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Search Results: 1 - 10 of 195600 matches for " Hyoung D. Shin "
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Genetic Effects of FTO and MC4R Polymorphisms on Body Mass in Constitutional Types
Seongwon Cha,Imhoi Koo,Byung L. Park,Sangkyun Jeong,Sun M. Choi,Kil S. Kim,Hyoung D. Shin,Jong Y. Kim
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep162
Abstract: Sasang constitutional medicine (SCM), a Korean tailored medicine, categorizes human beings into four types through states of physiological imbalances and responsiveness to herbal medicine. One SCM type susceptible to obesity seems sensitive to energy intake due to an imbalance toward preserving energy. Common variants of fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes have been associated with increased body mass index (BMI) by affecting energy intake. Here, we statistically examined the association of FTO and MC4R polymorphisms with BMI in two populations with 1370 Koreans before and after SCM typing, and with the lowering of BMI in 538 individuals who underwent a 1-month lifestyle intervention. The increased BMI replicated the association with FTO haplotypes (effect size ? 1.1 kg/m2) and MC4R variants (effect size ? 0.64 kg/m2). After the lifestyle intervention, the carriers of the haplotype represented by the minor allele of rs1075440 had a tendency to lose more waist-to-hip ratio (0.76%) than non-carriers. The constitutional discrepancy for the accumulation of body mass by the effects of FTO and/or MC4R variants seemed to reflect the physique differences shown in each group of SCM constitutional types. In conclusion, FTO and MC4R polymorphisms appear to play an important role in weight gain, while only FTO variants play a role in weight loss after lifestyle intervention. Different trends were observed among individuals of SCM types, especially for weight gain. Therefore, classification of individuals based on physiological imbalance would offer a good genetic stratification system in assessing the effects of obesity genes.
Chemotherapeutic Effect of Withaferin A in Human Oral Cancer Cells  [PDF]
In-Hyoung Yang, Lee-Han Kim, Ji-Ae Shin, Sung-Dae Cho
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.68080
Abstract: Withaferin A (WA) is a bioactive compound derived from a medicinal plant Withania somnifera and has potential therapeutic effects against various types of cancers. The purpose of this study is to investigate an apoptotic effect of WA and identify its molecular target in HSC-3 and HSC-4 human oral cancer cell lines using Trypan blue exclusion assay, DAPI staining and western blotting. WA inhibited cell viability and induced apoptosis in a concentration- or time-dependent manner, as evidenced by induction of nuclear condensation and fragmentation, activation of caspase 3 and poly (ADP-ribose) polymerase (PARP) cleavage. WA-induced apoptosis was partly diminished by Z-VAD, a pancaspase inhibitor. WA also increased Bim and Bax protein in HSC-3 and HSC-4 cells, respectively. These results suggest that WA may be a potential chemotherapeutic drug candidate against human oral cancer.
Density functional study of orbital-selective magnetism in FeAs-based superconductors
Hyungju Oh,Donghan Shin,Hyoung Joon Choi
Physics , 2010,
Abstract: We performed spin-polarized density functional calculations of lanthanide-series (Ln) iron oxypnictides LnFeAsO (Ln=La, Ce, Pr, Nd, Sm, and Gd) with constrained Fe magnetic moments, finding that in-plane dxy and out-of-plane dyz orbital characters are preferred for small Fe magnetic moments. Comparison of LnFeAsO compounds shows that the antiferromagnetism (AFM) from the Fe dxy orbital is itinerantly driven by orbital-dependent Fermi-surface nesting while AFM from the Fe dyz orbital is driven by superexchange mechanism. The Fe magnetic moments of the two orbital characters show different coupling strengths to Fermi-surface electrons orbital-selectively, suggesting that they may play different roles in superconductivity and in AFM, and making d orbital characters of the magnetic moment resolvable by measuring the electronic structures.
