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Search Results: 1 - 10 of 36701 matches for " HuaSheng Xiao "
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Progress in the detection of human genome structural variations
XueMei Wu,HuaSheng Xiao
Science China Life Sciences , 2009, DOI: 10.1007/s11427-009-0078-4
Abstract: The emerging of high-throughput and high-resolution genomic technologies led to the detection of submicroscopic variants ranging from 1 kb to 3 Mb in the human genome. These variants include copy number variations (CNVs), inversions, insertions, deletions and other complex rearrangements of DNA sequences. This paper briefly reviews the commonly used technologies to discover both genomic structural variants and their potential influences. Particularly, we highlight the array-based, PCR-based and sequencing-based assays, including array-based comparative genomic hybridization (aCGH), representational oligonucleotide microarray analysis (ROMA), multiplex amplifiable probe hybridization (MAPH), multiplex ligation-dependent probe amplification (MLPA), paired-end mapping (PEM), and next-generation DNA sequencing technologies. Furthermore, we discuss the limitations and challenges of current assays and give advices on how to make the database of genomic variations more reliable.
Perspectives of DNA microarray and next-generation DNA sequencing technologies
XiaoKun Teng,HuaSheng Xiao
Science China Life Sciences , 2009, DOI: 10.1007/s11427-009-0012-9
Abstract: DNA microarray and next-generation DNA sequencing technologies are important tools for high-throughput genome research, in revealing both the structural and functional characteristics of genomes. In the past decade the DNA microarray technologies have been widely applied in the studies of functional genomics, systems biology and pharmacogenomics. The next-generation DNA sequencing method was first introduced by the 454 Company in 2003, immediately followed by the establishment of the Solexa and Solid techniques by other biotech companies. Though it has not been long since the first emergence of this technology, with the fast and impressive improvement, the application of this technology has extended to almost all fields of genomics research, as a rival challenging the existing DNA microarray technology. This paper briefly reviews the working principles of these two technologies as well as their application and perspectives in genome research.
miRNAs modulate the drug response of tumor cells
XueMei Wu,HuaSheng Xiao
Science China Life Sciences , 2009, DOI: 10.1007/s11427-009-0114-4
Abstract: Chemotherapy is one of the major treatments of malignant carcinomas. However, its efficiency is affected by both intrinsic and acquired resistance to anticancer drugs. The cellular mechanisms of drug resistance include the overexpression of energy-dependent transporters that eject anticancer drugs from cells such as p-glycoprotein and multidrug resistance related protein (MRP), the mutation of drug targets, the activation of DNA repair pathways, the defects in cellular death pathways and so on. The genetic and epigenetic changes of these genes can lead to cancer drug resistance. Among these mechanisms, microRNAs (miRNAs) which are critical and essential for many important processes such as development, differentiation, and even carcinogenesis have been reported to regulate the chemo-sensitivity of tumor cells. In this paper we briefly review the relationship between miRNA and cancer drug resistance.
Aims and Methods of Civic Education in Today’s Universities of China
Ping Xiao,Huasheng Tong
Asian Social Science , 2010, DOI: 10.5539/ass.v6n4p44
Abstract: Civic education, as a way to foster civic awareness and civic responsibilities and to shape good citizens, should permeate through the whole process of a person’s socialization. At different stages of civic education, there should be corresponding educational aims, contents and methods consistent with the characteristics of different stages. For historical and cultural reasons, Chinese universities now have to complete the unfinished part of the contents of civic education which haven’t been dealt with in high schools. Universities should, on the basis of professional knowledge and skills, have the civic education related to occupational regulations and professional ethics in specific professions. The main aim of civic education in universities is to improve the students’ ability to independently judge the value and properly control their behavior and to achieve the aim, the system of content should be well designed and the teaching methods should also be employed properly.
Progress in the detection of human genome structural variations

