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Search Results: 1 - 10 of 87913 matches for " I Saadat "
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"Frequency of Glutathione S-transferase M1 (GSTM1) and GSTT1 Null Genotypes in Fars Population (South of Iran)"
M Saadat,DD Farhud,I Saadat
Iranian Journal of Public Health , 2001,
Abstract: The genes glutathione S-transferase M1 (GSTM1) and GSTT1 code for cytosolic enzymes GSTμ and GSTθ, respectively, which are involved in phase II metabolism. In human, both genes may be deleted. In the present study, the genetic polymorphisms of GSTM1 and GSTT1 were detected by PCR method in 236 healthy individuals from Shiraz population, Fars province, south of Iran. The frequency of GSTM1 and GSTT1-null genotypes were 37.7 and 31.8 percent, respectively. The studied population was then compared with reported frequencies for neighboring populations, as well as, with those for European and African populations.
Survey on Spam Filtering Techniques  [PDF]
Saadat Nazirova
Communications and Network (CN) , 2011, DOI: 10.4236/cn.2011.33019
Abstract: In the recent years spam became as a big problem of Internet and electronic communication. There developed a lot of techniques to fight them. In this paper the overview of existing e-mail spam filtering methods is given. The classification, evaluation, and comparison of traditional and learning-based methods are provided. Some personal anti-spam products are tested and compared. The statement for new approach in spam filtering technique is considered.
Two Approaches on Implementation of CBR and CRM Technologies to the Spam Filtering Problem  [PDF]
Rasim Alguliyev, Saadat Nazirova
Journal of Information Security (JIS) , 2012, DOI: 10.4236/jis.2012.31002
Abstract: Recently the number of undesirable messages coming to e-mail has strongly increased. As spam has changeable character the anti-spam systems should be trainable and dynamical. The machine learning technology is successfully applied in a filtration of e-mail from undesirable messages for a long time. In this paper it is offered to apply Case Based Reasoning technology to a spam filtering problem. The possibility of continuous updating of spam templates base on the bases of which new coming spam messages are compared, will raise efficiency of a filtration. Changing a combination of conditions it is possible to construct flexible filtration system adapted for different users or corporations. Also in this paper it is considered the second approach as implementation of CRM technology to spam filtration which is not applied to this area yet.
Glutathione S-transferase Omega 2 Genetic Polymorphism and Risk of Hepatic Failure that Lead to Liver Transplantation in Iranian Population
M Khosravi,I Saadat,MH Karimi,B Geramizadeh
International Journal of Organ Transplantation Medicine , 2013,
Abstract: Background: Liver transplantation is the treatment of choice for both acute and chronic hepatic failure. GSTs family is one of the most important genes in phase II detoxification interfering with the xenobiotics and free radical metabolism. GSTO2 (N142D) is a member of this family the polymorphism of which may influence the metabolism of active components and free radicals and may contribute to hepatic failure.Objective: To investigate the association between GSTO2 genetic polymorphism and the susceptibility of hepatic failure that would lead to liver transplantation.Methods: This case-control study included 330 healthy people and 302 patients with liver transplantation as a result of hepatic failure. To determine the variants of GSTO2, we used polymerase chain reactionrestriction fragment length polymorphism (PCR-RFLP) method.Results: There was a significant association between D allele and hepatic failure, thus, people with DD genotype are more susceptible to develop heaptic failure leading to liver transplantation (OR=1.8, 95% CI: 1.10–2.95). We also observed that male sex increases the chance of hepatic failure (OR=2.69, 95% CI: 1.95–3.71).Conclusion: D allele may reduce the detoxification ability of liver so people with mutant D allele are more prone to develop hepatic failure.
Anti-Spam Software for Detecting Information Attacks
Saadat Nazirova
International Journal of Intelligent Systems and Applications , 2012,
Abstract: In this paper the development of anti-spam software detecting information attacks is offered. For this purpose it is considered spam filtration system with the multilayered, multivalent architecture, coordinating all ISP’s in the country. All users and ISPs of this system involved in spam filtration process. After spam filtering process, saved spam templates are analyzed and classified. This parameterizing of spam templates give possibility to define the thematic dependence from geographical. For example, what subjects prevail in spam messages sent from the certain countries? Analyzing origins of spam templates from spam-base, it is possible to define and solve the organized social networks of spammers. Thus, the offered system will be capable to reveal purposeful information attacks if those occur.
