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Search Results: 1 - 10 of 180847 matches for " Huaping Xu;Jing Gao;Jianlong Li "
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A Variable Prf Imaging Method for High Squint Diving SAR
Huaping Xu;Jing Gao;Jianlong Li
PIER , 2013, DOI: 10.2528/PIER12112304
Abstract: The high squint diving SAR is widely used to provide the information in advance. Large squint angle deduces the deeper coupling of range and azimuth of SAR echoes which makes SAR imaging more difficult. Especially, the large range migration of the deep couple heavily burdens the imaging processing time and storage units. The diving motion of platform worsens the situation. This paper proposes the varied azimuth sample frequency (Pulse Repeat Frequency, PRF) to implement the high squint diving SAR imaging. Based on the signal model of the diving squint SAR, it is analyzed that the range walk is the prominent component of range migration in the high squint SAR. The varied PRF imaging method dramatically decreases the range walk of echoes by shifting the beginning position of transmitted pulses and received echoes and the shift is implemented by the PRF variation. Then the range migration is decreased and the couple of range and azimuth of SAR echoes is reduced. The PRF variation law is deduced and the applicable condition of varied PRF is presented. The simulation results show that the variable PRF method is efficient to reduce range walk of echoes. Comparison to the traditional constant PRF, the novel variable PRF method for high squint needs less storage and less time expense, which is helpful to real time SAR imaging. The non-uniform FFT can be used for the azimuth compressing of the variable PRF SAR. It will simplify the implementation of the variable PRF SAR imaging.
Smear-Negative Multidrug-Resistant Tuberculosis a Significance Hidden Problem for MDR-TB Control: An Analysis of Real World Data  [PDF]
Jingming Liu, Wei Wang, Jing Xu, Mengqiu Gao, Chuanyou Li
Journal of Tuberculosis Research (JTR) , 2014, DOI: 10.4236/jtr.2014.22011
Abstract: Purpose: The drug resistance pattern in tuberculosis (TB) is still under investigated. We analyzed the clinical data from the patients with smear positive TB and applied the model to predict the patients with smear-positive TB. Materials and Methods: Medical records information of 6977 cases was included from 11,950 inpatients from January 2009 to November 2013. The cases data were divided into a training set, test set and prediction set. Logistic regression analysis was applied to the training set data to establish a prediction classification model, the effect of which was then evaluated using the test set by receiver operating characteristic (ROC) analysis. The model was then applied to the prediction set to identify incidence of snMDR-TB. Results: Sixteen factors which correlate with MDR-TB-including frequency of hospitalization, province of origin, anti-TB drugs, and complications, were identified from the comparison between SP-TB and spMDR-TB. The area under the ROC curve (AUC) of the prediction model was 0.752 (sensitivity = 61.3%, specificity = 83.3%). The percentage of all inpatients with snMDR-TB (snMDR-TB/Total) was 28.7% ± 0.02%, while that of all SN-PTB with snMDR-TB (snMDR-TB/SN-PTB) was 26.5% ± 0.03%. The ratio of snMDR-TB to MDR-TB (snMDR-TB/MDR-TB) was 2.09 ± 0.33. Conclusion: snMDR-TB as an important source of MDR-TB is a significant hidden problem for MDR-TB control and can be identified by the prediction model. A kind of vicious circle with a certain delay effect exists between snMDR-TB and MDR-TB. To better control MDR-TB, it is necessary to pay greater attention to snMDR-TB, conduct further research and develop targeted therapeutic strategies.
