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Search Results: 1 - 10 of 34696 matches for " HuiJun Lu "
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Expression changes of Akt and GSK-3β during vascular inflammatory response and oxidative stress induced by high-fat diet in rats  [PDF]
Jingshang Wang, Huijun Yin, Ye Huang, Chunyu Guo, Chengdong Xia, Lu Zhang
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.65A001

Aim: To observe the expression changes of Akt and GSK-3β during vascular inflammatory response and oxidative stress induced by high-fat diet in rats. Methods: 20 male Sprague-Dawley rats were separately fed for 18 weeks with two types of diets; a normal diet (control group, CON) or high-fat diet hyperlipidmia group, HLP). Then the body weight, lipid parameter, plasma hepatocyte growth factor (HGF), serum superoxide dismutase (SOD) , malondialdehyde (MDA), Tumor necrosis factor-α (TNF-α), a Soluble intercellular adhesion molecule-1 (sICAM-1), Lectin-like oxidized cellulose low density lipoprotein receptor-1 (LOX-1), as well as aortic endothelial p-GSK-3β, GSK-3β, p-Akt, Akt expressions were determined. Results: In comparison with the control group, the model group showed a significant increase in the levels of serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol ( LDL-C) and significant decrease in the level of serum high density lipoprotein cholesterol (HDL-C) after high-fat diet for 18 weeks (p < 0.05 or p < 0.01). Meanwhile, a more obvious increase of plasma HGF, LOX-1 and serum MDA, TNF-α, and sICAM-1 levels were observed relative to the control group (p < 0.05 or p < 0.01). Moreover, high-fat diet significantly increased the phosphorylation of Akt and GSK-3β in rat aorta. Conclusion: Short-term high-fat diet could induce vascular endothelium injury by increasing inflammation and

A comparative study of small RNAs in Toxoplasma gondii of distinct genotypes
Wang Jielin,Liu Xiaolei,Jia Boyin,Lu Huijun
Parasites & Vectors , 2012, DOI: 10.1186/1756-3305-5-186
Abstract: Background Toxoplasma gondii is an intracellular parasite with a significant impact on human health. Inside the mammalian and avian hosts, the parasite can undergo rapid development or remain inactive in the cysts. The mechanism that regulates parasite proliferation has not been fully understood. Small noncoding RNAs (sncRNA) such as microRNAs (miRNAs) are endogenous regulatory factors that can modulate cell differentiation and development. It is anticipated that hundreds of miRNAs regulate the expression of thousands of genes in a single organism. SncRNAs have been identified in T. gondii, however the profiles of sncRNAs expression and their potential regulatory function in parasites of distinct genotypes has largely been unknown. Methods The transcription profiles of miRNAs in the two genetically distinct strains, RH and ME49, of T. gondii were investigated and compared by a high-through-put RNA sequencing technique and systematic bioinformatics analysis. The expression of some of the miRNAs was confirmed by Northern blot analysis. Results 1,083,320 unique sequences were obtained. Of which, 17 conserved miRNAs related to 2 metazoan miRNA families and 339 novel miRNAs were identified. A total of 175 miRNAs showed strain-specific expression, of which 155 miRNAs were up-regulated in RH strain and 20 miRNAs were up-regulated in ME49 strain. Strain-specific expression of miRNAs in T. gondii could be due to activation of specific genes at different genomic loci or due to arm-switching of the same pre-miRNA duplex. Conclusions Evidence for the differential expression of miRNAs in the two genetically distinct strains of T. gondii has been identified and defined. MiRNAs of T. gondii are more species-specific as compared to other organisms, which can be developed as diagnostic biomarkers for toxoplasmosis. The data also provide a framework for future studies on RNAi-dependent regulatory mechanisms in the zoonotic parasite.
Doubly Periodic Riemann Boundary Value Problem of Non-Normal Type for Analytic Functions on Two Parallel Curves  [PDF]
Lixia Cao, Huijun Zheng
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.51006
Abstract: In this paper, we present and study a kind of Riemann boundary value problem of non-normal type for analytic functions on two parallel curves. Making use of the method of complex functions, we give the method for solving this kind of doubly periodic Riemann boundary value problem of non-normal type and obtain the explicit expressions of solutions and the solvable conditions for it.
