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Search Results: 1 - 10 of 124807 matches for " Hung-I Lu "
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Minimally Invasive Surgery for Coronary Artery Disease with Associated Lung Cancer
Hung-I Lu,Yi-Cheng Wu,Ming-Ju Hsieh,Hui-Ping Liu
Chang Gung Medical Journal , 2002,
Abstract: Simultaneous surgical management of patients with co-existing ischemic heart diseaseand lung carcinoma remains controversial. Traditionally, these operations have been staged,with coronary artery revascularization first, followed by pulmonary resection at a later date.Under this procedure, tumor resection is delayed, and these staged procedures may increasemorbidity and cost. Our experience with minimally invasive surgery in the cardiac and thoracicfields suggests that both diseases can be resolved within the same operation. Thisreport presents a 65-year-old man with coronary artery disease (CAD), and left lung cancer.He received concomitant coronary artery bypass grafting for CAD and pulmonary resectionfor lung cancer via a left parasternal minithoracotomy. No complaints or clinical signs wereobserved during a 6 month follow-up. Therefore, major cardiac and thoracic procedures thatare performed via a minimally invasive approach using conventional instruments, can resultin a safer, quicker, and more economical procedure. The results of the a minimally invasiveapproach demonstrated the technical feasibility of treating a triple vessel cardiac diseasewith lung cancer.
Pseudoaneurysm Formation 12 Years after Ringed Intraluminal Graft Replacement for Type B Aortic Dissection.
Jen-Ping Chang,Hung-I Lu,Ming-Jang Hsieh,Chiung-Lun Kao
Chang Gung Medical Journal , 2004,
Abstract: A sutureless ringed intraluminal graft has been used as a substitute for the diseasedaorta with the advantage of decreasing the aortic cross-clamp time and blood loss. Concernsremain about implications of anecdotal accounts of late complications with this graft. Wereport on the experience of a 68-year-old man, successfully treated for type B aortic dissectionusing the sutureless technique, who developed a pseudoaneurysm and aortobronchialfistula over the distal anastomosis of the intraluminal graft 12 years after the operation.
Bronchoscopic Electrocautery for Palliation of Post-anastomotic Tracheal Stricture in a Patient with Complete Tracheal Transection Following Blunt Chest Trauma
Yu-Hsiu Chung,Hung-I Lu,An-Shen Lin,Meng-Chih Lin
Chang Gung Medical Journal , 2005,
Abstract: There are many strategies available to treat palliation of airway obstruction due tobenign or malignant conditions. The initial choice depends on the urgency of the situation,the extent of the disease process as assessed bronchoscopically, as well as the individualexperience and preference of the physician. We present a rare case of complete tracheal transectionfollowing a traffic accident. Respiratory distress, which resulted from post-anastomotictracheal stricture, developed progressively about 2 months after surgical repair.Symptomatic relief and improved ventilatory function were achieved in this patient oncepatency of the trachea was restored successfully using bronchoscopic electrocautery. Thetechnique is a straightforward, safe, and quick method to palliate airway obstruction.
Weaning of Long-Term Mechanically-Ventilated Patients Following Video Bronchoscopy-Guided Percutaneous Dilatational Tracheostomy
Chien-Tung Chiu,Yu-Hsiu Chung,Hung-I Lu,Meng-Chih Lin
Chang Gung Medical Journal , 2005,
Abstract: Chien-Tung Chiu, MD; Yu-Hsiu Chung, MD; Hung-I Lu1, MD; Meng-Chih Lin, MDBackground: This is a prospective study of peri-procedure and post-procedure complicationsand successful weaning of long-term mechanically-ventilated patientsfollowing video bronchoscopy-guided percutaneous dilatational tracheostomy(PDT).Methods: Video bronchoscopy guided PDT was performed for long-term mechanically-ventilated patients in a medical intensive care unit (ICU). Peri-procedureand post-procedure complications were prospectively observed and evaluated.The success of weaning and the factors affecting the outcomes of thesepatients after PDT were also investigated.Results: A total of 107 patients with mechanical ventilation were enrolled. The averageduration of trans-laryngeal intubation was 27.8 18.4 days which waslonger than reported in previous studies. There were 70 men and 37 women,all of whom underwent bedside PDT at a medical ICU. The complicationrates during and post-procedure were 8.4% and 14%, respectively. The mostcommon complications were desaturation during the procedure and bleedingduring the follow-up period. Only one death was procedure related (0.9%).After PDT, 50 patients (46.7%) were successfully weaned from mechanicalventilation. The rate of successful weaning (p = 0.02) increased while thedays to achievement (p 0.001) decreased with decreasing duration oftrans-laryngeal intubation. Gender, age, body weight, Acute Physiology andChronic Health Evaluation II (APACHE II) score, duration of procedure,endotracheal tube diameter and position, and history of self-extubation werenot related to successful weaning.Conclusions: PDT is a bedside procedure with relatively low complication and mortalityrates when performed for patients on long-term mechanical ventilation in amedical ICU. The previous duration of trans-laryngeal intubation was animportant determinant for successful weaning after PDT.
