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Search Results: 1 - 10 of 507820 matches for " Huwaida M.E. Hassaneen "
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Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives
Sobhi Mohamed Gomha,Huwaida M.E. Hassaneen
Molecules , 2011, DOI: 10.3390/molecules16086549
Abstract: A novel series of 7,7-diphenyl-1,2-dihydroimidazo[2,1-c][1,2,4]triazin-6(7H)-one 6a–h, were easily prepared via reactions of novel 2-hydrazinyl-4,4-diphenyl-1H-imidazol-5(4H)-one (2) with hydrazonoyl halides 3a–h. In addition, we also examined the reaction of compound 2 with commercially available active methylene compounds to afford new pyrazoles containing an imidazolone moiety, expected to be biologically active. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H-NMR and mass spectral data. The antifungal and antibacterial activities of the newly synthesized compounds were evaluated.
Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives  [PDF]
Hamdi M Hassaneen, Huwaida M. E Hassaneen, Yasmin Sh Mohammed
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.38089
Abstract: The reaction of 1-methylisoquinoline 1 with hy-drazonoyl halides 2 in ethanol in the presence of chitosan under microwave irradiation affords triazoloisoquinoline 4. Product 4 reacts with dimethylformamide-dimethylacetal to give ena- minones 7 which react with hydrazonoyl halides to give pyrazolyl triazoloisoquinoline 13. Also, 1-methylisoquinoline 1 reacts with arylisothio-cyanate to give thioanilide 15 which reacts with hydrazonoyl halides to give the corresponding thiadiazolyl isoquinoline derivatives 20, 24.
Reactivity of 3-Cyanoacetylindole Derivatives: Synthesisof 3-Hydrazonopyrazolyl and 3-Thiadiazolyl Indole Derivatives  [PDF]
Hamdi M. Hassaneen, Huwaida M. E. Hassaneen, Zakaria Ahmed Gomaa
International Journal of Organic Chemistry (IJOC) , 2011, DOI: 10.4236/ijoc.2011.13015
Abstract: The coupling reaction of 3-cyanoacetyl-2-methylindole 1a with the aromatic diazonium salts gave the corresponding arylhydrazones 2a-e. Compounds 2 were used for synthesis of 4-aminopyrazole-5-carbonitrile 4a-e and 5-amino-4-arylazo-3-pyrazoles 5a-e derivatives. Also, treatment of 3-cyanoacetyl-2-phenylindole 1b with phenyl isothiocyanate gave the corresponding thioacetanilide 7. The later compound 7 was utilized as the key intermediate for the synthesis of some new thiadiazole derivatives 9a-r. The structures of all new compounds were elucidated on the basis of elemental analysis and spectral data.
Chemistry of the Enaminone of 1-Acetylnaphthalene under Microwave Irradiation Using Chitosan as a Green Catalyst
Huwaida M. E. Hassaneen
Molecules , 2011, DOI: 10.3390/molecules16010609
Abstract: Enaminone 1 was reacted with hydrazonoyl halides 2a-d to yield 3,4-disubstituted pyrazoles 6a-d. Coupling with arenediazonium chlorides afforded the 2-(arylhydrazono)-3-(1-naphthalenyl)-3-oxopropionaldehydes 13a-c. Compounds 13 could be utilized for the synthesis of a variety of arylpyrazoles, arylazolopyrimidines, and pyridazinones via reaction with hydrazines, aminoazoles, and active methylene derivatives, respectively. A comparative study of aforementioned reactions was carried out with chitosan as a basic ecofriendly catalyst under conventional heating as well as under pressurized microwave irradiation conditions.
