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Search Results: 1 - 10 of 198431 matches for " Huang Richard H. "
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On the statistical properties of ergodic economic systems
Weihong Huang,Richard H. Day
Discrete Dynamics in Nature and Society , 2001, DOI: 10.1155/s102602260100019x
A Practical Approach to Managing Patients with HCV Infection
Huang Richard H.,Hu Ke-Qin
International Journal of Medical Sciences , 2006,
Abstract: Hepatitis C virus (HCV) infection is a major worldwide public health concern. It is a common cause of chronic liver disease and hepatocellular carcinoma. HCV antibody and HCV RNA testing are available diagnostic studies that offer high degree of accuracy. Current standard therapy includes a combination of pegylated interferon and ribavirin. Response rate is approximately 40% for genotype 1 and 80% for genotypes 2 and 3, respectively. Successful treatment can stop the progression of chronic liver disease, reduce the need for liver transplantation, and possibly decrease the risk for Hepatocellular carcinoma (HCC). Evaluating for potential treatment candidacy is an important initial step in the management of chronic HCV infection as not all individuals may need or qualify for the treatment. Understanding the natural history, the different diagnostic modalities, the current therapeutic options and, the treatment response and adverse effect profiles can help the practitioners better manage chronic HCV infection.
The Putative bZIP Transcripton Factor BzpN Slows Proliferation and Functions in the Regulation of Cell Density by Autocrine Signals in Dictyostelium
Jonathan E. Phillips,Eryong Huang,Gad Shaulsky,Richard H. Gomer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0021765
Abstract: The secreted proteins AprA and CfaD function as autocrine signals that inhibit cell proliferation in Dictyostelium discoideum, thereby regulating cell numbers by a negative feedback mechanism. We report here that the putative basic leucine zipper transcription factor BzpN plays a role in the inhibition of proliferation by AprA and CfaD. Cells lacking BzpN proliferate more rapidly than wild-type cells but do not reach a higher stationary density. Recombinant AprA inhibits wild-type cell proliferation but does not inhibit the proliferation of cells lacking BzpN. Recombinant CfaD also inhibits wild-type cell proliferation, but promotes the proliferation of cells lacking BzpN. Overexpression of BzpN results in a reduced cell density at stationary phase, and this phenotype requires AprA, CfaD, and the kinase QkgA. Conditioned media from high-density cells stops the proliferation of wild-type but not bzpN? cells and induces a nuclear localization of a BzpN-GFP fusion protein, though this localization does not require AprA or CfaD. Together, the data suggest that BzpN is necessary for some but not all of the effects of AprA and CfaD, and that BzpN may function downstream of AprA and CfaD in a signal transduction pathway that inhibits proliferation.
Identification of Markers that Distinguish Monocyte-Derived Fibrocytes from Monocytes, Macrophages, and Fibroblasts
Darrell Pilling,Ted Fan,Donna Huang,Bhavika Kaul,Richard H. Gomer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007475
Abstract: The processes that drive fibrotic diseases are complex and include an influx of peripheral blood monocytes that can differentiate into fibroblast-like cells called fibrocytes. Monocytes can also differentiate into other cell types, such as tissue macrophages. The ability to discriminate between monocytes, macrophages, fibrocytes, and fibroblasts in fibrotic lesions could be beneficial in identifying therapies that target either stromal fibroblasts or fibrocytes.
Discoidin Domain Receptors Promote α1β1- and α2β1-Integrin Mediated Cell Adhesion to Collagen by Enhancing Integrin Activation
Huifang Xu, Dominique Bihan, Francis Chang, Paul H. Huang, Richard W. Farndale, Birgit Leitinger
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0052209
Abstract: The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that bind to and are activated by collagens. Similar to collagen-binding β1 integrins, the DDRs bind to specific motifs within the collagen triple helix. However, these two types of collagen receptors recognize distinct collagen sequences. While GVMGFO (O is hydroxyproline) functions as a major DDR binding motif in fibrillar collagens, integrins bind to sequences containing Gxx’GEx”. The DDRs are thought to regulate cell adhesion, but their roles have hitherto only been studied indirectly. In this study we used synthetic triple-helical collagen-derived peptides that incorporate either the DDR-selective GVMGFO motif or integrin-selective motifs, such as GxOGER and GLOGEN, in order to selectively target either type of receptor and resolve their contributions to cell adhesion. Our data using HEK293 cells show that while cell adhesion to collagen I was completely inhibited by anti-integrin blocking antibodies, the DDRs could mediate cell attachment to the GVMGFO motif in an integrin-independent manner. Cell binding to GVMGFO was independent of DDR receptor signalling and occurred with limited cell spreading, indicating that the DDRs do not mediate firm adhesion. However, blocking the interaction of DDR-expressing cells with collagen I via the GVMGFO site diminished cell adhesion, suggesting that the DDRs positively modulate integrin-mediated cell adhesion. Indeed, overexpression of the DDRs or activation of the DDRs by the GVMGFO ligand promoted α1β1 and α2β1 integrin-mediated cell adhesion to medium- and low-affinity integrin ligands without regulating the cell surface expression levels of α1β1 or α2β1. Our data thus demonstrate an adhesion-promoting role of the DDRs, whereby overexpression and/or activation of the DDRs leads to enhanced integrin-mediated cell adhesion as a result of higher integrin activation state.
