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Search Results: 1 - 10 of 32616 matches for " Huang Yuqiang "
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Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters
Wang Degui,Huang Yuqiang,Huang Chukai,Wu Pengfei
BMC Ophthalmology , 2012, DOI: 10.1186/1471-2415-12-59
Abstract: Background To date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort. Methods In a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression. Results In either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P = 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (all P > 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P = 0.009 and 0.003), but no association with VCDR or IOP was observed (P > 0.05). Conclusions Although cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.
The gamma-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens
Zhenyu Fu, Hongfa Yang, Yuqiang Xiao, Gang Zhao, Haiyan Huang
Behavioral and Brain Functions , 2012, DOI: 10.1186/1744-9081-8-20
Abstract: We used morphine-induced behavioral sensitization model in rat to investigate the effects of baclofen on behavioral sensitization. Moreover, dopamine release in the shell of the nucleus accumbens was evaluated using microdialysis assay in vivo.The present study demonstrated that morphine challenge (3?mg/kg, s.c.) obviously enhanced the locomotor activity following 4-day consecutive morphine administration and 3-day withdrawal period, which indicated the expression of morphine sensitization. In addition, chronic treatment with baclofen (2.5, 5?mg/kg) significantly inhibited the development of morphine sensitization. It was also found that morphine challenge 3?days after repeated morphine administration produced a significant increase of extracellular dopamine release in nucleus accumbens. Furthermore, chronic treatment with baclofen decreased the dopamine release induced by morphine challenge.Our results indicated that gamma-aminobutyric acid system plays an important role in the morphine sensitization in rat and suggested that behavioral sensitization is a promising model to study the mechanism underlying drug abuse.Repeated morphine administration can induce the neurochemical effects including mainly protein components and neurotransmission adaptations in the brain, which results in behavioral response underlying opioid dependence [1]. There are abundant reports have shown that locomotion sensitization has been suggested to mimic the brain changes that occur in the human addict [1-3], so it is intriguing animal model used to study neural mechanisms related to opioid dependence [4,5]. Morphine administration can produce a robust enhancement of locomotor activity in mice [6,7]. However, it induced dramatically an initial decrease and then an increase in locomotor activity in rats [1,8]. Hence, investigation of sensitization in rats may be interesting to better understand the potential mechanisms resulting in opioid dependence.There are increasing findings have demons
Fluctuation limits of strongly degenerate branching systems
Yuqiang LI
Mathematics , 2011, DOI: 10.1007/s11425-011-4279-5
Abstract: Functional limit theorems for scaled fluctuations of occupation time processes of a sequence of critical branching particle systems in $\R^d$ with anisotropic space motions and strongly degenerated splitting abilities are proved in the cases of critical and intermediate dimensions. The results show that the limit processes are constant measure-valued Wienner processes with degenerated temporal and simple spatial structures.
Functional ergodic theorems of site-dependent branching Brownian motions in R
Yuqiang LI
Mathematics , 2011,
Abstract: In this paper, we studied the functional ergodic limits of the site-dependent branching Brownian motions in R. The results show that the limiting processes are non-degenerate if and only if the variance functions of branching laws are integrable. When the functions are integrable, although the limiting processes will vary according to the integrals, they are always positive, infinitely divisible and self-similar, and their marginal distributions are determined by a kind of 1/2-fractional integral equations. As a byproduct, the unique non-negative solutions of the integral equations are explicitly presented by the Levy-measure of the corresponding limiting processes.
Riemann-Liouville processes arising from Branching particle systems
Yuqiang Li
Mathematics , 2012, DOI: 10.1142/S0219493712500220
Abstract: It is proved in this paper that Riemann-Liouville processes can arise from the temporal structures of the scaled occupation time fluctuation limits of the site-dependent (d,\alpha,\sigma(x))branching particle systems in the case of 1=d<\alpha<2 and \int_{\R}\sigma(x)\d x<\infty.
QSAR Studies on Andrographolide Derivatives as α-Glucosidase Inhibitors
Jun Xu,Sichao Huang,Haibin Luo,Guoji Li,Jiaolin Bao,Shaohui Cai,Yuqiang Wang
International Journal of Molecular Sciences , 2010, DOI: 10.3390/ijms11030880
Abstract: Andrographolide derivatives were shown to inhibit α-glucosidase. To investigate the relationship between activities and structures of andrographolide derivatives, a training set was chosen from 25 andrographolide derivatives by the principal component analysis (PCA) method, and a quantitative structure-activity relationship (QSAR) was established by 2D and 3D QSAR methods. The cross-validation r 2 (0.731) and standard error (0.225) illustrated that the 2D-QSAR model was able to identify the important molecular fragments and the cross-validation r 2 (0.794) and standard error (0.127) demonstrated that the 3D-QSAR model was capable of exploring the spatial distribution of important fragments. The obtained results suggested that proposed combination of 2D and 3D QSAR models could be useful in predicting the α-glucosidase inhibiting activity of andrographolide derivatives.
