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Search Results: 1 - 10 of 6222 matches for " Hiroshi Mori "
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Secular Changes in Child Height in Japan and South Korea: Consumption of Animal Proteins and “Essential Nutrients”  [PDF]
Hiroshi Mori
Food and Nutrition Sciences (FNS) , 2018, DOI: 10.4236/fns.2018.912106
Abstract: Child height in Japan and South Korea increased dramatically over the past half century. At age 17 - 18 years, male students in Japan were 2 cm taller in the 1960s through 1970s, still barely taller in the 1980s than S. Korean students, but by the early 1990s they ceased to grow any taller in height, whereas their Korean peers kept increasing in height to overtake their Japanese peers by 3 cm in the mid-2000s. Economic growth was rapid in both countries, but S. Korea some two decades behind Japan. Per capita GDP in Japan was four times that in S. Korea in the mid-1980s and twice in the early-2000s. Food consumption increased conspicuously in both countries, with per capita net supply of animal products in Japan noticeably exceeding that in S. Korea in the early-2000s. However, per capita total caloric intake has been a few hundred kcal/day greater in S. Korea than in Japan since the end of 1970s, mainly from cereals. In particular, S. Koreans have consumed nearly twice as many vegetables as Japanese after the early 1980s. What may deserve attention is that Japanese youth, as compared to their older generations, drastically reduced their consumption of fruit and vegetables in the mid-1970s, whereas their S. Korean counterparts have maintained their consumption of these produce. These contrasts in food consumption patterns may have contributed to the differences in child height development in the two countries.
Period Variability of Coupled Noisy Oscillators
Fumito Mori,Hiroshi Kori
Physics , 2013, DOI: 10.1103/PhysRevE.87.030901
Abstract: Period variability, quantified by the standard deviation (SD) of the cycle-to-cycle period, is investigated for noisy phase oscillators. We define the checkpoint phase as the beginning/end point of one oscillation cycle and derive an expression for the SD as a function of this phase. We find that the SD is dependent on the checkpoint phase only when oscillators are coupled. The applicability of our theory is verified using a realistic model. Our work clarifies the relationship between period variability and synchronization from which valuable information regarding coupling can be inferred.
Inference Methods for Interaction and Noise Intensities Using Only Spike-time Data on Coupled Oscillators
Fumito Mori,Hiroshi Kori
Quantitative Biology , 2013,
Abstract: We propose theoretical methods to infer coupling strength and noise intensity simultaneously through an observation of spike timing in two well-synchronized noisy oscillators. A phase oscillator model is applied to derive formulae relating each of the parameters to some statistics from spike-time data. Using these formulae, each parameter is inferred from a specific set of statistics. We demonstrate the methods with the FitzHugh-Nagumo model as well as the phase model. Our methods do not require any external perturbation and thus are ready for application to various experimental systems.
Evaluation of xerostomia closely associated with systemic diseases using a dental approach  [PDF]
Hiroshi Mori, Noriyuki Hoshi, Motoe Taniguchi, Masako Banka, Katsuhiko Kimoto
Open Journal of Stomatology (OJST) , 2012, DOI: 10.4236/ojst.2012.24047
Abstract: Based on the findings of epidemiological surveys in western countries, the number of person with suspected xerostomia in Japan is estimated to be 30,000,000. Xerostomia is caused by: 1) Systemic diseases; 2) Medications; 3) Tumors or trauma; 4) Radiotherapy; and 5) Neurological factors. Its symptoms can be alleviated, and its progression can be stopped by close cooperation between the dental and medical departments. However, at present, symptomatic treatment methods such as water drinking, oral rinsing with water, and administration of Kampo medicines or parasymptomimetic drugs are mainly used, and a standard treatment has not been established. On the other hand, previous studies on xerostomia have reported improvement in dry mouth symptoms using dental approaches or a relationship between the development of candidiasis and the salivary flow rate. Therefore, in this study, to establish a dental method useful for improving xerostomia associated with systemic diseases and medications for them, we restored occlusal function, and as a result, increased the salivary flow rate, and evaluated changes in oral findings.