Bisphenol AF-Induced Endogenous Transcription Is Mediated by ERα and ERK1/2 Activation in Human Breast Cancer Cells
Ming Li, Jing Guo, Wenhui Gao, Jianlong Yu, Xiaoyu Han, Jing Zhang, Bing Shao
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0094725
Abstract: Bisphenol AF (BPAF)-induced transcriptional activity has been evaluated by luciferase reporter assay. However, the molecular mechanism of BPAF-induced endogenous transcription in human breast cancer cells has not been fully elucidated. In the present study, we investigated the effect and mechanism of BPAF-induced endogenous transcription detected by real-time PCR in human breast cancer cells. We found that BPAF stimulated transcription of estrogen responsive genes, such as trefoil factor 1 (TFF1), growth regulation by estrogen in breast cancer 1 (GREB1) and cathepsin D (CTSD), through dose-dependent and time-dependent manners in T47D and MCF7 cells. Gene-silencing of ERα, ERβ and G protein-coupled estrogen receptor 1 (GPER) by small interfering RNA revealed that BPAF-induced endogenous transcription was dependent on ERα and GPER, implying both genomic and nongenomic pathways might be involved in the endogenous transcription induced by BPAF. ERα-mediated gene transcription was further confirmed by inhibition of ER activity using ICI 182780 in ERα-positive T47D and MCF7 cells as well as overexpression of ERα in ERα-negative MDA-MB-231 breast cancer cells. Moreover, we utilized Src tyrosine kinase inhibitor PP2 and two MEK inhibitors PD98059 and U0126 to elucidate the rapid nongenomic activation of Src/MEK/ERK1/2 cascade on endogenous transcription. Our data showed that BPAF-induced transcription could be significantly blocked by PP2, PD98059 and U0126, suggesting activation of ERK1/2 was also required to regulate endogenous transcription. Taken together, these results indicate that BPAF-induced endogenous transcription of estrogen responsive genes is mediated through both genomic and nongenomic pathways involving the ERα and ERK1/2 activation in human breast cancer cells.
A Novel Estimation Approach of Dynamic and Coupling Baseline for Distributed Satellite SAR
Liang Feng;Huaping Xu;Chun-Sheng Li;Shuang Li;Han Gao
PIER , 2012, DOI: 10.2528/PIER11083105
Abstract: In distributed satellite synthetic aperture radar (DS-SAR), along-track and cross-track baselines couple with each other and change dynamically due to formation flying, which makes it difficult to estimate interferometric baseline accurately. To solve the problem, a novel high-precision baseline estimation approach based on interferometric phase is proposed. By modeling accurate relationship between coupling baselines and two-dimensional (azimuth and range) inteferometric fringe frequency under the ellipsoid earth model, the along-track and cross-track baseline can be estimated separately by interferometric phase decoupling. By selecting several segments from interferometric phase during the whole data-take time and estimating instantaneous baseline of each segment, the dynamic baseline can be obtained via a linear filtering. Besides, to improve the baseline estimation accuracy, Semi-Newton iterative method is applied to acquire high-precision fringe frequency estimation, which can make the baseline estimation achieve centimeter level precision. The simulation validates the approach.
2-(4,6-Dimethylpyrimidin-2-ylsulfanyl)-N-(4-methylpyridin-2-yl)acetamide
Dong Liang,Li-Xing Gao,Yan Gao,Jing Xu
Acta Crystallographica Section E , 2008, DOI: 10.1107/s1600536807064082
Abstract: The non-H atoms of the title molecule, C14H16N4OS, are coplanar, with an r.m.s. deviation of 0.039 . The dihedral angle between the two aromatic rings is 2.4 (2)°. An intramolecular C—H...O hydrogen bond is observed. The molecules exist as N—H...N hydrogen-bonded centrosymmetric dimers.
