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Search Results: 1 - 10 of 33726 matches for " Hui-Chi Lai "
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Hui-Chi Lee
Taiwan Journal of Linguistics , 2009,
Abstract: Taiwan Southern Min ka and hoo have been broadly investigated in the literature (e.g., Cheng et al. 1999, Lien 2002, Tsao 2005). However, very little of the previous research has focused on the interaction between these two functional words. This paper thus explores structures with a ka…hoo configuration. Through the examination of corpus data, this paper finds that ka…hoo constructions are mainly separated into two constructions: ditransitive and resultative constructions. Based on the constructional approach, the ditransitive construction is found to include four construction patterns which can help differentiate verb types. In addition, the event structure account of the resultative ka…hoo construction is explored. It is posited that the event telicity may change when the causative word hoo overtly occurs. The distinction between a ditransitive and a resultative ka…hoo construction significantly reduces the confusion in data where the ka…hoo configuration is found.
China’s Energy Diplomacy: SOE Relations in the Context of Global Distribution and Investment Pattern  [PDF]
Hui-Chi Yeh, Chi-Wei Yu
Advances in Applied Sociology (AASoci) , 2012, DOI: 10.4236/aasoci.2012.24043
Abstract: This article addresses the mercantilist connotations of China’s energy diplomacy through empirical and quantitative approaches by arguing that: firstly, the economic logic motivating Chinese enterprises is not the key variable in the formulation of foreign investment decisions; secondly, the energy security policies of the Chinese government are key variables which decide the distribution of SOEs’ foreign investment; thirdly, China’s energy diplomacy is mercantilist in nature due to the weakness of its SOEs in the structure of the international market; finally, under the premise of satisfying its government’s energy security policy, SOEs have autonomy in their approaches to investment. Therefore, it may be reasoned that under specific conditions, mercantilism and liberalism can both explain China’s energy diplomacy. This article provides compelling evidence supporting this reasoning, through analyzing cases studies in the Middle East, Central Asia and Africa.
Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells
Hui-Chi Lai, Ming-Jiuan Wu, Pei-Yi Chen, Ting-Ting Sheu, Szu-Ping Chiu, Meng-Han Lin, Chi-Tang Ho, Jui-Hung Yen
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0028280
Abstract: 5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavo?ne(5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and mechanism of 5-OH-HxMF in PC12 pheochromocytoma cells. We found that 5-OH-HxMF can effectively induce PC12 neurite outgrowth accompanied with the expression of neuronal differentiation marker protein growth-associated protein-43(GAP-43). 5-OH-HxMF caused the enhancement of cyclic AMP response element binding protein (CREB) phosphorylation, c-fos gene expression and CRE-mediated transcription, which was inhibited by 2-naphthol AS-E phosphate (KG-501), a specific antagonist for the CREB-CBP complex formation. Moreover, 5-OH-HxMF-induced both CRE transcription activity and neurite outgrowth were inhibited by adenylate cyclase and protein kinase A (PKA) inhibitor, but not MEK1/2, protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3K) or calcium/calmodulin-dependent protein kinase (CaMK) inhibitor. Consistently, 5-OH-HxMF treatment increased the intracellular cAMP level and downstream component, PKA activity. We also found that addition of K252a, a TrKA antagonist, significantly inhibited NGF- but not 5-OH-HxMF-induced neurite outgrowth. These results reveal for the first time that 5-OH-HxMF is an effective neurotrophic agent and its effect is mainly through a cAMP/PKA-dependent, but TrKA-independent, signaling pathway coupling with CRE-mediated gene transcription. A PKC-dependent and CREB-independent pathway was also involved in its neurotrophic action.
Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer's disease
Hui-Chi Cheng, Yu Sun, Liang-Chuan Lai, Shih-Yuan Chen, Wen-Chung Lee, Jen-Hau Chen, Ta-Fu Chen, Hua-Hsiang Chen, Li-Li Wen, Ping-Keung Yip, Yi-Min Chu, Wei J Chen, Yen-Ching Chen
Journal of Negative Results in BioMedicine , 2012, DOI: 10.1186/1477-5751-11-5
Abstract: This was a case-control study in a Chinese population. A total of 264 AD patients were recruited from three teaching hospitals between 2007 to 2010; 389 controls were recruited from elderly health checkup and volunteers of the hospital during the same period of time. Five common (frequency≥5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) were selected from NGFR to test the association between NGFR htSNPs and the risk of AD.Variant NGFR rs734194 was significantly associated with a decreased risk of AD [GG vs. TT copies: adjusted odds ratio (OR) = 0.43, 95% confidence interval (CI) = 0.20-0.95]. Seven common haplotypes were identified. Minor haplotype GCGCG was significantly associated with a decreased risk of AD (2 vs. 0 copies: adjusted OR = 0.39, 95% CI = 0.17-0.91). Type 2 DM significantly modified the association between rs2072446, rs741072, and haplotype GCTTG and GTTCG on the risk of AD among ApoE ε4 non-carriers (Pinteraction < 0.05).Inherited polymorphisms of NGFR were associated with the risk of AD; results were not significant after correction for multiple tests. This association was further modified by the status of type 2 DM.Dementia is a degenerative brain syndrome characterized by decline or loss in cognitive function [1]. About 30 million elders suffered from dementia worldwide in 2008 estimated by Alzheimer's Disease International. Alzheimer's disease (AD) is the most common causes of dementia and was the fifth leading cause of death for those aged 65 or older in the United States in 2006 [1]. In Taiwan, more than 160,000 people were demented in 2009 [2] and the number of AD patients keeps raising in many aging populations.Degeneration of basal forebrain cholinergic neurons (BFCN) has shown to modulate cognitive function in AD patients [3,4]. Nerve growth factor receptor (NGFR, also called p75NTR) is one of the receptors of NGF and is expressed at the end of cholinergic axon [5,6]. The gene encoding NGFR is located on chromosome 17q21-q2
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization
Kuo-Jang Kao, Kai-Ming Chang, Hui-Chi Hsu, Andrew T Huang
BMC Cancer , 2011, DOI: 10.1186/1471-2407-11-143
Abstract: Gene expression profiling was conducted on fresh frozen breast cancer tissue collected from 327 patients in conjunction with thoroughly documented clinical data. A method of molecular subtyping based on 783 probe-sets was established and validated. Statistical analysis was performed to correlate molecular subtypes with survival outcome and adjuvant chemotherapy regimens. Heterogeneity of molecular subtypes within groups sharing the same distant recurrence risk predicted by genes of the Oncotype and MammaPrint predictors was studied.We identified six molecular subtypes of breast cancer demonstrating distinctive molecular and clinical characteristics. These six subtypes showed similarities and significant differences from the Perou-S?rlie intrinsic types. Subtype I breast cancer was in concordance with chemosensitive basal-like intrinsic type. Adjuvant chemotherapy of lower intensity with CMF yielded survival outcome similar to those of CAF in this subtype. Subtype IV breast cancer was positive for ER with a full-range expression of HER2, responding poorly to CMF; however, this subtype showed excellent survival when treated with CAF. Reduced expression of a gene associated with methotrexate sensitivity in subtype IV was the likely reason for poor response to methotrexate. All subtype V breast cancer was positive for ER and had excellent long-term survival with hormonal therapy alone following surgery and/or radiation therapy. Adjuvant chemotherapy did not provide any survival benefit in early stages of subtype V patients. Subtype V was consistent with a unique subset of luminal A intrinsic type. When molecular subtypes were correlated with recurrence risk predicted by genes of Oncotype and MammaPrint predictors, a significant degree of heterogeneity within the same risk group was noted. This heterogeneity was distributed over several subtypes, suggesting that patients in the same risk groups require different treatment approaches.Our results indicate that the molecula
Modeling Truncated AR Expression in a Natural Androgen Responsive Environment and Identification of RHOB as a Direct Transcriptional Target
Hui-Chi Tsai, David L. Boucher, Anthony Martinez, Clifford G. Tepper, Hsing-Jien Kung
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0049887
Abstract: Recent studies identifying putative truncated androgen receptor isoforms with ligand-independent activity have shed new light on the acquisition of androgen depletion independent (ADI) growth of prostate cancer. In this study, we present a model system in which a C-terminally truncated variant of androgen receptor (TC-AR) is inducibly expressed in LNCaP, an androgen-dependent cell line, which expresses little truncated receptor. We observed that when TC-AR is overexpressed, the endogenous full length receptor (FL-AR) is transcriptionally downmodulated. This in essence allows us to “replace” FL-AR with TC-AR and compare their individual properties in exactly the same genetic and cellular background, which has not been performed before. We show that the TC-AR translocates to the nucleus, activates transcription of AR target genes in the absence of DHT and is sufficient to confer ADI growth to the normally androgen dependent LNCaP line. We also show that while there is significant overlap in the genes regulated by FL- and TC-AR there are also differences in the respective suites of target genes with each AR form regulating genes that the other does not. Among the genes uniquely activated by TC-AR is RHOB which is shown to be involved in the increased migration and morphological changes observed in LN/TC-AR, suggesting a role of RHOB in the regulation of androgen-independent behavior of prostate cancer cells.