Consanguinity Associated with Child and Adult Mortality in 24 Asian and African Countries, an Ecological Study
M Saadat
Iranian Journal of Public Health , 2007,
Abstract: Background: Although numerous studies have found deleterious effects of inbreeding on childhood and pre-reproductive mortality, one question remains inadequately addressed: Dose inbreeding lead to increased childhood mortality rates in countries with high level of consanguinity? Methods: To evaluate the public health impact of inbreeding on offspring mortality, the association between mean of inbreeding coefficient (α) and sex specific child and adult mortality rates in 24 countries from Asia and Africa was analyzed. Results: Statistical analysis showed that countries with relatively higher rates of consanguineous marriages have higher mortality rates than the countries with lower consanguinity rates. Also, countries with relatively higher GDP per capita have lower mortality rates. After controlling the GDP per capita, significant positive correlations between α and child (Female: r=0.4355, df=21, P=0.038; Male: r=0.3991, df=21, P=0.059) mortality rates were observed. There was no significant correlation between α and adult (Female: r=0.2977, df=21, P=0.168; Male: r=0.2207, df=21, P=0.312) mortality rates, after controlling for GDP per capita. Conclusion: It is concluded that consanguinity influences child deaths rate independent of the GDP per capita and that a large proportion of deaths could be attributed to inbreeding in several countries due to high frequencies of consanguinity.
Natural approach for Calcium regulating hormone maintenance: Beneficial effects of Black seed
Saadat Parhizkar
Asian Journal of Biomedical and Pharmaceutical Sciences , 2013,
Abstract: Introduction: Menopause is a permanent cessation of menstruation with thedecreasing of ovarian follicular functions. Hormone Replacement Therapy(HRT) is the most effective method in reducing the rate of bone loss in postmenopausalwomen with increasing the risks of breast cancer and uterinehyperplasia. So it is necessary to find a suitable treatment which is mimic tothe estrogen role in maintaining normal calcium balance without its sideeffects.Objectives: objective of the study was to determine the effect of Black seedon calcium homeostasis by measuring the level of calcium regulatinghormones, i.e. calcitonin, PTH; and serum calcium concentration inmenopause induced animal model.Methods and Materials: Thirty six ovariectomized (OVX) Sprague-Dawleyfemale rats with 250 – 350 g of weight were supplemented with Black seedfor 28 days. The rats were divided into 6 group as followed; Non-OVX + 0mg/day Black seed, OVX + 0 mg/day Black seed, OVX + 300 mg/day Blackseed, OVX + 600 mg/day Black seed, OVX + 1200 mg/day Black seed and OVX+ 0.05 mg/day Estradiol valerate. Statistical analyses have done through 2-way ANOVA using SPSS.Results: A significant PTH reduction was revealed with 1200 mg/day Blackseed treatment (p<0.05). A significant increase of calcitonin level on day 28 of600 and 1200 mg/day of Black seed treatment groups was noted incomparison with control group (p<0.05). Meanwhile serum calciumsignificantly increased (p<0.05) with supplementation duration on day 20 and28 compared to day 0 of supplementation.Conclusion: In conclusion, although the study does not completely describingthe whole spectrum of osteoporotic pathogenesis prevalence, the study hasreflected Black seed as a probable candidate possessing estrogenic-activity inregulating calcium-regulating hormones, responsible for calcium homeostasisfor menopausal women
Modulatory effects of unsaturated fatty acids on metabolic syndrome in menopause induced rats
Saadat Parhizkar
Asian Journal of Biomedical and Pharmaceutical Sciences , 2012,
Abstract: Aims: This study was aimed to compare the metabolic impact of unsaturated fatty acids in experimental menopause induced rats Study design: Animal model experimental design Methodology: Forty female Sprague Dawley rats, aged 16 weeks were ovariectomized in order to induce menopause pattern and were randomly allotted into five groups: negative control (taking 1 ml olive oil/ day); positive control (taking 0.2 mg/kg/day Conjucated Equine Estrogen: CEE); experimental groups (taking 50 mg/kg/day Linoleic acid or 10 mg/kg/day Gamma Linolenic acid or 15mg/kg/day Thymoquinone ). All of supplements administered via intragastric gavage for 21 consecutive days. Food and water intake were measured daily and body weight and biochemical parameters were measured at baseline, 11th day and at the end of experiment.Results: All treatment groups showed significant (P<.05) improvement with reference to blood glucose and serum HDL level in the first 10 days while the serum glucose level increased significantly (P<.05) until the end of experiment in all groups. Similarly, all treatment groups showed a decline in serum triglyceride 10 days, but the effect was much higher in LA and GLA groups respectively. Significant weight reducing effect (P<.05) existed in gamma linolenic group.Conclusion: These results suggested that supplementing with unsaturated fatty acids exert a therapeutic and protective effect by modifying weight gain, improving lipid profile and blood glucose which can reduce menopause burden in this context.
Gravitational lensing of STU black holes
Hassan Saadat
Physics , 2013, DOI: 10.1007/s10773-013-1775-0
Abstract: In this paper we study gravitational lensing by STU black holes. We considered extremal limit of two special cases of zero-charged and one-charged black holes, and obtain the deflection angle. We find that the black hole charge increases the deflection angle.
The center of mass energy of two colliding particles in the STU black holes
Hassan Saadat
Physics , 2013, DOI: 10.1139/cjp-2014-0236
Abstract: In this paper we consider collision of two particle near the STU black hole and calculate center of mass energy. In the case of uncharged black hole we find that the maximum energy obtained near the black hole horizon which similarly happen for charged black hole. We verify that the black hole charge may be decreased or increased the center of mass energy near the black hole horizon.
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