The Clinical Features of Infantile Hypertrophic Pyloric Stenosis in Chinese Han Population: Analysis from 1998 to 2010
Zhiqiang Feng, Yuqiang Nie, Youxiang Zhang, Qingning Li, HuiMing Xia, SiTang Gong, Hai Huang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0088925
Abstract: Objective To investigate clinical features of infantile hypertrophic pyloric stenosis (IHPS) in Chinese Han population. Methods Three hundred and sixteen hospitalized patients with IHPS from January 1998 to February 2010 were retrospectively reviewed, and data including patient's sex, onset age, other coexisting congenital defects, pyloric circular muscle thickness evaluated by ultrasonograph, serum electrolytes concentration, and results of arterial blood gas analysis on admission were collected. The patients were divided into two groups: the duration between first onset and admission less than or equal to 10 days (early onset group), and more than 10 days (late onset group). The results of arterial blood gas and serum electrolyte concentration were compared between the two groups. Results There were 271 males and 45 females in 316 patients; the onset age ranged between 1 and 351 (26.5±26.6) days. The birth weight ranged between 1.6 and 4.5 (3.23±0.44) kilograms; coexisting congenital defects were found in 65 cases (20.6%). Pyloric circular muscle thickness was 4–8 (5.4±1.0) millimetres (mm). For the early onset group, the rates of hypokalemia, hypochloraemia and hypercapnia were significantly lower than those in the late onset group (18.67% VS 50%, P<0.0001; 46.03% VS 71.01%, P = 0.003; 56.58% VS 83.44%, P = 2.17×10?5; respectively). Conclusions The symptom duration in Chinese Han population was longer than that in other populations. And as the prolongation of symptom duration, the incidence of acid-base imbalance increased significantly. Infants with persistent vomiting at the age of 3~5 weeks after birth should be considered IHPS, and go to hospital as soon as possible in order to reduce the incidence of hypokalemia, hypochloraemia and hypercapnia, and avoid deterioration.
Robust Optimization of Performance Scheduling Problem under Accepting Strategy  [PDF]
Hui Ding, Yuqiang Fan, Weiya Zhong
Open Journal of Optimization (OJOp) , 2018, DOI: 10.4236/ojop.2018.74004
Abstract: In this paper, the problem of program performance scheduling with accepting strategy is studied. Considering the uncertainty of actual situation, the duration of a program is expressed as a bounded interval. Firstly, we decide which programs are accepted. Secondly, the risk preference coefficient of the decision maker is introduced. Thirdly, the min-max robust optimization model of the uncertain program show scheduling is built to minimize the performance cost and determine the sequence of these programs. Based on the above model, an effective algorithm for the original problem is proposed. The computational experiment shows that the performance’s cost (revenue) will increase (decrease) with decision maker’s risk aversion.
Forced Notch Signaling Inhibits Commissural Axon Outgrowth in the Developing Chick Central Nerve System
Ming Shi,Zhirong Liu,Yonggang Lv,Minhua Zheng,Fang Du,Gang Zhao,Ying Huang,Jiayin Chen,Hua Han,Yuqiang Ding
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0014570
Abstract: A collection of in vitro evidence has demonstrated that Notch signaling plays a key role in the growth of neurites in differentiated neurons. However, the effects of Notch signaling on axon outgrowth in an in vivo condition remain largely unknown.
A combined field and modeling study of groundwater flow in a tidal marsh
Yuqiang Xia,Hailong Li
Hydrology and Earth System Sciences Discussions , 2011, DOI: 10.5194/hessd-8-5123-2011
Abstract: Bald mud beaches were found among the mangrove marshes in Dongzhaigang National Nature Reserve, Hainan, China. To investigate the possible reasons for this phenomenon, the intertidal zones of a mangrove transect and a bald beach transect with similar topography and same tidal actions were selected for comparison study. Along both transects, observed water table variations were significant in the high and low intertidal zones and negligible in the middle intertidal zones. Field investigations and observations invite two speculations: (1) existence of a high-permeability zone on each transect which underlies the low-permeability surface mud sediments and outcrops in the high intertidal zone, and (2) considerable inland freshwater recharge along the mangrove transect but negligible freshwater recharge along the bald beach transect. Two-dimensional numerical simulations based on these speculations gave results in line with the observed water table. The bald beach is most probably due to the lack of enough freshwater for generating a brackish beach soil condition essential to mangrove growth. It is also indicated that seawater infiltrated the high-permeability zone through its outcrop near the high intertidal zone, and discharged from the tidal river bank in the vicinity of the low tide line, thereby forming a tide-induced seawater-groundwater circulation which may provide considerable contribution to the total submarine groundwater discharge.
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