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Search Results: 1 - 10 of 87734 matches for " I. Passariello "
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Contribution of Radiocarbon Dating to the Chronology of Eneolithic in Campania (Italy)
I. Passariello, P. Talamo, A. D'Onofrio, P. Barta, C. Lubritto, F. Terrasi
Geochronometria , 2010, DOI: 10.2478/v10003-010-0008-2
Abstract: The paper presents new and important 14C data from eight Eneolithic sites in Campania measured at the Centre for Isotopic Research of Cultural and Environmental Heritage (CIRCE) AMS laboratory in Caserta (Italy). Twenty-four 14C determinations on bone and charcoal are used here for chronological reconstruction of human habitation and dating of some volcanic eruptions affecting the settlement activity. Our research has shed new light on absolute chronology of the whole Campanian Eneolithic, a period of profound cultural transformations triggered by introduction and use of metals, in particular copper.
Simulación del comportamiento dinámico del ventrículo izquierdo usando técnicas de deformación de forma libre
Bravo,Antonio; Medina,Rubén; Passariello,Gianfranco; Garreau,Mireille;
Universidad, Ciencia y Tecnología , 2005,
Abstract: this paper proposes a computational 4-d (3-d + time) graphical based model for the left ventricle (lv) anatomical shape of the human heart. the model considers functional and anatomical features of the endocardial and epicardial walls of the left ventricle in normal hearts. the left ventricle is obtained after segmentation and contour based 3-d reconstruction of the visual human database or a positron emission tomography database. the functional features are modeled based in parameters of lv motion models proposed in the literature. a free-form deformation (ffd) approach is hierarchically applied on the reconstructed endocardial and epicardial surfaces for simulating global and local deformations associated to the relaxation-contraction of the ventricular cavity. this methods allows one to synthesize the 3-d geometry of the left ventricle during the cardiac cycle. a set of parameters describing the left ventricle dynamics are extracted from the simulated sequences and compared with results previously reported in the literature. results of this comparison show that the proposed simulation model successfully reproduces the dynamical behavior of a real left ventricle.
Malpractice in Radiology: What Should You Worry About?
Alessandro Cannavale,Mariangela Santoni,Paola Mancarella,Roberto Passariello
Radiology Research and Practice , 2013, DOI: 10.1155/2013/219259
Abstract:
Malpractice in Radiology: What Should You Worry About?
Alessandro Cannavale,Mariangela Santoni,Paola Mancarella,Roberto Passariello,Paolo Arbarello
Radiology Research and Practice , 2013, DOI: 10.1155/2013/219259
Abstract: Over recent years the professional role of the radiologist has been evolved due to the increasing involvement in the clinical management of the patient. Radiologists have thus been increasingly charged by new duties and liabilities, exposing them to higher risks of legal claims made against them. Malpractice lawsuits in radiology are commonly related to inappropriate medical care or to the poor physician-patient relationship. In the present paper, we provide overview of the basic principles of the medical malpractice law and the main legal issues and causes of legal actions against diagnostic and interventional radiologists. We also address some issues to help radiologists to reduce risks and consequences of malpractice lawsuits. These include (1) following the standard of care to the best of their ability, (2) cautious use of off-label devices, (3) better communication skills among healthcare workers and with the patient, and (4) ensuring being covered by adequate malpractice insurance. Lastly, we described definitions of some medicolegal terms and concepts that are thought to be useful for radiologists to know. 1. Introduction Over the last years radiologists have become substantial part of the clinical-therapeutic management of patients. This implies new liabilities and duties related to interventional procedures which are now added to already existing professional liability from diagnostic exams. Errors in radiology practice are quite common amounting for about 4% of radiologic interpretations rendered by radiologists [1]. Hence, most of the committed errors are of such minor degree or are resolved before a patient’s injury may happen. Nevertheless many errors in clinical practice may harm the patients leading to medical malpractice lawsuits [1]. A lot of the problems of medical malpractice generally are related to two issues: the physician-patient relationship or improper medical care leading bodily harm. Both knowledge of state law and appropriateness criteria may help the physician to prevent complications and thereby any legal issues with patients. In the first part of our review we overviewed the current laws and rules concerning the medical malpractice among different countries. Moreover we reported frequency and burden of causes of malpractice among radiologists and the related legal sequelae. Finally four pieces of advice to reduce the risk to incurring a malpractice complaint are outlined: (1) follow as long as possible the standard of care; (2) be careful in the off-label use of devices (3); improve communication skills with colleagues,