WU XueMei &,XIAO HuaSheng,

中国科学C辑(英文版) , 2009,
Abstract: The emerging of high-throughput and high-resolution genomic technologies led to the detection of submicroscopic variants ranging from 1 kb to 3 Mb in the human genome. These variants include copy number variations (CNVs), inversions, insertions, deletions and other complex rearrangements of DNA sequences. This paper briefly reviews the commonly used technologies to discover both genomic structural variants and their potential influences. Particularly, we highlight the array-based, PCR-based and sequencing-based assays, including array-based comparative genomic hybridization (aCGH), representational oligonucleotide microarray analysis (ROMA), multiplex amplifiable probe hybridization (MAPH), multiplex ligation-dependent probe amplification (MLPA), paired-end mapping (PEM), and next-generation DNA sequencing technologies. Furthermore, we discuss the limitations and challenges of current assays and give advices on how to make the database of genomic variations more reliable. Supported by the National High Technology Research and Development Program of China (Grant No. 2006AA020704).
miRNAs modulate the drug response of tumor cells

WU XueMei &,XIAO HuaSheng,

中国科学C辑(英文版) , 2009,
Abstract: Chemotherapy is one of the major treatments of malignant carcinomas. However,its efficiency is affected by both intrinsic and acquired resistance to anticancer drugs. The cellular mechanisms of drug resistance include the overexpression of energy-dependent transporters that eject anticancer drugs from cells such as p-glycoprotein and multidrug resistance related protein (MRP),the mutation of drug targets,the activation of DNA repair pathways,the defects in cellular death pathways and so on. The genetic and ...
Perspectives of DNA microarray and next-generation DNA sequencing technologies

TENG XiaoKun &,XIAO HuaSheng,

中国科学C辑(英文版) , 2009,
Abstract: DNA microarray and next-generation DNA sequencing technologies are important tools for high-throughput genome research, in revealing both the structural and functional characteristics of genomes. In the past decade the DNA microarray technologies have been widely applied in the studies of functional genomics, systems biology and pharmacogenomics. The next-generation DNA sequencing method was first introduced by the 454 Company in 2003, immediately followed by the establishment of the Solexa and Solid techniques by other biotech companies. Though it has not been long since the first emergence of this technology, with the fast and impressive improvement, the application of this technology has extended to almost all fields of genomics research, as a rival challenging the existing DNA microarray technology. This paper briefly reviews the working principles of these two technologies as well as their application and perspectives in genome research. Supported by the National High-Tech Research Program of China (Grant No.2006AA020704) and Shanghai Science and Technology Commission (Grant No. 05DZ22201)
On Real Matrices to Least-Squares g-Inverse and Minimum Norm g-Inverse of Quaternion Matrices  [PDF]
Huasheng Zhang
Advances in Linear Algebra & Matrix Theory (ALAMT) , 2011, DOI: 10.4236/alamt.2011.11001
Abstract: Through the real representations of quaternion matrices and matrix rank method, we give the expression of the real ma-trices in least-squares g-inverse and minimum norm g-inverse. From these formulas, we derive the extreme ranks of the real matrices. As applications, we establish necessary and sufficient conditions for some special least-squares g-inverse and minimum norm g-inverse.
Impact of the next-generation sequencing data depth on various biological result inferences
Rui Hou,ZhenXing Yang,MingHui Li,HuaSheng Xiao
Science China Life Sciences , 2013, DOI: 10.1007/s11427-013-4441-0
Abstract: Next-generation sequencing (NGS) technologies have revolutionized the field of genomics and provided unprecedented opportunities for high-throughput analysis at the levels of genomics, transcriptomics and epigenetics. However, the cost of NGS is still prohibitive for many laboratories. It is imperative to address the trade-off between the sequencing depth and cost. In this review, we will discuss the effects of sequencing depth on the detection of genes, quantification of gene expression and discovering of gene structural variants. This will provide readers information on choosing appropriate sequencing depth that best meet the needs of their particular project.
A Survey on Civic Consciousness in Contemporary China
Huasheng Tong
International Education Studies , 2012, DOI: 10.5539/ies.v5n6p110
Abstract: In the current stage of China's modernization construction and social transformation, the cultivation of sound civic consciousness in the context of the servant consciousness lasting for thousands of years is the premise to cultivate citizens with civic rights and responsibilities, the foundation to achieve the modernization of individuals or the all-round development of individuals and the key to realize social modernization in this country. Through an empirical research we could see that a kind of modern civic consciousness in Chinese citizens’ mind is taking shape, but the influence of the servant consciousness is still obdurately existing, so on the whole, Chinese civic consciousness is relatively insufficient. And the current situation, the system of contents and methodology to cultivate the sound civic consciousness should be taken seriously.
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