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Search Results: 1 - 10 of 4340 matches for " Hunt Kelly "
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Breaking the Adhesive Bond between Dialyll Phthlate, Barco Bond 185 and PBX 9501  [PDF]
Matt Jackson, Benton Allen, Trent Kelly, Courtney Waddell, Emily M. Hunt, Stephanie Steelman, Neil Koone
Journal of Materials Science and Chemical Engineering (MSCE) , 2015, DOI: 10.4236/msce.2015.37026
Abstract:

Use of epoxy as an adhesive is a common practice. The most common applications are permanent sealants. Epoxies have a wide range of operating temperatures, and are very resistance to adhesive failure. When a need to remove this adhesive arises, it is not always easily accomplished especially if the part has excessive adhesive. To maintain fidelity of the parts attached by epoxy, a project evaluating several methods of epoxy removal was conducted. Methods evaluated included low wavelength, near-ultraviolet radiation, solvent dissolution, and thermal cycling. The UV method failed to demonstrate a repeatable dissociation. The solvent study did result in dissociation of bonds, but introduced chemicals that could make subsequent chemical analysis of parts suspect. Thermal cycling showed a high repeatability for dissociation of bonds and may prove to be relatively inexpensive to implement.

Fitting parametric random effects models in very large data sets with application to VHA national data
Gebregziabher Mulugeta,Egede Leonard,Gilbert Gregory E,Hunt Kelly
BMC Medical Research Methodology , 2012, DOI: 10.1186/1471-2288-12-163
Abstract: Background With the current focus on personalized medicine, patient/subject level inference is often of key interest in translational research. As a result, random effects models (REM) are becoming popular for patient level inference. However, for very large data sets that are characterized by large sample size, it can be difficult to fit REM using commonly available statistical software such as SAS since they require inordinate amounts of computer time and memory allocations beyond what are available preventing model convergence. For example, in a retrospective cohort study of over 800,000 Veterans with type 2 diabetes with longitudinal data over 5 years, fitting REM via generalized linear mixed modeling using currently available standard procedures in SAS (e.g. PROC GLIMMIX) was very difficult and same problems exist in Stata’s gllamm or R’s lme packages. Thus, this study proposes and assesses the performance of a meta regression approach and makes comparison with methods based on sampling of the full data. Data We use both simulated and real data from a national cohort of Veterans with type 2 diabetes (n=890,394) which was created by linking multiple patient and administrative files resulting in a cohort with longitudinal data collected over 5 years. Methods and results The outcome of interest was mean annual HbA1c measured over a 5 years period. Using this outcome, we compared parameter estimates from the proposed random effects meta regression (REMR) with estimates based on simple random sampling and VISN (Veterans Integrated Service Networks) based stratified sampling of the full data. Our results indicate that REMR provides parameter estimates that are less likely to be biased with tighter confidence intervals when the VISN level estimates are homogenous. Conclusion When the interest is to fit REM in repeated measures data with very large sample size, REMR can be used as a good alternative. It leads to reasonable inference for both Gaussian and non-Gaussian responses if parameter estimates are homogeneous across VISNs.
Elevated Mercury in Ambient Air and Soils Impacts of Historical Air Emissions (1897-1991) from a Chlor-Alkali Plant (CAP)  [PDF]
Gary Hunt
Journal of Environmental Protection (JEP) , 2016, DOI: 10.4236/jep.2016.73038
Abstract:

Mercury contamination was found to be widespread in soils at a property in Upstate New York. Historical site use suggested that the mercury did not result from prior industrial use of the property. Soil contamination may have resulted from atmospheric deposition of mercury released from properties in close proximity to the contaminated property. The purpose of this forensics investigation was to examine to what extent atmospheric deposition of elemental mercury may have influenced mercury levels found in surficial soils on the contaminated property and further to identify the source(s) of the mercury. Work efforts included an examination of historical records available for a chlor-alkali plant (CAP) upwind of the contaminated property to establish historical use and disposal practices for elemental mercury. Mercury emissions test data from the Upstate New York chlor-alkali facility were modeled (USEPA ISC3) as a means of estimating impacts on ambient air and soils vicinal to the facility. Mercury emissions from the facility were modeled as both a point source and volume source. For example, at a location 305 meters to the east and 30 meters to the north of the modeled source centerline elemental mercury concentrations in ambient air were estimated at 270 ng/m3 (average results based upon 5 years of meteorological data). This value is contrasted to a background concentration of 1.6 ng/m3 (USEPA Report to Congress 1997). As a result of the modeling data in combination with findings related to mercury use and disposal practices at the NY CAP documented from the records review, it was concluded that emissions from the CAP facility during the period of operation (1897-1991) most likely accounted for the concentrations of elemental mercury found in surficial soils at properties situated downwind of the CAP. These findings were further corroborated by information available in the open literature for CAPs world-wide.


