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Search Results: 1 - 10 of 29200 matches for " Huei-Jane Lee "
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Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2/M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway
Ting-Tsz Ou,Chau-Jong Wang,Guang-Uei Hung,Cheng-Hsun Wu,Huei-Jane Lee
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep016
Abstract: Shi-Liu-Wei-Liu-Qi-Yin (SLWLQY) was traditionally used to treat cancers. However, scientific evidence of the anticancer effects still remains undefined. In this study, we aimed to clarify the possible mechanisms of SLWLQY in treating cancer. We evaluated the effects of SLWLQY on apoptosis-related experiments inducing in TSGH-8301 cells by (i) 3-(4,5-dimethylthiazol-zyl)-2,5-diphenylterazolium bromide (MTT) for cytotoxicity; (ii) cell-cycle analysis and (iii) western blot analysis of the G2/M-phase and apoptosis regulatory proteins. Human bladder carcinoma TSGH-8301 cells were transplanted into BALB/c nude mice as a tumor model for evaluating the antitumor effect of SLWLQY. Treatment of SLWLQY resulted in the G2/M phase arrest and apoptotic death in a dose-dependent manner, accompanied by a decrease in cyclin-dependent kinases (cdc2) and cyclins (cyclin B1). SLWLQY stimulated increases in the protein expression of Fas and FasL, and induced the cleavage of caspase-3, caspase-9 and caspase-8. The ratio of Bax/Bcl2 was increased by SLWLQY treatment. SLWLQY markedly reduced tumor size in TSGH-8301 cells-xenografted tumor tissues. In the tissue specimen, SLWLQY up-regulated the expression of Fas, FasL and Bax proteins, and down-regulated Bcl2 as well as in in vitro assay. Our results showed that SLWLQY reduced tumor growth, caused cell-cycle arrest and apoptosis in TSGH-8301 cells via the Fas and mitochondrial pathway.
Aqueous Extract from Hibiscus sabdariffa Linnaeus Ameliorate Diabetic Nephropathy via Regulating Oxidative Status and Akt/Bad/14-3-3γ in an Experimental Animal Model
Shou-Chieh Wang,Shiow-Fen Lee,Chau-Jong Wang,Chao-Hsin Lee,Wen-Chin Lee,Huei-Jane Lee
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1093/ecam/nep181
Abstract: Several studies point out that oxidative stress maybe a major culprit in diabetic nephropathy. Aqueous extract of Hibiscus sabdariffa L. (HSE) has been demonstrated as having beneficial effects on anti-oxidation and lipid-lowering in experimental studies. This study aimed at investigating the effects of Hibiscus sabdariffa L. on diabetic nephropathy in streptozotocin induced type 1 diabetic rats. Our results show that HSE is capable of reducing lipid peroxidation, increasing catalase and glutathione activities significantly in diabetic kidney, and decreasing the plasma levels of triglyceride, low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL) value. In histological examination, HSE improves hyperglycemia-caused osmotic diuresis in renal proximal convoluted tubules (defined as hydropic change) in diabetic rats. The study also reveals that up-regulation of Akt/Bad/14-3-3γ and NF-κB-mediated transcription might be involved. In conclusion, our results show that HSE possesses the potential effects to ameliorate diabetic nephropathy via improving oxidative status and regulating Akt/Bad/14-3-3γ signaling.
Quantitative Flow Relaxographic Angiography  [PDF]
Jing-Huei Lee
Open Journal of Radiology (OJRad) , 2012, DOI: 10.4236/ojrad.2012.21006
Abstract: A powerful method, termed flow relaxography, allowing the practical and accurate determination of the water proton MR signal relaxation time distributions has been recently introduced with a phantom, having both flowing and non-flowing water. It was demonstrated that this method can discriminate the signals from the flowing and non-flowing spins, since flow affects the apparent T1 (T1*) value. In this report, it is demonstrated that this technique is effective also in the human leg in vivo. Flow relaxographic angiography is presented for the first time. This technique promises to accomplish the twin goals of flow studies in medical MRI, to display vascular anatomy and measure its blood flow rate, in the same image.
Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes
Wei-Jern Tsai, Chu-Ting Chang, Guei-Jane Wang, Tzong-Huei Lee, Shwu-Fen Chang, Shao-Chun Lu, Yuh-Chi Kuo
Chinese Medicine , 2011, DOI: 10.1186/1749-8546-6-12
Abstract: Cell proliferation was determined with enzyme immunoassays and the tritiated thymidine uptake method. Cytokine production and gene expression were analyzed with reverse transcription-polymerase chain reaction.AC inhibited primary human T lymphocytes proliferation activated by anti-CD3/CD28 Ab. Cell viability test indicated that the inhibitory effects of AC on primary human T lymphocyte proliferation were not due to direct cytotoxicity. AC suppressed interleukin-2 (IL-2) and interferon-γ (IFN-γ) production in a concentration-dependent manner. Furthermore, AC decreased the IL-2 and IFN-γ gene expression in primary human T lymphocytes induced by anti-CD3/CD28 Ab. Reporter gene analyses revealed that AC decreased NF-AT-mediated reporter gene expression.AC inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-γ and NF-AT.The central event in the generation of immune responses is the activation and clonal expansion of T cells. Interaction of T cells with antigens initiates a cascade of biochemical events and gene expression that induces the resting T cells to activate and proliferate [1]. Activation of nuclear factor of activated T cells (NF-AT) and a series of genes such as interleukin-2 (IL-2) and interferon-γ (IFN-γ) are pivotal in the growth of T lymphocytes induced by antigens [2,3]. Thus, growth modulators or other external events affecting T cell proliferation are likely to act by controlling the expression or function of the products of these genes [4]. The immune responses to invasive organisms, if inappropriately intense or prolonged, may paradoxically aggravate the injury or even cause death. The use of immunomodulatory medications must therefore be discreet. Regulation of T lymphocyte activation and proliferation and cytokine production is one of the action mechanisms [5,6].Chinese medicinal herbs are now widely acknowledged for their immunomodulatory activities [1]. A member of the Compositae family, Arctium lappa (Niubang) is re
On Improving Replenishment Lot Size of an Integrated Manufacturing System with Discontinuous Issuing Policy and Imperfect Rework  [PDF]
Ting J. Lee, Singa W. Chiu, Huei H. Chang
American Journal of Industrial and Business Management (AJIBM) , 2011, DOI: 10.4236/ajibm.2011.11003
Abstract: This paper proposes a cost reduction distribution policy for an integrated manufacturing system operating under quality assurance practice. We reexamine the problem studied by Chiu et al. [Numerical method for determination of the optimal lot size for a manufacturing system with discontinuous issuing policy and rework. International Journal for Numerical Methods in Biomedical Engineering, doi:10.1002/cnm.1369] and improve its replenishment lot-size solution in terms of lowering producer’s stock holding cost. Mathematical modeling and analysis is employed in this study and optimal replenishment lot size is derived. A numerical example is provided to show the practical usage of research result as well as to demonstrate significant savings in producer’s holding cost as compared to that in Chiu et al.
