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Search Results: 1 - 10 of 87764 matches for " I. Grandvuillemin "
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Developmental Origins of Chronic Renal Disease: An Integrative Hypothesis
F. Boubred,M. Saint-Faust,C. Buffat,I. Ligi,I. Grandvuillemin,U. Simeoni
International Journal of Nephrology , 2013, DOI: 10.1155/2013/346067
Abstract: Cardiovascular diseases are one of the leading causes of mortality. Hypertension (HT) is one of the principal risk factors associated with death. Chronic kidney disease (CKD), which is probably underestimated, increases the risk and the severity of adverse cardiovascular events. It is now recognized that low birth weight is a risk factor for these diseases, and this relationship is amplified by a rapid catch-up growth or overfeeding during infancy or childhood. The pathophysiological and molecular mechanisms involved in the “early programming” of CKD are multiple and partially understood. It has been proposed that the developmental programming of arterial hypertension and chronic kidney disease is related to a reduced nephron endowment. However, this mechanism is still discussed. This review discusses the complex relationship between birth weight and nephron endowment and how early growth and nutrition influence long term HT and CKD. We hypothesize that fetal environment reduces moderately the nephron number which appears insufficient by itself to induce long term diseases. Reduced nephron number constitutes a “factor of vulnerability” when additional factors, in particular a rapid postnatal growth or overfeeding, promote the early onset of diseases through a complex combination of various pathophysiological pathways. 1. Introduction Cardiovascular diseases ((CVD) hypertension, coronary disease and stroke, and heart failure) are one of the leading causes of mortality in industrialized countries, and the prevalence is increasing in emerging societies. All cardiovascular diseases account for 4.3 million deaths per year in the European Union, and the prevalence of chronic heart failure in the United States of America is approximately 6 million [1, 2]. In industrialized countries, hypertension (HT) affects 25% to 35% of the global population and reaches 60% to 70% of the population aged 60 or more. Hypertension is the principal risk factor of death worldwide [3]. It increases the severity of ischemic vascular diseases and, with obesity and type 2 diabetes, is one of the important risk factors for chronic kidney disease (CKD). Chronic kidney disease is defined as reduced glomerular filtration rate (GFR) up to end-stage renal disease (ESRD), proteinuria, or both. Prevalence of ESRD, estimated to be 0.5–2.5‰ worldwide, is increasing in several countries [4]. In turn, impaired renal factor favors the development of and amplifies the severity of CVD [5–7]. During the last two decades, it has been raised the concept of developmental programming of adult chronic
The Intensity of IUGR-Induced Transcriptome Deregulations Is Inversely Correlated with the Onset of Organ Function in a Rat Model
Daniel Vaiman, Géraldine Gascoin-Lachambre, Farid Boubred, Fran?oise Mondon, Jean-Marc Feuerstein, Isabelle Ligi, Isabelle Grandvuillemin, Sandrine Barbaux, Eric Ghigo, Vincent Achard, Umberto Simeoni, Christophe Buffat
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021222
Abstract: A low-protein diet applied during pregnancy in the rat results in intrauterine growth restricted (IUGR) fetuses. In humans, IUGR is associated with increased perinatal morbidity, higher incidence of neuro-developmental defects and increased risk of adult metabolic anomalies, such as diabetes and cardiovascular disease. Development and function of many organs are affected by environmental conditions such as those inducing fetal and early postnatal growth restriction. This phenomenon, termed “fetal programming” has been studied unconnectedly in some organs, but very few studies (if any) have investigated at the same time several organs, on a more comparative basis. However, it is quite probable that IUGR affects differentially most organ systems, with possible persistent changes in gene expression. In this study we address transcriptional alterations induced by IUGR in a multi-organ perspective, by systematic analysis of 20-days rat fetuses. We show that (1) expressional alterations are apparently stronger in organs functioning late in foetal or postnatal life than in organs that are functioning early (2) hierarchical classification of the deregulations put together kidney and placenta in one cluster, liver, lungs and heart in another; (3) the epigenetic machinery is set up especially in the placenta, while its alterations are rather mild in other organs; (4) the genes appear deregulated in chromosome clusters; (5) the altered expression cascades varies from organ to organ, with noticeably a very significant modification of the complement and coagulation cascades in the kidney; (6) we found a significant increase in TF binding site for HNF4 proteins specifically for liver genes that are down-regulated in IUGR, suggesting that this decrease is achieved through the action of HNF transcription factors, that are themselves transcriptionnally induced in the liver by IUGR (x 1.84 fold). Altogether, our study suggests that a combination of tissue-specific mechanisms contributes to bring about tissue-driven modifications of gene cascades. The question of these cascades being activated to adapt the organ to harsh environmental condition, or as an endpoint consequence is still raised.
