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Search Results: 1 - 10 of 238927 matches for " I. E. Messinis "
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The Effects of Antipsychotics on Prolactin Levels and Women’s Menstruation
S. I. Bargiota,K. S. Bonotis,I. E. Messinis,N. V. Angelopoulos
Schizophrenia Research and Treatment , 2013, DOI: 10.1155/2013/502697
Abstract: Introduction. Typical and atypical antipsychotic agent is currently used for treatment in the majority of patients with psychotic disorders. The aim of this review is to assess antipsychotic induced hyperprolactinaemia and the following menstrual dysfunction that affects fertility, quality of life, and therapeutic compliance of women. Method. For this purpose, Medline, PsychInfo, Cochrane library, and Scopus databases were accessed, with a focus on the publication dates between 1954 and 2012. Research of references was also performed and 78 studies were retrieved and used for the needs of this review. Results. A summary of several antipsychotics as well as frequency rates and data on hyperprolactinaemia and menstrual disorders for different agent is presented. Conclusion. Diverse prevalence rates of hyperprolactinaemia and menstrual abnormalities have been found about each medication among different studies. Menstruation plays an important role for women, thus, understanding, careful assessment, and management of hyperprolactinaemia could enhance their lives, especially when dealing with women that suffer from a psychotic disorder. 1. Introduction Acute psychotic episodes as well as psychotic relapses are treated effectively with antipsychotic drugs. Most patients with confirmed diagnoses of psychiatric disorders need to undergo antipsychotic drug therapy throughout their whole lives [1, 2]. Typical antipsychotic medications and some of the novel antipsychotics frequently cause an elevation of plasma prolactin levels. Among the several side reactions related with hyperprolactinaemia, are menstrual disorders such as amenorrhea or oligomenorrhea which have not been adequately evaluated. Menstrual dysfunction can be an important source of distress for women, as it influences their libido and fertility [1] and, thus, interferes with their quality of life, a consequence that should be taken into account by clinicians when antipsychotic treatment for each woman is chosen. This review aims to summarize the effects of antipsychotic agents on prolactin levels and menstruation and investigate the frequency of hyperprolactinaemia and menstrual abnormalities that affect female patients, depending on the selected antipsychotic therapy. It also indicates the need for further research on these adverse effects, the severity of which is not always reported in a clinically meaningful way to experts. 2. Background 2.1. How Do Antipsychotics Lead to Hyperprolactinaemia? A great number of studies have investigated antipsychotic medication and its important effects on human
Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone
Konstantinos Dafopoulos, Christos Venetis, Christina I Messini, Spyros Pournaras, George Anifandis, Antonios Garas, Ioannis E Messinis
Reproductive Biology and Endocrinology , 2011, DOI: 10.1186/1477-7827-9-59
Abstract: Ten women with PCOS and 8 normally cycling women participated in an experimental procedure (Exp) involving the administration of a single injection of recombinant FSH (450 IU sc). In the women with PCOS, the procedure was performed before (Exp 1) and after a 20-day treatment with progesterone (Exp 2), while in the normal women on day 2 of the cycle (Exp 3). Inhibin A and B levels were measured in blood samples taken before and 24 hours after the FSH injection.Basal LH levels were significantly higher and inhibin A levels were significantly lower in the PCOS group compared to the control group, while inhibin B levels were comparable in the two groups. In the PCOS group, after treatment with progesterone inhibin A and LH but not inhibin B levels decreased significantly (p < 0.05). After the FSH injection, inhibin A and B levels increased significantly in the women with PCOS (Exp 1 and Exp 2) but not in the control women (Exp 3).In women with PCOS, as compared to control women, the dissimilar pattern of inhibin A and inhibin B secretion in response to FSH appears to be independent of a preceding simulated luteal phase. It is possible that compared to normal ovaries, the PCOS ovaries are less sensitive to endogenous LH regarding inhibin A secretion and more sensitive to exogenous FSH stimulation in terms of inhibin A and inhibin B secretion.Data regarding inhibin levels in the circulation of women with polycystic ovary syndrome (PCOS) are conflicting. In particular, when compared to controls inhibin B concentrations have been found to be either increased [1,2] or similar [3-9]. On the other hand, most studies [3,7,10], but not all [2] have suggested that inhibin A levels are lower in women with PCOS than in control women. It has been suggested that in normal women, the intercycle rise of FSH is responsible for the increased secretion of inhibin B coming from the small antral follicles in the early follicular phase, while the midcycle LH increase stimulates inhibin A sec
Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome
Georgios M Anifandis, Konstantinos Dafopoulos, Christina I Messini, Nektarios Chalvatzas, Nikolaos Liakos, Spyros Pournaras, Ioannis E Messinis
Reproductive Biology and Endocrinology , 2010, DOI: 10.1186/1477-7827-8-91
Abstract: This prospective observational study included 101 consecutive women who underwent 101 IVF-ICSI ovarian stimulation cycles and were allocated to one of the three groups according to their follicular fluid 25-OH vitamin D concentrations. Group A (n = 31) with less than 20 ng/ml, group B (n = 49) with vitamin levels between 20.1 and 30 ng/ml and group C (n = 21) with more than 30 ng/ml vitamin concentration.Follicular fluid vitamin levels significantly correlated with the quality of embryos in total (r = -0.27, p = 0.027), while the quality of embryos of group C were of lower quality as compared to those of groups A and B (p = 0.009). Follicular fluid glucose levels were lower in women of group C as compared to the respective levels of groups A and B (p = 0.003). Clinical pregnancy rate demonstrated in 14.5% in women of group C and 32.3% and 32.7% in groups A and B, respectively (p = 0.047).The data suggests that excess serum and follicular fluid vitamin levels in combination with decreased follicular fluid glucose levels have a detrimental impact on the IVF outcome.Animal and in vitro studies have shown that 25-OH vitamin D may play a significant role in glucose tolerance through its effects on insulin secretion and insulin sensitivity [1]. Few data exist about the role of 25-OH vitamin D in reproduction. Insufficient levels during pregnancy are potentially associated with increased risk of preeclampsia, insulin resistance and gestational diabetes mellitus [2-4], while experimental data indicate that 25-OH vitamin D insufficiency is critical for fetal development, and especially for fetal brain development and immunological functions [5]. Evidence has shown that 25-OH vitamin D levels did not vary during the phases of the menstrual cycle [6] while endometriosis has been associated with higher serum levels of 25-OH vitamin D [7]. The most advantageous serum 25-OH vitamin D levels for its proper action appeared to be 30 ng/ml approximately [8], but the effects of higher
Polymorphisms of the endothelial nitric oxide synthase (NOS3) gene in preeclampsia: a candidate-gene association study
Nikos Zdoukopoulos, Chrysa Doxani, Ioannis E Messinis, Ioannis Stefanidis, Elias Zintzaras
BMC Pregnancy and Childbirth , 2011, DOI: 10.1186/1471-2393-11-89
Abstract: We examined the association of three common variants of the NOS3 gene (4b/a, T-786C and G894T) and their haplotypes in a case-control sample of 102 patients with preeclampsia and 176 women with a history of uncomplicated pregnancies. Genotyping for the NOS3 variants was performed and odds ratios and 95% confidence intervals were obtained to evaluate the association between NOS3 polymorphisms and preeclampsia.The single locus analysis for the three variants using various genetic models and a model-free approach revealed no significant association in relation to clinical status. The analysis of haplotypes also showed lack of significant association.Given the limitations of the candidate-gene approach in investigating complex traits, the evidence of our study does not support the major contributory role of these common NOS3 variants in preeclampsia. Future larger studies may help in elucidating the genetics of preeclampsia further.Preeclampsia is a medical condition in which high blood pressure and elevated urinary excretion of protein develop in pregnancy [1]. Family-based studies have shown that genetic factors may play a role in preeclampsia [2]. In addition, candidate-gene association studies (GAS) on preeclampsia have not produced conclusive results so far [3]. However, the pathogenesis of preeclampsia is poorly understood and the search for low-penetrance genes by hypothesis-driven candidate-gene studies (genetic association study-GAS) and hypothesis-free genome-wide association studies is ongoing [4].The leading hypotheses, concerning the pathogenesis of preeclampsia, are based on disturbed placental function and impaired remodelling of the spiral arteries [5]. Endothelial nitric oxide synthase (NOS3) is an important regulator of vascular tone and contributes to the reduction of the uteroplacental resistance seen in normal pregnancy [6-8]. Therefore, the endothelial nitric oxide synthase gene (NOS3), located at the 7q35-q36 region, has emerged as a logical candi
Combined logical and data-driven models for linking signalling pathways to cellular response
Ioannis N Melas, Alexander Mitsos, Dimitris E Messinis, Thomas S Weiss, Leonidas G Alexopoulos
BMC Systems Biology , 2011, DOI: 10.1186/1752-0509-5-107