The Genomes of Oryza sativa: A History of Duplications
Jun Yu,Jun Wang,Wei Lin,Songgang Li,Heng Li,Jun Zhou,Peixiang Ni,Wei Dong,Songnian Hu,Changqing Zeng,Jianguo Zhang,Yong Zhang,Ruiqiang Li,Zuyuan Xu,Shengting Li,Xianran Li,Hongkun Zheng,Lijuan Cong,Liang Lin,Jianning Yin,Jianing Geng,Guangyuan Li,Jianping Shi,Juan Liu,Hong Lv,Jun Li,Jing Wang,Yajun Deng,Longhua Ran,Xiaoli Shi,Xiyin Wang,Qingfa Wu,Changfeng Li,Xiaoyu Ren,Jingqiang Wang,Xiaoling Wang,Dawei Li,Dongyuan Liu,Xiaowei Zhang,Zhendong Ji,Wenming Zhao,Yongqiao Sun,Zhenpeng Zhang,Jingyue Bao,Yujun Han,Lingli Dong,Jia Ji,Peng Chen,Shuming Wu,Jinsong Liu,Ying Xiao,Dongbo Bu,Jianlong Tan,Li Yang,Chen Ye,Jingfen Zhang,Jingyi Xu,Yan Zhou,Yingpu Yu,Bing Zhang,Shulin Zhuang,Haibin Wei,Bin Liu,Meng Lei,Hong Yu,Yuanzhe Li,Hao Xu,Shulin Wei,Ximiao He,Lijun Fang,Zengjin Zhang,Yunze Zhang,Xiangang Huang,Zhixi Su,Wei Tong,Jinhong Li,Zongzhong Tong,Shuangli Li,Jia Ye,Lishun Wang,Lin Fang,Tingting Lei,Chen Chen,Huan Chen,Zhao Xu,Haihong Li,Haiyan Huang,Feng Zhang,Huayong Xu,Na Li,Caifeng Zhao,Shuting Li,Lijun Dong,Yanqing Huang,Long Li,Yan Xi,Qiuhui Qi,Wenjie Li,Bo Zhang,Wei Hu,Yanling Zhang,Xiangjun Tian,Yongzhi Jiao,Xiaohu Liang,Jiao Jin,Lei Gao,Weimou Zheng,Bailin Hao,Siqi Liu,Wen Wang,Longping Yuan,Mengliang Cao,Jason McDermott,Ram Samudrala,Jian Wang,Gane Ka-Shu Wong,Huanming Yang
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0030038
Abstract: We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested against a nonredundant collection of 19,079 full-length cDNAs, 97.7% of the genes are aligned, without fragmentation, to the mapped super-scaffolds of one or the other genome. We introduce a gene identification procedure for plants that does not rely on similarity to known genes to remove erroneous predictions resulting from transposable elements. Using the available EST data to adjust for residual errors in the predictions, the estimated gene count is at least 38,000–40,000. Only 2%–3% of the genes are unique to any one subspecies, comparable to the amount of sequence that might still be missing. Despite this lack of variation in gene content, there is enormous variation in the intergenic regions. At least a quarter of the two sequences could not be aligned, and where they could be aligned, single nucleotide polymorphism (SNP) rates varied from as little as 3.0 SNP/kb in the coding regions to 27.6 SNP/kb in the transposable elements. A more inclusive new approach for analyzing duplication history is introduced here. It reveals an ancient whole-genome duplication, a recent segmental duplication on Chromosomes 11 and 12, and massive ongoing individual gene duplications. We find 18 distinct pairs of duplicated segments that cover 65.7% of the genome; 17 of these pairs date back to a common time before the divergence of the grasses. More important, ongoing individual gene duplications provide a never-ending source of raw material for gene genesis and are major contributors to the differences between members of the grass family.
The Genomes of Oryza sativa: A History of Duplications
Jun Yu equal contributor ,Jun Wang equal contributor,Wei Lin equal contributor,Songgang Li equal contributor,Heng Li equal contributor,Jun Zhou equal contributor,Peixiang Ni equal contributor,Wei Dong,Songnian Hu,Changqing Zeng,Jianguo Zhang,Yong Zhang,Ruiqiang Li,Zuyuan Xu,Shengting Li,Xianran Li,Hongkun Zheng,Lijuan Cong,Liang Lin,Jianning Yin,Jianing Geng,Guangyuan Li,Jianping Shi,Juan Liu,Hong Lv,Jun Li,Jing Wang,Yajun Deng,Longhua Ran,Xiaoli Shi,Xiyin Wang,Qingfa Wu,Changfeng Li,Xiaoyu Ren,Jingqiang Wang,Xiaoling Wang,Dawei Li,Dongyuan Liu,Xiaowei Zhang,Zhendong Ji,Wenming Zhao,Yongqiao Sun,Zhenpeng Zhang,Jingyue Bao,Yujun Han,Lingli Dong,Jia Ji,Peng Chen,Shuming Wu,Jinsong Liu,Ying Xiao,Dongbo Bu,Jianlong Tan,Li Yang,Chen Ye,Jingfen Zhang,Jingyi Xu,Yan Zhou,Yingpu Yu,Bing Zhang,Shulin Zhuang,Haibin Wei,Bin Liu,Meng Lei,Hong Yu,Yuanzhe Li,Hao Xu,Shulin Wei,Ximiao He,Lijun Fang,Zengjin Zhang,Yunze Zhang,Xiangang Huang,Zhixi Su,Wei Tong,Jinhong Li,Zongzhong Tong,Shuangli Li,Jia Ye,Lishun Wang,Lin Fang,Tingting Lei,Chen Chen,Huan Chen,Zhao Xu,Haihong Li,Haiyan Huang,Feng Zhang,Huayong Xu,Na Li,Caifeng Zhao,Shuting Li,Lijun Dong,Yanqing Huang,Long Li,Yan Xi,Qiuhui Qi,Wenjie Li,Bo Zhang,Wei Hu,Yanling Zhang,Xiangjun Tian,Yongzhi Jiao,Xiaohu Liang,Jiao Jin,Lei Gao,Weimou Zheng,Bailin Hao,Siqi Liu,Wen Wang,Longping Yuan,Mengliang Cao,Jason McDermott,Ram Samudrala,Jian Wang ,Gane Ka-Shu Wong ,Huanming Yang
