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Search Results: 1 - 10 of 3790 matches for " Hj?llund Niels Henrik "
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No excess risk of adverse pregnancy outcomes among women with serological markers of previous infection with Coxiella burnetii: evidence from the Danish National Birth Cohort
Nielsen Stine Yde,Andersen Anne-Marie Nybo,M?lbak K?re,Hjllund Niels Henrik
BMC Infectious Diseases , 2013, DOI: 10.1186/1471-2334-13-87
Abstract: Background Q fever caused by Coxiella burnetii is transmitted to humans by inhalation of aerosols from animal birth products. Q fever in pregnancy is suspected to be a potential cause of fetal and maternal morbidity and fetal mortality but the pathogenesis is poorly understood, and even in Q fever endemic areas, the magnitude of a potential association is not established. We aimed to examine if presence of antibodies to C. burnetii during pregnancy or seroconversion were associated with adverse pregnancy outcomes. Methods The Danish National Birth Cohort collected blood samples and interview data from 100,418 pregnant women (1996–2002). We sampled 397 pregnant women with occupational or domestic exposure to cattle or sheep and a random sample of 459 women with no animal exposure. Outcome measures were spontaneous abortion, preterm birth, birth weight and Small for Gestational Age (SGA). Blood samples collected in pregnancy were screened for antibodies against C. burnetii by enzyme-linked immunosorbent assay (ELISA). Samples positive for IgG or IgM antibodies in the ELISA were confirmed by immunofluorescence antibody test (IFA). Results Among the 856 women, 169 (19.7%) women were IFA positive; 147 (87%) of these had occupational or domestic contact with livestock (IFA cutoff > =1:128). Two abortions were IFA positive vs. 6 IFA negative (OR: 1.5; 95%CI: 0.3-7.6). Three preterm births were IFA positive vs. 38 IFA negative (OR: 0.4; 95% CI: 0.1-1.1). There was a significant difference in birth weight of 168 g (95% CI: 70-267 g) with IFA positive being heavier, and the risk of being SGA was not increased in the newborns of IFA positive women (OR: 0.4; 95%CI: 0.8-1.0). Most seropositive women were IgG positive indicating previous exposure. Seroconversion during pregnancy was found in 10 women; they all delivered live babies at term, but two were SGA. Conclusion We found no increased risk of adverse pregnancy outcome in women with verified exposure to C. burnetii. To our knowledge, this is the first population-based seroepidemiologic study evaluating pregnancy outcome in women with serologically verified exposure to C. burnetii against a comparable reference group of seronegative women.
Presence of Antibodies Against Coxiella burnetii and Risk of Spontaneous Abortion: A Nested Case-Control Study
Stine Yde Nielsen, Niels Henrik Hjllund, Anne-Marie Nybo Andersen, Tine Brink Henriksen, Bj?rn Kants?, Karen Angeliki Krogfelt, K?re M?lbak
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031909
Abstract: Background and Aims Q fever is a bacterial zoonosis caused by infection with Coxiella burnetii. It is well established that Q fever causes fetal loss in small ruminants. The suspicion has been raised that pregnant women may also experience adverse pregnancy outcome when the infection is acquired or reactivated during pregnancy. The purpose of this study was to assess the potential association between serologic markers of infection with C.burnetii and spontaneous abortion. Methods A nested case-control study within the Danish National Birth Cohort, a cohort of 100,418 pregnancies recruited from 1996–2002. Women were recruited in first trimester of pregnancy and followed prospectively. Median gestational age at enrolment was 8 weeks (25 and 75 percentiles: 7 weeks; 10 weeks). During pregnancy, a blood sample was collected at gestational week 6–12 and stored in a bio bank. For this study, a case sample of 218 pregnancies was drawn randomly among the pregnancies in the cohort which ended with a miscarriage before 22 gestational weeks, and a reference group of 482 pregnancies was selected in a random fashion among all pregnancies in the cohort. From these pregnancies, serum samples were screened for antibodies against C. burnetii in a commercial enzyme-linked immunosorbent assay (ELISA). Samples that proved IgG or IgM antibody positive were subsequently confirmatory tested by an immunofluorescence (IFA) test. Results Among cases, 11 (5%) were C. burnetii positive in ELISA of which one was confirmed in the IFA assay compared to 29 (6%) ELISA positive and 3 IFA confirmed in the random sample. Conclusions We found no evidence of a higher prevalence of C.burnetii antibodies in serum samples from women who later miscarried and the present study does not indicate a major association between Q fever infection and spontaneous abortion in humans. Very early first trimester abortions were, however, not included in the study.