Methodology for the study of metabolic syndrome by heart rate variability and insulin sensitivity
Severeyn, Erika;Wong, Sara;Passariello, Gianfranco;Cevallos, José Luis;Almeida, Deyanira;
Revista Brasileira de Engenharia Biomédica , 2012, DOI: 10.4322/rbeb.2012.026
Abstract: this work presents a methodology for studying the heart rate variability (hrv) and insulin sensitivity (is) during the oral glucose tolerance test (ogtt) in subjects with metabolic syndrome (ms). for this, it was designed a clinical protocol that includes the acquisition of ecg signals during ogtt for 15 subjects with ms and 10 subjects for control group. hrv parameters were obtained from electrocardiographic recordings. significant differences in rr values were found between groups in the 30 minutes stage of the ogtt. in control subjects the rr values were higher compared with subjects with ms. the values of normalized low frequencies between baseline stages and the stage at 30 minutes in subjects with ms showed a significant increase in sympathetic tone during the ogtt, that was not observed in group control. the following methods were implemented for quantification of is: integral equation, insulin sensitivity index, insulin sensitivity, metabolic, homa and quicki. we found significantly lower values of is in the group with ms. it was concluded that there are changes in the hrv and the is in the subjects with ms, which is a pre-diabetic disease. these findings suggest that hrv and is can be used for diagnosis of ms and prevention of diabetes mellitus.
Diarrhea in neonatal intensive care unit
Annalisa Passariello, Gianluca Terrin, Maria Elisabetta Baldassarre, Mario De Curtis, Roberto Paludetto, Roberto Berni Canani
World Journal of Gastroenterology , 2010,
Abstract: AIM: To investigate the frequency, etiology, and current management strategies for diarrhea in newborn.METHODS: Retrospective, nationwide study involving 5801 subjects observed in neonatal intensive care units during 3 years. The main anamnesis and demographic characteristics, etiology and characteristics of diarrhea, nutritional and therapeutic management, clinical outcomes were evaluated.RESULTS: Thirty-nine cases of diarrhea (36 acute, 3 chronic) were identified. The occurrence rate of diarrhea was 6.72 per 1000 hospitalized newborn. Etiology was defined in 29 of 39 newborn (74.3%): food allergy (20.5%), gastrointestinal infections (17.9%), antibiotic-associated diarrhea (12.8%), congenital defects of ion transport (5.1%), withdrawal syndrome (5.1%), Hirschsprung’s disease (2.5%), parenteral diarrhea (2.5%), cystic fibrosis (2.5%), and metabolic disorders (2.5%). Three patients died due to complications related to diarrhea (7.7%). In 19 of 39 patients (48.7%), rehydration was performed exclusively by the enteral route.CONCLUSION: Diarrhea in neonates is a challenging clinical condition due to the possible heterogeneous etiologies and severe outcomes. Specific guidelines are advocated in order to optimize management of diarrhea in this particular setting.
Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns
Gianluca Terrin,Annalisa Passariello,Francesco Manguso,Gennaro Salvia,Luciano Rapacciuolo,Francesco Messina,Francesco Raimondi,Roberto Berni Canani
Clinical and Developmental Immunology , 2011, DOI: 10.1155/2011/291085
Abstract: To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight <1500 g and a postnatal age >72 hours of life. The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-total-neutrophil ratio, platelet count, and C-reactive protein). We found that the serum calprotectin concentration was significantly higher (<.001) in 62 newborns with confirmed sepsis (3.1±1.0  μg/mL) than in either 29 noninfected subjects (1.1±0.3 μg/ml) or 110 healthy controls (0.91±0.58 μg/ml). The diagnostic accuracy of serum calprotectin was greater (sensitivity 89%, specificity 96%) than that of the traditional markers of sepsis. In conclusion, serum calprotectin is an accurate marker of sepsis in very low birth weight newborns.