Research on Skill Testing Standard of Marketing Major of Wuhan City Vocational College  [PDF]
Hui Li, Huijun Chen
Creative Education (CE) , 2017, DOI: 10.4236/ce.2017.82017
Higher vocational education scale expands rapidly in the recent years, followed by the contradiction between expansion scale and education quality, which has become increasingly prominent nowadays. In order to improve the teaching quality, the most important is to improve daily teaching activity of the harmonious combination of teaching quality monitoring and evaluation system, which focuses on the teaching quality in higher vocational colleges through monitoring and the objective requirement of the long-term quality assurance mechanism. Based on investigation and analysis of present situation, analysis of professional practice skill testing of students majoring in marketing of Wuhan City Vocational College, we develop skill-testing standard in the hope of improving students’ marketing professional skills in future.
The Application of PLC in Sewage Treatment  [PDF]
Huijun Zhu, Xinglei Qiu
Journal of Water Resource and Protection (JWARP) , 2017, DOI: 10.4236/jwarp.2017.97056
Abstract: The environmental protection has become one of the factors that affect and restrict the development of human society. With the continuous development of industry and the rapid increase of urban population, a large number of industrial and domestic sewage discharges into rivers and lakes without treatment, so that the environment and the application of water are seriously polluted. In this paper, the principle and characteristics of PLC(PLC is the abbreviation of Programmable Logic Controller)are introduced; the process of PLC sewage treatment is expounded, and the application of PLC in sewage treatment is described.
Pronominal Anaphor Resolution and the Underlying Cognitive Mechanism  [PDF]
Huijun Tang, Wei Li
Open Journal of Modern Linguistics (OJML) , 2018, DOI: 10.4236/ojml.2018.82002
Abstract: When people tend to refer to a previous mentioned discourse entity, they can use various types of anaphoric expressions, such as pronouns, definite noun phrases, proper names or expressions that are introduced by a lexical modifier or a comparative adjective. Among the different types of anaphoric expressions, pronoun is most common and frequently used which contains only a little information about the referent, while definite expressions contain much richer semantic information. As pronouns contain very little information on their own, they are always ambiguous. The cognitive mechanism that underlies the comprehension of pronouns, especially the ones with ambiguities, catches the interests of many researchers. Various tasks have been used to investigate this issue and the results did not go for the same direction. A combination of multiple research methods is needed for a better and deeper understanding of anaphora.
Protection against H1N1 influenza challenge by a DNA vaccine expressing H3/H1 subtype hemagglutinin combined with MHC class II-restricted epitopes
Lei Tan, Huijun Lu, Dan Zhang, Mingyao Tian, Bo Hu, Zhuoyue Wang, Ningyi Jin
Virology Journal , 2010, DOI: 10.1186/1743-422x-7-363
Abstract: Here we report a multi-epitope DNA vaccine targeted towards multiple subtypes of the influenza virus. The protective hemagglutinin (HA) antigens from H5/H7/H9 subtypes were screened for MHC II class-restricted epitopes overlapping with predicted B cell epitopes. We then constructed a DNA plasmid vaccine, pV-H3-EHA-H1, based on HA antigens from human influenza H3/H1 subtypes combined with the H5/H7/H9 subtype Th/B epitope box.Epitope-specific IFN-γ ELISpot responses were significantly higher in the multi-epitope DNA group than in other vaccine and control groups (P < 0.05). The multi-epitope group significantly enhanced Th2 cell responses as determined by cytokine assays. The survival rate of mice given the multi-epitope vaccine was the highest among the vaccine groups, but it was not significantly different compared to those given single antigen expressing pV-H1HA1 vaccine and dual antigen expressing pV-H3-H1 vaccine (P > 0.05). No measurable virus titers were detected in the lungs of the multi-epitope immunized group. The unique multi-epitope DNA vaccine enhanced virus-specific antibody and cellular immunity as well as conferred complete protection against lethal challenge with A/New Caledonia/20/99 (H1N1) influenza strain in mice.This approach may be a promising strategy for developing a universal influenza vaccine to prevent multiple subtypes of influenza virus and to induce long-term protective immune against cross-species transmission.Over the years, influenza has become a serious public health problem. With the potential for sudden outbreaks, rapid spread, and high incidence of complications, the prevalence of influenza infections has caused tremendous loss of human life and material resources [1,2]. Thus, it is important to develop new approaches towards preventing seasonal infections as well as potential pandemics of influenza.Based on their internal protein antigens, different influenza viruses can be divided into 3 types: A, B, or C. The surface antigens,
Interaction between tetrasulfophthalocyanines and colloidal titanium dioxide and photoelectric behavior on sensitized microporous TiO2 electrodes
Haifang Mao,Hongjian Tian,Qingfu Zhou,Huijun Xu,Yaochun Shen,Zuhong Lu
Chinese Science Bulletin , 1997, DOI: 10.1007/BF02883056
Abstract: Strong interaction between sulfophthalocyanines and TiO2 occur when the former is adsorbed on the colloidal TiO2 surface. Upon excitation, electron transfer from excited singlet state of sulfophthalocyanine to the conduction band of TiO2 occurs, leading to the quenching of sulfophthalocyanine fluorescence. Sensitization of the TiO2 microporous electrode with sulfophthalocyanine extends the photoresponse of the electrode to visible and near IR region as shown by the photocurrent spectra. It is indicated that only monomeric sulfophthalocyanine plays a dominant role in the photoresponse of the electrode, while the sulfophthalocyanine aggregates give less or even no contribution to the conversion of visible light into electricity.
