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Search Results: 1 - 10 of 35937 matches for " Hong SC "
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Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups
Hong SC,Lee JH,Lee J,Kim HY
International Journal of Nanomedicine , 2011,
Abstract: Seong Cheol Hong1,*, Jong Ho Lee1,*, Jaewook Lee1, Hyeon Yong Kim1, Jung Youn Park2, Johann Cho3, Jaebeom Lee1, Dong-Wook Han11Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience and Nanotechnology, Pusan National University, 2Department of Biotechnology Research, National Fisheries Research and Development Institute, Busan, 3Electronic Materials Lab, Samsung Corning Precision Materials Co, Ltd, Gumi City, Gyeongsangbukdo, Korea*These authors contributed equally to this workAbstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely utilized for the diagnosis and therapy of specific diseases, as magnetic resonance imaging (MRI) contrast agents and drug-delivery carriers, due to their easy transportation to targeted areas by an external magnetic field. For such biomedical applications, SPIONs must have multifunctional characteristics, including optimized size and modified surface. However, the biofunctionality and biocompatibility of SPIONs with various surface functional groups of different sizes have yet to be elucidated clearly. Therefore, it is important to carefully monitor the cytotoxicity and genotoxicity of SPIONs that are surfaced-modified with various functional groups of different sizes. In this study, we evaluated SPIONs with diameters of approximately 10 nm and 100~150 nm, containing different surface functional groups. SPIONs were covered with –O-groups, so-called bare SPIONs. Following this, they were modified with three different functional groups – hydroxyl (–OH), carboxylic (–COOH), and amine (–NH2) groups – by coating their surfaces with tetraethyl orthosilicate (TEOS), (3-aminopropyl)trimethoxysilane (APTMS), TEOS-APTMS, or citrate, which imparted different surface charges and sizes to the particles. The effects of SPIONs coated with these functional groups on mitochondrial activity, intracellular accumulation of reactive oxygen species, membrane integrity, and DNA stability in L-929 fibroblasts were determined by water-soluble tetrazolium, 2',7'-dichlorodihydrofluorescein, lactate dehydrogenase, and comet assays, respectively. Our toxicological observations suggest that the functional groups and sizes of SPIONs are critical determinants of cellular responses, degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity. Nanoparticles with various surface modifications and of different sizes induced slight, but possibly meaningful, changes in cell cytotoxicity and genotoxicity, which would be significantly valuable in further studies of bioconjugation
Supporting the Success of Students—One of the Factors to Optimize the Role of the School through Its Cooperation with the Family  [PDF]
Sc. Vlora Sylaj
Creative Education (CE) , 2013, DOI: 10.4236/ce.2013.45044
Abstract:

This article aims to contribute to the growing interest and consideration to support the success of students by the school and the family. This actually leads to the optimization of the role of the school. Through answering the research questions, the paper could serve readers to reflect for the better cooperation between parents and school in terms of supporting the success of students. This study reflects upon the importance of qualitative collaboration, namely to enrich the public opinion with the valuable information about the cooperation between school and home. The purpose of this article is to ascertain whether it affects the level of contacts between school and family by supporting the success of students from the school. This study used quantitative method and aims to find answers to the following questions: What are the school and the family factors that support the success of students? Does this affect the level of contacts between the family and the school? Research hypothesis: The level of contacts between the school and families affected by the support by the school for students’ success. We have included 400 teachers and 400 parents from rural areas in this study, as well as 300 teachers and 300 parents of fourth classes’ from the urban areas. They come from the various city schools in Kosovo. Systematic sample was randomly selected, and we have compiled the questionnaire. A team of pedagogues, who have been previously trained to use this questionnaire, took attitudes of both subjects. Data were analyzed by SPSS 20 program. The study has reached some findings and conclusions. Participants’ responses indicate that the level of contact between the school and families is affected by the factor supporting the success of students by the school.