A Dual-Mode Aperature-Coupled Stack Antenna for WLAN Dual-Band and Circular Polarization Applications
Ji-Chyun Liu;Bing-Hao Zeng;Chin-Yen Liu;Hui-Chi Wu;Chung-Chi Chang
PIER C , 2010, DOI: 10.2528/PIERC10100902
Abstract: A compact stack antenna consisting of square loop resonators, aperture couples, feed line and the perturbation for dual-band and circular polarization (CP) applications is proposed in this paper. This perturbation applies both dual-mode and orthogonal mode effects existing in the square loop resonator to present wide-band and CP characteristics simultaneously. The stack antenna presents the desired bands of 2.46 GHz with bandwidth (BW) = 160 MHz (6.58%) and 5.28 GHz with BW = 450 MHz (8.52%). The circular polarizations for dual-band are demonstrated with axial ratio (AR) spectrum and orthogonal modes. The proposed antenna is successfully simulated and measured with frequency responses, radiation patterns and current distributions.
CPW-FED Sleeve Monopole Antenna with Complementary Sir Radiators for Dtv Signal Reception and Circularly Polarized Applications
Ji-Chyun Liu;Ssu-Hung Chiu;Kuan-Dih Yeh;Bing-Hao Zeng;Hui-Chi Wu;Tian-Fu Hung
PIER C , 2010, DOI: 10.2528/PIERC10042703
Abstract: A new circularly-polarized (CP) sleeve antenna fed by a CPW for DTV signal reception applications is presented in this paper. The CPW-fed sleeve monopole antenna consists of square loop sleeve, CPW-fed and complementary SIR radiators. The lower and upper resonance frequencies of the desired band are controlled by the complementary SIR arms, making designs of the wide-band antenna very easy. To demonstrate the idea, the proposed antenna was designed at the band with 470-863 GHz (BW=393 MHz, 58.9%) for DTV UHF-bands. The antenna gains are varied about 2.2 to 4.0 dBi. An omnidirectional radiation property is also shown. The CP operation for the proposed design can be achieved by properly adjusting the asymmetrical radiators. The reflection coefficient, axial ratio, radiation pattern and gain of the proposed antenna were studied, and reasonable agreement between the simulated and measured results was obtained.
Cytotoxic Phenylpropanoids and a New Triterpene, Turformosinic Acid, from Turpinia formosana Nakai
Hui-Chi Huang,Chun-Tang Chiou,Ping-Chun Hsiao,Chia-Ching Liaw,Li-Jie Zhang,Chao-Lin Chang,Ih-Sheng Chen,Wen-Chi Chen,Kuo-Hsiung Lee,Yao-Haur Kuo
Molecules , 2012, DOI: 10.3390/molecules17021837
Abstract: One new phenylpropanoid, turformosin A (1), and one new triterpene, turformosinic acid (2), together with 16 known compounds, were isolated from the stems of Turpinia formosana Nakai. All structures were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR techniques and MS analysis. Selected isolated compounds were evaluated for in vitro cytotoxicity against four human cancer cell lines and antioxidant scavenging effects on DPPH. (?)-(7′S,8′S)-threo-carolignan X (3) exhibited cytotoxicity against Hep2, WiDr, Daoy, and MCF-7 cell lines with ED50 values of 3.60, 4.45, 6.07, and 13.7 μg/mL, respectively. Turformosin A (1), (?)-(7′S,8′S)- threo-carolignan X (3), methoxyhydroquinone-4-β-d-glucopyranoside (5), and methoxy-hydroquinone-1-β-d-glucopyranoside (6), exhibited similar anti-oxidative activity. Hep2 cells treated with 10 μg/mL of 3 showed elevation of sub-G1 population (from 20% at 8 h to 60% at 48 h), and activation of caspase-9/caspase-3/PARP cascade. Compound 3 induced intrinsic apoptotic pathway in Hep2 cells with dose and time dependence (10 μg/mL for 8 h).
A New Butanolide Compound from the Aerial Part of Lindera akoensis with Anti-inflammatory Activity
Chung-Ping Yang,Guan-Jhong Huang,Hui-Chi Huang,Yu-Chang Chen,Chi-I Chang,Sheng-Yang Wang,Ih-Sheng Chen,Yen-Hsueh Tseng,Shih-Chang Chien,Yueh-Hsiung Kuo
Molecules , 2012, DOI: 10.3390/molecules17066585
Abstract: A new butanolide, 3b-((E)-dodec-1-enyl)-4b-hydroxy-5b-methyldihydrofuran-2-one (1) and four known butanolides: Akolactone A (2), (3Z,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (3), (3E,4a,5b)-3-(dodec-11-enylidene)-4-hydroxy-5-methylbutalactone (4) and dihydroisoobtusilactone (5), were isolated from the aerial parts of Lindera akoensis. These butanolides showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitrite in RAW264.7 cell, with IC50 values of 1.4–179.9 mM.
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