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OALib Journal期刊

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Pattern-reversal electroretinograms for the diagnosis and management of disorders of the anterior visual pathway
Hokazono, Kenzo;Oyamada, Maria Kiyoko;Monteiro, Mário Luiz Ribeiro;
Arquivos Brasileiros de Oftalmologia , 2011, DOI: 10.1590/S0004-27492011000300017
Abstract: the pattern electroretinogram is an electrophysiological test that assesses the function of inner retinal layers, particularly the ganglion cells layer of retina, using a reversing checkerboard or grating pattern that produces no change in average luminance over time. the normal pattern electroretinogram is composed of a proeminent positive component (p50) and a large later negative component (n95). since structural damage that compromises the retinal ganglion cell layer can lead to pattern electroretinogram changes, particularly in the n95 amplitude, the test can be useful in the treatment of a number of anterior visual pathway diseases. in this article, we review the methods for recording pattern electroretinogram and its usefulness in the diagnosis and management of diseases including inflammatory, hereditary, ischemic and compressive lesions of the anterior visual pathway.
Tratamento da retinopatia por radia??o com inje??o intravítrea de bevacizumab (Avastin?): relato de caso
Lavezzo, Marcelo Mendes;Hokazono, Kenzo;Takahashi, Walter Yukihiko;
Arquivos Brasileiros de Oftalmologia , 2010, DOI: 10.1590/S0004-27492010000400016
Abstract: purpose: to report a case of radiation retinopathy treatment with intravitreal injection of bevacizumab (avastin?) in a patient undergoing radiotherapy for lymphoma in the right orbit. patient of 55 years-old male, diabetic, diagnosed with an orbital malt lymphoma three years ago, treated with local radiotherapy (dose: 35gy) two years ago, complaining of reduced visual acuity of the right eye for about four months. during the ophthalmologic evaluation, he had an exam suggestive of radiation retinopathy. macular thickness at the optical coherence tomography was 480 μm. patient was referred to intravitreal injection (0.05 ml) of bevacizumab (avastin?) in the right eye, showing reduction of macular edema and mild improvement of visual acuity. in this case, the treatment of radiation retinopathy with intravitreal injection of bevacizumab (avastin?) was relatively useful, with mild improvement of visual acuity due to the regression of macular edema.
Meningioma do nervo óptico simulando progress?o de dano axonal glaucomatoso: relato de caso
Hokazono, Kenzo;Moura, Frederico Castelo;Monteiro, Mário Luiz Ribeiro;
Arquivos Brasileiros de Oftalmologia , 2008, DOI: 10.1590/S0004-27492008000500023
Abstract: to report a case of an optic nerve sheath meningioma located at the optic canal area mimicking the progression of a glaucomatous axonal damage. a 60-year-old female patient developed progressive visual field loss and enlargement of the optic disc cup in the left eye while in treatment for primary open-angle glaucoma. because of the rapid progression of axonal loss, the asymmetry of the visual field defect and the fact that intraocular pressure had been under control, a compressive optic neuropathy was suspected. a computerized tomography scan of the orbit was normal but a high-resolution magnetic resonance imaging demonstrated an optic nerve sheath meningioma located at the optic canal area. compressive lesions of the anterior visual pathways are uncommon causes of optic disc cupping but should be considered in patients suspected of or undergoing treatment for glaucoma that present with atypical progression of visual loss.
Perfluoroctano em cavidade orbitária após vitrectomia posterior e sutura de perfurante ocular: relato de caso
Lavezzo, Marcelo Mendes;Hokazono, Kenzo;Zacharias, Leandro Cabral;Ttakahashi, Walter Yukihiko;
Arquivos Brasileiros de Oftalmologia , 2011, DOI: 10.1590/S0004-27492011000400015
Abstract: a case of a perfluoro-n-octane leakage into the orbital cavity after corneoscleral suture, scleral buckling and pars plana vitrectomy in an eye with perforating injury after trauma is reported for the first time. a previously healthy 39-year-old man was sent for ophthalmic evaluation one day after suffering a penetrating ocular trauma in his right eye while hammering a nail. on the initial evaluation, the patient presented sudden reduction of visual acuity on his right eye with a perforating corneoscleral injury, intraocular foreign body and retinal detachment. the patient was submitted to corneoscleral suture, pars plana vitrectomy with perfluoro-n-octane administration to flatten the retina and scleral buckling, when it was found transfixation of the globe by the intraocular foreign body. postoperatively, computed tomography scans of the orbit were ordered due to proptosis, which showed the presence of hyperdense images, suggesting leakage of perfluoro-n-octane into the orbital cavity. thus, in cases of perforating eye injury, one should be suspicious about the possibility of intraocular foreign body, as well as possible occurrence of transfixation of the globe when scheduling the surgery.