Risk factors in patients with AFB smear-positive sputum who receive inappropriate antituberculous treatment
Chang CY, Hong JY, Yuan MK, Chang SJ, Lee YM, Chang SC, Hsu LC, Cheng SL
Drug Design, Development and Therapy , 2013, DOI: http://dx.doi.org/10.2147/DDDT.S39247
Abstract: k factors in patients with AFB smear-positive sputum who receive inappropriate antituberculous treatment Original Research (932) Total Article Views Authors: Chang CY, Hong JY, Yuan MK, Chang SJ, Lee YM, Chang SC, Hsu LC, Cheng SL Published Date January 2013 Volume 2013:7 Pages 53 - 58 DOI: http://dx.doi.org/10.2147/DDDT.S39247 Received: 16 October 2012 Accepted: 21 November 2012 Published: 31 January 2013 Cheng-Yu Chang,1,* Jen-Yee Hong,2,* Mei-Kang Yuan,3,4 Shu-Ju Chang,5 Yuan-Ming Lee,6 Shih-Chieh Chang,2,4 Li-Cho Hsu,2,* Shin-Lung Cheng1 1Division of Chest Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan; 2Department of Internal Medicine, 3Department of Radiology, 4Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 5Department of Industrial Management and Enterprise Information, Aletheia University, Taipei, Taiwan; 6Department of Laboratory Medicine, National Yang-Ming University Hospital, Yilan, Taiwan *These authors contributed equally to this work Background: Acid-fast bacilli (AFB) smear-positive sputum is usually an initial clue in the diagnosis of pulmonary tuberculosis (TB); however, the test is not disease-specific. Nontuberculous mycobacterium-related colonization or lung disease often has AFB smear-positive sputum results, and physicians may prescribe unnecessary antituberculous drugs for these patients. The aim of this study was to analyze the clinical characteristics of patients with AFB smear-positive sputum who received unnecessary anti-TB treatment. Methods and patients: From January 2008 to July 2011, we retrospectively enrolled 97 patients with AFB smear-positive sputum who did not have pulmonary TB according to mycobacterial cultures and clinical judgment. We analyzed the clinical and radiographic features of the patients who received inappropriate and unnecessary anti-TB treatment. Preliminary analyses of chi-square and Fisher's exact tests were applied to determine factors unlikely to be associated with the independent variables. The relationship between independent covariates was then analyzed using multivariate logistic regression. Results: Of the 97 enrolled patients, 25 (25.8%) were diagnosed with pulmonary TB and prescribed anti-TB drugs (mostly a combination of isoniazid, rifampicin, ethambutol, and pyrazinamide). The other 72 (74.2%) patients were not initially diagnosed with pulmonary TB and were classified as the control group. Compared to the control group, the patients who received inappropriate anti-TB treatment had more chronic cough as presentation symptom and heavy AFB Ziehl–Neelsen staining in sputum (>10/100 fields, grading 2+ to 4+). There were no significant differences in the radiographic analysis between the two groups. Conclusion: Among the patients with AFB smear-positive sputum that did not have pulmonary TB, chronic cough and heavy AFB staining (2+ to 4+) were risk factors for the inappropriate administration of unnecessar
Efficacy of quetiapine in patients with bipolar I and II depression: a multicenter, prospective, open-label, observational study
Jeong JH, Bahk WM, Woo YS, Seo HJ, Hong SC, Jon DI, Min KJ, Yoon BH
Neuropsychiatric Disease and Treatment , 2013, DOI: http://dx.doi.org/10.2147/NDT.S41081
Abstract: acy of quetiapine in patients with bipolar I and II depression: a multicenter, prospective, open-label, observational study Original Research (869) Total Article Views Authors: Jeong JH, Bahk WM, Woo YS, Seo HJ, Hong SC, Jon DI, Min KJ, Yoon BH Published Date February 2013 Volume 2013:9 Pages 197 - 204 DOI: http://dx.doi.org/10.2147/NDT.S41081 Received: 03 December 2012 Accepted: 08 January 2013 Published: 12 February 2013 Jong-Hyun Jeong,1 Won-Myong Bahk,1 Young Sup Woo,1 Ho-Jun Seo,1 Seung-Chul Hong,1 Duk-In Jon,2 Kyung Joon Min,3 Bo-Hyun Yoon4 1Department of Psychiatry, College of Medicine, The Catholic of University of Korea, Seoul, 2Department of Psychiatry, College of Medicine, Hallym University, Anyang, 3Department of Neuropsychiatry, College of Medicine, Chung-Ang University, Seoul, 4Naju National Hospital, Naju, Korea Purpose: To evaluate and compare the therapeutic efficacy of quetiapine in bipolar I and II depression patients in the clinical setting. Patients