Abstract: In this work, we measure the signalling activity (phosphorylation levels) and phenotypic behavior (cytokine secretion) of normal and cancer hepatocytes treated with a combination of cytokines and inhibitors. Using the two datasets, we construct "extended" pathways that integrate intracellular activity with cellular responses using a hybrid logical/data-driven computational approach. Boolean logic is used whenever a priori knowledge is accessible (i.e., construction of canonical pathways), whereas a data-driven approach is used for linking cellular behavior to signalling activity via non-canonical edges. The extended pathway is subsequently optimised to fit signalling and behavioural data using an Integer Linear Programming formulation. As a result, we are able to construct maps of primary and transformed hepatocytes downstream of 7 receptors that are capable of explaining the secretion of 22 cytokines.We developed a method for constructing extended pathways that start at the receptor level and via a complex intracellular signalling pathway identify those mechanisms that drive cellular behaviour. Our results constitute a proof-of-principle for construction of "extended pathways" that are capable of linking pathway activity to diverse responses such as growth, death, differentiation, gene expression, or cytokine secretion.Construction of signalling pathways is a major endeavour in biology. Signalling cascades, starting at the receptor level, orchestrate a variety of normal or pathological responses via a complex network of kinases, adaptor molecules, and other signalling proteins [1]. Several gene- and protein-based approaches have emerged for elucidating the complex intracellular signalling activity. Gene-based analysis has the advantage of whole genome exploration [2-4] whereas proteomic approaches are applicable on small pathways but with a more reliable view of pathway function, since proteins are the ultimate reporters of cellular activity [5,6]. Both approaches
Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1alpha) expression in serous ovarian cancer: an immunohistochemical study
Alexandros Daponte, Maria Ioannou, Ilias Mylonis, George Simos, Marcos Minas, Ioannis E Messinis, George Koukoulis
BMC Cancer , 2008, DOI: 10.1186/1471-2407-8-335
Abstract: One hundred (n = 100) neoplastic and 20 benign (controls) pathological samples from paraffin-embedded tissue were included. They were classified after surgery as stage I (n = 23) and stage III G3 (n = 55). Also 22 borderline serous adenocarcinoma patients and 20 benign controls were stained. The mean follow up was 3 years. Only patients with the diagnosis of serous carcinoma of stage III, G3 who received 6 cycles of postoperative TC (175–180 mg/m2 paclitaxel and carboplatin after calculating the area under the concentration curve) with complete medical records (n = 55) were selected for survival analysis. The survival analysis of the samples compared two groups after the patients were dichotomized by HIF-1α final score to positive and negative.The frequency of the nuclear expression of HIF-1α in benign tumours was significantly lower (median: no expression) than in borderline and ovarian cancer tumours combined (p < 0.001). HIF-1α expression in serous ovarian carcinoma was not stage dependent. The overall survival of patients with tumours that stained strongly for HIF-1α was significantly shorter than that of patients with tumours that stained weakly or were negative for HIF-1α (p = 0.01). Kaplan-Meier survival curves confirmed that HIF-1α "positive" had decreased overall survival compared to HIF-1α "negative" patients (p = 0.003) and this was an independent adverse prognostic factor (multivariable analysis p = 0.006). HIF-1α "positive" patients displayed a shorter median progress free interval (PFI) (not statistically significant p > 0.05). Interestingly the overall PFI of the subgroup of patients that have undergone suboptimal cytoreduction at primary surgery (n = 21) with tumours that stained strongly for HIF-1α was significantly worse than that of patients with tumours that stained weakly or were negative for HIF-1α (p = 0.03).Our report confirms the prognostic value of HIF-1α when restricted to poorly differentiated serous ovarian carcinoma. In addition it show
Activin A and Follistatin as Biomarkers for Ectopic Pregnancy and Missed Abortion
Alexandros Daponte,Efthimios Deligeoroglou,Antonios Garas,Spyros Pournaras,Christos Hadjichristodoulou,Ioannis E. Messinis
Disease Markers , 2013, DOI: 10.1155/2013/969473
Abstract: Activin A as a predictor of pregnancy failure has been the focus of heated debate, but the value of a combined activin A and follistatin (FS) measurement in serum to predict pregnancy failure has not been reported yet. We assessed whether a single serum measurement of the two physiological antagonists at 6–8 weeks gestation could differentiate ectopic pregnancies (EP) or missed abortions (MA) from healthy intrauterine pregnancies (IUP). activin A concentrations were significantly lower in women with EP ( = 30, median value of 264?pg/mL) and women with MA ( = 30, median value of 350?pg/mL) compared to IUP ( = 33, median value of 788?pg/mL); . At a threshold value of 505?pg/mL, activin A had 87.9% sensitivity and 100% specificity and negative predictive value of 0.974 for discriminating an ectopic pregnancy from viable pregnancies. FS was able to discriminate IUP from EP (ROC curve ) as was their ratio (ROC curve ), but was unable to discriminate a MA from an EP. In EP, activin A did not correlate with beta HCG levels. The present findings support the thesis that activin A or FS could be considered promising biomarkers for the discrimination between an IUP and a failed pregnancy (MA or EP). 