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The imaging of HIV-related brain disease
J Hoare
Southern African Journal of HIV Medicine , 2009,
Abstract: Advanced HIV disease is strongly associated with an increased occurrence of various neuropsychiatric disorders,1 and highly active antiretroviral therapy (HAART) is an important aspect of managing these conditions effectively. 2 In addition, there is growing recognition that many HIV-infected individuals will develop neuropsychiatric disorders relatively early in the course of HIV disease, in many cases before CD4 cell counts drop below 500 cells/μl.3 However, it is not known who in the earlier phases of the disease will go on to develop neurocognitive disorders, or who will respond to treatment.4,5 New approaches in neuro-imaging have the potential to detect early HIV-associated damage in the brain. Preliminary evidence suggests that the neurotoxic effects of HIV result in damage to white matter tracts in the brain.6 Once damage is established and related cognitive disorders ensue, the ability of HAART to reverse existing dysfunction is probably limited.7 Earlier treatment with HAART in at-risk or minimally symptomatic patients may prevent further decline in cognition and delay the course of HIV disease.
The Toxic Effect on Children of a Degraded U.S. Society, Family, and Educational Context: How Will This Nation Respond?
Carol Hoare
Integral Review , 2008,
Abstract: This paper explores the relationship among conditions in U.S. society andfamilies and U.S. educational achievement data. Such information, along with relateddata from 30 OECD countries, shows a marked decline in the U.S. as a context for childdevelopment and learning. The focus of the paper is on indicators of decline. Data fromthe 2008-2009 Measure of America Human Development Report of the Social ScienceResearch Council, as well as related economic and educational data, are highlighted. Apoint elaborated throughout is that schools are but a microcosm of society, and that theyalone cannot rectify educational deficits. In the concluding section questions are posedabout the will of U.S. citizens and representative institutions and groups to engage inserious change efforts.
Purchasing instruments and consumables
Ingrid Mason,Phil Hoare
Community Eye Health Journal , 2011,
Abstract: Good practice procedures for purchasing surgical instruments and consumables.
Purchasing equipment for an eye unit
Cross C,Hoare P.
Community Eye Health Journal , 2010,
Abstract: If VISION 2020 is to meet its objective of eliminating avoidable blindness in ten years’ time, eye units have to ensure that they have the equipment they need so they can work quickly and effectively. In this article, we aim to show you how to get the best results when purchasing (procuring) equipment.
Instruments for cataract surgery: results from our survey
Daksha Patel,Phil Hoare
Community Eye Health Journal , 2011,
Abstract: For any operation, including cataract surgery, the appropriate instruments must be available and in good working order. If instruments are not available, or are blunt, or do not function properly, it may be necessary to delay or postpone surgery. Using such instruments in an operation can result in a poor outcome, or even pose a risk to surgeons and their assistants.The impact is therefore considerable, and can damage the reputation of the hospital in the community.
An IR Study of the Velocity Structure of the Cometary Compact HII region G29.96-0.02
Stuart Lumsden,Melvin Hoare
Physics , 1996, DOI: 10.1086/177319
Abstract: We have mapped the velocity structure of the cometary compact HII region G29.96-0.02 using long-slit echelle spectra of the HI Br gamma line. This technique detects line emission over a much wider area at the necessary spatial resolution compared to radio recombination line observations. Significant structure in both the velocity centroids and the line widths is seen over the entire nebula. Large line widths are seen ahead of the bow and in the tail which may be due to turbulent motions in shocked and interface regions respectively. We construct analytic models of the density and velocity structure in order to attempt to distinguish between the bow shock and champagne flow models which have been put forward to explain the cometary morphology of many compact HII regions. The bow shock model is unable to explain the large velocity gradient that we see right across the tail of the cometary region which can only be explained by the streaming motions towards low density regions in the champagne model. However, our approximation to the champagne model is also not able to fit all of the features of the data. More realistic versions of this model which include the effects of stellar winds and density gradients may be able to provide a better match to these data.
Determining the Age of Young Embedded Clusters
Joseph Stead,Melvin Hoare
Physics , 2011, DOI: 10.1111/j.1365-2966.2011.19522.x
Abstract: A new Monte Carlo method has been developed in order to derive ages of young embedded clusters within massive star forming regions where there is strong differential reddening. After foreground and infrared excess source candidates are removed, each cluster candidate star is individually dereddened. Simulated clusters are constructed using isochrones, an IMF, realistic photometric errors, simulated background field populations and extinction distributions. These synthetic clusters are then dereddened in the same way as the real data, obtained from a deep near infrared survey, and used to derive the ages of 3 embedded clusters. Results were found to be consistent with those determined using spectrophotometric methods. This new method provides way to determine the ages of embedded clusters when only photometric data are available and there is strong differential reddening.
Four Principles Fundamental to Design Practice for Human Centred Systems
Vita Hinze-Hoare
Computer Science , 2004,
Abstract: A Survey of the principal literature on Human Centred Design reveals the four most referenced principles. These are discussed with reference to the application of a particular website, and a user survey is constructed based upon the four principles.
Should Cyberspace Chat Rooms be closed to protect Children?
Vita Hinze-Hoare
Computer Science , 2004,
Abstract: The explosion of people networking in cyberspace, disseminating terabytes of information, is being promoted through the use of broadband, bluetooth technology, and wireless mobile computing facilities. New communities within such venues as virtual chat rooms discussion groups, newsgroups etc are being created daily and even hourly. This is raising issues of cyberethics concerning privacy,security, crime, human needs, e-business, e-healthcare, e-government and intellectual property among others that need to be evaluated and reflected upon. With this new freedom come new moral and ethical responsibilities, which raise questions as to whether anything can be published or whether there should be restrictions. This paper addresses one specific area, that has come into the public eye, the closure by Microsoft of all of its free chat rooms.
From Digital Television to Internet?
Vita Hinze-Hoare
Computer Science , 2004,
Abstract: This paper provides a general technical overview of the Multimedia Home Platform (MHP) specifications. MHP is a generic interface between digital applications and user machines, whether they happen to be set top boxes, digital TV sets or Multimedia PC's. MHP extends the DVB open standards. Addressed are MHP architexture, System core and MHP Profiles.
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