oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

2019 ( 115 )

2018 ( 689 )

2017 ( 630 )

2016 ( 608 )

Custom range...

Search Results: 1 - 10 of 46081 matches for " Hu Ke-Qin "
All listed articles are free for downloading (OA Articles)
Page 1 /46081
Display every page Item
A Practical Approach to Management of Chronic Hepatitis B
Hu Ke-Qin
International Journal of Medical Sciences , 2005,
Abstract: Chronic hepatitis B (CHB) is one of the important public health problems worldwide. Major advances have been made in the treatment of CHB during the past several years. This article systemically reviews advances in the application of HBV DNA quantitation and three approved drugs for HBV treatment, and presents an updated and practical clinical approach to managing CHB. Highly sensitive PCR-based quantitation of HBV DNA makes it possible to precisely determine pre-treatment HBV load and monitor HBV DNA response during treatment. HBV DNA level, HBeAg status, degree of hepatic histological activity and fibrosis, and serum transaminases are the most important parameters in determining indication, regimen, and duration of HBV treatment. Although interferon alfa-2b, lamivudine, and adefovir are all approved as initial HBV treatment, understanding the advantages and advantages of each agent is important in choosing the best treatment for each individual patient with CHB.
Guest Editor's Editorial: Advances in Managing Hepatitis C Virus (HCV) Infection (A Special Issue)
Hu Ke-Qin
International Journal of Medical Sciences , 2006,
Abstract:
Advances in Hepatitis B Research: From Virology to Clinical Management (A Special Issue)
Lu Xuanyong,Hu Ke-Qin
International Journal of Medical Sciences , 2005,
Abstract:
A Practical Approach to Managing Patients with HCV Infection
Huang Richard H.,Hu Ke-Qin
International Journal of Medical Sciences , 2006,
Abstract: Hepatitis C virus (HCV) infection is a major worldwide public health concern. It is a common cause of chronic liver disease and hepatocellular carcinoma. HCV antibody and HCV RNA testing are available diagnostic studies that offer high degree of accuracy. Current standard therapy includes a combination of pegylated interferon and ribavirin. Response rate is approximately 40% for genotype 1 and 80% for genotypes 2 and 3, respectively. Successful treatment can stop the progression of chronic liver disease, reduce the need for liver transplantation, and possibly decrease the risk for Hepatocellular carcinoma (HCC). Evaluating for potential treatment candidacy is an important initial step in the management of chronic HCV infection as not all individuals may need or qualify for the treatment. Understanding the natural history, the different diagnostic modalities, the current therapeutic options and, the treatment response and adverse effect profiles can help the practitioners better manage chronic HCV infection.
Hepatitis C Virus (HCV) Infection and Hepatic Steatosis
Yoon Eugene J.,Hu Ke-Qin
International Journal of Medical Sciences , 2006,
Abstract: There are two discrete forms of steatosis that may be found in patients infected with hepatitis C virus (HCV). Metabolic steatosis can coexist with HCV, regardless of genotype, in patients with risk factors such as obesity, hyperlipidemia, and insulin resistance. The second form of hepatic steatosis in HCV patients is a result of the direct cytopathic effect of genotype 3 viral infections. There have been proposed mechanisms for this process but it remains elusive. Both categories of steatosis tend to hasten the progression of liver fibrosis and therefore prompt recognition and management should be initiated in patients with HCV and steatosis. The authors review the current understanding of the relationship between hepatitis C infection and hepatic steatosis and discuss future research directions.
Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice
Wei Cui, Fan Gu, Ke-Qin Hu
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate the in vivo effects and mechanisms of silibinin on the growth of hepatocellular carcinoma (HCC) xenografts in nude mice.METHODS: Nude mice bearing HuH7 xenografts were used to assess the anti-HCC effects and mechanisms of silibinin.RESULTS: Silibinin resulted in a potent dose-dependent reduction of HuH7 xenografts in association with a significant decrease in Ki-67 and α-fetoprotein production, nuclear NF-κB content, polo-like kinase 1, Rb phosphorylation, and E2F1/DP1 complex, but increased p27/CDK4 complex and checkpoint kinase 1 expression, suggesting that the in vivo effects of silibinin are mediated by inhibiting G1-S transition of the cell cycle. Silibinin-induced apoptosis of HuH7 xenografts was associated with inhibited survivin phosphorylation. Silibinin-reduced growth of HuH7 xenografts was associated with decreased p-ERK, increased PTEN expression and the activity of silibinin was correlated with decreased p-Akt production, indicating involvement of PTEN/PI3K/Akt and ERK pathways in its in vivo anti-HCC effects. Silibinin-reduced growth of HuH7 xenografts was also associated with a significant increase in AC-H3 and AC-H4 expression and the production of superoxide dismutase (SOD)-1.CONCLUSION: Silibinin reduces HCC xenograft growth through the inhibition of cell proliferation, cell cycle progression and PTEN/P-Akt and ERK signaling, inducing cell apoptosis, and increasing histone acetylation and SOD-1 expression.