Tolerance to a new free amino acid-based formula in children with IgE or non-IgE-mediated cow's milk allergy: a randomized controlled clinical trial
Roberto Berni Canani, Rita Nocerino, Ludovica Leone, Margherita Di Costanzo, Gianluca Terrin, Annalisa Passariello, Linda Cosenza, Riccardo Troncone
BMC Pediatrics , 2013, DOI: 10.1186/1471-2431-13-24
Abstract: Consecutive patients affected by IgE- or non-IgE-mediated CMA, aged <= 4 years, were enrolled. DBPCFC was carried out with increasing doses of the new Aaf (Sineall, Humana, Milan, Italy), using validated Aaf as placebo. Faecal concentrations of calprotectin (FC) and eosinophilic cationic protein (ECP) were monitored.Sixty patients (44 male, 73.3%, median age 37, 95%CI 34.5--39.6 months, IgE-mediated CMA 29, 48.3%) were enrolled. At the diagnosis clinical symptoms were gastrointestinal (46.6%), cutaneous (36.6%), respiratory (23.3%), and systemic (10.0%). After DBPCFC with the new Aaf, no patient presented early or delayed clinical reactions. Faecal concentration of calprotectin and of ECP remained stable after the exposure to the new Aaf.The new Aaf is well tolerated in children with IgE- or non-IgE-mediated CMA, and it could be used as a safe dietotherapy regimen for children with this condition.Trial registration: The trial was registered in the ClinicalTrials.gov Protocol Registration System (ID number: NCT01622426).
Congenital Diarrheal Disorders: An Updated Diagnostic Approach
Gianluca Terrin,Rossella Tomaiuolo,Annalisa Passariello,Ausilia Elce,Felice Amato,Margherita Di Costanzo,Giuseppe Castaldo,Roberto Berni Canani
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13044168
Abstract: Congenital diarrheal disorders (CDDs) are a group of inherited enteropathies with a typical onset early in the life. Infants with these disorders have frequently chronic diarrhea of sufficient severity to require parenteral nutrition. For most CDDs the disease-gene is known and molecular analysis may contribute to an unequivocal diagnosis. We review CDDs on the basis of the genetic defect, focusing on the significant contribution of molecular analysis in the complex, multistep diagnostic work-up.
Serum Calprotectin: An Antimicrobial Peptide as a New Marker For the Diagnosis of Sepsis in Very Low Birth Weight Newborns
Gianluca Terrin,Annalisa Passariello,Francesco Manguso,Gennaro Salvia,Luciano Rapacciuolo,Francesco Messina,Francesco Raimondi,Roberto Berni Canani
Journal of Immunology Research , 2011, DOI: 10.1155/2011/291085
Abstract: To determine the diagnostic utility of serum calprotectin, a mediator of innate immune response against infections, we performed a multicenter study involving newborns with a birth weight ?g and a postnatal age hours of life. The diagnostic accuracy of serum calprotectin was compared with that of the most commonly used markers of neonatal sepsis (white blood cell count, immature-to-total-neutrophil ratio, platelet count, and C-reactive protein). We found that the serum calprotectin concentration was significantly higher ( ) in 62 newborns with confirmed sepsis ( ?μg/mL) than in either 29 noninfected subjects ( ?μg/ml) or 110 healthy controls ( ?μg/ml). The diagnostic accuracy of serum calprotectin was greater (sensitivity 89%, specificity 96%) than that of the traditional markers of sepsis. In conclusion, serum calprotectin is an accurate marker of sepsis in very low birth weight newborns. 1. Introduction The neonatal immune response to many pathogens is largely immature [1]. At this age, infections are characterized by a high mortality and morbidity [2, 3]. An early diagnosis is crucial because the clinical course may be fulminating, particularly in very low birth weight (VLBW) babies, in whom the onset is often inconspicuous, with minimal, subtle, and nonspecific signs [1–3]. Isolation of bacteria from central body fluid (usually blood) is the standard test for neonatal systemic infection; however, the result of culture is not available before 24–48?h and is negative in many instances, even in cases of a clear clinical picture of sepsis [4–6]. Neonatal septicaemia is associated with hyperinflammatory host responses that subtend activation of immune system. A broad spectrum of inflammatory markers has been proposed for the diagnosis of neonatal sepsis [4]. However, most of these markers are mediators of an acquired immunity response, which is largely immature in the neonatal period [4]. On the contrary, innate immunity is fully developed in the first weeks of life, but the potential diagnostic role of components of innate immunity has not been investigated [7, 8]. Calprotectin (aka MRP8/14, calgranulin, cystic fibrosis-associated antigen, and S100), a major product of innate immunity cells, is an antimicrobial peptide that protects cells against invasive microorganisms and regulates adhesion of leukocytes to the endothelium and extracellular matrix during the inflammatory process [4, 9]. Calprotectin is released by innate immunity cells immediately after host-pathogen interaction [9] and is detectable in body fluids by means of a simple ELISA technique
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