Effect of Two Models of Intrauterine Growth Restriction on Alveolarization in Rat Lungs: Morphometric and Gene Expression Analysis
Elodie Zana-Taieb, Laura Butruille, Marie-Laure Franco-Montoya, Emmanuel Lopez, Flore Vernier, Isabelle Grandvuillemin, Danièle Evain-Brion, Philippe Deruelle, Olivier Baud, Christophe Delacourt, Pierre-Henri Jarreau
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0078326
Abstract: Intrauterine growth restriction (IUGR) in preterm infants increases the risk of bronchopulmonary dysplasia, characterized by arrested alveolarization. We evaluated the impact of two different rat models (nitric oxide synthase inhibition or protein deprivation) of IUGR on alveolarization, before, during, and at the end of this postnatal process. We studied IUGR rat pups of dams fed either a low protein (LPD) or a normal diet throughout gestation and pups of dams treated by continuous infusion of Nω-nitro-L-arginine methyl ester (L-NAME) or its diluent on the last four days of gestation. Morphometric parameters, alveolar surface (Svap), mean linear intercept (MLI) and radial alveolar count (RAC) and transcriptomic analysis were determined with special focus on genes involved in alveolarization. IUGR pups regained normal weight at day 21 in the two treated groups. In the LPD group, Svap, MLI and RAC were not different from those of controls at day 4, but were significantly decreased at day 21, indicating alveolarization arrest. In the L-NAME group, Svap and RAC were significantly decreased and MLI was increased at day 4 with complete correction at day 21. In the L-NAME model, several factors involved in alveolarization, VEGF, VEGF-R1 and –R2, MMP14, MMP16, FGFR3 and 4, FGF18 and 7, were significantly decreased at day 4 and/or day 10, while the various factors studied were not modified in the LPD group. These results demonstrate that only maternal protein deprivation leads to sustained impairment of alveolarization in rat pups, whereas L-NAME impairs lung development before alveolarization. Known growth factors involved in lung development do not seem to be involved in LPD-induced alveolarization disorders, raising the question of a possible programming of altered alveolarization.
Strategy of Ukraine : Economics, Sociology, Law , 2011,
Abstract: The question of origin of failures is considered in a global market, influence of TNK on an origin and functioning of such processes. Analysis of redistribution of development of countries. Рассмотрены вопросы возникновения провалов в глобальном рынке, влияние ТНК на возникновение и функционирование таких процессов. Проанализированы перераспределение развития стран. Розглянуто питання виникнення провал в у глобальному ринку, вплив ТНК на виникнення та функц онування таких процес в. Проанал зовано перерозпод л розвитку кра н.
Strategy of Ukraine : Economics, Sociology, Law , 2011,
Abstract: Розглядаються питання розвитку нтеграц йних процес в в С, а саме основна увага прид лена процесам дез нтеграц , вид ленн основних геопол тичних центр в, та наростанню протир ч у диному економ чному простор м ж кра нами-учасницями. The questions of development of integration processes are examined in ES, namely basic attention is directed on the processes of disintegration, determination of geopolitical centers, to growth of contradictions in single economic space between countries-participants. Рассматриваются вопросы развития интеграционных процессов в ЕС, а именно основное внимание направлено на процессы дезинтеграции, определение геополитических центров, нарастанию проти-воречий в едином экономическом пространстве между странами-участницами.
АНАЛ З ВПЛИВУ В ДПРАЦЬОВАНИХ АВТОМОБ ЛЬНИХ ГАЗ В НА СТАН АТМОСФЕРНОГО ПОВ ТРЯ В ГУСТОНАСЕЛЕНИХ РАЙОНАХ Analysis of spent automobile emissions on the state of atmospheric air in populated areas Анализ отработанных автомобильных газов на состояние атмосферного воздуха в густонаселенных районах
Г.?. Арх?пова,I.С. Ткачук,?.?. Глушков
Proceedings of National Aviation University , 2009,
Abstract: Розглянуто питання захисту атмосферного пов тря в густонаселених пунктах в д негативного впливу в д-працьованих автомоб льних газ в. Запропоновано способи м н м зац антропогенного впливу на довк лля в урбокомплексах: вдосконалення процесу техн чного обслуговування та забезпечення автомоб льно галуз , використання високояк сних та альтернативних вид в палива, розвиток та автоматизац я системи управл ння транспортним потоком. The article discussed about protection of air in settlements, from the negative impact of automobile exhaust gases. We propose ways to minimize the human impact on the environment in some inhabited locality: one of them is the improvement of maintenance and road sectors, used of high quality and alternative fuels, development and Automate the management of traffic flows. Рассмотрены вопросы защиты атмосферного воздуха в густонаселенных пунктах от негативного влияния отработавших автомобильных газов. Предложены способы минимизации антропогенного воздействия на окружающую среду в урбокомплексах: совершенствование процесса технического обслуживания и обеспечения автомобильной отрасли, использование высококачественных и альтернативных видов топлива, развитие и автоматизация системы управления транспортным потоком.
