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Search Results: 1 - 10 of 2458 matches for " Hisao Ito "
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Long-term Monitoring in Deep Boreholes in the Nankai Subduction Zone
Hisao Ito
Scientific Drilling , 2007, DOI: 10.2204/iodp.sd.s01.43.2007
BABHY—A New Strategy of Hydrofracturing for Deep Stress Measurements
Takatoshi Ito,Kentaro Omura,Hisao Ito
Scientific Drilling , 2007, DOI: 10.2204/iodp.sd.s01.38.2007
Gender difference in QTc prolongation of people with mental disorders
Hiroto Ito, Toshiaki Kono, Shigenobu Ishida, Hisao Maeda
Annals of General Psychiatry , 2004, DOI: 10.1186/1475-2832-3-3
Abstract: We retrospectively reviewed medical charts of patients discharged from a university psychiatric unit between November 1997 and December 2000. Subjects were 328 patients (145 males and 183 females) taking psychotropics at their admission. We examined patient characteristics, medical history, diagnosis, and medication before admission.Mean QTc interval was 0.408 (SD = 0.036). QTc intervals in females were significantly longer than those in males. QTc of females without comorbidity was significantly longer than that of males.The influence of gender difference on QTc prolongation in people with mental disorders merits further research.QT interval prolongation is regarded as an indicator of potential for malignant ventricular arrhythmia [1]. Many antiarryhythmic drugs are known to prolong ventricular repolarisation, and result in the QT interval prolongation. Since prolonged ventricular repolarisation may provoke torsades de pointes and sudden death, measurement of QT interval prolongation is important to identify the high-risk patients and prevent avoidable negative outcomes.Female gender is regarded as a high-risk group of QTc interval prolongation. QTc interval has been reported to be longer in females than in males [2]. A meta-analysis of 332 published cases of torsades de pointes associated with cardiovascular drugs [3] suggested that female were more prone than male to prolong cardiac repolarization. Although females appear to be more protected from coronary heart diseases than males in general population [4], gender differences in QTc interval prolongation and cardiovascular diseases for people with mental disorders are still unknown.In addition to cardiac drugs, there are recently many reports on non-cardiac drugs' effects on QT interval prolongation [5-10]. Such drugs include some antihistamines, antibiotics, antimalarials, antifungal agents, and psychotropic drugs [4]. As to psychotropic drugs for people with mental disorders, some tricyclic antidepressants and
Joint IODP-ICDP Workshop Examines Challenges of Fault Zone Drilling
Harold Tobinjavascript:addMore('auCount'),Hisao Ito,Jan Behrmann,Steve Hickman
Scientific Drilling , 2007, DOI: 10.2204/iodp.sd.s01.80.2007
Estimation of Minimum Principal Stress from an Extended Leak-off Test Onboard the Chikyu Drilling Vessel and Suggestions for Future Test Procedures
Weiren Lin,Koji Yamamoto,Hisao Ito,Hideki Masago
Scientific Drilling , 2008, DOI: 10.2204/iodp.sd.6.06.2008
Abstract: To understand the physics of faulting and rupture propagation for the great M8-class Nankai earthquakes that recur approximately every 100 years, a comprehensive drilling project is underway: the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE; Tobin and Kinoshita, 2007), which is part of the Integrated Ocean Drilling Program (IODP). Stress levels along seismogenic faults must be known in order to understand processes controlling the timing, energetics, and extent of earthquake ruptures. For scientific drilling projects such as NanTroSEIZE, it is very important to determine the in situ stress state at the decollement and the mega splay fault in the Nankai Trough.
Representation of the Basic Laws of Thermodynamics in Quantum Mechanics  [PDF]
Akira Suzuki, Hisao Taira
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.914155
Abstract: We propose a representation of the basic laws, namely the zeroth, first, second and third law, in quantum thermodynamics. The zeroth law is represented by some parameters (\"\") that specify respective quantum states. The parameters are the elements of thermodynamic state space\"\". The introduction of such parameters is based on a probabilistic nature of quantum theory. A quantum analog of the first law can be established by utilizing these parameters. The notion of heat in quantum systems is clarified from the probabilistic point of view in quantum theory. The representation of the second law can be naturally described in terms of these parameters introduced for the respective quantum systems. In obtaining the representation of quantum thermodynamics, consistency between quantum theory and classical thermodynamics should have been preserved throughout our formulation of quantum thermodynamics. After establishing the representation of the second law, the third law is discussed briefly. The relationship between thermodynamic temperatures and the parameters in \"\" is also discussed.
Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver
Yuki Ito,Toshiki Nakamura,Yukie Yanagiba,Doni Hikmat Ramdhan,Nozomi Yamagishi,Hisao Naito,Michihiro Kamijima,Frank J. Gonzalez,Tamie Nakajima
PPAR Research , 2012, DOI: 10.1155/2012/201284
Abstract: Dibutylphthalate (DBP), di(2-ethylhexyl)phthalate (DEHP), and di(2-ethylhexyl)adipate (DEHA) are used as plasticizers. Their metabolites activate peroxisome proliferator-activated receptor (PPAR) α, which may be related to their toxicities. However, species differences in the receptor functions between rodents and human make it difficult to precisely extrapolate their toxicity from animal studies to human. In this paper, we compared the species differences in the activation of mouse and human hepatic PPARα by these plasticizers using wild-type (mPPARα) and humanized PPARα (hPPARα) mice. At 12 weeks old, each genotyped male mouse was classified into three groups, and fed daily for 2 weeks per os with corn oil (vehicle control), 2.5 or 5.0?mmol/kg DBP (696, 1392?mg/kg), DEHP (977, 1953?mg/kg), and DEHA (926, 1853?mg/kg), respectively. Generally, hepatic PPARα of mPPARα mice was more strongly activated than that of hPPARα mice when several target genes involving β-oxidation of fatty acids were evaluated. Interestingly, all plasticizers also activated hepatic constitutive androstane receptor (CAR) more in hPPARα mice than in mPPARα mice. Taken together, these plasticizers activated mouse and human hepatic PPARα as well as CAR. The activation of PPARα was stronger in mPPARα mice than in hPPARα mice, while the opposite was true of CAR. 1. Introduction Dibutylphthalate (DBP), di(2-ethylhexyl)phthalate (DEHP), and di(2-ethylhexyl)adipate (DEHA) are used as representative industrial plasticizers, though the use of the first two considerably decreased recently. These chemicals are involved in peroxisome proliferations, similar to endogenous fatty acids, exogenous fibrates, and thiazolidinediones [1–4]. Once most plasticizers are taken into the body, they are metabolized by lipase in several organs such as liver and small intestine, and their metabolites, especially mono-carboxylic acids, activate peroxisome proliferator-activated receptor alpha (PPARα), and influence the receptor-related lipid metabolism, anti-inflammation, glucose metabolism, and ketogenesis [5]. Peroxisome proliferators (PPs) cause hepatocarcinogenesis in rodents, and PPARα is involved in the mode of action [6]. However, the lower expression of PPARα in human liver [7] and ligand affinity for the agonists [2, 3] has been discussed within the context of how the risk of these chemicals is extrapolated to human from the animal data [8]. Indeed, the International Agency for Research on Cancer downgraded the DEHP carcinogenicity potential from 2B to 3, which produced some conflicting views over the
Mechanism of Cancer Cell Death Induced by Depletion of an Essential Replication Regulator
Sayuri Ito, Ai Ishii, Naoko Kakusho, Chika Taniyama, Satoshi Yamazaki, Rino Fukatsu, Asako Sakaue-Sawano, Atsushi Miyawaki, Hisao Masai
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036372
Abstract: Background Depletion of replication factors often causes cell death in cancer cells. Depletion of Cdc7, a kinase essential for initiation of DNA replication, induces cancer cell death regardless of its p53 status, but the precise pathways of cell death induction have not been characterized. Methodology/Principal Findings We have used the recently-developed cell cycle indicator, Fucci, to precisely characterize the cell death process induced by Cdc7 depletion. We have also generated and utilized similar fluorescent cell cycle indicators using fusion with other cell cycle regulators to analyze modes of cell death in live cells in both p53-positive and -negative backgrounds. We show that distinct cell-cycle responses are induced in p53-positive and -negative cells by Cdc7 depletion. p53-negative cells predominantly arrest temporally in G2-phase, accumulating CyclinB1 and