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Search Results: 1 - 10 of 388110 matches for " I. S. Edelman "
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Review of the Book “Magnetooptical Spectroscopy of the Rare-Earth Compounds: Development and Application”  [PDF]
I. S. Edelman
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2012, DOI: 10.4236/jemaa.2012.45030
Abstract: This book reviews and provides numerous theoretical calculations for the first time relevant to the optics and magneto-optics of the trivalent rare earth ions (RE3+) and their compounds. The RE3+ have unique spectroscopic properties that make them exceptionally attractive to both scientists, who probe the fundamental properties of these systems, and engineers, who develop these systems into photonic devices eagerly marketed in expanded technologies. Magneto-optical effects in compounds doped with RE3+ have been studied since the dawn of modern physics and have had a profound impact on their development in terms of practical opto-electronic devices. The authors of this new, exciting, and fresh text are world famous in this field, with over 150 years of experience in developing important theoretical and experimental contributions and over fifty years of more than 500 refereed publications in this field in the Soviet Union and the United States. They offer both a conceptual description of magneto-optical phenomena, as well as clear, detailed theoretical development published for the first time of many of the phenomena only briefly addressed in the literature. The book is based on the author’s original work in theoretical and experimental investigations in magneto-optics. Numerous graphs and simple examples model the phenomena described in the text, making it a highly desirable treatise for scientists beginning their studies in the field of magneto-optics.
Multiscale behavior and fractional kinetics from the data of solar wind - magnetosphere coupling
G. M. Zaslavsky,P. N. Guzdar,M. Edelman,M. I. Sitnov,A. S. Sharma
Physics , 2005,
Abstract: Multiscale phenomena are ubiquitous in nature as well in laboratories. A broad range of interacting space and time scales determines the dynamics of many systems which are inherently multiscale. In most research disciplines multiscale phenomena are not only prominent, but also they have often played the dominant role. In the solar wind - magnetosphere interaction, multiscale features coexist along with the global or coherent features. Underlying these phenomena are the mathematical and theoretical approaches such as phase transitions, turbulence, self-organization, fractional kinetics, percolation, etc. The fractional kinetic equations provide a suitable mathematical framework for multiscale behavior. In the fractional kinetic equations the multiscale nature is described through fractional derivatives and the solutions of these equations yield non-convergent moments, showing strong multiscale behavior. Using a L\'{e}vy-flights approach, we analyze the data of the magnetosphere and the solar wind. Based on this analysis we propose a model of the multiscale features and compare it with the solutions of diffusion type equations. The equation with fractional spatial derivative shows strong multiscale behavior with divergent moments. On the other hand the equation with space dependent diffusion coefficients yield convergent moments, indicating Gaussian type solutions and absence of long tails typically associated with multiscale behavior.
Beyond Universality in Random Matrix Theory
A. Edelman,A. Guionnet,S. Péché
Mathematics , 2014,
Abstract: In order to have a better understanding of finite random matrices with non-Gaussian entries, we study the $1/N$ expansion of local eigenvalue statistics in both the bulk and at the hard edge of the spectrum of random matrices. This gives valuable information about the smallest singular value not seen in universality laws. In particular, we show the dependence on the fourth moment (or the kurtosis) of the entries. This work makes use of the so-called complex deformed GUE and Laguerre ensembles.
Leisure among the Retired Indos of the Hague  [PDF]
Henny N. Edelman, David J. Edelman
Advances in Applied Sociology (AASoci) , 2011, DOI: 10.4236/aasoci.2011.11003
Abstract: The ethnic mixture in Europe has been changing rapidly since the end of World War II, and many of these immigrant groups are now reaching retirement. The Netherlands is one of the countries affected in this way. This study focuses on mixed race people (Indos) originating in the former Dutch East Indies (now Indonesia) and residing in The Hague and its surrounding area. Their situation is relevant to other immigrant groups in other European countries. There are several important issues that are studied here with regard to their leisure from which a typology of Indo leisure lifestyles is developed. These issues include :1) how this group is able to avail itself of leisure activities with which its members feel comfortable during retirement and old age; 2) whether this group has integrated itself completely into the host society and feels happy in its social life; 3) whether the leisure activities of retired Indos are a way for them to keep healthy mentally and physically, thereby leading to satisfaction with life; and 4) how this particular group of people feels about its unique identity and culture after many years of living in the Netherlands.
A Spatial Analysis of the Recreation Potential of Cirebon, Indonesia’s Kratons  [PDF]
Henny N. Edelman, David J. Edelman
Advances in Applied Sociology (AASoci) , 2013, DOI: 10.4236/aasoci.2013.38042
Abstract: Cirebon is an important port city located on the provincial, as well as cultural, border of West and Central Java. Historically, an important Indonesian melting pot, it is an expanding center of commerce and industry. There remain, however, a number of special artistic and cultural features of the city revealed by motifs reflecting the traditions of the Kratons, or former palaces of the Sultanate of Cirebon, which reached its height in the fifteenth century. This paper presents an analysis of the Kratons of Cirebon as a recreational and tourism resource within the concept of the spatial analysis of recreational behavior. It is structured around various aspects of the relationship between human spatial behavior and leisure environments.
Managing the Urban Environment of Manila  [PDF]
David J. Edelman
Advances in Applied Sociology (AASoci) , 2016, DOI: 10.4236/aasoci.2016.63010
Abstract: This article brings the contemporary thinking and practice of Urban Environmental Management (UEM) to the solution of real problems in a major city of a developing country in Southeast Asia. Such cities confront more pressing problems than those in the developed world and have fewer resources to deal with them. The study first considers urban issues, poverty alleviation, industry, transportation, energy, water, sewage and sanitation, and finance, and then proposes a 5-year plan to help solve the urban environmental problems of Metro Manila, the Philippines, an environmentally complex, sprawling metropolitan region with over 24 million inhabitants.
