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Search Results: 1 - 10 of 100846 matches for " Hui-Chuan Chen "
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Analysis of Studies from 2000-2010 in Real Option Theory and Application to OM  [PDF]
Hui-Chuan Chen
American Journal of Operations Research (AJOR) , 2011, DOI: 10.4236/ajor.2011.11003
Abstract: Traditional project investment methods, such as the discounted cash flow (DCF) with a fixed static plan, are no longer sufficient to assist the corporate strategies of seizing opportunities and profitability. The option pricing formula includes a theoretical framework for pricing financial options, assuming that the risk in a financial hedged position is zero, if the option is adjusted continuously in a short position. Hence, the real options revolution arose in response to the dissatisfaction of corporation practitioners with traditional capital budgeting techniques, such as standard discount cash flow. This paper analyzes relevant articles from the “Journal of Operations Management” and “Management Sciences” as related to real options theory in the field of operations management. The goal of this study is to review and identify the gaps in application to real option theory in their studies. Finally, this paper provides suggestions for future researchers.
Modeling Knowledge of Mathematics Teaching for Students with Mathematical Learning Difficulties: A Knowledge Management Perspective
Hui-Chuan Chu,Yuh-Min Chen
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
English-for-Science-and-Technology Teaching Materials: Phase One Evaluation
Hui-Chuan Liao,Yeh-uh Hsueh Chen
English Language Teaching , 2012, DOI: 10.5539/elt.v5n6p89
Abstract: The importance of English for the workplace, in addition to that of general English proficiency, is receiving increasing attention from educators and policy makers in the field of teaching English as a foreign language. In order to prepare college students for their professional development, appropriate English-for-specific-purposes (ESP) materials, including those for engineering majors, are needed for college courses. This study evaluated teaching materials on English for Science and Technology (EST), in hope of making contributions to the growth of EST materials that meet the educational needs of students in Taiwan. The EST materials were designed for college engineering majors. In the present study, it was used with two engineering junior classes in Taiwan for three weeks. After the trial teaching period, a questionnaire and a focus group interview were administered to collect learner perception on the EST materials. While the overall results of the questionnaire have indicated a positive attitude toward the materials, a careful examination of the statistics and further exploration of the interview data have revealed certain areas of the materials to be improved. Suggestions to the revision of the materials are provided at the end of the paper.
Ontology-Based Knowledge Integration for Distributed Product Knowledge Service
Yuh-Min Chen,Yuh-Jen Chen,Chiung-Cheng Wen,Hui-Chuan Chu
Lecture Notes in Engineering and Computer Science , 2009,
Abstract:
EL ESTUDIO DE LAS ETAPAS DEL APRENDIZAJE LéXICO BASADO EN EL CATE-CIC
Hui-Chuan Lu
Revista de Lingüística y Lenguas Aplicadas , 2008, DOI: 10.4995/rlyla.2008.687
Abstract: Taking the base of the Corpus of Taiwanese Learners of Spanish, created by Lu, and applying as special analytical instruments, we've tried to study the lexical development of the students learning Spanish as second foreign language. We've focused on the comparison of the combination of words used in different levels of learning in which we proposed a continuum for the degree of learnablity form the easiest to the most difficult as follows VPrep- V/N-Prep-N, V-Conj, V-Adv/V-N, N-Adj, V-Adj, Adj-N, N-V, Det-N. Moreover, we not only derived, in the developmental stages of learning, an order from early stage to late stage exists that comes from the orthographic type to the grammatical and then to lexical types; but we also identified that the semantic meaning appears in a stage later than the vocabulary with regard to the lexical type of the combinative words Taking the base of the Corpus of Taiwanese Learners of Spanish, created by Lu, and applying as special analytical instruments, we've tried to study the lexical development of the students learning Spanish as second foreign language. We've focused on the comparison of the combination of words used in different levels of learning in which we proposed a continuum for the degree of learnablity form the easiest to the most difficult as follows VPrep- V/N-Prep-N, V-Conj, V-Adv/V-N, N-Adj, V-Adj, Adj-N, N-V, Det-N. Moreover, we not only derived, in the developmental stages of learning, an order from early stage to late stage exists that comes from the orthographic type to the grammatical and then to lexical types; but we also identified that the semantic meaning appears in a stage later than the vocabulary with regard to the lexical type of the combinative words
Experimental investigation on partially coherent higher-order non-diffractive beams

Chen Guang-Ming,Hua Li-Min,Lin Hui-Chuan,Pu Ji-Xiong,

中国物理 B , 2011,
Abstract: We experimentally study the generation of a partially coherent non-diffractive beam by focusing a partially coherent vortex beam with an axicon. The investigation results show that when the partially coherent vortex beam is focused by the axicon, the beam is transferred into a partially coherent higher-order non-diffractive beam. In the non-diffractive zone, the transverse intensity distribution of the partially coherent higher-order non-diffractive beam is invariant during propagation. In addition, the range of the non-diffractive zone is related to the coherence of the partially coherent vortex beam. The poorer the coherence of the partially coherent vortex beam, the shorter the range of the non-diffractive zone.