Analysis of dendritic cells in tumor-free and tumor-containing sentinel lymph nodes from patients with breast cancer
Nancy J Poindexter, Aysegul Sahin, Kelly K Hunt, Elizabeth A Grimm
Breast Cancer Research , 2004, DOI: 10.1186/bcr808
Abstract: Fifty paraffin-embedded SLN sections, 25 tumor-free and 25 tumor-containing, from patients with breast cancer were analyzed by immunohistochemistry to determine the immune maturation state of their DCs. In addition, 12 lymph nodes from noncancer-containing breasts were analyzed. Tissues were stained with antibodies against CD3, MHC class II, CD1a, CD83, IL-10, and IL-12. Mature DCs were defined by CD83 expression and immature DCs by CD1a expression.We found a trend toward higher numbers of mature CD83-positive DCs in tumor-free SLNs than in tumor-containing SLNs (P = 0.07). In addition, tumor-free SLNs were more likely to contain cells expressing IL-10 (P = 0.02) and, to a lesser extent, IL-12 (P = 0.12). In contrast, when all SLNs, both tumor-free and tumor-containing, were compared with uninvolved lymph nodes, the numbers of mature and immature DCs were similar.Our results suggest tumor-free SLNs are immunologically competent and potentially a site of tumor-specific T-cell activation, as evidenced by the presence of greater numbers of mature DCs and cytokine-producing cells in tumor-free SLNs.Tumor-specific T-cell activation begins in the primary tumor when dendritic cells (DCs) encounter antigens in the form of apoptotic or necrotic tumor cells. The DCs engulf dying tumor cells and process their antigens into peptides that are presented in the context of MHC class I and class II molecules [1,2]. The function of a DC is highly influenced by its level of maturation. Immature DCs are capable of antigen uptake and processing but cannot, unless given the proper cytokine signals, present antigen to T cells [1,3,4]. After receiving the correct cytokine signals, the mature, peptide-loaded DCs migrate from the tumor to the first draining lymph node, referred to as the sentinel lymph node (SLN). In the SLN, na?ve T cells are activated by the peptide-loaded mature DCs. These T cells then undergo clonal expansion, gain effector function, and circulate back to the tumor, wher
Simulated Estimates of Pre-Pregnancy and Gestational Diabetes Mellitus in the US: 1980 to 2008
Maria E. Mayorga, Odette S. Reifsnider, David M. Neyens, Mulugeta G. Gebregziabher, Kelly J. Hunt
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073437
Abstract: Purpose To simulate national estimates of prepregnancy and gestational diabetes mellitus (GDM) in non-Hispanic white (NHW) and non-Hispanic black (NHB) women. Methods Prepregnancy diabetes and GDM were estimated as a function of age, race/ethnicity, and body mass index (BMI) using South Carolina live singleton births from 2004–2008. Diabetes risk was applied to a simulated population. Age, natality and BMI were assigned to women according to race- and age-specific US Census, Natality and National Health and Nutrition Examination Surveys (NHANES) data, respectively. Results From 1980–2008, estimated GDM prevalence increased from 4.11% to 6.80% [2.68% (95% CI 2.58%–2.78%)] and from 3.96% to 6.43% [2.47% (95% CI 2.39%–2.55%)] in NHW and NHB women, respectively. In NHW women prepregnancy diabetes prevalence increased 0.90% (95% CI 0.85%–0.95%) from 0.95% in 1980 to 1.85% in 2008. In NHB women from 1980 through 2008 estimated prepregnancy diabetes prevalence increased 1.51% (95% CI 1.44%–1.57%), from 1.66% to 3.16%. Conclusions Racial disparities in diabetes prevalence during pregnancy appear to stem from a higher prevalence of prepregnancy diabetes, but not GDM, in NHB than NHW.