Don’t burn the baby: Advice from Australian nurses recommending therapeutic sun exposure during infancy  [PDF]
Simone Lee Harrison, Jane Nikles, Madeleine Nowak
Open Journal of Preventive Medicine (OJPM) , 2013, DOI: 10.4236/ojpm.2013.32029
Abstract:

Background: Previous studies have demonstrated inappropriate advice from health profes- sionals advocating therapeutic sun exposure during infancy and the post-partum period. This study examines the proportion of Australian midwives and related hospital nursing staff who recommend therapeutic sun exposure during this period. Methods: Questionnaires were completed by 363 Australian nurses (57.2% response) responsible for nursing post-partum women in 11 maternity hospitals in Queensland (QLD) and the Australian Capital Territory (ACT). Results: Many nurses believed sun exposure was beneficial in treating: cracked nipples (QLD 41.3%, ACT 65.8%; p < 0.001), neonatal jaundice (QLD 49.6%, ACT 75.3%; p < 0.001), nappy rash (QLD 23.2%, ACT 30.3%; p = 0.207) and acne (QLD 12.3%, ACT 16.9%; p = 0.291) and made recommendations consistent with their beliefs. Relatively few nurses stipulated sunning through glass or specified exposure time limits. Nursing staff from public hospitals in QLD, but not the ACT, were more likely than nurses from private hospitals to hold one or more such beliefs (p = 0.008). Approximately 40% of respondents thought people generally looked healthier with a suntan; 79% of this group also held one or more risky beliefs about therapeutic sun exposure (p = 0.043). Conclusion: A high proportion of these nurses held risky beliefs about the beneficial uses of sunlight for post-partum women and their infants and made recommendations consistent with their beliefs. Professional education is needed to change the beliefs and practices of nursing staff about intentional sun exposure of women and their babies to reduce

Mitochondrial DNA Instability and Metabolic Shift in Human Cancers
Hsin-Chen Lee,Yau-Huei Wei
International Journal of Molecular Sciences , 2009, DOI: 10.3390/ijms10020674
Abstract: A shift in glucose metabolism from oxidative phosphorylation to glycolysis is one of the biochemical hallmarks of tumor cells. Mitochondrial defects have been proposed to play an important role in the initiation and/or progression of various types of cancer. In the past decade, a wide spectrum of mutations and depletion of mtDNA have been identified in human cancers. Moreover, it has been demonstrated that activation of oncogenes or mutation of tumor suppressor genes, such as p53, can lead to the upregulation of glycolytic enzymes or inhibition of the biogenesis or assembly of respiratory enzyme complexes such as cytochrome c oxidase. These findings may explain, at least in part, the well documented phenomena of elevated glucose uptake and mitochondrial defects in cancers. In this article, we review the somatic mtDNA alterations with clinicopathological correlations in human cancers, and their potential roles in tumorigenesis, cancer progression, and metastasis. The signaling pathways involved in the shift from aerobic metabolism to glycolysis in human cancers are also discussed.
Massive pontine hemorrhagic transformation associated with an anticoagulant for basilar artery occlusion
Hsiao Ming-Chang,Lee Jiann-Der,Lee Meng,Weng Hsu-Huei
Neurology India , 2006,
Abstract: Symptomatic hemorrhagic transformation is common in supratentorial and cerebellar infarction, but is rare in brainstem infarction. It is seldom reported in basilar artery occlusion. Although early arterial recanalization by thrombolytic agent has became the new trend of treatment, for some neurologists anticoagulant is still a conventional alternative treatment of basilar artery occlusion, especially in longer-existing ischemic deficits. We report a case of massive pontine hemorrhage associated with enoxaparin (low-molecular-weight heparin) treatment for basilar artery occlusion. On the basis of the clinical information and neuroimaging, an embolism was the most likely cause of stroke. The case presented herein adds massive pontine hemorrhagic transformation to the list of possible complications of anticoagulants for basilar artery occlusion. Apart from no evidence-based benefit in treatment of basilar artery occlusion, anticoagulant may contribute to devastating hemorrhagic transformation.
Decentralized Policy in Resolving Environmental Disputes with Private Information  [PDF]
Huei-Chin Lin
Theoretical Economics Letters (TEL) , 2011, DOI: 10.4236/tel.2011.12006
Abstract: We have design a private-information game to incorporate independent experts’ assistance. With the better information provided by experts, the mistrust of the uninformed party might be dissolved. And we may get an effective and efficient resolution outcome. We will investigate conditions under which the experts’ information may help the economy to get an efficient outcome or an effective resolution result.
The Economic Challenge and Opportunity of Sport Industry in Taiwan  [PDF]
Huei-Fu Lu
Modern Economy (ME) , 2012, DOI: 10.4236/me.2012.31007
Abstract: Heavily influenced by the development of globalized sport, the sport industry in Taiwan faced a tremendous growth and challenge in recent years. The purpose of this article is to describe and analyze the current market environment and development trends in Taiwan, and the challenges and opportunities for future development are also introduced. The short communication is solely based on the official reports, industry experience and practical observation to explain the current performance of Taiwan’s sport industry.
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