In Vivo Effects of Cyclooxygenase-2 Deletion on Cellular Signaling in Hepatocellular Carcinoma Xenografts in Nude Mice
Wei Cui,Shirley X Hu,Zhen-Ya Tang,Ke-Qin Hu
Journal of Cancer Molecules , 2007,
Abstract: AIM: It is known that cyclooxygenase-2 (COX-2) overexpression is associated with growth of hepatocellular carcinoma (HCC) cells, but its in vivo mechanisms remain to be determined. METHODS: In the present study, the parental HuH7, a human HCC cell line, and COX-2 deleted HuH7 cells were inoculated to nude mice to assess the in vivo effects of COX-2 deletion (C2D) on cellular signaling in HCC xenografts. RESULTS: We found that C2D significantly inhibited Ki-67 and increased peroxisome proliferator-activated receptor-gamma (PPAR-gamma) expression, and reduced plasma prostaglandin E2 and a-fetoprotein levels in association with reduced Rb phosphorylation and cyclin D1/CDK4 complex, and increased p21/CDK4 complex, indicating COX-2 overexpression promotes G1-S transition of the cell cycle in human HCC xenografts via a series of complicated signaling. C2D also resulted in significantly reduced phosphorylation of Akt, indicating a potential role of PTEN/PI3K/Akt pathway in COX-2-mediated alteration of HCC growth. We also demonstrated that C2D significantly inhibited histone deacetylase-2 (HDAC-2) expression, but increased the acetylation levels of histone-3 and histone-4, indicating that altered histone acetylation by histone deacetylases may be involved in COX-2-mediated HCC cell proliferation. In contrast to previous in vitro reports, we found that C2D did not significantly affect apoptosis and formation of activated caspase-3 and 9 in HCC xenografts. CONCLUSION: Our results revealed that C2D results in a series of in vivo alteration of cellular signaling in HCC xenografts that demonstrated important pathogenic mechanisms of COX-2 overexpression in HCC growth and provided valuable information on searching novel approaches to HCC chemoprevention.
Clinical Profiles of Chronic Hepatitis C in a Major County Medical Center Outpatient Setting in United States
Hu Ke-Qin,Yang Huiying,Lin Ying-Chao,Lindsay Karen L
International Journal of Medical Sciences , 2004,
Abstract: The estimated prevalence of hepatitis C virus (HCV) infection in the US is 1.8 %. Data are limited on the clinical profile of the disease at first presentation and dynamic follow-up of ALT level, especially in publicly-funded patients. This information is critical for optimal management of these patients. The present study is aimed to assess the clinical profiles of chronic hepatitis C (CHC) at first presentation and clinical implication of dynamic follow-up of ALT level in a county medical center setting. A total of 294 patients were selected from the population consecutively evaluated in the Hepatitis Clinic at Los Angeles County-USC Medical Center between Jan. 1990 and Dec. 1998. Ethnicity of the patients was Hispanics-49.0%, Caucasian-28.6%, African American-13.6%, and Asian-8.8%. Risk factors were identifiable in 84.0% of patients, and injection drug use (IDU) represented the leading risk factor for HCV acquisition (47.4%). History of alcoholism was present in 39.1%. The initial clinical diagnoses were chronic hepatitis 76.9%; compensated cirrhosis 20.4%; and decompensated cirrhosis 2.7%. Elevation of ALT, alpha fetoprotein (AFP), ferritin, and anti-nuclear antibody (ANA) titer were seen in 219/294 (74.5%), 60/194 (30.9%), 20/83 (24.1%), and 35/97 (36.1%) patients, respectively. Anti-HBc (total) test was positive in 65/129 (50.5%) patients. The presence of cirrhosis was significantly associated with age greater than 55 years at entry, female gender, non-African American ethnicity, history of transfusion, lower level of albumin and elevated level of AFP. Longitudinal observation of ALT changes in 178 patients who had neither evidence of cirrhosis at entry nor received interferon treatment showed persistently normal, intermittently or persistently elevated ALT level in 15.2%, 38.3%, and 46.6% patients, respectively. The frequency of developing clinical evidence of cirrhosis during follow-up was significantly higher in patients with persistently (16.0%) or intermittently (7.0%) elevated ALT than that in patients with persistently normal ALT (4.0%). In conclusion, the present study analyzed the clinical profiles of CHC, assessed risk factors for developing cirrhosis, and demonstrated the clinical value of dynamic follow-up of ALT level in a cohort of publicly-funded patients. These data have major implications in designing optimal strategies for disease management, antiviral therapy, and screening for hepatocellular carcinoma in patients with CHC.
The Water Use Effeciency of the Goldspur Apple Tree
金矮生苹果水分利用效率研究

