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Search Results: 1 - 10 of 1541 matches for " Hitoshi Yamanaka "
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Intersection of stable and unstable manifolds for invariant Morse functions
Hitoshi Yamanaka
Mathematics , 2010,
Abstract: We study the structure of the smooth manifold which is defined as the intersection of a stable manifold and an unstable manifold for an invariant Morse-Smale function.
Equivariant hyperbolic diffeomorphisms and representation coverings
Hitoshi Yamanaka
Mathematics , 2013,
Abstract: Let G be a compact Lie group and X be a compact smooth G-manifold with finitely many G-fixed points. We show that if X admits a G-equivariant hyperbolic diffeomorphism having a certain convergence property, there exists an open covering of X indexed by the G-fixed points so that each open set is G-stable and G-equivariantly diffeomorphic to the tangential G-representation at the corresponding G-fixed point. We also show that the converse is also true in case of holomorphic torus actions
Weights of Markov traces for Alexander polynomials of mixed links
Hitoshi Yamanaka
Mathematics , 2011,
Abstract: Using the Fourier expansion of Markov traces for Ariki-Koike algebras over $\mathbb{Q}(q,u_{1},...,u_{e})$, we give a direct definition of the Alexander polynomials for mixed links. We observe that under the corresponding specialization of a Markov parameter, the Fourier coefficients of Markov traces take quite simple form. As a consequence, we show that the Alexander polynomial of a mixed link is essentially equal to the Alexander polynomial of the link obtained by resolving the twisted parts.
Treatment of vitiligo vulgaris with the combination therapy of topical steroid and vitamin D3 compound
Yoko Konishi,Keiichi Yamanaka,Hitoshi Mizutani
Dermatology Reports , 2012, DOI: 10.4081/dr.2012.e8
Abstract: We reported here two cases of vitiligo vulgaris successfully treated with the combination therapy of topical steroid and vitamin D3 compound and currently maintained by vitamin D3 analog without any adverse effects: skin atrophy, striae or telangiectasia on the exposed areas. The best-known mechanism of topical vitamin D3 analog is the enhancement of keratinocytes differentiation and anti-proliferative effects. Vitamin D3 analog is also reported to suppress T-cell mediated immunity, T-cell skin recruitment, and skin infiltration via down-regulating cutaneous lymphocyte antigen expression. Furthermore, vitamin D3 compounds are known to influence melanocyte maturation and differentiation and also to up-regulate melanogenesis. Autoreactive lymphocytes against melanocytes are one of the causes. Topical vitamin D3 analog may control vitiligo itself, however stronger immunosuppressive effects of topical corticosteroid may contribute to rapid re-pigmentation suppressing auto-reactive lymphocytes. The topical combination therapy is a simple, effective and safe option for vitiligo vulgaris in sun-exposed areas.
Investigation of Specifics of Self-Management towards Dealing with Cancer Pain among Adult Outpatients  [PDF]
Masako Yamanaka
Health (Health) , 2018, DOI: 10.4236/health.2018.1011116
Abstract: Purpose: This study aimed to identify specifics of self-management towards dealing with cancer pains among adult outpatients. Methods: Semi-structured interviews were conducted with 16 adult outpatients (9 males and 7 females) who suffered from cancer pain and the data obtained were analyzed using the qualitative synthesis method of KJ Ho. Results: An analysis of the results revealed these key findings for the following symbolic wording of the semi-structured interviews: Cooperative relationship with medical professionals; Problems originating from cancer pain; Self-regulation of analgesic medications based on the interactions with medical professionals; Self-regulation of the analgesic medications based on the physical perceptions of the effects; Self-regulation to maintain a balanced and calm mind, Fulfilling life by the pain alleviation and liberation from the restrictions imposed by the cancer; and Efforts to maintain their lives by themselves. Conclusion: Based on the cooperative relationship established with medical professionals, the patient carried out the self-regulation of cancer pain using analgesics, and self-regulation to maintain a balanced and calm mind. Nurses must therefore sufficiently educate patients regarding how to communicate successfully with medical professionals in order to improve cancer patients’ pain management regarding both physical and mental aspects.
Ustekinumab Improves Psoriasis without Altering T Cell Cytokine Production, Differentiation, and T Cell Receptor Repertoire Diversity
Kenshiro Tsuda, Keiichi Yamanaka, Makoto Kondo, Kimiko Matsubara, Ryogen Sasaki, Hidekazu Tomimoto, Esteban C. Gabazza, Hitoshi Mizutani
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0051819
Abstract: Ustekinumab is a fully human IgG1κ monoclonal antibody targeting interleukin (IL)-12/23 p40 subunit. The role of IL-12/23-mediated pathway in the mechanism of various inflammatory disorders especially psoriasis has been well recognized. Recently the long-term efficacy and safety of ustekinumab in patients with moderate-to-severe psoriasis has been evaluated in phase 2/3 clinical trials, and the results showed no significant risk for serious adverse effects, infections, or malignancies. Ustekinumab inhibits the function of the IL-12/23 p40 subunit, and therefore it is believed that inhibition of IL-12 p40 pathway decreases IFN-γ production. The major concern for the use of ustekinumab is the possibility of increased immunosuppression due to low IFN-γ production. However, the effects of ustekinumab on CD4+ T cell function have not been fully investigated so far. In this study, we explored changes in cytokine production by memory CD4+ T cells as well as in the differentiation of na?ve T cells to helper T cell (Th) 1, Th2, or Th17 cells in psoriasis patients treated with ustekinumab. The effect of the treatment on T cell receptor repertoire diversity was also evaluated. The results showed that ustekinumab improves clinical manifestation in patients with psoriasis without affecting cytokine production in memory T cells, T cell maturation, or T cell receptor repertoire diversity. Although the number of patients is limited, the present study suggests that T cell immune response remains unaffected in psoriasis patients treated with ustekinumab.
The Use of Cavitation Peening to Increase the Fatigue Strength of Duralumin Plates Containing Fastener Holes  [PDF]
Hitoshi Soyama
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.56047