and methods: This was an 8-week, multicenter, open-label, observational study for bipolar depression. The dosage of quetiapine was flexible, and concomitant medications were permitted on clinician's judgments. A total of 1097 patients were enrolled, and 764 bipolar depression patients who exhibited good therapeutic compliance (>75% compliance rate) were analyzed. Results: Clinical Global Impression – Bipolar scale and Montgomery–Asberg Depression Rating Scale scores were significantly improved at weeks four and eight compared with the baseline scores. At the end of the 8-week study, the response rate was 58.9%, and the remission rate was 42.1%. However, there were no significant differences in the response and remission rates between bipolar I and II disorder (BD-I and BD-II) patients (response rate 60.1% versus 56.3%; remission rate 44.5% versus 37.0%). Montgomery–Asberg Depression Rating Scale score at baseline (β = 0.612, P < 0.001), duration of current episode (β = 0.152, P = 0.001), and presence of remission on previous episode (β = 0.111, P = 0.012) were significantly associated with improvements in depressive symptoms. Fatigue (16.0%), somnolence (14.9%), and manic/hypomanic switching (0.6% at week four, 0.3% at week eight) were observed throughout the study period. Conclusion: The results of this study suggest that quetiapine improves depressive symptoms in BD-I and BD-II patients with a minimal incidence of manic switching. The therapeutic efficacy of quetiapine increased with time. Quetiapine could be an effective and safe modality for the treatment of BD-I and BD-II.
Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups
Hong SC, Lee JH, Lee J, Kim HY, Park JY, Cho J, Lee J, Han DW
International Journal of Nanomedicine , 2011, DOI: http://dx.doi.org/10.2147/IJN.S26355
Abstract: btle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups Original Research (4218) Total Article Views Authors: Hong SC, Lee JH, Lee J, Kim HY, Park JY, Cho J, Lee J, Han DW Published Date December 2011 Volume 2011:6 Pages 3219 - 3231 DOI: http://dx.doi.org/10.2147/IJN.S26355 Seong Cheol Hong1,*, Jong Ho Lee1,*, Jaewook Lee1, Hyeon Yong Kim1, Jung Youn Park2, Johann Cho3, Jaebeom Lee1, Dong-Wook Han1 1Department of Nanomedical Engineering, BK21 Nano Fusion Technology Division, College of Nanoscience and Nanotechnology, Pusan National University, 2Department of Biotechnology Research, National Fisheries Research and Development Institute, Busan, 3Electronic Materials Lab, Samsung Corning Precision Materials Co, Ltd, Gumi City, Gyeongsangbukdo, Korea *These authors contributed equally to this work Abstract: Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely utilized for the diagnosis and therapy of specific diseases, as magnetic resonance imaging (MRI) contrast agents and drug-delivery carriers, due to their easy transportation to targeted areas by an external magnetic field. For such biomedical applications, SPIONs must have multifunctional characteristics, including optimized size and modified surface. However, the biofunctionality and biocompatibility of SPIONs with various surface functional groups of different sizes have yet to be elucidated clearly. Therefore, it is important to carefully monitor the cytotoxicity and genotoxicity of SPIONs that are surfaced-modified with various functional groups of different sizes. In this study, we evaluated SPIONs with diameters of approximately 10 nm and 100~150 nm, containing different surface functional groups. SPIONs were covered with –O-groups, so-called bare SPIONs. Following this, they were modified with three different functional groups – hydroxyl (–OH), carboxylic (–COOH), and amine (–NH2) groups – by coating their surfaces with tetraethyl orthosilicate (TEOS), (3-aminopropyl)trimethoxysilane (APTMS), TEOS-APTMS, or citrate, which imparted different surface charges and sizes to the particles. The effects of SPIONs coated with these functional groups on mitochondrial activity, intracellular accumulation of reactive oxygen species, membrane integrity, and DNA stability in L-929 fibroblasts were determined by water-soluble tetrazolium, 2',7'-dichlorodihydrofluorescein, lactate dehydrogenase, and comet assays, respectively. Our toxicological observations suggest that the functional groups and sizes of SPIONs are critical determinants of cellular responses, degrees of cytotoxicity and genotoxicity, and potential mechanisms of toxicity. Nanoparticles with various surface modifications and of different sizes induced slight, but possibly meaningful, changes in cell cytotoxicity and genotoxicity, which would be significantly valuable in further studies of bioconjugation and cell interaction for drug delivery, cell cu