Violation of Richardson's Criterion via Introduction of a Magnetic Field
Daniel Lecoanet,Ellen G. Zweibel,Richard H. D. Townsend,Yi-Min Huang
Physics , 2010, DOI: 10.1088/0004-637X/712/2/1116
Abstract: Shear flow instabilities can profoundly affect the diffusion of momentum in jets, stars, and disks. The Richardson criterion gives a sufficient condition for instability of a shear flow in a stratified medium. The velocity gradient $V'$ can only destabilize a stably stratified medium with squared Brunt-Vaisala frequency $N^2$ if $V'^2/4>N^2$. We find this is no longer true when the medium is a magnetized plasma. We investigate the effect of stable stratification on magnetic field and velocity profiles unstable to magneto-shear instabilities, i.e., instabilities which require the presence of both magnetic field and shear flow. We show that a family of profiles originally studied by Tatsuno & Dorland (2006) remain unstable even when $V'^2/4
Excessive participation in on-line internet action games by two American teenagers: Case report, description of extent of overuse, and adverse consequences  [PDF]
Richard H. Schwartz
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.33035

In the past 15 years, there have been more than 40 articles in the medical literature about excessive participation in on-line internet action games by adolescents and young adults. The following case reports provide detailed information on two boys, ages 16 and 20 years respectively, who are compulsive and enthusiastic internet gamers, to the exclusion of family communication, school activities, academic performance, participation in sports and dating. They have not mastered any of the usual goals of adolescent development.

Assay of the Multiple Energy-Producing Pathways of Mammalian Cells
Barry R. Bochner,Mark Siri,Richard H. Huang,Shawn Noble,Xiang-He Lei,Paul A. Clemons,Bridget K. Wagner
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018147
Abstract: To elucidate metabolic changes that occur in diabetes, obesity, and cancer, it is important to understand cellular energy metabolism pathways and their alterations in various cells.
Feeding problems and GI dysfunction in children with asperger syndrome or pervasive developmental disorder not otherwise specified; comparison with their siblings  [PDF]
Vahe Badalyan, Richard H. Schwartz
Open Journal of Pediatrics (OJPed) , 2011, DOI: 10.4236/ojped.2011.14014
Abstract: Objective: There are few previously published studies of feeding problems and/or gastrointestinal dysfunction among children with Asperger syndrome (AS) or Pervasive Developmental Disorder (PDD-NOS), compared to sibling controls. Study Design: On-line parent autism groups 90% from North America. Statistical analysis: Chi square and binomial logistic regression statistical analysis Results: Completed surveys were received for 64 children with AS, 44 with PDD-NOS, total = 108), and 82 normal sibling matches. Children with high-functioning autism had higher likelihood of frequent (>50% of the time) problematic feeding behaviors and gastrointestinal dysfunction, such as unusual food preferences (OR 23.9, 95% CI 7.3 - 78.7), insistence on unusual food presentation (OR 5.8, 95% CI 1.8 - 18.4), and poor mealtime social behavior (OR 16.1, 95% CI 4.1 - 64.1). These children also had higher odds of frequent constipation (OR 8.3, 95% CI 2.2 - 31.9) and fecal incontinence (OR 5.4, 95% CI 1.1 - 27.3). Nine children in AS/PDD-NOS group (4%) were believed by parent to have celiac disease (3 or 1% had intestinal biopsy), compared to 2 in control group. Conclusion: 57% of the AS/PDD-NOS group had frequent unusual food preferences vs. 5% of controls. Forty-eight percent of children with AS/PDD-NOS had frequent dislikes of new foods, compared to 6% of controls. For symptoms of specific gastrointestinal dysfunction, children with AS/PDD-NOS had higher prevalence of frequent constipation (30% vs. 4%) and fecal incontinence (22% vs. 2%).
Mealtime feeding behaviors and gastrointestinal dysfunction in children with classic autism compared with normal sibling controls  [PDF]
Vahe Badalyan, Richard H. Schwartz
Open Journal of Pediatrics (OJPed) , 2012, DOI: 10.4236/ojped.2012.22025
Abstract: Introduction: We compared the frequency and duration of specific mealtime behaviors and GI dysfunction in children with classic autism to typically-developing siblings. Survey Method: A 41-item on-line parent survey. Statistics: Chi square and binomial logistical regression. Results: 79 children with classic autism matched with a normally-developing sibling. Logistic Regression Analysis Revealed: Dislike of new foods and bizarre mealtime mannerisms, were more frequent in those with classic autism (p < 0.01). They also had higher odds ratio of constipation and fecal incontinence (p < 0.01). 40% of children with classic autism had been on GFCF diets (p < 0.01). Only 1% of those children on a gluten-free diet had a biopsy-proven diagnosis of celiac disease. Conclusion: Children with classic autism had more frequent dislike of new foods, bizarre mealtime behaviors, constipation, and fecal incontinence.
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