other mitotic regulators. Prolonged arrest at G2-phase and abrupt entry into aberrant M-phase in the presence of accumulated CyclinB1 are followed by cell death at the post-mitotic state. Abrogation of cytoplasmic CyclinB1 accumulation partially decreases cell death. The ATR-MK2 pathway is responsible for sequestration of CyclinB1 with 14-3-3σ protein. In contrast, p53-positive cancer cells do not accumulate CyclinB1, but appear to die mostly through entry into aberrant S-phase after Cdc7 depletion. The combination of Cdc7 inhibition with known anti-cancer agents significantly stimulates cell death effects in cancer cells in a genotype-dependent manner, providing a strategic basis for future combination therapies. Conclusions Our results show that the use of Fucci, and similar fluorescent cell cycle indicators, offers a convenient assay system with which to identify cell cycle events associated with cancer cell death. They also indicate genotype-specific cell death modes induced by deficient initiation of DNA replication in cancer cells and its potential exploitation for development of efficient cancer therapies.
Serum type IV collagen level is predictive for esophageal varices in patients with severe alcoholic disease
Satoshi Mamori, Yasuyuki Searashi, Masato Matsushima, Kenichi Hashimoto, Shinichiro Uetake, Hiroshi Matsudaira, Shuji Ito, Hisato Nakajima, Hisao Tajiri
World Journal of Gastroenterology , 2008,
Abstract: AIM: To determine factors predictive for esophageal varices in severe alcoholic disease (SAD).METHODS: Abdominal ultrasonography (US) was performed on 444 patients suffering from alcoholism. Forty-four patients found to have splenomegaly and/or withering of the right liver lobe were defined as those with SAD. SAD patients were examined by upper gastrointestinal (UGI) endoscopy for the presence of esophageal varices. The existence of esophageal varices was then related to clinical variables.RESULTS: Twenty-five patients (56.8%) had esophageal varices. A univariate analysis revealed a significant difference in age and type IV collagen levels between patients with and without esophageal varices. A logistic regression analysis identified type IV collagen as the only independent variable predictive for esophageal varices (P = 0.017). The area under the curve (AUC) for type IV collagen as determined by the receiver operating characteristic (ROC) for predicting esophageal varices was 0.78.CONCLUSION: This study suggests that the level of type IV collagen has a high diagnostic accuracy for the detection of esophageal varices in SAD.
Pronuclear microinjection is not suitable for RNA polymerase III promoter driven constitutive RNAi transgenesis in mice for XY male-to-female sex reversal by Sry gene knockdown  [PDF]
Masanori Ito
Open Journal of Genetics (OJGen) , 2012, DOI: 10.4236/ojgen.2012.21008
Abstract: Silencing of gene expression by RNA interference (RNAi) has become a widely used tool. For the study of mammalian gene function expression vectors for short hairpin RNA (shRNA) were developed. However the standard methods of shRNA transgenic (Tg) mice production have not been established. Sry (sex-determining region on the Y chromosome) is a mammalian sex-determining gene on the Y chromosome. In mice, the transient expression of Sry in supporting cell precursor cells between 10.5 and 12.5 days post-coitus (dpc) triggers the differentiation of Sertoli cells from granulosa cells. Then high efficiency of Sry gene silencing in Tg mice should induce XY male-to-female sex reversal. An shRNA Tg mouse targeting Sry gene was attempted to be generated by pronuclear microinjection. A low rate (Tg pups/all pups born after microinjection = 2/154 to 7/178) of Tg pups was observed. These Tg mice showed no XY male-to-female sex reversal. The results suggest that exogenous expression of small RNA might exert a negative effect on embryonic development and another approach should be needed for RNAi transgenesis in mice.
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