PLOS Biology , 2005, DOI: 10.1371/journal.pbio.0030038
Abstract: We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over the drafts of 2002. Tested against a nonredundant collection of 19,079 full-length cDNAs, 97.7% of the genes are aligned, without fragmentation, to the mapped super-scaffolds of one or the other genome. We introduce a gene identification procedure for plants that does not rely on similarity to known genes to remove erroneous predictions resulting from transposable elements. Using the available EST data to adjust for residual errors in the predictions, the estimated gene count is at least 38,000–40,000. Only 2%–3% of the genes are unique to any one subspecies, comparable to the amount of sequence that might still be missing. Despite this lack of variation in gene content, there is enormous variation in the intergenic regions. At least a quarter of the two sequences could not be aligned, and where they could be aligned, single nucleotide polymorphism (SNP) rates varied from as little as 3.0 SNP/kb in the coding regions to 27.6 SNP/kb in the transposable elements. A more inclusive new approach for analyzing duplication history is introduced here. It reveals an ancient whole-genome duplication, a recent segmental duplication on Chromosomes 11 and 12, and massive ongoing individual gene duplications. We find 18 distinct pairs of duplicated segments that cover 65.7% of the genome; 17 of these pairs date back to a common time before the divergence of the grasses. More important, ongoing individual gene duplications provide a never-ending source of raw material for gene genesis and are major contributors to the differences between members of the grass family.
Dissection of genetic overlap of salt tolerance QTLs at the seedling and tillering stages using backcross introgression lines in rice
JinPing Zang,Yong Sun,Yun Wang,Jing Yang,Fang Li,YongLi Zhou,LingHua Zhu,Reys Jessica,Fotokian Mohammadhosein,JianLong Xu,ZhiKang Li
Science China Life Sciences , 2008, DOI: 10.1007/s11427-008-0081-1
Abstract: QTLs for salt-tolerance (ST) related traits at the seedling and tillering stages were identified using 99 BC2F8 introgression lines (IL) derived from a cross between IR64 (indica) as a recurrent parent and Binam (japonica) from Iran as the donor parent. Thirteen QTLs affecting survival days of seedlings (SDS), score of salt toxicity of leaves (SST), shoot K+ concentration (SKC) and shoot Na+ concentration (SNC) at the seedling stage and 22 QTLs underlying fresh weight of shoots (FW), tiller number per plant (TN) and plant height (PH) at the tillering stage were identified. Most QTLs detected at the tillering stage showed obvious differential expression to salt stress and were classified into three types based on their differential behaviors. Type I included 11 QTLs which were expressed only under the non-stress condition. Type II included five QTLs expressed in the control and the salt stress conditions, and three of them (QPh5, QPh8 and QTn9) had similar quantity and the same direction of gene effect, suggesting their expression was less influenced by salt stress. Type III included six QTLs which were detectable only under salt stress, suggesting that these QTLs were apparently induced by the stress. Thirteen QTLs affecting trait difference or trait stability of ILs between the stress and non-stress conditions were identified and the Binam alleles at all loci except QPh4, QTn2 and QFw2a decreased trait difference. The three QTLs less influenced by the stress and 13 QTLs affecting trait stability were considered as ST QTLs which contributed to ST. Comparing the distribution of QTLs detected at the seedling and tillering stages, most (69%) of them were genetically independent. Only four were the same or adjacent regions on chromosomes 1, 2, 8 and 11 harboring ST QTLs detected at the two stages, suggesting that partial genetic overlap of ST across the two stages occurs. It is likely, therefore, to develop ST rice variety for both stages by pyramiding of ST QTLs of different stages or selection against the overlapping QTLs between the two stages via marker-assisted selection (MAS).