Religion in der ffentlichkeit: Die Zwei-Regimente-Lehre zwischen Privatisierung und Gouvernementalisierung
Niels Henrik Gregersen
Forum Historiae Iuris , 2008,
Det gr nne uddannelsesimperativ
Niels Henrik Hooge
Studier i P?dagogisk Filosofi , 2012,
Abstract: The paper defines the green education imperative as a normative proposition that expresses a fundamental norm – sustainable development. The proposition combines directions for action, i.e. the right to receive environmental training and education and the duty to provide it, with a specific situation, resulting in an individual norm-based assessment. The imperative has two main interpretations: The strong version, which in its strongest form consists of binding norms that guarantee definitive subjective rights to ecological and sustainable training and education services and an obligation to provide them. The weak version signifies that students have a moral or non-mandatory right to receive environmental training and education, which is not related to any particular institution in any particular professional context at any particular point in time.
The Naturalness of Religious Imagination and the Idea of Revelation
Henrik Gregersen, Niels
Ars Disputandi : the Online Journal for Philosophy of Religion , 2002,
The Naturalness of Religious Imagination and the Idea of Revelation
Henrik Gregersen, Niels
Ars Disputandi : the Online Journal for Philosophy of Religion , 2003,
Abstract: In this article the phenomenon of religious imagination is taken as a test case for discussing the relevance of cognitive science to philosophy of religion and theology. With Lakoff and Johnson ¢ € s Philosophy in the Flesh, it is argued that all human cognitive faculties are both propelled and constrained by metaphors originating from the movements of self-aware bodies in space; accordingly, religious concepts and images are to be treated on par with all other concepts and images. Pascal Boyer ¢ € s Religion Explained is then critically discussed. It is argued that Boyer ¢ € s claim of having ¢ € explained ¢ € religious imagination as counterintuitive blendings of evolutionarily inherited templates is highly problematic. Evolutionary psychology has not yet given any evidence of an evolutionary hard-wiring of religious concepts, and Boyer ¢ € s reference to the mind-set of hunterers and gatherers does not catch the complexity of later developments in religious thought. For all, the internal systematization of religious imageries, and the possibility of a religious self-criticism in terms of philosophy is not reflected in Boyer ¢ € s theory. Religious imagination may indeed be natural; but its naturalness neither counts for nor against the truth-claims involved in religious images.
Tema 2: Brugerinvolvering i design af l reprocesser – refleksioner over et st rre forsknings- og udviklingsprojekt
Simon Heilesen,Niels Henrik Helms
L?ring og Medier , 2012,
Abstract: Innovationsprojektet ELYK har gennem fors g med brugerdrevne, eksperimentelle metoder udviklet forskellige e-l ringskoncepter. Underliggende disse aktiviteter har der v ret arbejdet med forskellige metoder og v ret foretaget begrebsafklaringer. Artiklen introducerer projektets vigtigste metodiske nyskabelser samt de overvejelser om brugere, design og netv rk, der har dannet baggrund for dem. Vi h vder, at "brugeren" er en konstruktion, der m forst s i en given aktivitet og sammenh ng, som rammes ttes af samspillet mellem virksomheder, myndigheder og vidensinstitutioner. Dette anskueligg res gennem en quadruple helix model. Begrebet "didaktisk design" problematiseres ud fra betragtningen, at der i design-aktiviteter er behov for at medt nke og involvere forskellige tilgange samt forskellige kompetencer hos akt rerne. "Design thinking" inddrages for at pointere, at design er en eksplorativ, dialogisk og til dels ogs emotionel og intuitiv proces. Disse overvejelser f rer frem til Firefelt-modellen, en metadesign-model, der har v ret anvendt som grundlag for alle ELYK-udviklingsfors g. Afslutningsvis anskues ELYK-projektet i et bredere perspektiv som afs t for at reflektere over, hvordan en e-l ringsdidaktik kan t nkes i forhold til nye kommunikations- og samarbejdsformer – en f rste skitse til en netv rksdidaktik. De l ringsmuligheder, der ligger i netv rk, transformeres ikke til l ring uden en forst else for s vel l ringsmuligheder og -potentialer, som hvordan potentialerne kan realiseres i forhold til de skiftende kontekster, som mennesker indg r i.