Síndrome do ápice orbitário causada por herpes zóster oftálmico: relato de caso e revis?o da literatura
Hokazono, Kenzo;Oliveira, Marcelo;Moura, Frederico Castelo;Monteiro, Mário Luiz Ribeiro;
Revista Brasileira de Oftalmologia , 2009, DOI: 10.1590/S0034-72802009000500009
Abstract: herpes zoster ophthalmicus (hzo) is caused by a varicella-zoster virus infection which remains latent in the ganglion of gasser until it is reactivated and compromise the ophthalmic division of the trigeminal nerve. hzo commonly causes neuro-ophthalmic complications such as vesicular lesions in the eyelids, keratoconjunctivitis, sclertis, uveitis, ocular palsy, orbital miositis and optic neuritis. hzo rarely presents as an orbital apex syndrome. this paper describes a patient with of orbital apex syndrome associate and meningitis caused by hzo which was treated with systemic steroids and acyclovir.
Púrpura trombocitopênica imunológica como manifesta??o inicial de lúpus eritematoso sistêmico juvenil
Braga, Josefina Aparecida Pellegrini;Hokazono, Mary;Terreri, Maria Teresa R. A.;Hilário, Maria Odete E.;
Revista Brasileira de Reumatologia , 2003, DOI: 10.1590/S0482-50042003000600013
Abstract: patients with idiopathic thrombocytopenic purpura (itp) present a high trend to develop systemic lupus erythematosus (sle), especially those with chronic presentation. some authors observed that female gender, older patients and familial history of autoimmune disease in patients with idiopathic thrombocytopenic purpura are factors that lead to increased susceptibility for the development of systemic lupus erythematosus. based on these facts, we decided to study 5 children with chronic idiopathic thrombocytopenic purpura and late systemic lupus erythematosus. in this paper, we describe the clinical and laboratorial features of 5 female children with idiopathic thrombocytopenic purpura that later developed systemic lupus erythematosus. all patients were girls, 3 caucasian, with idiopathic thrombocytopenic purpura onset age ranged between 6 years and 3 months and 12 years and 1 month (mean - 9 years and 2 months). the age at systemic lupus erythematosus diagnosis ranged between 8 years and 13 years and 8 months (mean - 10 years and 10 months). though, the gap between idiopathic thrombocytopenic purpura and systemic lupus erythematosus diagnosis ranged between 11 months and 2 years and 9 months (mean - 1 year and 10 months). all patients presented chronic idiopathic thrombocytopenic purpura (thrombocytopenia lasts longer than 6 months). the systemic lupus erythematosus classification criteria were (in decreasing frequency): malar erythema and positivity of ana in 5 patients; arthritis, hematological (thrombocytopenia) and immunological alterations (positivity of anti-dna) in 4 patients; photosensitivity and positivity of anti-cardiolipin in 3 patients. other manifestations included oral ulcers, renal involvement, leukopenia and auto-immune hemolytic anemia, serositis (pericarditis), neurological involvement and positivity of anti-sm antibody. we would like to emphasize this form of presentation of systemic lupus erythematosus, in which the idiopathic thrombocytopenic pu
Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study
Hokazono, Mary;Silva, Gisele Sampaio;Silva, Edina Mariko Koga;Braga, Josefina Aparecida Pellegrini;
Sao Paulo Medical Journal , 2011, DOI: 10.1590/S1516-31802011000300003
Abstract: context and objective: transcranial doppler (tcd) detects stroke risk among children with sickle cell anemia (sca). our aim was to evaluate tcd findings in patients with different sickle cell disease (scd) genotypes and correlate the time-averaged maximum mean (tamm) velocity with hematological characteristics. design and setting: cross-sectional analytical study in the pediatric hematology sector, universidade federal de s?o paulo. methods: 85 scd patients of both sexes, aged 2-18 years, were evaluated, divided into: group i (62 patients with sca/s?0 thalassemia); and group ii (23 patients with sc hemoglobinopathy/s?+ thalassemia). tcd was performed and reviewed by a single investigator using doppler ultrasonography with a 2 mhz transducer, in accordance with the stroke prevention trial in sickle cell anemia (stop) protocol. the hematological parameters evaluated were: hematocrit, hemoglobin, reticulocytes, leukocytes, platelets and fetal hemoglobin. univariate analysis was performed and pearson's coefficient was calculated for hematological parameters and tamm velocities (p < 0.05). results: tamm velocities were 137 ± 28 and 103 ± 19 cm/s in groups i and ii, respectively, and correlated negatively with hematocrit and hemoglobin in group i. there was one abnormal result (1.6%) and five conditional results (8.1%) in group i. all results were normal in group ii. middle cerebral arteries were the only vessels affected. conclusion: there was a low prevalence of abnormal doppler results in patients with sickle-cell disease. time-average maximum mean velocity was significantly different between the genotypes and correlated with hematological characteristics.
