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Objective: To evaluate the efficacy of Yiqi Fumai freeze-dry powder (YFP) on ischemic diastolic heart failure. Methods: 100 patients diagnosed with unstable angina accompanying ischemic diastolic heart failure (IDHF) were selected randomly. 52 patients with TCM syndrome of qi-yin deficiency were divided into Chinese and Western combination therapy group. 48 patients have no TCM syndrome of qi-yin deficiency, and were treated with standard western medicine. After treatment, Seattle Angina Questionnaire Evaluation, ECG, conventional and stress echocardiography (SE) index, NT-proBNP were compared between before and after treatment. Results: The differences of PL, TS, DP between before and after treatment by YFP were statistically significant (P < 0.05). SE parameters of LVEF, E/A were significantly increase; E/e' decreased. The differences were statistically significant. However, echocardiography parameters showed no significant differences after treatment. After the combination treatment, NT-proBNP level had negative correlation with LVEF, E/A (r = -0.432, -0.643, both P < 0.01). Conclusion: Yiqi Fumai freeze-dry powder is safe and effective to patients with ischemic diastolic heart failure. Stress echocardiography can improve the diagnostic of ischemic diastolic heart failure, and maybe an effectively predict treatment response.