Synthesis of New Derivatives of Heterocyclic Compounds Containing Pyridine, Pyrimidine and Triazole Ortho-Fused to Isoquinoline Moiety
Hamdi M. Hassaneen,Nada M. Abunada,Huwaida M. E. Hassaneen,Omar A. Miqdad
International Journal of Chemistry , 2012, DOI: 10.5539/ijc.v4n3p86
Abstract: 4-Amino-9,10-dimethoxy-2-phenyl-6,7-dihydro-2(H)-pyrido[2,1-a]isoquinoline-1,3-dicarbonitrile derivatives 4a-c were obtained from the reaction of 6,7-dimethoxy-3,4-dihydroisoqinoline-1-acetonitrile 1 with arylidenemalononitrile 2a-c in boiling acetonitile in the presence of piperidine. The reaction of 4a-c with triethyl orthoformate in acetic anhydride at reflux give the ethoxymethyleneamino derivatives 5a-c. Compounds 5a-c were reacted with hydrazine hydrate and give the corresponding 4-amino-3-imino-2-aryl-3,4,8,9-tetrahydro-2(H)-pyrimido[5?,4?:5,6]pyrido[2,1-a]isoquinoline-1-carbonitrile derivatives 6a-c. Refluxing compound 6a in an excess of triethyl orthoformate give 7a. When compounds 6a-c were refluxed with acetic anhydride or benzoyl chloride in pyridine, they afford the corresponding 4-methyl and 4-phenyl derivatives 8a-c and 9a-c, respectively. Compound 6a was refluxed in diethyloxalate and give product 10. Also, the reaction of 6a with C-acylhydrazonoyl halides 13a,b in refluxing chloroform in the presence of triethylamine afford 14a,b. Correct elemental analyses and spectral data (IR, 1H NMR, 13C NMR and MS) confirm the structure of the synthesized compounds.
Synthesis of some new Indeno[1,2-e]pyrazolo[5,1-c]-1,2,4-triazin-6-one and Indeno[2,1-c]pyridazine-4-carbonitrile Derivatives  [PDF]
Hamdi M. Hassaneen, Nada M. Abunada, Huwaida M. Hassaneen
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.212164
Abstract: Diazonium chlorides of 5-amino-3-methypyrazole 1a and 5-amino-4-phenylpyrazole 1b coupled with 1,3-indanedione 2 and led to the formation of acyclic hydrazone 3a and a cyclic product indenopyrazolotriazine 4b respectively. Cyclization of the hydrazone 3a by boiling in acetic acid afforded the corresponding 4a. The hydrazone 3a reacted with malononitrile in boiling ethanol in the presence of piperidine and gave indeno[2,1-c]pyridazine-4-carbonitrile derivatives 5a,b. Also, coupling of 6 with aryl diazonium chlorides gave the corresponding indenopyridazine derivatives 8a-e. Acetylation, benzoylation and hydrolysis of compound 8a afforded the corresponding substitution products 10-12, respectively. The structures of the newly synthesized compounds were established on the basis of chemical and spectral evidences.
Electrochemical Behaviour Of Carbon Dioxide On Platinum And Rhodium
Anales de la Asociaci?3n Qu?-mica Argentina , 2005,
Abstract: the electroadsorption and electroreduction of carbon dioxide, and the subsequent electrooxidation of reduced carbon dioxide was studied on polycrystalline and electrofaceted pt and on polycrystalline rh electrodes. the influence of the adsorption potential and the adsorption time was established. combining voltammetric charge measurements and differential electrochemical mass spectrometry (dems) analysis, three adsorbates were tentatively identified, namely cooh and co in bridge and linear configurations on pt, and coh in triple and single adsorption configurations on rh. by applying medium frequency potential routines on the pt-adsorbate/sulphuric acid interface, the existence of equilibrium between adsorbates was demonstrated.
The effect of Diazepam in pain reduction following mandibular impacted third molar surgery
Daneshvar M.E
Journal of Dental Medicine , 2004,
Abstract: Pain control is of high importance in dentistry. Prescribing sedatives such a"nDiazepam, as an anti-depressant and pain threshold elevator drug is able to influence the patient's reaction to"npain and reduce it."nPurpose: The aim of the current study was to evaluate the effect of Diazepam in pain reduction following"nmandibular impacted third molar surgery."nMaterials and Methods: In this study, which was conducted in the department of Oral and Maxillofacial"nsurgery Faculty of Dentistry, Tehran University of Medical sciences. The patients were divided into two equal"ngroups (n=30). For controls, antibiotics and analgesics were prescribed after surgery. However, except the"naforementioned drugs, Diazepam (5mg), three times per day, was prescribed for the experimental group. The"namount of mouth opening was also measured as an auxiliary sign after one week. The data were compared by"nX2 test after one week."nResults: 60% of the experimental group and 13.8% of the control group felt a weak pain. Statistically"nsignificant differences were observed regarding pain feeling between two groups (P<0.001). Severe pain"nfeeling was 34.5% and 10%, for control and experimental groups, respectively."nConclusion: It is suggested that Diazepam is an effective pain reduction drug following third molar surgery."nThis drug has also a relative effect on temporary trismus resulting probably from muscle trauma or pain.
