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Search Results: 1 - 10 of 12 matches for " IYAN SOPYAN "
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Ofloxacin analysis validation method in human blood plasma (in vitro) using solid-phase extraction HPLC
Medical and Health Science Journal , 2011,
Abstract: Until now, analysis of Ofloxacin in human blood plasma using solidphase extraction (SPE) by HPLC UV detector has not been reported. This study aims to determine the validity of analytical methods in Ofloxacin study in human blood plasma (in vitro) using an HPLC SPE UV detector. Plasma samples were extracted by SPE. Analytes were analyzed using a C18 column (octadecylsilane) 250x4.6 mm, particle size 10 0m, mobile phase 85,5:14,5 v v 0.025 M phosphate buffer (pH 2.2) and acetonitrile with a flow rate of 2 ml/min, detection performed at 294 nm with the internal standard ciprofloxacin. Validated analytical method was based on the parameters: selectivity, accuracy, precision, repeatability, linearity, LOD, LOQ, and the suitability of the system. Validation analysis showed selectivity test Rs>1.5, test repeatability with CV(%) <10%, linearity was obtained in the range of 0.1 to 6 ;g/ml with correlation coefficient (r) from 0.9998 to 0.9999. Based on the area ratio of peak height and a segment of the chromatogram obtained LOD values 0.023 and 0.024 ;g/ml, LOQ value of 0.076 and 0.080 tg/ml, percent accuracy from 94.32 to 100.45% and 97.68 to 101.63%, and precision CV (%) 0.31 to 0.85% and 0.84 to 1.08%. System suitability test results on the retention time, area ratio, and high ratios of peak chromatogram shows the CV(%) <10%. Can be concluded that the analytical methods used have validity in accordance with the requirements.
Kinetic analysis on photocatalytic degradation of gaseous acetaldehyde, ammonia and hydrogen sulfide on nanosized porous TiO2 films
Iis Sopyan
Science and Technology of Advanced Materials , 2007,
Abstract: The characteristics of the UV illumination-assisted degradation of gaseous acetaldehyde, hydrogen sulfide, and ammonia on highly active nanostructured-anatase and rutile films were investigated. It was found that the anatase film showed a higher photocatalytic activity than the counterpart did, however, the magnitude of difference in the photocatalytic activity of both films decreased in the order ammonia>acetaldehyde>hydrogen sulfide. To elucidate the reasons for the observation, the adsorption characteristics and the kinetics of photocatalytic degradation of the three reactants on both films were analyzed. The adsorption analysis examined using a simple Langmuir isotherm, showed that adsorbability on both films decreased in the order ammonia>acetaldehyde>hydrogen sulfide, which can be explained in terms of the decreasing electron-donor capacity. Acetaldehyde and ammonia adsorbed more strongly and with higher coverage on anatase film (1.2 and 5.6 molecules/nm2, respectively) than on rutile (0.6 and 4.7 molecules/nm2, respectively). Conversely, hydrogen sulfide molecules adsorbed more strongly on rutile film (0.7 molecules/nm2) than on anatase (0.4 molecules/nm2). Exposure to UV light illumination brought about the photocatalytic oxidation of the three gases in contact with both TiO2 films, and the decrease in concentration were measured, and their kinetics are analyzed in terms of the Langmuir–Hinshelwood kinetic model. From the kinetic analysis, it was found that the anatase film showed the photocatalytic activities that were factors of ~8 and ~5 higher than the rutile film for the degradation of gaseous ammonia and acetaldehyde, respectively. However, the activity was only a factor of ~1.5 higher for the photodegradation of hydrogen sulfide. These observations are systematically explained by the charge separation efficiency and the adsorption characteristics of each catalyst as well as by the physical and electrochemical properties of each reactant.
Architecture Model of Bussines, Information System and Technology in BAKOSURTANAL Based on TOGAF
Iyan Supriyana
Abstract: The information technology (IT) is a necessary in BAKOSURTANAL to support business in relation with data and spatial information. Users will get the advantage through easy and fast access to data and spatial information. The important of the enterprise architecture (EA) to play a role to support company is proven because it provides technology and process structure which are fundamental aspects in IT strategy. Enterprise architecture framework (EAF) will accelerate and simplify the development of EA by ascertaining comprehensive coverage of solutions, ensuring the result of EA is always in line with the growth of enterprise. This paper explains the open group architecture framework (TOGAF) from several of EAF. The result shows that the most suitable EAF for BAKOSURTANAL in Blueprint development is by proposing EA model that covers business, information system, and technology architecture which are relied on recommended technical basics that is possible to be implemented.