Measurement of Salivary Resistin Level in Patients with Type 2 Diabetes
Jinhua Yin,Hongfei Gao,Jing Yang,Lu Xu,Ming Li
International Journal of Endocrinology , 2012, DOI: 10.1155/2012/359724
Abstract: Serum resistin was initially hypothesized as a link between obesity and insulin resistance in mice. The latest evidence suggests that serum resistin is proinflammatory cytokines. Inflammation plays a key role in the pathogenesis of type 2 diabetes mellitus (T2DM). Many reports have previously identified changed serum resistin levels in patients with T2DM, but little is known of the levels of resistin in saliva. In our study, saliva and serum samples were collected from 38 patients with newly diagnosed T2DM at each time point of OGTT and 35 nondiabetic controls at fasting state. Resistin concentrations were measured using ELISA. We have demonstrated the presence of resistin in saliva of T2DM and nondiabetic subjects. Saliva resistin levels of T2DM are significantly higher than those of nondiabetic controls. Resistin levels in saliva are not affected by eating activity and correlated with serum resistin levels at any time points of OGTT. A positive correlation of serum and salivary resistin with BMI and HOMA-IR existed in T2DM. Measurement of resistin in saliva is a simple, noninvasive and may be an acceptable alternative to blood sampling for evaluatinginflammation/obesity/insulin resistance state. 1. Introduction Resistin is peptide hormone produced by adipocytes and macrophages. It was originally proposed as the link between obesity and diabetes in mice [1]. In addition, resistin was found to be an in vitro antagonist of insulin on human preadipocytes [2]. Human hepatic cells overexpressing resistin had impaired glucose uptake and glycogen synthesis [3]. The latest evidence suggests that resistin is proinflammatory cytokines [4]. It was positively correlated with proinflammatory factors in adults with pathophysiological conditions such as atherosclerosis, renal disease, inflammation of respiratory tracts, and type 2 diabetes mellitus [5–8]. Human saliva mirrors the body's health and can be collected noninvasively, does not require specialized skills and is suitable for large population-based screening programs [9]. Cortisol levels in saliva at 0:00 are detected to diagnose Cushing’s syndrome. Salivary endothelin concentrations are assessed chronic heart failure [10, 11]. Currently, it is reported that adipokines, such as adiponectin, leptin, resistin, and visfatin, can be detected in saliva of healthy subjects [12–14]. To the best of our knowledge, no data on saliva resistin levels in T2DM patients are available at present. The aim of this study was to measure and compare the saliva resistin and serum resistin levels in newly diagnostic T2DM patients
Inspection on Reality of Kindergarten Teachers’ Educational Behaviors
—A Case Study in China
 [PDF]

Jing Li, Xu Li
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.29048
Abstract: The research selects 20 kindergarten teachers in urban and rural areas in Chongqing as the samples and adopts time sampling observation method to investigate into kindergarten teachers’ educational behaviors from seven perspectives, i.e. education & teaching, participation into children’s activities, daily behavioral management, observation& monitoring, custody and emotional expression, teachers’ daily activities and teachers’ personal activities. Research results show that kindergarten teachers’ educational behaviors have improved better than before and become more and more reasonable. However, there are still some problems, such as excessive teaching and requirements, inadequate listening to children’s ideas and stimulation of their initiatives, low effectiveness of evaluation on children’s behaviors, excessive orders and interventions in daily management, inadequate emotional exchanges between teachers and children, insufficient care for children’s individual demands, etc.
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