Human Sebaceous Cis-6-Hexadecenoic Acid: Possible Application of an Innate Antimicrobial Substance to Cosmetic Products for Mucous Membrane  [PDF]
Hiroyuki Araki, Mori Hajime, Eiko Tamura, Hiroshi Hagihara, Hirofumi Takigawa
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2017, DOI: 10.4236/jcdsa.2017.72012
Abstract: The antimicrobial properties of cis-6-hexadecenoic acid (C16:1Δ6), a component of the innate human metabolome, were studied and its application to cosmetic products was investigated in detail. A variety of the resident and transient microbial flora of the skin, oral cavity, and intestine was applied to an investigation of the antimicrobial activity of C16:1Δ6. C16:1Δ6 showed selective antibacterial activity against human microbial pathogens such as Clostridium perfringens (one of the most common causes of food poisoning) and Streptococcus mutans (one of the tooth-decaying bacteria), as well as Staphylococcus aureus. C16:1Δ6 seemed to possess a “species-selective” antibacterial activity against bacteria belonging to the genera Staphylococcus and Clostridium. We performed a preliminary assessment of the application of C16:1Δ6 as an antimicrobial component in a liquid lip gloss by performing preservation efficacy and home-use tests. We noted that the amount of p-hydroxybenzoate was needed in an oily cosmetic, especially liquid lip gloss, could be reduced by replacing p-hydroxybenzoate with C16:1Δ6. We suggest that C16:1Δ6 may find application as a stable antimicrobial substance gentle enough for use in consumer products by its selective antimicrobial characteristics.
Comparison of High-Dose Dexamethasone and Prednisone for Initial Treatment of Adult Primary Immune Thrombocytopenia  [PDF]
Masanao Teramura, Midori Ishiyama, Hiroshi Kazama, Kentaro Yoshinaga, Masayuki Shiseki, Naoki Mori, Toshiko Motoji
Open Journal of Blood Diseases (OJBD) , 2012, DOI: 10.4236/ojbd.2012.24016
Abstract: Prednisone is the most common first-line treatment for adult primary immune thrombocytopenia (ITP). However, the best initial therapeutic approach is still a matter of debate. Prior studies have shown that high-dose dexamethasone (HD-DXM) produces a high sustained efficacy not achieved by conventional prednisone therapy. However, the definition of response widely differs between individual reports, and this heterogeneity makes comparison of the efficacy difficult. The aim of our study was to compare the therapeutic outcomes of a conventional dose of prednisone with HD-DXM for adult ITP patients as initial therapy. Thirty patients treated with prednisone and 22 patients treated HD-DXM were retrospectively analyzed. No significant differences between the HD-DXM and prednisone groups were observed for the rates of complete response (68% vs. 70%) and response (18% vs. 17%). However, 1 year probability of sustained response was significantly greater in the HD-DXM group than in the prednisone group (78% vs. 38%; P = 0.008). No adverse events necessitating discontinuation of treatment were observed in either group. Our retrospective analysis showed that initial treatment with HD-DXM produced longer response duration compared to a conventional dose of prednisone. Randomized clinical trials are warranted to establish the optimal initial steroid therapy for adult ITP.
VITCOMIC: visualization tool for taxonomic compositions of microbial communities based on 16S rRNA gene sequences
Hiroshi Mori, Fumito Maruyama, Ken Kurokawa
BMC Bioinformatics , 2010, DOI: 10.1186/1471-2105-11-332
Abstract: We introduce a web tool named VITCOMIC (VIsualization tool for Taxonomic COmpositions of MIcrobial Community) that can analyze millions of bacterial 16S rRNA gene sequences and calculate the overall taxonomic composition for a microbial community. The 16S rRNA gene sequences of genome-sequenced strains are used as references to identify the nearest relative of each sample sequence. With this information, VITCOMIC plots all sequences in a single figure and indicates relative evolutionary distances.VITCOMIC yields a clear representation of the overall taxonomic composition of each sample and facilitates an intuitive understanding of differences in community structure between samples. VITCOMIC is freely available at http://mg.bio.titech.ac.jp/vitcomic/ webcite.The number of sequenced bacterial genomes has increased rapidly and now exceeds 1,000 [1]; however, we have little information regarding environmental microbes, largely because the majority of them are unculturable [2]. The taxonomic composition of a microbial community can provide important clues to better understand its structure and ecology [3]. Analysis using 16S rRNA genes is a frequently used method to obtain the taxonomic composition of a microbial community [4,5]. Features of 16S rRNA genes include essentiality for all Bacteria and Archaea, mosaic structures of highly conserved regions and variable regions [6,7], and little possibility for horizontal gene transfer [8]. Moreover, the availability of numerous tools and databases specific for the 16S rRNA genes has potentiated taxonomic analyses [9-12].Ultra-deep sequencing of microbial communities using a massively parallel pyrosequencer has recently uncovered relatively rare species in communities [5,13-15]. However, the enormous amounts of sequencing data produced by recent pyrosequencing studies are difficult to effectively analyze using existing computational tools (Additional file 1) [16]. For example, the overall taxonomic composition of each sample i
