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Search Results: 1 - 10 of 1442 matches for " Hossain Mokarram "
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Pharmacological Inhibition of p38 Mitogen-Activated Protein Kinases Affects KC/CXCL1-Induced Intraluminal Crawling, Transendothelial Migration, and Chemotaxis of Neutrophils In Vivo
Najia Xu,Mokarram Hossain,Lixin Liu
Mediators of Inflammation , 2013, DOI: 10.1155/2013/290565
Inhibition of nitric oxide synthesis enhances leukocyte rolling and adhesion in human microvasculature
Hossain Mokarram,Qadri Syed M,Liu Lixin
Journal of Inflammation , 2012, DOI: 10.1186/1476-9255-9-28
Abstract: Background Nitric oxide (NO) is a multifunctional signaling molecule that regulates important cellular events in inflammation including leukocyte recruitment. Previous studies have shown that pharmacological inhibition of NO synthesis induces leukocyte recruitment in various in vitro and animal models. However, it is not known whether NO modulation has similar effects on leukocyte-endothelial cell interactions within the human microvasculature. The present study explored the effect of systemic L-NAME treatment on leukocyte recruitment in the SCID-hu mouse model. Methods Human skin xenografts were transplanted in SCID mice to study human leukocyte dynamics in human vasculature. Early events of human leukocyte recruitment in human vasculature were studied using intravital microscopy. NO synthesis was pharmacologically inhibited using NG-nitro-L-arginine methyl ester (L-NAME). Immunohistochemical analysis was performed to elucidate E-selectin expression in human xenograft skin. Human neutrophil-endothelial cell interactions were also studied in an in vitro flow chamber assay system. P- and E-selectin expression on cultured human umbilical vein endothelial cells (HUVECs) was measured using ELISA. Platelet-activating factor (PAF) synthesis was detected using a TLC-based assay. Results L-NAME treatment significantly enhanced the rolling and adhesion of human leukocytes to the human vasculature. Functional blocking of P- and E-selectins significantly inhibited rolling but not adhesion induced by inhibition of NO synthesis. Systemic L-NAME treatment enhanced E-selectin expression in human xenograft skin. L-NAME treatment significantly enhanced P- and E-selectin expression on HUVECs. L-NAME treatment did not significantly modify neutrophil rolling or adhesion to HUVECs indicating that L-NAME induced subtle P- and E-selectin expression was insufficient to elicit dynamic neutrophil-HUVEC interactions in vitro. Moreover, synthesis of endothelial-derived PAF was not significantly modified by L-NAME treatment. These results point to the accelerated leukocyte recruitment in human vasculature following suppression of NO synthesis, effects that are mediated by P- and E-selectins. The findings are, however, not supported by the in vitro data. Conclusion Inhibition of endogenous NO triggers early events of human leukocyte recruitment in human vasculature, involving complex cellular or molecular mechanisms in addition to P- and E-selectin-mediated leukocyte rolling.
A theory of finite deformation magneto-viscoelasticity
Prashant Saxena,Mokarram Hossain,Paul Steinmann
Physics , 2015, DOI: 10.1016/j.ijsolstr.2013.07.024
Abstract: This paper deals with the mathematical modelling of large strain magneto-viscoelastic deformations. Energy dissipation is assumed to occur both due to the mechanical viscoelastic effects as well as the resistance offered by the material to magnetisation. Existence of internal damping mechanisms in the body is considered by decomposing the deformation gradient and the magnetic induction into `elastic' and `viscous' parts. Constitutive laws for material behaviour and evolution equations for the non-equilibrium fields are derived that agree with the laws of thermodynamics. To illustrate the theory the problems of stress relaxation, magnetic field relaxation, time dependent magnetic induction and strain are formulated and solved for a specific form of the constitutive law. The results, that show the effect of several modelling parameters on the deformation and magnetisation process, are illustrated graphically.
A Proposed Design for The Development of Vital Sign(Electrocardiogram) Patient Monitoring System
International Journal of Engineering Science and Technology , 2010,
Abstract: The vital signs monitor is essentially a real time device that displays certain received signals from the human body. It is widely used in medical institutes. The projects of this sort under taken so far have used windows to display the output whereas this project aims to generate a real time display of the signals received from thehuman body using Linux. Linux was preferred for its ability to simultaneously process data and display it in real time. This includes creating appropriate sensors, proper modifying circuits and ensuring real time display. The project has a channel for the variable that will be continuously measured and displayed by the device. The variable is electrocardiogram. The development of this project was circled around the need for real time display. Appropriate circuits modified the input signals to make them suitable for DAQ card reading. Linux was used to display the output of DAQcard in real time. This enhanced the real time characteristic of the output.