Species versus gene selection
SC Tsakas
Genetics Selection Evolution , 1989, DOI: 10.1186/1297-9686-21-3-247
Abstract:
Other new radiotherapy techniques
SC Formenti
Breast Cancer Research , 2009, DOI: 10.1186/bcr2271
Abstract: Five consecutive prospective trials explored hypofractionated, accelerated regimens of breast radiotherapy that also aim at optimal normal tissue sparing.After pilot-testing a 3-week prone regimen of IMRT to the breast with a concomitant boost to the tumor bed, we have prospectively studied in a cohort of 400 women whether a prone versus a supine setup for treatment was superior at sparing lung and heart tissue, while assuring target (index breast) coverage. The results of this trial indicate that the prone setup is superior in >90% of patients.The prone setup also characterizes our two studies of partial breast irradiation delivered over five fractions of 6 Gy each. At NYU this approach is only offered to the subset of patients at the lowest risk of local recurrence after breast-conserving surgery, postmenopausal women with T1 lesions, resected with negative margins. Results at a median follow-up of 5 years demonstrate 2% local recurrence rate.Breast radiotherapy after breast-conserving surgery can be safely delivered over 3 weeks. A prone technique enables optimal sparing of the lung and heart in the majority of patients. Current research focuses on a prone setup that includes level III and supraclavicular lymph nodes in patients with positive lymph nodes, to enhance sparing of the lung and heart.
Problems of Indexing Classes of News Based on the Computed Importance of Words
SC Echezona
Bayero Journal of Pure and Applied Sciences , 2008,
Abstract: News is classified. Such classes as sports, politics, news on crime, gossips, business, etc., are common amongst newspapers in Nigeria. Interestingly most readers and patrons of newspapers adopt the rule of the thumb in choosing a suitable newspaper to read/buy. However, most newspapers try to cover all classes but end up in strikingly stress areas. This paper firstly explains the basic steps in generation of Document Indexes then secondly, highlights some of the problems associated with using full automation in classifications. Some of the problems identified are loss of relevance, loss of coverage and partial automation.
A note on the development of biosafety regulations in Zimbabwe and prospects for harmonisation
SC Muchena
African Crop Science Journal , 1995,
Abstract:
Effects of Climate Change on Agricultural Productivity in the Federal Capital Territory (FCT), Abuja, Nigeria
SC Aondoakaa
Ethiopian Journal of Environmental Studies and Management , 2012,
Abstract: The effects of the dynamics of climate on agricultural production are the thrust of this paper. Temperature, rainfall and crops (rice, maize, cassava, groundnut and garden eggs) data were collected for a period of 10 years from the meteorological and agricultural department of the Agricultural development programme (ADP) Gwagwalada. The work assembled and analysed all available data which are needed for evaluating the implication of climate change on agricultural production in the FCT. Some measure of central tendencies were used to critically analyse the parametres such as arithmetic mean, standard deviation, coefficient of variance, simple regression, correlation and multiple regression model to correlate the relationship among rainfall, temperature and crop yield. The paper concludes there exists positive relationship between each climatic element and crop yield but on a very weak significance; there has been constant increase in temperature over the years with 2009 having the highest of 35oC; there is decline in rainfall over the years, and subsequent decline in the productivity of the crops from the correlation carried out in the study. These recommendations were forwarded: Crop yield should be regressed on other environmental factors such as soil fertility etc.; A longer period of data could be collected for better analysis; and data on rainfall, temperature and other crops could be collected and investigated upon to correlate the result with this finding.
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