Metaphors, domains and embodiment
M.E. Botha
Koers : Bulletin for Christian Scholarship , 2005, DOI: 10.4102/koers.v70i3.277
Abstract: Investigations of metaphorical meaning constitution and meaning (in-) variance have revealed the significance of semantic and semiotic domains and the contexts within which they function as basis for the grounding of metaphorical meaning. In this article some of the current views concerning the grounding of metaphorical meaning in experience and embodiment are explored. My provisional agreement with Lakoff, Johnson and others about the “conceptual” nature of metaphor rests on an important caveat, viz. that this bodily based conceptual structure which lies at the basis of linguistic articulations of metaphor, is grounded in a deeper ontic structure of the world and of human experience. It is the “metaphorical” (actually “analogical”) ontological structure of this grounding that is of interest for the line of argumentation followed in this article. Because Johnson, Lakoff and other’s proposal to ground metaphorical meaning in embodiment and neural processes is open to being construed as subjectivist and materialist, I shall attempt to articulate the contours of an alternative theory of conceptual metaphor, meaning and embodiment which counteracts these possibilities. This theory grounds metaphorical meaning and meaning change in an ontological and anthropological framework which recognises the presence and conditioning functioning of radially ordered structures for reality. These categorisations in which humankind, human knowledge and reality participate, condition and constrain (ground) analogical and metaphorical meaning transfer, cross-domain mappings, and blends in cognition and in language, provide the basis for the analogical concepts found in these disciplines.
Clusters, roots and hierarchies of metaphors in Scripture and the quest for Christian scholarship
M.E. Botha
Koers : Bulletin for Christian Scholarship , 2004, DOI: 10.4102/koers.v69i3.315
Abstract: This article explores how the confessional thrust of Scriptural and root metaphors relates to the Christian scholar’s quest and how choices for hermeneutical keys to Scripture relate to metaphorical keys chosen as means of access to reality. With respect to Biblical interpretation it is argued that the text of Scripture itself provides the theologian or reader with leads concerning the kind of metaphorical access that functions as its hermeneutical key. I argue that there are clusters or hierarchies of metaphors, central and root metaphors, that regulate the interpretation of Scriptural texts and that a redemptive historical reading of Scripture as a confessional text guides the meaning of such clusters and hierarchies of metaphors. I argue that root metaphors in Scripture set the certitudinal parameters for the metaphors chosen and utilised in the disciplines. Regarding reality I argue that the recognition of the multidimensionality of reality and the plurivocity of meaning and signification on which we rely in both literal and metaphorical language use and reference assumes the existence of non-linguistic and preconceptual bases that guide the recognition of similarities, differences and analogies in reality. They in turn are pointers to a design plan for reality which one could call a God-given order of creation. Metaphorical meaning appeals to and presupposes such an ordered and categorised world to which language and texts refer and which provides limits and boundaries to the multiplicity of deferrals of meaning that intertextual relationships seem to imply. In disciplines concerned metaphorical models play a hermeneutical role in the understanding and interpretation of reality. In these metaphorical models, control beliefs steer, guide and condition the access of the discipline to reality. For Christian scholars the ultimate presuppositions embedded in control beliefs need to comport with the thrust of Scripture and its root metaphors. Scholars are at work in God’s creation and their metaphorical approximations of the structures of this creation are guided by the contours of created reality. These approximations in turn are influenced and constrained by what they attribute ultimacy to in the process of attempting to understand this reality. Stable God-given order provides the conditions and parameters for the common differentiation of contexts within which the interpretation of God’s Word in creation is to take place.
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