An effective method for improving the fatigue life of Duralumin plates with fastener holes, such as those used in the construction of aircraft, is to introduce a compressive residual stress around the fastener holes. Cavitation peening is a novel peening method that uses the cavitation impact produced when a high-speed water jet is injected into a water-filled chamber. In this paper, Duralumin plate specimens with holes were treated by cavitation peening under various conditions, and the fatigue strength of the specimens was determined using a plate bending fatigue test. It was revealed that a compressive residual stress was introduced not only on surfaces perpendicular to the axis of the cavitating jet but also on the walls of holes which were parallel to this. It was found that a 51% improvement in fatigue strength could be achieved by cavitation peening. Note that this is first report demonstrating an improvement in the fatigue life of Duralumin plates with fastener holes by cavitation peening.

Is Independent Choice Possible?  [PDF]
Hitoshi Inamori
Journal of Quantum Information Science (JQIS) , 2016, DOI: 10.4236/jqis.2016.61005
Abstract: This paper questions the generally accepted assumption that one can make a random choice that is independent of the rest of the universe. We give a general description of any setup that could be conceived to generate random numbers. Based on the fact that the initial state of such setup together with its environment cannot be known, we show that the independence of its generated output cannot be guaranteed. Some consequences of this theoretical limitation are discussed.
No Quantum Process Can Explain the Existence of the Preferred Basis: Decoherence Is Not Universal  [PDF]
Hitoshi Inamori
Journal of Quantum Information Science (JQIS) , 2016, DOI: 10.4236/jqis.2016.63014
Abstract: Environment induced decoherence, and other quantum processes, have been proposed in the literature to explain the apparent spontaneous selection—out of the many mathematically eligible bases—of a privileged measurement basis that corresponds to what we actually observe. This paper describes such processes, and demonstrates that—contrary to common belief—no such process can actually lead to a preferred basis in general. The key observation is that environment induced decoherence implicitly assumes a prior independence of the observed system, the observer and the environment. However, such independence cannot be guaranteed, and we show that environment induced decoherence does not succeed in establishing a preferred measurement basis in general. We conclude that the existence of the preferred basis must be postulated in quantum mechanics, and that changing the basis for a measurement is, and must be, described as an actual physical process.
Dust Resulting from Tire Wear and the Risk of Health Hazards  [PDF]
Masakazu Yamashita, Shohei Yamanaka
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.46059

The present study examined the effects of air pollutants on people’s health, focusing on dust produced from automobile tires while cars drive on roads. The annual volume of dust resulting from tire wear, calculated based on the number of automobiles registered in Japan, was 1747245.4 m3. To put it simply, this translates to approximately 1.4 times the volume of the Tokyo Dome, a famous Japanese baseball stadium. Particulate substances are categorized into three groups depending on their size, and dust resulting from tire wear is classified into the coarse particle mode along with mold spores, pollen, and dust produced from brake pads. This study examined whether or not tire dust causes health damage similarly to pollen, a particulate substance in the same group. There were 38/cm2 dust particles resulting from tire wear on a busy road in Osaka Prefecture, and this number was larger than that of cedar pollen/cm2 (35), a cause of hay fever, identified in Hokkaido. The results suggest that tire dust may also adversely affect the health of people if any of its constituents has a toxicity or causes allergies.

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