Surgical Procedures for External Auditory Canal Carcinoma and the Preservation of Postoperative Hearing
Hiroshi Hoshikawa,Takenori Miyashita,Nozomu Mori
Case Reports in Surgery , 2012, DOI: 10.1155/2012/841372
Surgical Procedures for External Auditory Canal Carcinoma and the Preservation of Postoperative Hearing
Hiroshi Hoshikawa,Takenori Miyashita,Nozomu Mori
Case Reports in Surgery , 2012, DOI: 10.1155/2012/841372
Abstract: Carcinoma of the external auditory canal (EAC) is an unusual head and neck malignancy. The pathophysiology of these tumors is different from other skin lesions because of their anatomical and functional characteristics. Early-stage carcinoma of the EAC can be generally cured by surgical treatment, and reconstruction of the EAC with a tympanoplasty can help to retain hearing, thus improving the patients’ quality of life. In this study, we present two cases of early-stage carcinoma of the EAC treated by canal reconstruction using skin grafts after lateral temporal bone resection. A rolled-up skin graft with a temporal muscle flap was useful for keeping the form and maintaining the postoperative hearing. An adequate size of the skin graft and blood supply to the graft bed are important for achieving a successful operation. 1. Introduction The majority of skin cancers of the head and neck are nonmelanoma skin cancers (NMSCs). Basal cell carcinoma and squamous cell carcinoma (SCC) are the most common types of NMSC. Carcinoma of the external auditory canal (EAC) is a rare form of malignancy encountered in otologic or head and neck surgical practices. The characteristic of these tumors are different from those of other skin lesions because of their pathogenesis and location. Although advanced carcinomas of the temporal bone, including the EAC, retain a poor prognosis, a good survival rate in earlier-stage patients was suggested to be possible in 100% of cases [1–3]. Therefore, the posttherapeutic functional and cosmetic preservation are of importance. In this study, we present two cases of early-stage EAC carcinoma and describe the surgical management and postoperative hearing and complications. 2. Case Reports 2.1. Case 1 A 59-year-old female presented with adenoid cystic carcinoma in the posterior-upper region of the EAC (T2N0M0). Magnetic resonance imaging (MRI) showed the tumor in the EAC, and no extension beyond the organ of origin was observed. Computed tomography (CT) showed evidence of bone destruction. No apparent lymph node swelling or distant metastasis was observed. Lateral temporal bone resection with preservation of the stapes was performed. A full thickness skin graft was taken from the posterior part of the auricle. The anterior and inferior parts of the EAC were covered by the skin graft, and a superior extremity of the skin graft was sutured to the inlet of the EAC. A piece of auricle cartilage was placed on the stapes head for conductive reconstruction, and the cartilage and mastoid cavity were sheeted with the fascia. The postoperative
Proliferative Brenner Tumor with Borderline Mucinous Cystadenocarcinoma of the Ovary in a 75-Year-Old Woman  [PDF]
Kenji Niwa, Hiroshi Makino, Yoshio Yamaguchi, Sakae Mori, Nozomi Narikawa, Takuji Tanaka
Open Journal of Pathology (OJPathology) , 2014, DOI: 10.4236/ojpathology.2014.42008

We report here an extremely rare case of proliferative Brenner tumor with borderline mucinous cystadenocarcinoma of the ovary, metastasizing to the pleura in a 75-year-old woman. Massive pleural effusion were present due to metastasis and pseudo-Meigs’ syndrome. The cytological findings from pleural effusion, ascites and tumor imprint were similar, suggesting mucus-producing malignant tumors. After receiving a thoracic drainage for pleural effusion, the patient underwent an exploratory laparotomy to remove the left-ovarian tumor. Histopathological examination revealed proliferative Brenner ovarian tumor with borderline mucinous cystadenocarcinoma, and immunohistochemical examinations for the tumors, even mucus-rich tumor cells were positive for CK 7 and negative for CK 20, suggesting the tumor arising from transitional cells, not from mucus-producing ovarian surface epithelial tumor cells. She underwent four courses of chemotherapy with paclitaxel and carboplatin. The patient showed no signs of recurrence 16 months after the surgery.

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