Cancerous Inhibitor of Protein Phosphatase 2A Mediates Bortezomib-Induced Autophagy in Hepatocellular Carcinoma Independent of Proteasome
Hui-Chuan Yu, Duen-Ren Hou, Chun-Yu Liu, Chen-Si Lin, Chung-Wai Shiau, Ann-Lii Cheng, Kuen-Feng Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0055705
Abstract: Previously, we reported that cancerous inhibitor of protein phosphatase 2A (CIP2A) mediates the apoptotic effect of bortezomib in hepatocellular carcinoma (HCC). Here, we report a proteasome-independent mechanism by which bortezomib induces autophagy in HCC. Our data indicate that bortezomib activated autophagy in a dose- and time- dependent manner in HCC cell lines including Huh-7, Sk-Hep1, and Hep3B. Bortezomib downregulated CIP2A, phospho-Akt (P-Akt) and phospho-4EBP1 (P-4EBP1) in a dose- and time-dependent manner in all tested HCC cells. Ectopic expression of CIP2A abolished the effect of bortezomib on autophagy. Co-treatment of bortezomib and calyculin A, a PP2A inhibitor, reduced the effect of bortezomib on P-Akt, P-4EBP1, and autophagy. Increased phosphorylation of either Akt or 4EBP1 by ectopic overexpression protected cells from bortezomib-induced autophagy. Furthermore, we examined the effect of ΔBtz, a bortezomib derivative that closely resembles bortezomib structurally but has no proteasome activity, in HCC. Interestingly, ΔBtz demonstrated similar effects to bortezomib on autophagy, CIP2A, P-Akt and P-4EBP1, suggesting that the effect of bortezomib on autophagy is independent of proteasome inhibition. Moreover, our in vivo data showed that both bortezomib and ΔBtz inhibited tumor growth, downregulated CIP2A, P-Akt and induced autophagy in Huh-7 tumors. In conclusion, bortezomib induces autophagy in HCC through a CIP2A-PP2A-Akt-4EBP1 pathway.
Bortezomib Congeners Induce Apoptosis of Hepatocellular Carcinoma via CIP2A Inhibition
Duen-Ren Hou,Ann-Chi Huang,Chung-Wai Shiau,Chun-Yi Wang,Hui-Chuan Yu,Kuen-Feng Chen
Molecules , 2013, DOI: 10.3390/molecules181215398
Abstract: CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation and survival. The proteasome inhibitor bortezomib has been shown to reduce CIP2A and lead to cell apoptosis. Here; we modified the functional group of bortezomib to generate a series of novel compounds and conducted a structure–activity relationship ( SAR) study. The results showed that compound 1 was able to repress CIP2A expression and cell apoptosis in the same manner as bortezomib, but with less potency in inhibition of proteasome activity. This finding provides a new direction for the design of CIP2A inhibitors.
The Frizzled family: receptors for multiple signal transduction pathways
Hui-Chuan Huang, Peter S Klein
Genome Biology , 2004, DOI: 10.1186/gb-2004-5-7-234
Abstract: The frizzled genes were first identified in Drosophila in a screen for mutations that disrupt the polarity of epidermal cells in the adult fly [1]. Subsequently, frizzleds have been found in diverse metazoans [2], including at least ten in vertebrates, four in Drosophila, and three in Caenorhabditis elegans. Frizzleds have also been identified in primitive metazoans, including the sponge Suberites domuncula [3] and in Hydra vulgaris [4], but they have not been described in protozoans. They have been shown to encode receptors for Wnt proteins [5]. The smoothened (smo) gene, which functions in the Hedgehog signaling pathway in various developmental processes, is distantly related to frizzled genes. Additional information on the Wnt pathway can be found on the Wnt gene homepage [6] and in various comprehensive reviews [1,7-9].Sequence analysis suggests that the ten human frizzled (FZD) genes fall into four main clusters [10]. FZD1, FZD2, and FZD7 share approximately 75% identity; FZD5 and FZD8 share 70% identity; FZD4, FZD9, and FZD10 share 65% identity; and FZD3 and FZD6 share 50% amino acid identity [10]. Frizzled genes from different clusters share between 20% and 40% sequence similarity. A dendrogram of human and selected invertebrate frizzled genes is shown in Figure 1. The overall genomic organization of frizzled genes does not appear to be highly conserved across this broad species diversity. Several frizzled genes appear to lack introns, however, including vertebrate orthologs of human FZD1, FZD2, and FZD7 to FZD10 (this is also a feature of many G-protein-coupled receptor (GPCR) genes); other frizzled genes, such as human FZD5 and Drosophila frizzled2 (Dfz2), contain one intron but the entire open reading frame is encoded by a single exon. Interestingly, the intron-deficient frizzled genes appear to be derived from a common ancestor, as they cluster into a subfamily that includes Dfz2 (Figure 1).Frizzled proteins range in length from about 500 to 700 amino aci
ESTUDIO DEL USO DEL ARTíCULO A PARTIR DE UN CORPUS PARALELO DE APRENDICES, CPATEI
Lu Hui-Chuan,Lu Lo Hsueh
Revista de Lingüística y Lenguas Aplicadas , 2012, DOI: 10.4995/rlyla.2012.1135
Abstract: El principal objetivo de nuestro trabajo es averiguar los usos del articulo por parte de alumnos taiwaneses que estudian espanol como segunda lengua extranjera e ingles como primera lengua extranjera, aplicando herramientas de corpus desarrolladas para facilitar la eficacia en el analisis sistematico del lenguaje. El presente estudio se basa en datos extraidos del Corpus Paralelo de Aprendices Taiwaneses de Espanol e Ingles (CPATEI) que construimos desde 2006. Basandonos en los estudios previos, utilizamos varias herramientas auxiliares con la intencion de facilitar, semi-automaticamente, la anotacion y el procesamiento de los usos del articulo. Ademas, examinamos errores como el uso excesivo, insuficiente e inapropiado del articulo, asi como las caracteristicas de los participantes. Tambien nos dedicamos a contrastar los datos, tanto de aprendices como de nativos. Esperamos que los resultados de la investigacion puedan proporcionar referencias utiles para el desarrollo de estrategias didacticas en el aprendizaje del espanol como lengua extranjera.
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