Universal dynamics in the onset of a Hagen-Poiseuille flow
Niels Asger Mortensen,Henrik Bruus
Physics , 2005, DOI: 10.1103/PhysRevE.74.017301
Abstract: The dynamics in the onset of a Hagen-Poiseuille flow of an incompressible liquid in a channel of circular cross section is well-studied theoretically. We use an eigenfunction expansion in a Hilbert space formalism to generalize the results to channels of arbitrary cross section. We find that the steady state is reached after a characteristic time scale tau = (A/P)^2 (1/nu) where A and P are the cross-sectional area and perimeter, respectively, and $\nu$ is the kinematic viscosity of the liquid. For the initial dynamics of the flow rate Q for t<
Neuroinflammation Screening in Immunotherapy Trials against Alzheimer's Disease
Niels Andreasen,Kaj Blennow,Henrik Zetterberg
International Journal of Alzheimer's Disease , 2010, DOI: 10.4061/2010/638379
Abstract: Due to side effects in the form of meningoencephalitis in the interrupted phase II AN1792 trial of active antiamyloid β(Aβ) immunization against Alzheimer's disease (AD), there has been concern that anti-Aβ immunization may cause destructive neuroinflammation. Here, we report on two patients fulfilling clinical AD criteria who were diagnosed with Lyme neuroborreliosis during screening before inclusion in anti-Aβ immunotherapy trials. The two cases illustrate the necessity of careful biochemical screening for neuroinflammatory/neuroinfectious conditions before an AD diagnosis is made and before clinical AD patients are included in trials of therapy that could impact the immune system. Should the two cases have been included and deteriorated, additional investigations might have led to the erroneous conclusion that therapy-induced meningoencephalitis had occurred. 1. Introduction Clinical trials of disease-modifying treatments for AD have been struck by adverse events involving the immune system. In the clinical trial of the active antiamyloid β(Aβ) vaccine AN1792, a small but notable number of patients developed meningoencephalitis [1], and treatment with the passive anti-Aβ immunotherapy AAB001 led to vasogenic edema in some individuals [2]. The Aβ immunogens that are now being used in the second generation of active immunization trials have been modified to reduce the risk of meningoencephalitis. However, academia, industry, and regulators are on their toes to identify immunological side effects as early as possible to avoid patient injury. Therefore, it is of utmost importance to identify and exclude patients who fulfill clinical AD criteria but who already before the start of therapy show biochemical signs of neuroinflammation. A number of standard laboratory tests are useful for this purpose. Typical laboratory findings in patients with neuroinflammatory/neuroinfectious conditions include impaired blood-brain barrier function, as reflected by an elevated ratio of albumin concentrations in cerebrospinal fluid (CSF) and serum/plasma, CSF monocytosis and IgG and IgM bands selectively in CSF [3, 4]. These changes are also seen in therapy-induced meningoencephalitis [1]. We here present two clinical AD cases who were diagnosed with Lyme neuroborreliosis (LNB) during screening for eligibility to enter an anti-Aβ immunotherapy trial. Should the two cases have been included and deteriorated, additional investigations might have led to the erroneous conclusion that therapy-induced meningoencephalitis had occurred. 2. Case Descriptions NO is a 70-year-old
Livestock grazing intensity affects abundance of Common shrews (Sorex araneus) in two meadows in Denmark
Niels M Schmidt, Henrik Olsen, Herwig Leirs
BMC Ecology , 2009, DOI: 10.1186/1472-6785-9-2
Abstract: High grazing intensity had a significant negative effect on Common shrew number compared to low grazing intensity and no grazing. Common shrew abundance was generally, but not significantly, higher on the low grazing intensity plots than on the ungrazed controls. No differences in body mass, sex ratio, or reproductive output between Common shrew individuals from the various grazing treatments were found.No negative effects of low intensity grazing on Common shrew abundance were found compared to the ungrazed control. Low intensity grazing thus seems a suitable management regime for Common shrews, when grazing is needed as part of the meadow management scheme. High intensity grazing on the other hand is not a suitable management tool.In Denmark as well as in most other European countries, the amount of land covered by semi-natural grassland has decreased dramatically during the 20th century concurrent with the general intensification of the agricultural production. To reverse this trend, actions are being taken in many places to either maintain or re-establish this biotope, and in particular, the meadow community. Today's nature conservation is a return to the old extensive agricultural methods, and includes grazing and hay cutting, as well as the abandonment of draining. Semi-natural grassland and in particular meadows constitute important habitat types for a large number of animal species in today's fragmented and intensively cultivated landscape in Europe.Hay cutting and livestock grazing is known to affect a number of organisms, but the response to grazing may vary across classes of organisms and with the intensity of grazing [[1], and references therein]. The effect of haying and grazing on plant diversity and composition is well-documented [e.g. [2-4]]. Also, many avian species may respond to grazing, and certain grazing intensities may favour some species over others [e.g. [5]]. In contrast to this, only limited data on the response of the mammalian vertebrate
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