Comparative Study of Esophageal Stent and Feeding Gastrostomy/Jejunostomy for Tracheoesophageal Fistula Caused by Esophageal Squamous Cell Carcinoma
Yen-Hao Chen, Shau-Hsuan Li, Yi-Chun Chiu, Hung-I Lu, Cheng-Hua Huang, Kun-Ming Rau, Chien-Ting Liu
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042766
Abstract: Background A malignant tracheoesophageal/bronchoesophageal fistula (TEF) is a life-threatening complication of esophageal squamous cell carcinoma. A feeding gastrostomy/jejunostomy had been the most common treatment method for patients with TEF before the era of stenting. The aim of this retrospective study is to compare the prognosis of esophageal squamous cell carcinoma patients with TEF treated with an esophageal metallic stent to those treated with a feeding gastrostomy/jejunostomy. Methods We retrospectively reviewed a total of 1011 patients with esophageal squamous cell carcinoma between 1996 and 2011 at Kaohsiung Chang Gung Memorial Hospital, and 86 patients with TEF (8.5%) were identified. The overall survival and other clinical data were compared between 30 patients treated with an esophageal metallic stent and 35 patients treated with a feeding gastrostomy/jejunostomy. Results Among the 65 patients receiving either an esophageal metallic stent or a feeding gastrostomy/jejunostomy, univariate analysis showed that treatment modality with an esophageal metallic stent (P = 0.007) and radiotherapy treatment after fistula diagnosis (P = 0.04) were predictive of superior overall survival. In the multivariate comparison, treatment modality with an esophageal metallic stent (P = 0.026, odds ratio: 1.859) represented the independent predictive factor of superior overall survival. There were no significant differences between groups in mean decrease in serum albumin or mean body weight loss. Compared to the feeding gastrostomy/jejunostomy group, a significantly higher proportion of patients in the stenting group (53% versus 14%, P = 0.001) were able to receive chemotherapy within 30 days after fistula diagnosis, indicating better infection control in the stenting group. Conclusions Compared with a feeding gastrostomy/jejunostomy, an esophageal metallic stent significantly improves overall survival in patients with malignant TEF in our retrospective analysis. Esophageal metallic stent placement may be considered the first-line of treatment for patients with malignant TEF.
Localized pericarditis leading to clinical tamponade with profound shock status and syncope as a major clinical manifestation after posterior wall myocardial infarction—Characterization and descriptive findings by real-time 3-dimensional echocardiography  [PDF]
Po-Ching Chi, Chi-In Lo, Charles Jia-Yin Hou, Hung-I Yeh, Chung-Lieh Hung
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.24072

Pericarditis and hemopericardium causing cardiac tamponade, caused by large and transmural ventricular infarction with subsequent rupture into the pericardium, is a rare complication post acute myocardial infarction. This is frequently fatal with rapid clinical course. We reported a 65-year-old female who presented with persistent diaphoresis and dyspnea for several hours followed by syncope. Acute myocardial infarction was diagnosed with primary percutaneous coronary intervention performed though persistent hypotension was observed. Moderate amount of hemopericardium leading to tamponade was found. It was relieved after pericardiocentesis. Real-time three-dimensional echocardiography revealed blood clot with specific whirling pattern around the infracted ventricular wall with suspected leak.

Identifying Biomagnetic Sources in the Brain by the Maximum Entropy Approach
Hung-I Pai,Chih-Yuan Tseng,HC Lee
Quantitative Biology , 2005, DOI: 10.1063/1.2149834
Abstract: Magnetoencephalographic (MEG) measurements record magnetic fields generated from neurons while information is being processed in the brain. The inverse problem of identifying sources of biomagnetic fields and deducing their intensities from MEG measurements is ill-posed when the number of field detectors is far less than the number of sources. This problem is less severe if there is already a reasonable prior knowledge in the form of a distribution in the intensity of source activation. In this case the problem of identifying and deducing source intensities may be transformed to one of using the MEG data to update a prior distribution to a posterior distribution. Here we report on some work done using the maximum entropy method (ME) as an updating tool. Specifically, we propose an implementation of the ME method in cases when the prior contain almost no knowledge of source activation. Two examples are studied, in which part of motor cortex is activated with uniform and varying intensities, respectively.