Striatal Neuroinflammation Promotes Parkinsonism in Rats
Dong-Young Choi, Mei Liu, Randy L. Hunter, Wayne A. Cass, Jignesh D. Pandya, Patrick G. Sullivan, Eun-Joo Shin, Hyoung-Chun Kim, Don M. Gash, Guoying Bing
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005482
Abstract: Background Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disorder with unknown cause, but it has been suggested that neuroinflammation may play a role in pathogenesis of the disease. Neuroinflammatory component in process of PD neurodegeneration was proposed by postmortem, epidemiological and animal model studies. However, it remains unclear how neuroinflammatory factors contribute to dopaminergic neuronal death in PD. Findings In this study, we analyzed the relationship among inducible nitric oxide synthase (iNOS)-derived NO, mitochondrial dysfunction and dopaminergic neurodegeneration to examine the possibility that microglial neuroinflammation may induce dopaminergic neuronal loss in the substantia nigra. Unilateral injection of lipopolysaccharide (LPS) into the striatum of rat was followed by immunocytochemical, histological, neurochemical and biochemical analyses. In addition, behavioral assessments including cylinder test and amphetamine-induced rotational behavior test were employed to validate ipsilateral damage to the dopamine nigrostriatal pathway. LPS injection caused progressive degeneration of the dopamine nigrostriatal system, which was accompanied by motor impairments including asymmetric usage of forelimbs and amphetamine-induced turning behavior in animals. Interestingly, some of the remaining nigral dopaminergic neurons had intracytoplasmic accumulation of α-synuclein and ubiquitin. Furthermore, defect in the mitochondrial respiratory chain, and extensive S-nitrosylation/nitration of mitochondrial complex I were detected prior to the dopaminergic neuronal loss. The mitochondrial injury was prevented by treatment with L-N6-(l-iminoethyl)-lysine, an iNOS inhibitor, suggesting that iNOS-derived NO is associated with the mitochondrial impairment. Conclusions These results implicate neuroinflammation-induced S-nitrosylation/nitration of mitochondrial complex I in mitochondrial malfunction and subsequent degeneration of the nigral dopamine neurons.
Systematic Approach for Scheduling of Tasks and Messages under Noise Environment
Hyoung Yuk Kim,Hye Min Shin,Hong Seong Park
Journal of Systemics, Cybernetics and Informatics , 2003,
Abstract: High degree of EMI (Electro-Magnetic Interference) or noise is generated in the plant environment, where control systems consist of smart sensors, smart actuators, and controllers connected via a fieldbus. The noise generated by some devices such as high-power motors may cause communication errors and delay the successful transmission of data. Therefore, the noise condition is one of the important parameters considered in the design of a reliable network-based control system. This paper presents the scheduling method of task and message to guarantee the given end-to-end constraints under noise environments. The presented scheduling method is applied to an example of a control system that uses CAN (Controller Area Network), considering two kinds of noise models. The comparison results for each noise condition shows the importance of considering the noise condition in system design. System designers are able to design the control system, guaranteeing its requirements under a noise environment by using the proposed scheduling method.
Acupuncture for Spinal Cord Injury and Its Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
In Heo,Byung-Cheul Shin,Young-Dae Kim,Eui-Hyoung Hwang
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/364216
Abstract:
Brief review on iron-based superconductors: are there clues for unconventional superconductivity?
Hyungju Oh,Jisoo Moon,Donghan Shin,Chang-Youn Moon,Hyoung Joon Choi
Physics , 2011,
Abstract: Study of superconductivity in layered iron-based materials was initiated in 2006 by Hosono's group, and boosted in 2008 by the superconducting transition temperature, Tc, of 26 K in LaFeAsO1-xFx. Since then, enormous researches have been done on the materials, with Tc reaching as high as 55 K. Here, we review briefly experimental and theoretical results on atomic and electronic structures and magnetic and superconducting properties of FeAs-based superconductors and related compounds. We seek for clues for unconventional superconductivity in the materials.
Development of Micro-Heaters with Optimized Temperature Compensation Design for Gas Sensors
Woo-Jin Hwang,Kyu-Sik Shin,Ji-Hyoung Roh,Dae-Sung Lee,Sung-Hoon Choa
Sensors , 2011, DOI: 10.3390/s110302580
Abstract: One of the key components of a chemical gas sensor is a MEMS micro-heater. Micro-heaters are used in both semiconductor gas sensors and NDIR gas sensors; however they each require different heat dissipation characteristics. For the semiconductor gas sensors, a uniform temperature is required over a wide area of the heater. On the other hand, for the NDIR gas sensor, the micro-heater needs high levels of infrared radiation in order to increase sensitivity. In this study, a novel design of a poly-Si micro-heater is proposed to improve the uniformity of heat dissipation on the heating plate. Temperature uniformity of the micro-heater is achieved by compensating for the variation in power consumption around the perimeter of the heater. With the power compensated design, the uniform heating area is increased by 2.5 times and the average temperature goes up by 40?°C. Therefore, this power compensated micro-heater design is suitable for a semiconductor gas sensor. Meanwhile, the poly-Si micro-heater without compensation shows a higher level of infrared radiation under equal power consumption conditions. This indicates that the micro-heater without compensation is more suitable for a NDIR gas sensor. Furthermore, the micro-heater shows a short response time of less than 20ms, indicating a very high efficiency of pulse driving.
Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population
Hyoung Shin, Yoon-Kyoung Sung, Chan-Bum Choi, Soo Lee, Hye Lee, Sang-Cheol Bae
Arthritis Research & Therapy , 2007, DOI: 10.1186/ar2152
Abstract: Recently, two studies provided convincing evidence that IFN regulatory factor 5 (IRF5 [MIM 607218]) gene polymorphisms are significantly associated with systemic lupus erythematosus (SLE [MIM 152700]). The studies included – seven independent SLE cohorts from white populations (Sweden-1, Finland, Iceland, USA, Spain, Sweden-2 and Argentina) and involved both family-based and case-control cohorts [1,2]. In both studies, the dbSNP rs2004640 (T > G) of IRF5 showed strong associations with the risk of SLE, for example higher frequencies in SLE cases than controls (combined analysis, 61% in SLE cases versus 51% in controls; P = 4.2 × 10-21). Graham and colleagues, through further experiments in the later study, also identified a common (frequency, 50.0% in white populations) IRF5 haplotype that has both a splice donor site, which allows expression of multiple IRF5 isoforms containing exon 1B, and a separate genetic effect associated with elevated levels of expression of IRF5 [1]. To replicate the association with SLE in an Asian population, we examined the genetic effects in our SLE cohort from a Korean population.A total of 593 Korean SLE patients (mean age, 32.36 (6.99–70.7); male = 35 and female = 558) who fulfilled the 1997 American College of Rheumatology (ACR) criteria for SLE [3] were consecutively enrolled between September 1998 and February 2005 at the Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea. The following clinical and laboratory data were obtained: sex, age, ages at onset of first symptom and clinical diagnosis, ACR diagnosis, and Systemic Lupus International Collaborating Clinics (SLICC)/ACR damage index [4]. As a control group, we included 971 healthy, ethnic-matched subjects (mean age, 37.2 (16.6–78.6); male = 139 and female = 832).Four SNPs (rs729302 (A > C), rs2004640 (G > T), rs752637 (T > C) and rs2280714 (T > C)) were genotyped, using the TaqMan? (Applied Biosystems, Foster City, CA, USA) method [5], in our SLE cases and contro
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells
Jung-Young Shin, Jeong-Oh Kim, Suk Lee, Hiun-Suk Chae, Jin-Hyoung Kang
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-425
Abstract: After single treatment and sequential combination of 5-FU and LY, cytotoxic activity was measured by MTS assay. When 5-FU and LY were treated in single and sequential combinations, the expression of p-AKT, p-NFkB, p-p53 and bcl-2 was observed on different concentrations by Western blot analysis. We also investigated the effect on apoptosis and cell cycle distribution using flow cytometry. The LMP2A siRNA inhibition was done to confirm the reversal of decreased 5-FU activity and p-AKT.When 5-FU was sequentially combined with LY, the combination index (CI) value indicated synergistic anti-proliferative effect. The expression of p-AKT and p-NFκB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY decreased the expression of both p-AKT and p-NFκB. When 5-FU was combined with LY, G0/G1 and sub G1 cell population (%) increased. When 5-FU was added to the cells transfected with LMP2A siRNA, its anti-proliferative effect increased and the expression of p-AKT decreased. In sequential combination of 5-FU and LY, the expression of p-p53 was increased and bcl-2 expression was diminished compared to 5-FU alone.These data suggest that sequential combination of 5-FU and LY induce synergistic cytotoxicity and overcome intrinsic and acquired resistance of 5-FU via downregulation of activated p-AKT and mitochondria-dependent apoptosis in EBV gastric cancer cell line, SNU-719.The worldwide incidence of gastric adenocarcinoma is estimated to exceed 75,000 cases/year, and recent studies have shown that Epstein-Barr virus (EBV) is associated with 10%-18% of gastric cancers. In Korea, EBV-positive cells are found in 7%-10% of gastric cancers and the occurrence of EBV-positive gastric cancers is estimated to be around 4,500-6,400 cases/year based on the fact that gastric cancer has the highest incidence of all cancers.EBV not only causes infectious mononucleosis, but is also a herpes virus with oncogenic potential, giving rise to Burkitt's lymphoma, nasopharyngeal carcino
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