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Search Results: 1 - 10 of 139305 matches for " Holly K. Tabor? "
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"Women Who Don't Give a Crap"
Holly Tabor
PLOS Genetics , 2015, DOI: 10.1371/journal.pgen.1005736
Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis
Mary J. Emond?,Tin Louie?,Julia Emerson?,Jessica X. Chong?,Rasika A. Mathias?,Michael R. Knowles?,Mark J. Rieder?,Holly K. Tabor,Debbie A. Nickerson?,Kathleen C. Barnes
PLOS Genetics , 2015, DOI: 10.1371/journal.pgen.1005273
Abstract: Discovery of rare or low frequency variants in exome or genome data that are associated with complex traits often will require use of very large sample sizes to achieve adequate statistical power. For a fixed sample size, sequencing of individuals sampled from the tails of a phenotype distribution (i.e., extreme phenotypes design) maximizes power and this approach was recently validated empirically with the discovery of variants in DCTN4 that influence the natural history of P. aeruginosa airway infection in persons with cystic fibrosis (CF; MIM219700). The increasing availability of large exome/genome sequence datasets that serve as proxies for population-based controls affords the opportunity to test an alternative, potentially more powerful and generalizable strategy, in which the frequency of rare variants in a single extreme phenotypic group is compared to a control group (i.e., extreme phenotype vs. control population design). As proof-of-principle, we applied this approach to search for variants associated with risk for age-of-onset of chronic P. aeruginosa airway infection among individuals with CF and identified variants in CAV2 and TMC6 that were significantly associated with group status. These results were validated using a large, prospective, longitudinal CF cohort and confirmed a significant association of a variant in CAV2 with increased age-of-onset of P. aeruginosa airway infection (hazard ratio = 0.48, 95% CI=[0.32, 0.88]) and variants in TMC6 with diminished age-of-onset of P. aeruginosa airway infection (HR = 5.4, 95% CI=[2.2, 13.5]) A strong interaction between CAV2 and TMC6 variants was observed (HR=12.1, 95% CI=[3.8, 39]) for children with the deleterious TMC6 variant and without the CAV2 protective variant. Neither gene showed a significant association using an extreme phenotypes design, and conditions for which the power of an extreme phenotype vs. control population design was greater than that for the extreme phenotypes design were explored.
Analysis of fracture mechanism in austenitic ductile iron with 30%Ni after impact test
P. Putyra,A. Tabor,K. Zar?bski
Archives of Foundry Engineering , 2008,
Abstract: The study presents the results of impact tests carried out on austenitic ductile iron with 30% Ni. The examined material was subjected to dynamic loads within a wide range of temperatures from (–196°C) to (+400°C). The fractures were examined under a JEOL JSM 6460LV scanning electron microscope. Additionally, microstructural examinations were carried out and chemical analysis in microregions was done by EDS.
The quality of cast parts of printing machines
A. Tabor,K. Zar?bski,W. Dziadur
Archives of Foundry Engineering , 2008,
Abstract: Thc study prcscnts thc rcsults of mctnIlognphic cxaminarions and mechanical rcsts cnrrictl out to cvnltlnlc thc cast iron toolhcdwhccl dsmagcd tluring stilndard opcti~tionn s an clcmcnt of thc printing machinc. Thc rcscsrch proccdurcs wcrc tlcscrihcd as wvcll as lhcmsttlrs of invcsligat ions which cnahrcd spccificiit ion of thc supplicd rnntcrial and cvnlunt ion in rcrrns ~ litfs opplirohili~yin thc ninnufncturcor toothcd whccl csslings.
Plastic properties of cold-deformed ironbased sintered materials
K. Zar?bski,S. Okoński,P. Putyra,A. Tabor
Archives of Foundry Engineering , 2010,
Abstract: Cold plastic forming of sintered metal powders has limited practical application because of, among others, the deformation degree andinitial porosity of preforms. Cold forming is combined with a very drastic drop of plastic properties observed in final products. One of the methods that enable regaining the lost plasticity is annealing of sinters after deformation at temperatures above the recrystallisation point. The results of the investigations were presented which aimed at the determination of an effect that the annealing conditions of colddeformed sintered metal powder can have on its structure and mechanical properties. Special attention was drawn to a combined effect of the deformation degree and heat treatment temperature on final plastic properties of the sinters and on their ultimate tensile strength.
Morphology of graphite precipitates in austenitic ductile iron
K. Zar?bski,P. Putyra,B. Khatemi,A. Tabor
Archives of Foundry Engineering , 2011,
Abstract: The final mechanical properties of cast iron depend on the nature and properties of the matrix and on the morphology of graphiteprecipitates. The article presents the results of studies of the structure of austenitic ductile iron with different nickel content. The studies include the identification and stereological description of graphite precipitates. The volume fraction of graphite in cast iron was determined in function of the size of the precipitates and the adopted shape coefficient of single particles, enabling the content of regular spheroids to be estimated.
Austenitic ductile iron for low temperature applications
A. Tabor,P. Putyra,K. Zar?bski,T. Maguda
Archives of Foundry Engineering , 2009,
Abstract: The study presents the results of mechanical tests carried out on austenitic ductile iron with varied nickel content and additions ofchromium and vanadium. The tests and investigations were carried out over a wide range of temperatures, i.e. from -196
Signalling Pathways that Inhibit the Capacity of Precursor Cells for Myelin Repair
Jennifer K. Sabo,Holly S. Cate
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms14011031
Abstract: In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are promising strategies for treatment in demyelinating disorders. Endogenous precursor cells or exogenous transplanted cells are potential sources for remyelinating oligodendrocytes in the central nervous system (CNS). Several signalling pathways have been implicated in regulating the capacity of these cell populations for myelin repair. Here, we review neural precursor cells and oligodendrocyte progenitor cells as potential sources for remyelinating oligodendrocytes and evidence for the functional role of key signalling pathways in inhibiting regeneration from these precursor cell populations.
Selenium and Prostate Cancer Prevention: Insights from the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Holly L. Nicastro,Barbara K. Dunn
Nutrients , 2013, DOI: 10.3390/nu5041122
Abstract: The Selenium and Vitamin E Cancer Prevention Trial (SELECT) was conducted to assess the efficacy of selenium and vitamin E alone, and in combination, on the incidence of prostate cancer. This randomized, double-blind, placebo-controlled, 2 × 2 factorial design clinical trial found that neither selenium nor vitamin E reduced the incidence of prostate cancer after seven years and that vitamin E was associated with a 17% increased risk of prostate cancer compared to placebo. The null result was surprising given the strong preclinical and clinical evidence suggesting chemopreventive activity of selenium. Potential explanations for the null findings include the agent formulation and dose, the characteristics of the cohort, and the study design. It is likely that only specific subpopulations may benefit from selenium supplementation; therefore, future studies should consider the baseline selenium status of the participants, age of the cohort, and genotype of specific selenoproteins, among other characteristics, in order to determine the activity of selenium in cancer prevention.
Nonperturbative calculation of Born-Infeld effects on the Schroedinger spectrum of the hydrogen atom
Holly Carley,Michael K. -H. Kiessling
Mathematics , 2005, DOI: 10.1103/PhysRevLett.96.030402
Abstract: We present the first nonperturbative numerical calculations of the nonrelativistic hydrogen spectrum as predicted by first-quantized electrodynamics with nonlinear Maxwell-Born-Infeld field equations. We also show rigorous upper and lower bounds on the ground state. When judged against empirical data our results significantly restrict the range of viable values of the new electromagnetic constant which is introduced by the Born-Infeld theory. We assess Born's own proposal for the value of his constant.
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