Data Processing Approach for Localizing Bio-magnetic Sources in the Brain
Hung-I Pai,Chih-Yuan Tseng,H. C. Lee
Quantitative Biology , 2009,
Abstract: Magnetoencephalography (MEG) provides dynamic spatial-temporal insight of neural activities in the cortex. Because the number of possible sources is far greater than the number of MEG detectors, the proposition to localize sources directly from MEG data is notoriously ill-posed. Here we develop an approach based on data processing procedures including clustering, forward and backward filtering, and the method of maximum entropy. We show that taking as a starting point the assumption that the sources lie in the general area of the auditory cortex (an area of about 40 mm by 15 mm), our approach is capable of achieving reasonable success in pinpointing active sources concentrated in an area of a few mm's across, while limiting the spatial distribution and number of false positives.
AGE-BSA down-regulates endothelial connexin43 gap junctions
Chi-Young Wang, Hung-Jen Liu, Heng-Ju Chen, Yi-Chun Lin, Hsueh-Hsiao Wang, Ta-Chuan Hung, Hung-I Yeh
BMC Cell Biology , 2011, DOI: 10.1186/1471-2121-12-19
Abstract: In human aortic endothelial cells (HAEC) treated with a series concentrations of AGE-BSA (0-500 μg/ml) for 24 and 48 hours, Cx43 transcript and Cx43 protein were reduced in a dose dependent manner. In addition, gap-junction communication was reduced. To clarify the mechanisms underlying the down-regulation, MAPKs pathways in HAEC were examined. Both a MEK1 inhibitor (PD98059) and a p38 MAPK inhibitor (SB203580) significantly reversed the reductions of Cx43 mRNA and protein induced by AGE-BSA. Consistently, phosphorylation of ERK and p38 MAPK was enhanced in response to exposure to AGE-BSA. However, all reversions of down-regulated Cx43 by inhibitors did not restore the functional gap-junction communication.AGE-BSA down-regulated Cx43 expression in HAEC, mainly through reduced Cx43 transcription, and the process involved activation of ERK and p38 MAPK.Diabetes is known to accelerate the process of atherosclerosis, in which endothelial dysfunction plays a key role [1]. Previous studies have shown that diabetes alters the expression of a variety of molecules involved in maintenance of endothelial function [2]. Animal experiments also demonstrated that induction of diabetes, either alone or on top of hyperlipidemia, suppress the expression of endothelial gap junctions [3,4]. Gap junctions are cell membrane channels made of paired hexamers of connexins, which allow exchange of ions and small signaling molecules between the cytoplasmic compartments of adjacent cells. In mammals endothelial cells mainly express connexin43 (Cx43), Cx40, and Cx37 [5], of which Cx43 is by far the predominant in the cultured endothelial cells [6,7]. Several reports have shown that endothelial Cx43 gap junctions are down-regulated by factors causing endothelial dysfunction [8], such as aging [9], hypertension [10], and arsenic trioxide [11], the last of which was even reported to induce endothelial lesion. In contrast, other factors causing endothelial dysfunction, such as oscillatory shear str
Androgen-Responsive MicroRNAs in Mouse Sertoli Cells
Subbarayalu Panneerdoss, Yao-Fu Chang, Kalyan C. Buddavarapu, Hung-I Harry Chen, Gunapala Shetty, Huizhen Wang, Yidong Chen, T. Rajendra Kumar, Manjeet K. Rao
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041146
Abstract: Although decades of research have established that androgen is essential for spermatogenesis, androgen's mechanism of action remains elusive. This is in part because only a few androgen-responsive genes have been definitively identified in the testis. Here, we propose that microRNAs – small, non-coding RNAs – are one class of androgen-regulated trans-acting factors in the testis. Specifically, by using androgen suppression and androgen replacement in mice, we show that androgen regulates the expression of several microRNAs in Sertoli cells. Our results reveal that several of these microRNAs are preferentially expressed in the testis and regulate genes that are highly expressed in Sertoli cells. Because androgen receptor-mediated signaling is essential for the pre- and post-meiotic germ cell development, we propose that androgen controls these events by regulating Sertoli/germ cell-specific gene expression in a microRNA-dependent manner.
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