An Econometric Analysis for CO2 Emissions, Energy Consumption, Economic Growth, Foreign Trade and Urbanization of Japan  [PDF]
Sharif Hossain
Low Carbon Economy (LCE) , 2012, DOI: 10.4236/lce.2012.323013
Abstract: This paper examines the dynamic causal relationship between carbon dioxide emissions, energy consumption, economic growth, foreign trade and urbanization using time series data for the period of 1960-2009. Short-run unidirectional causalities are found from energy consumption and trade openness to carbon dioxide emissions, from trade openness to energy consumption, from carbon dioxide emissions to economic growth, and from economic growth to trade openness. The test results also support the evidence of existence of long-run relationship among the variables in the form of Equation (1) which also conform the results of bounds and Johansen conintegration tests. It is found that over time higher energy consumption in Japan gives rise to more carbon dioxide emissions as a result the environment will be polluted more. But in respect of economic growth, trade openness and urbanization the environmental quality is found to be normal good in the long-run.
Application of Resource Efficient and Cleaner Production (RECP) in the Energy Intensive Industry to Promote Low Carbon Industrial Development in Bangladesh  [PDF]
Tahazzud Hossain
Low Carbon Economy (LCE) , 2015, DOI: 10.4236/lce.2015.63009
Abstract: The consumption of natural resources (e.g. raw material, water & energy) in the industries is bringing welfare to the society but per unit of product from the industry is linked with the generation of environmental pollutants and emissions. Resource constraints and climate crisis have come into focus globally; particularly it has become one of the major concerns in the Asia Pacific region. At present, the countries in the Asia Pacific use resources three times greater than the rest of the world to generate one unit of GDP. These countries are more vulnerable to the impacts of resource constraints and climate change. Resource Efficient and Cleaner Production (RECP) has come as a preventive environmental measure to facilitate pollution prevention and reduce carbon intensity per unit of products along with financial profit of the industry. Bangladesh has been considered as one of the transition economies in the South Asia. Industrial sector supports second largest share to the GDP of Bangladesh. The industrial productivity in the country is solely dependent on the locally available natural gas and imported raw materials. Energy Efficiency (EE) and Cleaner Production (CP) measures in the industry can facilitate the promotion of low carbon industrial development through pollution prevention and energy conservation. The main objective of this research is to identify the policy instruments for the promotion of low carbon industrial development in Bangladesh within RECP framework. In this research, ceramics sector has been taken as a research unit. Based on the research objective, three research strategies have been followed which are: 1) review of the existing Environmental Policy, Industrial Policy and Energy Policy of Bangladesh, 2) review of the relevant measures adopted in the regional countries, and 3) case study in a ceramic industry. Stakeholder consultation has been conducted to identify appropriate policy instruments based on multi-criteria evaluation. Through this research, eleven policy instruments have been identified in connection with the promotion of RECP measures in the country with the target of developing low carbon industrial operation. Among the eleven policy instruments seven policy instruments have been identified as prioritized policy instruments based on multi-criteria evaluation through stakeholder consultation. Apart from the prioritized policy instruments the Government of Bangladesh (GoB) has to make realistic sector wise policies and specific policy targets to be achieved within timeline. The GoB has to increase
Preparation and Evaluation of Diphtheria Toxoid-Containing Microspheres
Seyed Alireza Mortazavi,Ali Rezaei Mokarram
Iranian Journal of Pharmaceutical Research , 2004,
Abstract: Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidificationmethod was adopted for microencapsulation of DT. In the first step, following the purification of semi-crude DT by the ion-exchange column chromatography technique, the antigenicity and biological characteristics of DT were investigated by the bicinchoninic acid protein assay, ELISA and western blot techniques. Results showed that the purification process was successful and the purified toxoid gave an activity of 1500 Lf/ml; which was three times more than that of the semi-crude toxoid. Next, DT-loaded microspheres were prepared and characterized for their surface morphology, particle size distribution, loading efficiency and invitro antigenically active DT release. This study showed that the loading efficiency of CS microspheres depends on the MW, as well as the type of cross-linker used, such that, microspheres prepared by high MW CS and glutaraldehyde (cross-linking agent) had the highest DT loading level (95.61±3.57 percent). Size distribution studies showed that theparticle size of microspheres prepared by low and medium MW CS solutions with a concentration of 1 %w/v was below 10 mm. These microspheres also had a smoother surface morphology than those prepared using high MW CS solutions with concentrations above1 %w/v. In addition, by investigating the antigenicity of the prepared CS microsphere, no significant reduction in the activity of DT before and after microencapsulation was noted.Finally, in-vitro release studies showed an initial burst effect followed by an extended release of antigenically active DT over a period of 15 days.of antigenically active DT over a period of 15 days.