Quantifying the Impact of Gestational Diabetes Mellitus, Maternal Weight and Race on Birthweight via Quantile Regression
Caitlyn N. Ellerbe, Mulugeta Gebregziabher, Jeffrey E. Korte, Jill Mauldin, Kelly J. Hunt
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0065017
Abstract: Background Quantile regression, a robust semi-parametric approach, was used to examine the impact of gestational diabetes mellitus (GDM) across birthweight quantiles with a focus on maternal prepregnancy body mass index (BMI) and gestational weight gain (GWG). Methods Using linked birth certificate, inpatient hospital and prenatal claims data we examined live singleton births to non-Hispanic white (NHW, 135,119) and non-Hispanic black (NHB, 76,675) women in South Carolina who delivered 28–44 weeks gestation in 2004–2008. Results At a maternal BMI of 30 kg/m2 at the 90th quantile of birthweight, exposure to GDM was associated with birthweights 84 grams (95% CI 57, 112) higher in NHW and 132 grams (95% CI: 104, 161) higher in NHB. Results at the 50th quantile were 34 grams (95% CI: 17, 51) and 78 grams (95% CI: 56, 100), respectively. At a maternal GWG of 13.5 kg at the 90th quantile of birthweight, exposure to GDM was associated with birthweights 83 grams (95% CI: 57, 109) higher in NHW and 135 grams (95% CI: 103, 167) higher in NHB. Results at the 50th quantile were 55 grams (95% CI: 40, 71) and 69 grams (95% CI: 46, 92), respectively. Summary Our findings indicate that GDM, maternal prepregnancy BMI and GWG increase birthweight more in NHW and NHB infants who are already at the greatest risk of macrosomia or being large for gestational age (LGA), that is those at the 90th rather than the median of the birthweight distribution.
Facilitating Transdisciplinary Research in an Evolving Approach to Science  [PDF]
Fen Hunt, Suzanne Thornsbury
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.24038
Abstract: Transdisciplinary research is changing the way research is conducted and supported by incorporating linkages between disciplinary fields, across geographic boundaries, and among scientists and broader societal stakeholder groups. There is a compelling opportunity and important role for social scientists to participate in both transdisciplinary projects addressing societal challenge issues and in research projects focused on the development of transdisciplinary project methodology and management. A shift in approach to scientific inquiry requires adjustments in institutional support structures as well as individual research projects and specific programs. US funding agencies, including the National Institute of Food and Agriculture (NIFA) have clearly built trans-disciplinarity into their portfolio of research programs.
Is There an Association between Social Connectedness, Social Identity, Alcohol Consumption and Mental Health among Young University Students?  [PDF]
Kristen Hunt, Sharyn Burns
Open Journal of Preventive Medicine (OJPM) , 2017, DOI: 10.4236/ojpm.2017.76009
Abstract: Social connectedness has been identified as a protective factor for a range of health issues however the literature is not conclusive. The high prevalence of hazardous alcohol consumption and mental health problems among university students along with the potential for the university as a setting for health promotion prompted this study. The study aims to explore the association between levels of alcohol consumption, mental health, social connectedness and social identity among university students. Online data were collected from a random sample of university undergraduate students (n = 2506) aged 18 - 24 years old. Outcomes were measured using the Alcohol Use Disorders Identification Test (AUDIT), the Kessler Psychological Distress Scale, Social Connectedness Scale, Social Identity Scale and measures of paid employment and study (hours), and participation in sports and other clubs. The majority of students had consumed alcohol in the last 12 months (87%). Of these students 38% reported to drink at hazardous levels (AUDIT ≥ 8). When all factors were considered: gender, living arrangements, being a domestic student, hours spent at work, participation in university and community sport, higher levels of psychological distress, higher levels of social connectedness, and lower levels of social identity were significant predictors of hazardous alcohol consumption. The finding highlights the need for the inclusion of integrated, multi-strategy health promotion interventions on campus. Further exploration of the associations between social connectedness and social identity as influences of health behaviors will better inform the development of targeted strategies for specific groups.
Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein
Timothy M Pawlik, David H Hawke, Yanna Liu, Savitri Krishnamurthy, Herbert Fritsche, Kelly K Hunt, Henry M Kuerer
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-68
Abstract: Paired NAF samples from 18 women with stage I or II unilateral invasive breast carcinoma and 4 healthy volunteers were analyzed using ICAT labeling, sodium dodecyl sulfate-polyacrylamide gel (SDS-PAGE), liquid chromatography, and MS. Proteins were identified by sequence database analysis. Western blot analysis of NAF from an independent sample set from 12 women (8 with early-stage breast cancer and 4 healthy volunteers) was also performed.353 peptides were identified from tandem mass spectra and matched to peptide sequences in the National Center for Biotechnology Information database. Equal numbers of peptides were up- versus down-regulated. Alpha2HS-glycoprotein [Heavy:Light (H:L) ratio 0.63] was underexpressed in NAF from tumor-bearing breasts, while lipophilin B (H:L ratio 1.42), beta-globin (H:L ratio 1.98), hemopexin (H:L ratio 1.73), and vitamin D-binding protein precursor (H:L ratio 1.82) were overexpressed. Western blot analysis of pooled samples of NAF from healthy volunteers versus NAF from women with breast cancer confirmed the overexpression of vitamin D-binding protein in tumor-bearing breasts.ICAT tandem MS was able to identify and quantify differences in specific protein expression between NAF samples from tumor-bearing and disease-free breasts. Proteomic screening techniques using ICAT and NAF may be used to find markers for diagnosis of breast cancer.Despite the widespread adoption of screening mammography, many breast cancers still escape detection at an early stage [1,2]. Identifying relevant biologic markers could improve our ability to diagnose early-stage breast cancer [3-7]. Compared with DNA analysis (genomics) and RNA analysis (expression profiling), the examination of protein expression (proteomics) may be more relevant to tumor physiology as protein stability and activity are largely what determine cellular phenotype and function [8]. Recent developments in proteomics have enabled high-throughput analysis of thousands of proteins, making
Outcomes of Sentinel Lymph Node Dissection Alone vs. Axillary Lymph Node Dissection in Early Stage Invasive Lobular Carcinoma: A Retrospective Study of the Surveillance, Epidemiology and End Results (SEER) Database
Jun Wang, Elizabeth A. Mittendorf, Aysegul A. Sahin, Min Yi, Abigail Caudle, Kelly K. Hunt, Yun Wu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0089778
Abstract: Background The American College of Surgeons Oncology Group (ACOSOG) Z0011 trial demonstrated no difference in local-regional recurrence (LRR), disease-specific survival (DSS) or overall survival (OS) for sentinel lymph node dissection (SLND) and completion axillary lymph node dissection (ALND) among patients undergoing breast-conserving therapy for clinical T1–T2, N0 breast cancer with 1 or 2 positive SLNs. However, Only 7% of study participants had invasive lobular carcinoma (ILC). Because ILC has a different pattern of metastases, frequently presenting as small foci requiring immunohistochemistry for detection, the applicability of ACOSOG Z0011 trial data to ILC patients is unclear. Study Design We identified all ILC patients in the Surveillance, Epidemiology, and End Results (SEER) database (1998–2009) who met the ACOSOG Z0011 eligibility criteria. Patients were evaluated on the basis of the extent of axillary surgery (SLND alone or ALND), and the clinical outcomes of these 2 groups were compared. Results 1269 patients (393 SLND and 876 ALND) were identified from the SEER database. At a median follow-up time of 71 months, there were no differences in OS or disease-specific survival between the two groups. Conclusion SLND alone may result in outcomes comparable to those achieved with ALND for patients with early-stage ILC who meet the ACOSOG Z0011 eligibility criteria.
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