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Search Results: 1 - 10 of 81397 matches for " Hsuan Liu "
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Structure-Based Pharmacophore Modeling to Discover Novel CCR5 Inhibitors for HIV-1/Cancers Therapy  [PDF]
Hsuan-Yu Lin, Yih Ho, Hsuan-Liang Liu
Journal of Biomedical Science and Engineering (JBiSE) , 2019, DOI: 10.4236/jbise.2019.121002
Abstract: CC chemokine receptor 5 (CCR5), a member of G protein-coupled receptors (GPCRs), not only plays a significant role in inflammatory responses, but also correlates with HIV-1 infection and cancer progression. Recently, blocking of CCR5 has been considered as an effective strategy in HIV-1/cancers therapy. So far, only Maraviroc has been approved by FDA in 2007, while the other CCR5 inhibitors have failed in their clinical trials. In this study, a highly selective structure-based pharmacophore model was constructed, validated, and applied for virtual screening to retrieve novel CCR5 inhibitors from NCI database. Finally, one potential CCR5 inhibitor candidate, NSC13165, was identified after molecular docking, molecular dynamics (MD) simulations, binding free energy analyses and ADMET prediction. Docking and MD simulation results not only suggested that NSC13165 reserves the common binding mode of the most known CCR5 inhibitors, but also provided important insights toward the allosteric inhibition mechanism of CCR5. The results of binding free energy analyses indicated that the binding affinity of NSC13165 is much better than that of Maraviroc and that van der Waals interaction is the key driving force during the binding process. ADMET prediction suggested that NSC13165 exhibits very low risk of causing lethal side effects. Altogether, our results strongly suggest that NSC13165 has great potential to serve as a novel CCR5 inhibitor, which may be further tested in vitro/in vivo as a drug target for HIV-1/cancers therapy or be used as a lead compound for improving its efficacy through chemical modifications.
Application of the Variational Iteration Method to Strongly Nonlinear -Difference Equations
Hsuan-Ku Liu
Journal of Applied Mathematics , 2012, DOI: 10.1155/2012/704138
Abstract: The theory of approximate solution lacks development in the area of nonlinear -difference equations. One of the difficulties in developing a theory of series solutions for the homogeneous equations on time scales is that formulas for multiplication of two -polynomials are not easily found. In this paper, the formula for the multiplication of two -polynomials is presented. By applying the obtained results, we extend the use of the variational iteration method to nonlinear -difference equations. The numerical results reveal that the proposed method is very effective and can be applied to other nonlinear -difference equations.
The Convexity of the Free Boundary for the American put option
Hsuan-Ku Liu
Quantitative Finance , 2013,
Abstract: This paper studies the parabolic free boundary problem arising from pricing American-style put options on an asset whose index follows a geometric Brownian motion process. The contribution is to propose a condition for that the early exercise boundary is a convex function.
The pricing formula for cancellable European options
Hsuan-Ku Liu
Quantitative Finance , 2013,
Abstract: This paper examines the value of a cancellable European option in a finite time horizon setting. The specifications of this generalized European option allow the seller to cancel the option at any point in time for a fixed penalty paid directly to the holder. Here, we provide an explicit valuation formula for the European game call where the early cancellation time is obtained iteratively.
Metal-Insulator-Semiconductor Photodetectors
Chu-Hsuan Lin,Chee Wee Liu
Sensors , 2010, DOI: 10.3390/s101008797
Abstract: The major radiation of the Sun can be roughly divided into three regions: ultraviolet, visible, and infrared light. Detection in these three regions is important to human beings. The metal-insulator-semiconductor photodetector, with a simpler process than the pn-junction photodetector and a lower dark current than the MSM photodetector, has been developed for light detection in these three regions. Ideal UV photodetectors with high UV-to-visible rejection ratio could be demonstrated with III-V metal-insulator-semiconductor UV photodetectors. The visible-light detection and near-infrared optical communications have been implemented with Si and Ge metal-insulator-semiconductor photodetectors. For mid- and long-wavelength infrared detection, metal-insulator-semiconductor SiGe/Si quantum dot infrared photodetectors have been developed, and the detection spectrum covers atmospheric transmission windows.
Research on Prospective Innovation Design of Smart Electric Vehicle
Shuo Fang Liu, Meng Hsuan Lee
Advances in Industrial Engineering and Management , DOI: 10.7508/AIEM-V2-N2-63-67
Abstract: This study aims at developing prospective electric vehicles, proposing a complete development procedure. We begin with SET trend analysis to explore future opportunity points, centering on Quality Function Deployment (QFD), integrating with Kano’s Model and Scenario to increase accuracy for transforming customer requirements into design requirements. After executing the procedure, we not only obtain innovation concept of “Motherboard Smart Light Electric Vehicle”, but also propose a systematic procedure for innovation product development.