Effect of simvastatin on the atherosclerotic plaque stability and the angiogenesis in the atherosclerotic plaque of rabbits
Lu Zhang,YueRong Jiang,Mei Xue,CaiFeng Wu,JingShang Wang,HuiJun Yin
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0509-4
Abstract: In this study, the effect of simvastatin on the atherosclerotic plaque stability and the angiogenesis in the atherosclerotic plaque of rabbits was observed. Thirty New Zealand rabbits were randomly divided into the normal control group, the model control group and the simvastatin group, 10 in each group. Rabbits in the normal control group were fed with normal forage, while rabbits in the rest two groups were fed with high fat forage. The balloon injury was performed two weeks later to establish an abdominal aortic atherosclerosis model, and then high fat forage was successively fed to them. Meanwhile, simvastatin at the daily dose of 2.5 mg/kg body weight was administered to rabbits in the simvastatin group. After 6 weeks of successive administration, levels of blood lipids were measured after blood sampling, and the serum high sensitivity C-reactive protein (hsCRP) and matrix metalloproteinase-3,-9 (MMP-3,-9) were detected using enzyme-linked immunosorbent assay. The macroscopically pathological indices of the plaque tissue were observed using hematoxylin and eosin (HE) staining of abdominal aorta specimens under a light microscope, and the plaque area (PA), cross-sectional vascular area (CVA) and correcting plaque area (PA/CVA) were determined quantitatively using imaging software. The protein expressions of the vascular endothelial growth factor (VEGF), factor VIII related antigen (FVIIIRAg), MMP-3 and cluster of differentiation antigen 40 ligand (CD40L) in the plaque were detected with the immunohistochemical method. Compared with the model control group, the levels of VEGF, FVIIIRAg, MMP-3, CD40L protein expression and the serum expression levels of hsCRP, MMP-3, MMP-9 in the simvastatin group were significantly reduced (P<0.05, P<0.01). The ratio PA/CVA in the simvastatin group was more significantly reduced when compared with that in the model control group (P<0.01). The levels of serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL) were significantly reduced in the simvastatin group when compared with those in the model control group (P<0.05, P<0.01). Simvastatin plays a certain role in stabilizing the atherosclerotic plaque, and inhibiting the angiogenesis in the atherosclerotic plaque may be one of possible mechanisms.
Abrupt Motion Tracking via Nearest Neighbor Field Driven Stochastic Sampling
Tianfei Zhou,Yao Lu,Feng Lv,Huijun Di,Qingjie Zhao,Jian Zhang
Computer Science , 2014, DOI: 10.1016/j.neucom.2015.03.024
Abstract: Stochastic sampling based trackers have shown good performance for abrupt motion tracking so that they have gained popularity in recent years. However, conventional methods tend to use a two-stage sampling paradigm, in which the search space needs to be uniformly explored with an inefficient preliminary sampling phase. In this paper, we propose a novel sampling-based method in the Bayesian filtering framework to address the problem. Within the framework, nearest neighbor field estimation is utilized to compute the importance proposal probabilities, which guide the Markov chain search towards promising regions and thus enhance the sampling efficiency; given the motion priors, a smoothing stochastic sampling Monte Carlo algorithm is proposed to approximate the posterior distribution through a smoothing weight-updating scheme. Moreover, to track the abrupt and the smooth motions simultaneously, we develop an abrupt-motion detection scheme which can discover the presence of abrupt motions during online tracking. Extensive experiments on challenging image sequences demonstrate the effectiveness and the robustness of our algorithm in handling the abrupt motions.
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