A High-Speed High-Input Range Four Quadrant Analog Multiplier
M. Mokarram,A. Khoei,Kh. Hadidi
Majlesi Journal of Electrical Engineering , 2010, DOI: 10.1234/mjee.v4i1.2
Abstract: In this paper, a CMOS four quadrant multiplier based on flipped voltage follower and differential squaring circuit is presented. The proposed circuit has a compact architecture operating at a higher speed and a higher input voltage range compared to the previously presented structures. The transistors operate in the both saturation and ohmic regions. The circuit operates with a single supply voltage of 3.3V in a 0.35 μm CMOS technology where the total harmonic distortion (THD) is less than 1.1%, the linearity error is also less than 3%, -3db frequency is more than 180 MHz and the voltage input range is 3V . Simulation results are given to verify the functionality of the proposed multiplier.
Recurrent Support and Relevance Vector Machines Based Model with Application to Forecasting Volatility of Financial Returns  [PDF]
Altaf Hossain, Mohammed Nasser
Journal of Intelligent Learning Systems and Applications (JILSA) , 2011, DOI: 10.4236/jilsa.2011.34026
Abstract: In the recent years, the use of GARCH type (especially, ARMA-GARCH) models and computational-intelligence-based techniques—Support Vector Machine (SVM) and Relevance Vector Machine (RVM) have been successfully used for financial forecasting. This paper deals with the application of ARMA-GARCH, recurrent SVM (RSVM) and recurrent RVM (RRVM) in volatility forecasting. Based on RSVM and RRVM, two GARCH methods are used and are compared with parametric GARCHs (Pure and ARMA-GARCH) in terms of their ability to forecast multi-periodically. These models are evaluated on four performance metrics: MSE, MAE, DS, and linear regression R squared. The real data in this study uses two Asian stock market composite indices of BSE SENSEX and NIKKEI225. This paper also examines the effects of outliers on modeling and forecasting volatility. Our experiment shows that both the RSVM and RRVM perform almost equally, but better than the GARCH type models in forecasting. The ARMA-GARCH model is superior to the pure GARCH and only the RRVM with RSVM hold the robustness properties in forecasting.
In Vitro Organogenesis of Colocasia esculenta cv. Antiquorum L.  [PDF]
Md. Jahangir Hossain
American Journal of Plant Sciences (AJPS) , 2012, DOI: 10.4236/ajps.2012.36085
Abstract: In vitro organogenesis of an upland species of Colocasia esculenta cv. antiquorum L. was examined in relation to different explants like meristem and parenchymatous storage tissues with or without anthocyanin layer, four levels of each of Kn, 2,4-D, NAA and BAP and four incubation environments such as: 1) 16 h 3 Kl light intensity + 24°C ± 2°C; 2) 24 h dark + 24°C ± 2°C; 3) 24 h dark + 30°C ± 3°C and 4) 12 h diffuse light + 30°C ± 3°C. Only meristems showed proliferation with various degree of intensity both at 16 h 3 Kl light + 24°C ± 2°C and 24 h dark + 24°C ± 2°C conditions and poor response with different levels of Kn + NAA either in light or in the dark. Cultures with NAA + BAP were proliferated very quickly with very high degree of intensity. The cultures under dark did not proliferate for 20 days which upon transfer to light showed high degree of proliferation. Cultures with NAA + BAP formed calluses more pronouncedly at dark than that occurred in the light. Parenchymatous tissues with or without anthocyanin did not proliferate but the tissues with anthocyanin lost pigmentation after 25 - 30 days and turned to grey colour after 50 days while tissues without anthocyanin turned to green colour with shinny pimples indicating that protocorm may be developed. No culture under high temperature environment (30°C ± 3°C) neither survived nor proliferated. The meristems in culture were died within 15 - 20 days while others within 25-30 days. In conclusion, a combination of NAA (0.5 - 3.0 mg/l) and BAP (0.5 - 2.0 mg/l) and an incubation photoperiod of 16 h coupled with temperature of 24°C ± 2°C were found most suitable for in vitro culture of Colocasia esculenta cv. antiquorum L.
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