WANG Ke-Qin,
王克勤

生态学报 , 2002,
Abstract: After measuring the photosynthetic rate and transpiration rate of the leaves of seven-year field and two-year potted Malus pumila CV. Goldspur under different soil water and illumination conditions, together with the calculation of water use efficiency (WUE), the result showed that because photosynthetically active radiation (PAR) and soil water content (SWC) affected the photosynthetic rate and transpiration rate of Goldspur, they thus influenced WUE. The response of WUE to different illumination condition...
The Effect of Soil Moisture Upon Net Photosynthetic Rate of the Goldspur apple Tree
土壤水分对金矮生苹果光合速率的影响

WANG Ke-Qin,
王克勤

生态学报 , 2002,
Abstract: 通过对 7年生田间和 2年生盆栽金矮生苹果 ( Maluspumila CV.goldspur)进行不同土壤水分和光照条件下叶片光合速率测定研究 ,结果表明 ,光合速率 ( Pn)与光照强度 ( PAR)和土壤水分 ( SWC)之间存在着密切的关系。当林木供水充足 ,即 SWC( >1 5 % )达到田间持水量 ( FC)的 75 %以上时 ,Pn的光响应曲线为直角双曲线 ,但 SWC低于这一水平时 ,Pn的光响应曲线则为二次抛物线 ,表现出不同程度的光抑制 ,水分胁迫越严重 ,出现光抑制越早。弱光下 ( PAR<5 0 0 μmol· s- 1· m- 2 ) ,光合速率最大值 Pmax出现在 SWC比较低的范围内 ( 70 %~ 75 % FC) ,如果 SWC继续增大时 ,Pn反而下降 ;随着光强的增大 ,Pmax出现的 SWC水平随之提高。金矮生苹果 Pn的日变化规律在不同 SWC下并不相同 ,水分胁迫存在时 ,Pn的日变化表现出“午休”现象 ,水分胁迫越严重 ,“午休”时间越长 ;水分供应充足时 ,Pn从 1 0∶ 0 0的最大值直线下降 ,下午不再回升。轻度水分胁迫时 ,Pn日平均值接近或达到最大值 ;随着 SWC的提高 Pn日平均值反而有下降趋势。在正常光照条件下 (日均值 80 0~ 1 0 0 0μmol· s- 1· m- 2 ) ,当林木处于严重水分胁迫 ,即 SWC低于 FC的 5 5 %时 ,Pn随土壤水分的增加直线上升 ;当土壤水分供应充足 ( SWC>75 % F
Page 1 /46081
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.