1. Introduction The timely recognition of the outcome in pregnant women presenting with vaginal bleeding is of paramount importance for their clinical management but is presently based on costly, lengthy followup which includes serial beta HCG measurements, ultrasound scanning, and at times diagnostic laparoscopy [1]. In search of markers which can predict the outcome of a pregnancy, several serum factors have been extensively studied [2–4]. None of these investigations have systematically analyzed the role of follistatin (FS) as a credible biomarker of ectopic pregnancy (EP). FS is a regulatory protein which exerts its pleiotropic effects via neutralization of activins. The coordinated synthesis of FS with activin is the main regulator of the local bioactivity of activin, as binding of activin to FS is almost irreversible [5, 6]. Amongst activins, the role of serum activin A as a predictor of pregnancy failure has been the focus of heated debate amongst researchers suggesting that measurements of activin A can identify pregnant women at risk of developing missed abortion (MA) or EP, while others have failed to report such an association [2, 7–14]. We considered that the study of serum FS and activin A and their relation with beta HCG levels in women with EP and MA is of interest, due to findings in support of activin A as a prognostic indicator of failed pregnancy,
Citius Altius Fortius , 2010,
Abstract: The pace in swimming is very important because it allows swimmers to allocate their forces accordingly, and therefore a distance to travel as quickly as possible. The training pace at different swimmingspeeds and combinations thereof, is an important part of training before the competitions.The definition and maintenance of the stable and swimmer specific speed is difficult to achieve and requires considerable effort and experience. To determine the desired rate of accuracy by the researchers and their coaches used till now, various audio and visual media.However, some of these institutions did not very accurately measure the rate and not all styles of swimming, while other aspects affect the proper swimming. In this construction, a key objective is to solve the problems occurring in the previous constructions, the modern technological development of them and the adaption of the specificities of different swimming styles.This device consists of an electro 3 / 8 of the horse, a flange, a single inverter from 3 / 8 to of the horse, pulleys with taper Bush, flange axle, pulleys, platforms and a 52 meters cable. The assembly and operation is as follows: At the edge of the pool next to the platform is placed the base of pulleys, the electro setis connected to the inverter and the axle flange.Precisely opposite is positioned the other base. Along the pool moves the cable that connects the two bases, located 150 cm above the water. A fixed point on the cable is marked with paint in order to be visible to the swimmer during backstroke swimming while for other styles we adapt a lamination at the cable vertically inthe pool, above the surface a sheet of 15 cm which is painted with strong color that is visible from the athlete and will precede him. Setting the speed with inverter it starts from one end of the tank leading to the other, doing a circular motion.The swimmer is required to follow the marked point of the cable in the backstroke or lamination in other styles. Practical applications of the use of speed regulator: 1) Determination of constant speed (rate) of the athlete, without movement problems 2) Growth rate of change in perception of the athlete. 3) Verification ofproper technique 4) Training in the change of pace, planning and competition tactics
Geometrization of Radial Particles in Non-Empty Space Complies with Tests of General Relativity  [PDF]
I. E. Bulyzhenkov
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.329172
Abstract: Curved space-time 4-interval of any probe particle does not contradict to flat non-empty 3-space which, in turn, assumes the global material overlap of elementary continuous particles or the nonlocal Universe with universal Euclidean geometry. Relativistic particle’s time is the chain function of particles speed and this time differs from the proper time of a motionless local observer. Equal passive and active relativistic energy-charges are employed to match the universal free fall and the Principle of Equivalence in non-empty (material) space, where continuous radial densities of elementary energy-charges obey local superpositions and mutual penetrations. The known planetary perihelion precession, the radar echo delay, and the gravitational light bending can be explained quantitatively by the singularity-free metric without departure from Euclidean spatial geometry. The flatspace precession of non-point orbiting gyroscopes is non-New- tonian one due to the Einstein dilation of local time within the Earth’s radial energy-charge rather than due to unphysical warping of Euclidean space.
Phonological Fluency Strategy of Switching Differentiates Relapsing-Remitting and Secondary Progressive Multiple Sclerosis Patients
L. Messinis,M. H. Kosmidis,C. Vlahou,A. C. Malegiannaki
ISRN Neurology , 2013, DOI: 10.1155/2013/451429
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