracetamol pediatric suspension were made using sodium carboxymethylcellulose (Na CMC) as the suspending agent. Some physicochemical properties of the paracetamol pediatric suspensions such as viscosity, easy of redispersion and sedimentation volume were evaluated. The viscosity of the suspension formulations ranged from 71-119 cP, which was a function of the concentration and type of suspending agent as well as the duration of storage of the suspension. Sedimentation volume, ease of redispersion and the flow rate of the formulations were characteristic of the suspending agent used and were influenced by the concentration of the agent. Overall, the profiles of paracetamol pediatric suspension formulations containing AD were better than those of Na CMC irrespective of the concentration of the suspending agent. At the same time the internal phase in all the formulations remained suspended for well enough time to assure withdrawal of accurate and uniform doses during the period of therapy.It was concludedthat AD gum could be a potential suspending agent in formulation of pharmaceutical suspensions.
Condition-Based Diagnostic Approach for Predicting the Maintenance Requirements of Machinery  [PDF]
Engineering (ENG) , 2009, DOI: 10.4236/eng.2009.13021
Abstract: Wise maintenance-procedures are essential for achieving high industrial productivities and low energy expenditure. A major part of the energy used in any production process is expended during the maintenance of the employed equipment. To ensure plant reliability and equipment availability, a condition-based maintenance policy has been developed in this investigation. In particular, this project explored the use of vibration parameters in the diagnosis of equipment failure. A computer-based diagnostic tool employing an artificial neural-network (ANN) was developed to analyse the ensuing machinery faults, their causes and consequences. For various categories of this type of machinery, a vibration-severity chart (ISO 12372 / BS 4675: 1971) appropriately colour coded according to defined mechanical faults, was used in training of the ANN. The model was validated using data obtained from a centrifugal pump on full load and fed into the program written in Visual Basic. The results revealed that, for centrifugal pumps within 15 to 300kw power range, vibration-velocity amplitude of between 0.9 and 2.7mm/s was within acceptable limits. When the values rose to between 2.8 and 7.0mm/s, closer monitoring and improved understanding of the equipment condition was needed. The evolved diagnostic and prognostic model is applicable for other rotary equipment that is used within the same power limits.
Vibration Monitoring of Rotating Systems  [PDF]
Engineering (ENG) , 2010, DOI: 10.4236/eng.2010.21006
Abstract: Most energy-conversion machines (e.g. vehicle engines and electric motors) involve rotating components (e.g. roller bearings and gears), which generate vibrations. The behavior of a pump which includes a deliberate fault was chosen to illustrate this assertion. The test bearing at the driven end of the pump’s motor was deliberately damaged using a 1.5mm wire-cutting method and an adjustable coupling disk introduced to impose a shaft misalignment of 40. The resulting undesirable behavior of the pump was observed. Experimental data were measured at various speeds of the rotor. The sample period at various operating frequencies were 0.9, 0.6 and 0.45s respectively. The ball-passage frequency was observed at 4.4, 8.8, 13.2 and 17.6Hz. A computer-based analytical model was developed, in visual basic, for monitoring the machine failures: this led to an integrated system-process algorithm for diagnosis of faults in rotating components.
Design of Software for Maintenance Workforce Scheduling (A Case Study of Afam Power Station, Nigeria)  [PDF]
Ikuobase Emovon, Macaulay Thomas Lilly, Stephen Ogajiye Tamuno-Ojuemi Ogaji
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.45031
Abstract: This paper is concerned with the optimization of the workforce scheduling for solving maintenance problems. To achieve this aim an optimsation software for (5, 7) problem was developed. The programme was written in Quick Basic. The software was designed to produce a seven day schedule for organization operating a seven day week. Hence organization operating a five day schedule wishing to change to a seven day schedule we find this software very useful. The Quick-Basic computer programme was based on Alfares [1, 2] algorithm for solving (5,7) schedule problem. Data collected from Afam power station, Nigeria was used as input data. The test result shows the software is capable of determining workforce size and assigning workers to day-off pattern. The seven-day schedule produced savings of 11% maintenance labour cost when compared with the 5-day schedule currently being practiced by the Power station [3].
Sexuality, Contraception And Unintended Pregnancy Among Female Student Nurses In Calabar, Nigeria
WO Ndifon, DST Ogaji, SJ Etuk
Benin Journal of Postgraduate Medicine , 2006,
Abstract: Background – There has been increased concern on human sexuality, especially with respect to contraception and the control of sexually transmissible infections. There is need to identify the sociodemographic characteristics that influence sexual behaviour and contraceptive use among young women. Methods – A descriptive cross sectional study that focused on the socio-demographic characteristics, sexuality, knowledge and use of modern contraceptive technology as well as interventions taken in the event of inadvertent pregnancy was conducted. A structured, close- ended questionnaire was randomly administered to 195 female nursing students with 60, 65 and 70 of them in their first, second and third year respectively. Results – Majority (76.7%) of the students were in the age bracket of 20 – 24years. While 65.6% of them were sexually active, only 54.9% had knowledge of family planning. Condom was the commonest contraceptive used (37.4%) and the main reasons were that of effectiveness (31.8%) and safety (30.3%). There was a significant relationship between respondents with multiple sexual partners and incidence of unwanted pregnancies (p=0.003). The majority (51.2%) of those with unwanted pregnancies resorted to induced abortion. Conclusion – In view of the high prevalence of induced abortion among the respondents, current nursing training programmes need to be reviewed to meet the peculiar reproductive health needs of female student nurses.
Analysis of different modeling approach at determining of backward extrusion force on AlCu5PbBi material
B. Bari?i?,Z. Car,M. Ikoni
Metalurgija , 2008,
Abstract: The goal of the paper is to present an outline of different modeling approach at determining of backward extrusion force on AlCu5PbBi material and to compare them with experimental obtained results. Stochastic modeling in the paper is based on the statistic processing of central composite experimental design i.e. in this investigations central composite circumscribed (CCC) design. The numerical modeling is based on the finite element method (FEM) using ABAQUS 6.4.1. Explicit software.
Planning of Material Consumption in Serial Production of the Castings
Ikoni, M.,Mikac, T.,Perini?, M.
Metalurgija , 2007,
Abstract: The production of castings can be considered as production in transport. Is necessary to plan and supply the huge quantity of different materials. The expenses of these materials reach 80 % of all expenses which give the importance to planning of working materials for serial production. To perform all mentioned in planning phase of production is necessary to define satisfactory method of determination of kind and quantity of working materials and carriers of necessary information for planning. As entrance have information from Operational sheet, List of operations and List of tools.
Possibilities of implementing bimetallic hammer castings in crushing industries
S. ?ic,I. D?ambas,M. Ikoni
Metalurgija , 2009,
Abstract: For decades manganese steel casts have been most used materials for manufacturing elements subjected to impact and high stress abrasion. These materials are used in countless industrial applications that involve crushing of raw material by impact. Some of most important characteristics of manganese cast steels are work-hardening and high strength. Opposite from manganese steels, highly alloyed white cast irons are materials with high amount of hard carbide phases that shows better abrasion resistance but have lower strength and impact energy. Aim of this paper is to investigate possibilities to reduce costs and maintenance periods by implementing bimetallic materials.

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