Research on Prospective Innovation Design of Smart Electric Vehicle
Shuo Fang Liu, Meng Hsuan Lee
Frontiers in Manufacturing Engineering , DOI: 10.7508/FME-V1-N2-1-9
Abstract: This study aims at developing prospective electric vehicles, proposing a complete development procedure. We begin with SET trend analysis to explore future opportunity points, centering on Quality Function Deployment (QFD), integrating with Kano’s Model and Scenario to increase accuracy for transforming customer requirements into design requirements. After executing the procedure, we not only obtain innovation concept of “Motherboard Smart Light Electric Vehicle”, but also propose a systematic procedure for innovation product development.
Discovery of Novel Irreversible HER2 Inhibitors for Breast Cancer Treatment  [PDF]
Jhih-Yan Tang, Yih Ho, Chun-Yi Chang, Hsuan-Liang Liu
Journal of Biomedical Science and Engineering (JBiSE) , 2019, DOI: 10.4236/jbise.2019.124016
Abstract: It has been widely known that human epidermal growth factor receptor 2 (HER2) inhibitors exhibit distinct antitumor responses against HER2-positive breast cancer. To date, Lapatinib (Tykerb®) has been approved by the U.S. Food and Drug Administration (FDA) as a reversible HER2 inhibitor for treating breast cancer. However, HER2 L755S, T798I and T798M mutations confer drug resistance to lapatinib, restricting its efficacy toward HER2-positive breast cancer. Thus, novel therapy toward mutant HER2 is highly desired. Although several irreversible HER2 inhibitors have been developed to overcome these drug resistance problems, most of them were reported to cause severe side effects. In this study, three pharmacophore models based on HER2 L755S, T798I and T798M mutant structures were constructed and then validated through receiver operating characteristic (ROC) curve analysis and Güner-Henry (GH) scoring methods. Subsequently, these well-validated models were utilized as 3D queries to identify novel irreversible HER2 inhibitors from National Cancer Institute (NCI) database. Finally, two potential irreversible HER2 inhibitor candidates, NSC278329 and NSC718305, were identified and validated through molecular docking, molecular dynamics (MD) simulations and ADMET prediction. Furthermore, the analyses of binding modes showed that both NSC278329 and NSC718305 exhibit good binding interactions with HER2 L755S, T798I and T798M mutants. All together, the above results suggest that both NSC278329 and NSC718305 can serve as novel and effective irreversible HER2 inhibitors for treating breast cancers with HER2 L755S, T798I and T798M mutants. In addition, they may act as lead compounds for designing new irreversible HER2 inhibitors by carrying out structural modifications and optimizations in future studies.
Drug Loading on Microneedles  [PDF]
Meng-Hsuan Hsiao, Hsiu-Feng Ye, Ta-Jo Liu, Jane Wang
Advances in Chemical Engineering and Science (ACES) , 2019, DOI: 10.4236/aces.2019.92016
Abstract: An experimental study was carried out to investigate the amount of drugs loaded on microneedles. The microneedles were made with poly (lactic acid). Aqueous poly (vinyl alcohol) solutions were prepared as drug solutions. Two drug loading approaches, i.e., dropping and dipping, were examined. It was found that capillary number is the only relevant dimensionless group for the two methods. For the dropping approach, dried drugs will spread near the bottom of a microneedle patch provided the surface tension is low. As for the dipping approach, both a single microneedle and an array of nine microneedles were examined. For a single microneedle, high capillary rises before pulling and pulling speed are two key factors to increase the drug loading volume. For an array of microneedles, the effect of capillary rise owing to the interaction between microneedles would increase the drug loading volume several times higher than a single microneedle of the same dimension.
Peak to Average Power Ratio Reduction for Multicarrier Systems Using Dirty Paper Coding
Pin-Hsun Lin,Shih-Chun Lin,Hsuan-Tien Liu,Hsuan-Jung Su
Journal of Communications , 2007, DOI: 10.4304/jcm.2.3.9-16
Abstract: In this paper, we improve the peak to average power ratio reduction scheme for multicarrier systems proposed by Collings and Clarkson by applying dirty paper coding with peak power constraint. We compare the bit error rate performance among conventional orthogonal frequency division multiplexing, Collings and Clarkson’s method, and our proposed scheme with bit loading. From simulation we find that when channel coding is considered, Collings and Clarkson’s method is the worst. The proposed method performs the best when the number of bits is large and hence is suitable for high speed transmission.
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