The algorithm of modelizing of crack development in structural material Алгоритм моделирования развития усталостной трещины в конструкционном материале АЛГОРИТМ МОДЕЛЮВАННЯ РОЗВИТКУ ТР ЩИНИ В Д УТОМЛЕНОСТ В КОНСТРУКЦ ЙНОМУ МАТЕР АЛ
Т.?. Матченко,А.В. Зубець,О.I. Яворська,Л.Г. М?нневал??ва
Proceedings of National Aviation University , 2004,
Abstract: The algorithm and method of modelizing of fatigue crack growth velocity of a small tone at the top of crack depending on cycle's forms of loading and way of loading was proposed. Предложен алгоритм и методика моделирования скорости роста усталостной трещины в конст-рукции с учетом повреждаемости малой зоны у вершины трещины в зависимости от формы цикла нагружения и программы нагружения. Запропоновано алгоритм методику моделювання швидкост зростання тр щини в д утомленост в конструкц з урахуванням пошкоджуваност мало зони б ля вершини тр щини залежно в д форми циклу навантаження та програми навантаження.
The flight data monitoring method for the flight simulator Метод мониторинга полетных данных для пилотажного тренажера МЕТОД МОН ТОРИНГУ ПОЛЬОТНИХ ДАНИХ ДЛЯ П ЛОТАЖНОГО ТРЕНАЖЕРА
I.П. Сердюк
Proceedings of National Aviation University , 2005,
Abstract: Submitted the monitoring of the flight data method for a flight simulator, which is based on the analysis of probability density of distribution characteristics of the transport plane crew activity in tasks of the Capitan minimum confirming at meteominimum that corresponding to 1-st and to 2-nd ICAO categories on a flight simulator in conditions of small volume of the experimental data. Complexitie degree of an density function estimation, i.e. number of the decompose members, depending on volume of sample and select with the help of a risk structural minimization method. Рассмотрен метод мониторинга полетных данных для пилотажного тренажера, основанный на анализе плот-ности вероятности распределения характеристик деятельности экипажа транспортного самолета в задачах подтверджения минимума командира воздушного судна при метеоминимуме, соответствующем 1-й и 2-й категориям ICAO, на пилотажном тренажере в условиях небольшого количества экспериментальных данных. Cтепень сложности оценки функций плотности вероятности, т.е. число членов разложения в зависимости от объема выборки, выбрана с помощью метода структурной минимизации риска. Розглянуто метод мон торингу польотних даних для п лотажного тренажера, заснований на анал з густини ймов рност розпод лу характеристик д яльност ек пажу транспортного л така в задачах п дтвердження м н муму командира пов тряного судна при метеом н мум , в дпов дному 1-й 2-й категор ям ICAO, на п лотажному тренажер в умовах невелико к лькост експериментальних даних. Cтупень складност оц нки функц й густини ймов рност , тобто к льк сть член в розкладання залежно в д обсягу виб рки, вибраний за допомогою методу структурно м н м зац ризику.
I.Д. Малицька
Information Technologies and Learning Tools , 2011,
Abstract: Importance of information and communication technologies introduction in education systems is admited by all foreign countries. Information processes, creation of uniform information space, using ICT, become one of priority approaches of the European states and Ukraine development. In the article the international documents of the European Union, the Great Britain, Russia, Ukraine, which form perspective approaches of education systems development are analysed. The priority areas of ICT introduction are outlined by the European countries, the basic tendencies concerning ICT use at schools of the Great Britain are defined, the basic initiatives of the Russian Federation and Ukraine on this problem are considered. Важлив сть впровадження нформац йно-комун кац йних технолог й в системах осв ти визна ться практично вс ма заруб жними кра нами. Процеси нформатизац , створення диного нформац йного простору завдяки КТ стають одними з пр оритетних напрям в розвитку вропейських держав й Укра ни. В статт проанал зован м жнародн нормативн документи вропейського Союзу, Великобритан , Рос , Укра ни, як формують перспективн напрями розвитку систем осв ти. Визначен пр оритетн област з впровадження КТ, окреслен вропейськими кра нами, основн тенденц щодо використання КТ у школах Великобритан , розглянуто основн н ц ативи Рос йсько Федерац й Укра ни з ц проблеми.
В.Ю. Биков,I.М. Ромашко
Information Technologies and Learning Tools , 2010,
Abstract: In the article the up-to-date situation of education is analyzed, the new model of education – open education which answers to the lifelong learning principles and aims and to actual requirements of society, considering the use of information and communication technologies in education is considered; creation and development of such phenomena as the open educational environment, which is based on principles of open education is analyzed, there are conceptualized and determined such terms as uniform educational space and global information space of education systems . У статт анал зу ться сучасний стан системи осв ти, розгляда ться нова модель осв ти – в дкрита осв та, яка в дпов да принципам та ц лям осв ти впродовж життя та нагальним потребам сучасност з огляду на використання нформац йно-комун кац йних технолог й в осв т ; проанал зовано створення та розвиток таких явищ, як в дкрите навчальне середовище, що базу ться на принципах в дкрито осв ти, концептуал зуються та розкриваються поняття диний осв тн й прост р та глобальний нформац йний прост р системи осв ти .
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