Nanosized TiO2 Photocatalyst Powder via Sol-Gel Method: Effect of Hydrolysis Degree on Powder Properties
Nor Hafizah,Iis Sopyan
International Journal of Photoenergy , 2009, DOI: 10.1155/2009/962783
Abstract: Nanosized TiO2 powder was synthesized via sol-gel method using titanium tetraisopoxide (TPT) as the precursor. Mol ratios of water to TPT were varied from 1 (Powder A), 2 (Powder B), 3 (Powder C), and 4 (Powder D) to evaluate effect of hydrolysis degree. TG/DTA curves showed that amorphous phase turned to anatase crystal structure at ca. 415, 337, 310, and 339°C for Powders A, B, C, and D, respectively. XRD analysis showed that all the synthesized TiO2 powders were 100% in anatase form with Powders B and C showing considerably higher crystallinities. The powders obtained at lower water to TPT mol ratios were spherical in shape and they became bar-like shapes higher mol ratios. The lower hydrolysis degree led to higher surface area of the Powder A (24.8 m2/g) compared to Powder B (14.6 m2/g). From phenol photocatalytic measurement, Powder B was the most efficient attributed to its higher crystallinity.
Porous hydroxyapatite for artificial bone applications
I. Sopyan et al
Science and Technology of Advanced Materials , 2007,
Abstract: Hydroxyapatite (HA) has been used clinically for many years. It has good biocompatibility in bone contact as its chemical composition is similar to that of bone material. Porous HA ceramics have found enormous use in biomedical applications including bone tissue regeneration, cell proliferation, and drug delivery. In bone tissue engineering it has been applied as filling material for bone defects and augmentation, artificial bone graft material, and prosthesis revision surgery. Its high surface area leads to excellent osteoconductivity and resorbability providing fast bone ingrowth. Porous HA can be produced by a number of methods including conversion of natural bones, ceramic foaming technique, polymeric sponge method, gel casting of foams, starch consolidation, microwave processing, slip casting, and electrophoretic deposition technique. Some of these methods have been combined to fabricate porous HA with improved properties. These combination methods have yielded some promising results. This paper discusses briefly fundamental aspects of porous HA for artificial bone applications as well as various techniques used to prepare porous HA. Some of our recent results on development of porous HA will be presented as well.
KINETIKA FERMENTASI SELULOSA MURNI OLEH Trichoderma reesi QM 9414 MENJADI GLUKOSA DAN PENERAPANNYA PADA JERAMI PADI BEBAS LIGNIN [Kinetics of Pure Cellulose Fermentation by Trichoderma Reesei QM 9414 to Glucose and Its Application of on Lignin Free Rice Straw]
M Iyan Sofyan
Jurnal Teknologi dan Industri Pangan , 2004,
Abstract: The objectives of this research were: 1) to determine aeration rate and substrate concentration of pure cellulose to produce maximum glucose by Trichoderma reesei QM 9414 at 30 oC, and agitation 150 rpm; 2) to study the kinetics of pure cellulose fermentation by Trichoderma reesei QM 9414 to glucose and its implication upon fermentation of the lignin free rice straw. The experiment was arranged in factorial randomized complete design in three times replication. Treatments consisted of three levels of aeration (1,00 vvm; 1,5 vvm; 2,0 vvm) and three levels of substrate concentration (0,75 ; 1,00 ; 1,25 % w/v). The results showed that at the exponential phase the average specific growth of Trichoderma reesei QM 9414 was 0,05374 hour-1, the maximum glucose product concentration of pure cellulose was 0.1644 gL-1,and the oxygen transfer was 0,0328 mg L-1 hour-1. According to t-test, the kinetics of pure cellulose fermentation model just the same as the lignin free rice straw fermentation.The enzymes produced by Trichoderma reesei QM 9414 in pure cellulose fermentation media followed the Michaelis-Menten model. The enzyme kinetic parameters were the maximum growth rate was 37x10-3 hour-1 and Michaelis-Menten constant was maximum μ =17,5x10-3 hour-1. The volumetric oxygen transfer (KLa) using rice straw was 0,0337 mg.hour-1. The value of KLa could be used for conversion from bioreactor at laboratory scale to commercial scale design.
The Growth Study of Vero Cells in Different Type of Microcarrier  [PDF]
Yusilawati Ahmad Nor, Nurul Hafizah Sulong, Maizirwan Mel, Hamzah Mohd Salleh, Iis Sopyan
Materials Sciences and Applications (MSA) , 2010, DOI: 10.4236/msa.2010.15038
Abstract: The fact of microcarrier (MC) culture introduces new possibilities and makes possible the practical high-yield culture of anchorage-dependent cells has generated a considerable focus in this study. The objective of this research was to study the comparison of Vero cell growth on different types of commercial microcarriers; Cytodex-1, Cytodex-3, Hil-lex® II and Plastic Plus in spinner vessel and two liters bioreactor cultured for 96 hours. Biological performance of the microcarrier in RPMI media showed the preference of Vero cell grew on Cytodex 3 microcarriers with highest maximum viable cell number (2.4 × 105 cells/ml) followed by Cytodex 1, Hillex and Plustic Plus. Vero cell on Cyto-dex-3 data in spinner flask was compared in bioreactor and result showed higher viable cell number in biorector. Thus, this dextran-crosslink gelatin microcarrier (Cytodex 3) provided the best surface for cell attachment and fast proliferation. At the end of this cell growth improvement will be used for virus transfection producing a vaccine in bioreactor.
Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12, and VCAM-1 Levels with Further Post-Coronary Angiogram Endothelial Injury in Elderly and Younger Patients  [PDF]
Deeraj Mungun, Iyan Zakaria, Xiangming Wang, Tiantian Tu, Chuyan Feng, Yan Guo
World Journal of Cardiovascular Diseases (WJCD) , 2018, DOI: 10.4236/wjcd.2018.81006
Abstract: Objective: Coronary Angiography (CAG) refers to an aggressive process that is likely to lead to endothelial injury and possibly drive further interpretation of the cause for patients within current atherosclerotic illnesses. Therefore, this study aims to test certain correlations among concentration of sRAGE, VCAM-1, as well as S100A12 pre- and post-coronary angiography alongside likelihood of endothelial injury among various patients in different ages including the younger and the geriatric groups, thereby offering a full connection upon CAG impacts of patients having atherosclerosis. Method: In this study, the whole patients chosen had been grouped into two major groups on the basis of ages: the younger patient aged less than 65 years old (Group 1), and the elderly patient aged over 65 years old (Group 2). Soluble RAGE (sRAGE), VCAM-1 and S100A12 degrees in blood sampling gathered followed by measurements of CAG session for evaluating the inflammatory responses and likelihood of endothelial injury caused via CAG. All data was analyzed using SPSS version 21.0. Findings: Significant enhancement among concentration of serum VCAM-1 (P = 0.007) in younger patients and sRAGE (P = 0.019) in elderly patients had been observed, but that of serum S100A12 was still unaltered. Conclusions: Enhanced concentration of sRAGE and VCAM-1 post-CAG of patients having CAD are able to be related to follow-up endothelial injury, thus contributing to different pathway in exacerbating endothelial injury among younger and elderly patients.
Low-Temperature Degradation (LTD) Behaviour of CuO-Doped Tetragonal Zirconia Ceramic
S. Ramesh,J. Purbolaksono,M. Hamdi,I. Sopyan
Ceramics-Silikáty , 2012,
Abstract: In the present work, the low-temperature degradation (LTD) behavior of undoped and copper oxide (CuO) doped yttriatetragonal zirconia polycrystals ceramics sintered at 1300oC was investigated. The zirconia samples were tested in three different media i.e. superheated steam at 180°C/10 bar, refluxing conditions in 20% hydrochloric solution at 110oC and in hot air at 180oC to determine the effect of hydroxyl content in triggering the tetragonal to monoclinic phase transformation. The study found that the additions of CuO significantly reduced the rate of LTD phase transformation in all media tested. The undoped zirconia exhibited severe LTD when exposed to media containing 100% hydroxyl content. Although the CuO-doped samples were generally found to have better LTD characteristics, cross-sections of aged specimens (after 200 hours of exposure in superheated steam) revealed that very thin measurable monoclinic layers were developed. The presence of hydroxyl in the test media was found to have played a significant role in controlling the LTD of zirconia ceramics.
Blood Biochemical Indices and Productivity of Broilers on Diet Supplemented with Mannan Oligosacharide, Baker Yeast, or Combined Baker Yeast and Noni Leaves Extracts
Retno Murwani,Anantasia Indriani,Iyan Yuliana,Kinanthi Wihardani
International Journal of Poultry Science , 2011,
Abstract: A research was carried out to study the inclusion of MOS, inactivated baker yeast or combined baker yeast and Noni leaves extracts into corn-mungbean basal diet on broilers blood biochemical indices and productivity. Lohman MB-202 day old chicks were randomly assigned into four treatment diets i.e. 1) commercial/control diet (Dc), 2) basal diet plus MOS (DM), (3) basal diet plus inactivated baker yeast (DY), (4) basal diet plus inactivated baker yeast and Noni leaves extracts (DY+L). Treatment diets and water were given ad libitum. Whole blood were sampled on day 21 for determination of hemoglobin and haematocrit, Serum Glutamic Pyruvic Transaminases, Glutamic Oxaloacetic Transaminases, creatinine, lipid profile, alkaline phosphatase and lactic acid. Relative organs weight, abdominal fat, productivity were also determined. Feed intake, body weight and feed conversion of broilers fed DM, DY, DY+L were the same but they were lower than control diet (p<0.05). Serum triglyceride, GPT, creatinine, cholesterol, VLDL+LDLchol and HDLchol were significantly affected by the diets (p<0.05). No effect was found for other serum biochemical indices. For relative internal organs weight, a significant effect was found for heart, liver, ileum, duodenum and pancreas. These results were discussed in terms of the possible underlying mechanism. Our results here provide evidence that MOS, inactivated baker yeast alone or its combination with Noni leave extract could produce low serum TG, total cholesterol, VLDL+LDLchol, HDLchol and abdominal fat in broilers fed corn-mungbean basal diet with no negative effect on other serum biochemical indices.
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