The City in Cinema: A Global Perspective  [PDF]
David J. Edelman
Current Urban Studies (CUS) , 2016, DOI: 10.4236/cus.2016.42010
Abstract: Commercial cinema is a worldwide form of entertainment enjoyed by most of the planet’s population and variety of cultures. Films are produced on six continents and marketed successfully internationally. However, cinema is more than a medium for telling stories of adventure, intrigue, comedy and romance. As most of the world’s population now lives in cities, many films take place in urban settings, where a large number of those cities’ physical and social problems are exposed. Commercial film, then, plays a useful role in determining how such issues can be confronted through the lenses of their many countries and cultures. That is, solutions to urban problems must be culturally sensitive. Moreover, as cities dominate life on planet Earth in the 21st century far beyond what their population alone would warrant, they are at the core of some of the most influential films of the last century. This paper, then, is significant in that it looks at some of these urban focused films and identifies the universal themes they consider.
Managing the Urban Environment of Lima, Peru  [PDF]
David J Edelman
Advances in Applied Sociology (AASoci) , 2018, DOI: 10.4236/aasoci.2018.83014
Abstract: This article brings the contemporary thinking and practice of Urban Environmental Management (UEM) to the solution of real problems in a major city of a developing country in Latin America. Such cities both face more immediate problems than the developed world and have fewer resources to deal with them. The study first considers the Latin American context and then reviews issues of poverty alleviation, industry, sewage and sanitation, water, energy, transportation and finance in Lima, Peru. Finally, it proposes a 5-year plan to help solve the urban environmental problems of Metropolitan Lima, an environmentally difficult, but important Latin American metropolitan area located between the Pacific Ocean and a hilly desert, utilizing a real-world database and a limited budget.
Population Pharmacokinetics of UCN-01  [PDF]
Charlene A. Baksh, Martin J. Edelman, Edward A. Sausville, William D. Figg, Hao Zhu, Kenneth S. Bauer
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.410183

UCN-01 (7-Hydroxystaurosporine) is an investigational anticancer agent that is currently being evaluated as targeted therapy in phase II clinical studies. The aims of this work were to describe the population pharmacokinetics of UCN-01 in patients with advanced solid tumors, and to identify covariates in patients with advanced solid tumors that affected the pharmacokinetic parameters of UCN-01. The utility of performing this research is to provide optimization of treatment and individualized dose therapy for minimization of toxicity. So, in addition to elucidating the population pharmacokinetic parameter estimates from a Phase I trial where UCN-01 was given in combination with carboplatin in patients with advanced solid tumors, and a trial where the drug was given alone as a 72-hour infusion in the same type of population, a covariate analysis was performed in order to identify pharmacokinetic determinants of UCN-01. Using NONMEM to perform nonlinear mixed-effects modeling, a linear two-compartment model was found to provide the best fit for UCN-01 data. A meta-analysis was performed, which included pooled 3-hour and 72-hour infusion data, and provided population pharmacokinetic estimates for CL (0.0157 L/hr [6.1%RSE]), V1 (2.51 L [10.0% RSE]), Q (4.05 L/hr [14.3% RSE]), and V2 (8.39 L [6.6% RSE]). Inter-individual variability was found for each of the main pharmacokinetic parameters to be ETACL (44.9% [20.8% RSE]), ETAV1 (43.9% [39.8% RSE]), ETAQ (6.09% [62.5% RSE]), and ETAV2 (4.17% [30.0% RSE]). Body surface area was found to be a statistically-significant variable from one of the individual study analyses (3-hour infusion). Population PK modeling has contributed to a better understanding of the clinical pharmacology of UCN-01. Dose individualization may improve treatment with UCN-01. Further clinical development may be supported by optimization of combination

Drosophila Interspecific Hybrids Phenocopy piRNA-Pathway Mutants
Erin S. Kelleher,Nathaniel B. Edelman,Daniel A. Barbash
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1001428
Abstract: The Piwi-interacting RNA (piRNA) pathway defends the germline of animals from the deleterious activity of selfish transposable elements (TEs) through small-RNA mediated silencing. Adaptation to novel invasive TEs is proposed to occur by incorporating their sequences into the piRNA pool that females produce and deposit into their eggs, which then propagates immunity against specific TEs to future generations. In support of this model, the F1 offspring of crosses between strains of the same Drosophila species sometimes suffer from germline derepression of paternally inherited TE families, caused by a failure of the maternal strain to produce the piRNAs necessary for their regulation. However, many protein components of the Drosophila piRNA pathway exhibit signatures of positive selection, suggesting that they also contribute to the evolution of host genome defense. Here we investigate piRNA pathway function and TE regulation in the F1 hybrids of interspecific crosses between D. melanogaster and D. simulans and compare them with intraspecific control crosses of D. melanogaster. We confirm previous reports showing that intraspecific crosses are characterized by derepression of paternally inherited TE families that are rare or absent from the maternal genome and piRNA pool, consistent with the role of maternally deposited piRNAs in shaping TE silencing. In contrast to the intraspecific cross, we discover that interspecific hybrids are characterized by widespread derepression of both maternally and paternally inherited TE families. Furthermore, the pattern of derepression of TE families in interspecific hybrids cannot be attributed to their paucity or absence from the piRNA pool of the maternal species. Rather, we demonstrate that interspecific hybrids closely resemble piRNA effector-protein mutants in both TE misregulation and aberrant piRNA production. We suggest that TE derepression in interspecific hybrids largely reflects adaptive divergence of piRNA pathway genes rather than species-specific differences in TE-derived piRNAs.
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