Sensibilidade ao contraste na retinopatia diabética tratada por panfotocoagula??o com laser de arg?nio
Maia Júnior, Otacílio de Oliveira;Takahashi, Walter Yukihiko;Sampaio, Marcos Wilson;Hokazono, Kenzo;Misawa, Alexandre Kazuo;
Arquivos Brasileiros de Oftalmologia , 2007, DOI: 10.1590/S0004-27492007000500007
Abstract: purpose: to evaluate contrast sensitivity in patients with diabetic retinopathy (dr) treated with argon laser panphotocoagulation. methods: prospective study of patients with diabetic retinopathy and 20/20 visual acuity, treated with retinal panphotocoagulation, following etdrs criteria. the patients were submitted, initially, to complete ophthalmologic evaluation and contrast sensitivity testing (vision contrast test system). after 3 months of treatment, they were reevaluated by means of visual acuity and contrast sensitivity. results: the sample comprised 28 patients (28 eyes), all with type ii diabetes. a ranged from 45 to 77 years (mean 57.8 ± 8.0), 19 (67.9%) patients were male and 9 (32.1%) female. regarding the type of retinopathy, 18 (64.3%) had proliferative dr and 10 (35.7%) very severe non proliferative rd. no visual acuity alteration was observed after treatment. in relation to contrast sensitivity, there were no alterations between pre and post-treatment in all evaluated spacial frequencies 1.5 (p=0.191); 3.0 (p=0.850); 6.0 (p=0.374); 12.0 (p=0.674) e 18.0 (p=0.443). conclusion: there was no significant alteration in the contrast sensitivity of patients with diabetic retinopathy after panphotocoagulation with argon laser in the studied period.
Influence of Mg, Ag and Al substitutions on the magnetic excitations in the triangular-lattice antiferromagnet CuCrO2
R. Kajimoto,K. Nakajima,S. Ohira-Kawamura,Y. Inamura,K. Kakurai,T. Hokazono,S. Oozono,T. Okuda
Physics , 2012, DOI: 10.7566/JPSJ.82.054702
Abstract: Magnetic excitations in CuCrO$_{2}$, CuCr$_{0.97}$Mg$_{0.03}$O$_{2}$, Cu$_{0.85}$Ag$_{0.15}$CrO$_{2}$, and CuCr$_{0.85}$Al$_{0.15}$O$_{2}$ have been studied by powder inelastic neutron scattering to elucidate the element substitution effects on the spin dynamics in the Heisenberg triangular-lattice antiferromagnet CuCrO$_{2}$. The magnetic excitations in CuCr$_{0.97}$Mg$_{0.03}$O$_{2}$ consist of a dispersive component and a flat component. Though this feature is apparently similar to CuCrO$_{2}$, the energy structure of the excitation spectrum shows some difference from that in CuCrO$_{2}$. On the other hand, in Cu$_{0.85}$Ag$_{0.15}$CrO$_{2}$ and CuCr$_{0.85}$Al$_{0.15}$O$_{2}$ the flat components are much reduced, the low-energy parts of the excitation spectra become intense, and additional low-energy diffusive spin fluctuations are induced. We argued the origins of these changes in the magnetic excitations are ascribed to effects of the doped holes or change of the dimensionality in the magnetic correlations.
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